JP2010524435A5 - - Google Patents
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- JP2010524435A5 JP2010524435A5 JP2010501433A JP2010501433A JP2010524435A5 JP 2010524435 A5 JP2010524435 A5 JP 2010524435A5 JP 2010501433 A JP2010501433 A JP 2010501433A JP 2010501433 A JP2010501433 A JP 2010501433A JP 2010524435 A5 JP2010524435 A5 JP 2010524435A5
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- JP
- Japan
- Prior art keywords
- seq
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- set forth
- region
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000282577 Pan troglodytes Species 0.000 claims 1
- 241000288959 Saguinus Species 0.000 claims 1
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 230000009831 antigen interaction Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07006990 | 2007-04-03 | ||
| EP07006988 | 2007-04-03 | ||
| US91366807P | 2007-04-24 | 2007-04-24 | |
| EP07020641 | 2007-10-22 | ||
| EP07020640 | 2007-10-22 | ||
| EP07020646 | 2007-10-22 | ||
| EP08004741 | 2008-03-13 | ||
| PCT/EP2008/002663 WO2008119566A2 (en) | 2007-04-03 | 2008-04-03 | Cross-species-specific bispecific binders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013218769A Division JP6016747B2 (ja) | 2007-04-03 | 2013-10-22 | 種間特異的二重特異性バインダー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010524435A JP2010524435A (ja) | 2010-07-22 |
| JP2010524435A5 true JP2010524435A5 (enrdf_load_stackoverflow) | 2011-05-19 |
Family
ID=42582614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501433A Revoked JP2010524435A (ja) | 2007-04-03 | 2008-04-03 | 種間特異的二重特異性バインダー |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JP2010524435A (enrdf_load_stackoverflow) |
| DK (1) | DK2155788T3 (enrdf_load_stackoverflow) |
| ES (1) | ES2390243T3 (enrdf_load_stackoverflow) |
| NZ (1) | NZ580746A (enrdf_load_stackoverflow) |
| PT (1) | PT2155788E (enrdf_load_stackoverflow) |
| RS (1) | RS52492B (enrdf_load_stackoverflow) |
| RU (1) | RU2535992C2 (enrdf_load_stackoverflow) |
| SI (1) | SI2155788T1 (enrdf_load_stackoverflow) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20130883T4 (hr) * | 2007-04-03 | 2022-11-25 | Amgen Research (Munich) Gmbh | Međuvrsno specifična cd3-epsilon-vežuća domena |
| CN101675077B (zh) * | 2007-04-03 | 2013-09-04 | 安进研发（慕尼黑）股份有限公司 | 跨种特异性的双特异性结合剂 |
| EP2640750A1 (en) * | 2010-11-16 | 2013-09-25 | Boehringer Ingelheim International GmbH | Agents and methods for treating diseases that correlate with bcma expression |
| WO2012158818A2 (en) * | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| CA2836857C (en) * | 2011-05-21 | 2019-12-03 | Macrogenics, Inc. | Cd3-binding molecules capable of binding to human and non-human cd3 |
| SI3736292T1 (sl) | 2013-12-17 | 2024-08-30 | Genentech, Inc. | Protitelesa proti CD3 in postopki uporabe |
| KR20170003591A (ko) * | 2014-05-28 | 2017-01-09 | 에프. 호프만-라 로슈 아게 | 인간 및 사이노몰구스 cd3 엡실론에 결합하는 항체 |
| JP7020909B2 (ja) * | 2014-07-25 | 2022-02-16 | シトムクス セラピューティクス，インコーポレイティド | 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法 |
| JP6698065B2 (ja) * | 2014-07-31 | 2020-05-27 | アムゲン リサーチ （ミュンヘン） ゲーエムベーハーＡＭＧＥＮ Ｒｅｓｅａｒｃｈ（Ｍｕｎｉｃｈ）ＧｍｂＨ | 組織分布が向上した二重特異性単鎖抗体コンストラクト |
| EP3778640A1 (en) * | 2015-05-01 | 2021-02-17 | Genentech, Inc. | Masked anti-cd3 antibodies and methods of use |
| AU2017233121B2 (en) | 2016-03-15 | 2023-12-21 | Itabmed (Hk) Limited | Multispecific Fab fusion proteins and use thereof |
| KR20190074300A (ko) | 2016-11-15 | 2019-06-27 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이적 항체에 의한 치료를 위한 투약 |
| US10426424B2 (en) | 2017-11-21 | 2019-10-01 | General Electric Company | System and method for generating and performing imaging protocol simulations |
| BR112020016169A2 (pt) | 2018-02-08 | 2020-12-15 | Genentech, Inc. | Moléculas de ligação ao antígeno biespecíficas, ácido nucleico isolado, vetor, célula hospedeira, métodos para produzir a molécula de ligação, conjunto de ácidos nucleicos isolados, conjunto de vetores, conjunto de células hospedeiras, imunoconjugado, composição, uso da molécula de ligação, métodos para tratar ou retardar a progressão de um câncer, métodos para aperfeiçoar a função imune e kit |
| US20230067182A1 (en) * | 2019-11-29 | 2023-03-02 | Boe Technology Group Co., Ltd. | Data Processing Device and Method, and Computer Readable Storage Medium |
| CN114867494B9 (zh) | 2019-12-13 | 2024-01-12 | 基因泰克公司 | 抗ly6g6d抗体及使用方法 |
| JP2022087602A (ja) * | 2020-12-01 | 2022-06-13 | 株式会社バイオピーク | 組換え大腸菌による有用タンパク質の生産性を向上するための培養方法 |
| AU2022273541A1 (en) | 2021-05-14 | 2023-11-30 | Genentech, Inc. | Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin |
| CN115932808B (zh) * | 2022-11-04 | 2025-05-27 | 四川九洲电器集团有限责任公司 | 一种基于多特征融合的被动声纳智能探测方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2179862C1 (ru) * | 2000-12-26 | 2002-02-27 | Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" | Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки |
| RU2005137325A (ru) * | 2003-05-31 | 2006-09-10 | Микромет Аг (De) | Фармацевтическая композиция, содержащая конструкт, специфичный к ерсам |
| US7235641B2 (en) * | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| EP1753783B1 (en) * | 2004-06-03 | 2014-08-06 | Novimmune SA | Anti-cd3 antibodies and methods of use thereof |
| AU2006291005A1 (en) * | 2005-09-12 | 2007-03-22 | Novimmune S.A. | Anti-CD3 antibody formulations |
| US8236308B2 (en) * | 2005-10-11 | 2012-08-07 | Micromet Ag | Composition comprising cross-species-specific antibodies and uses thereof |
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2008
- 2008-04-03 PT PT08735000T patent/PT2155788E/pt unknown
- 2008-04-03 RU RU2009136913/10A patent/RU2535992C2/ru active
- 2008-04-03 ES ES08735000T patent/ES2390243T3/es active Active
- 2008-04-03 RS RS20120412A patent/RS52492B/en unknown
- 2008-04-03 DK DK08735000.5T patent/DK2155788T3/da active
- 2008-04-03 JP JP2010501433A patent/JP2010524435A/ja not_active Revoked
- 2008-04-03 SI SI200830762T patent/SI2155788T1/sl unknown
- 2008-04-03 NZ NZ580746A patent/NZ580746A/en unknown