JP2010523680A5 - - Google Patents
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- JP2010523680A5 JP2010523680A5 JP2010503084A JP2010503084A JP2010523680A5 JP 2010523680 A5 JP2010523680 A5 JP 2010523680A5 JP 2010503084 A JP2010503084 A JP 2010503084A JP 2010503084 A JP2010503084 A JP 2010503084A JP 2010523680 A5 JP2010523680 A5 JP 2010523680A5
- Authority
- JP
- Japan
- Prior art keywords
- erbb
- met
- agent
- therapeutic
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003814 drug Substances 0.000 claims 133
- 229940124597 therapeutic agent Drugs 0.000 claims 71
- 239000003795 chemical substances by application Substances 0.000 claims 65
- 206010028980 Neoplasm Diseases 0.000 claims 42
- 201000011510 cancer Diseases 0.000 claims 42
- 210000004027 cell Anatomy 0.000 claims 41
- 230000004544 DNA amplification Effects 0.000 claims 33
- 230000035772 mutation Effects 0.000 claims 32
- 230000001225 therapeutic effect Effects 0.000 claims 27
- 101150105382 MET gene Proteins 0.000 claims 20
- 230000003213 activating effect Effects 0.000 claims 19
- 229940079593 drug Drugs 0.000 claims 17
- 230000004913 activation Effects 0.000 claims 16
- 238000011282 treatment Methods 0.000 claims 14
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 12
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 230000001404 mediated effect Effects 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 6
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 6
- 150000003384 small molecules Chemical class 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 5
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 5
- 230000026731 phosphorylation Effects 0.000 claims 5
- 238000006366 phosphorylation reaction Methods 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 229960005395 cetuximab Drugs 0.000 claims 4
- 229960000575 trastuzumab Drugs 0.000 claims 4
- 101150039808 Egfr gene Proteins 0.000 claims 3
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 3
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 3
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 3
- -1 PF00299804 Chemical compound 0.000 claims 3
- 108020004459 Small interfering RNA Proteins 0.000 claims 3
- 229960001686 afatinib Drugs 0.000 claims 3
- ULXXDDBFHOBEHA-CWDCEQMOSA-N afatinib Chemical compound N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 0.000 claims 3
- 229950002826 canertinib Drugs 0.000 claims 3
- OMZCMEYTWSXEPZ-UHFFFAOYSA-N canertinib Chemical compound C1=C(Cl)C(F)=CC=C1NC1=NC=NC2=CC(OCCCN3CCOCC3)=C(NC(=O)C=C)C=C12 OMZCMEYTWSXEPZ-UHFFFAOYSA-N 0.000 claims 3
- 230000003247 decreasing effect Effects 0.000 claims 3
- 108700021358 erbB-1 Genes Proteins 0.000 claims 3
- 229960001433 erlotinib Drugs 0.000 claims 3
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 3
- 229960002584 gefitinib Drugs 0.000 claims 3
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 229960004891 lapatinib Drugs 0.000 claims 3
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 3
- ZAJXXUDARPGGOC-UHFFFAOYSA-N n-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide Chemical compound C1CN(C)CCN1C(C)(C)C#CC1=CC2=NC=NC(NC=3C=C(Cl)C(F)=CC=3)=C2C=C1NC(=O)C=C ZAJXXUDARPGGOC-UHFFFAOYSA-N 0.000 claims 3
- 229950008835 neratinib Drugs 0.000 claims 3
- ZNHPZUKZSNBOSQ-BQYQJAHWSA-N neratinib Chemical compound C=12C=C(NC\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC(C=C1Cl)=CC=C1OCC1=CC=CC=N1 ZNHPZUKZSNBOSQ-BQYQJAHWSA-N 0.000 claims 3
- WVUNYSQLFKLYNI-AATRIKPKSA-N pelitinib Chemical compound C=12C=C(NC(=O)\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC1=CC=C(F)C(Cl)=C1 WVUNYSQLFKLYNI-AATRIKPKSA-N 0.000 claims 3
- HVXKQKFEHMGHSL-QKDCVEJESA-N tesevatinib Chemical compound N1=CN=C2C=C(OC[C@@H]3C[C@@H]4CN(C)C[C@@H]4C3)C(OC)=CC2=C1NC1=CC=C(Cl)C(Cl)=C1F HVXKQKFEHMGHSL-QKDCVEJESA-N 0.000 claims 3
- 229960000241 vandetanib Drugs 0.000 claims 3
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010064571 Gene mutation Diseases 0.000 claims 2
- 239000002176 L01XE26 - Cabozantinib Substances 0.000 claims 2
- UCEQXRCJXIVODC-PMACEKPBSA-N LSM-1131 Chemical compound C1CCC2=CC=CC3=C2N1C=C3[C@@H]1C(=O)NC(=O)[C@H]1C1=CNC2=CC=CC=C12 UCEQXRCJXIVODC-PMACEKPBSA-N 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- BCZUAADEACICHN-UHFFFAOYSA-N SGX-523 Chemical compound C1=NN(C)C=C1C1=NN2C(SC=3C=C4C=CC=NC4=CC=3)=NN=C2C=C1 BCZUAADEACICHN-UHFFFAOYSA-N 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 229960001292 cabozantinib Drugs 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 229960005061 crizotinib Drugs 0.000 claims 2
- 229940121647 egfr inhibitor Drugs 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 229950007540 glesatinib Drugs 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 229940043355 kinase inhibitor Drugs 0.000 claims 2
- 238000002430 laser surgery Methods 0.000 claims 2
- 238000002647 laser therapy Methods 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- YRCHYHRCBXNYNU-UHFFFAOYSA-N n-[[3-fluoro-4-[2-[5-[(2-methoxyethylamino)methyl]pyridin-2-yl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]carbamothioyl]-2-(4-fluorophenyl)acetamide Chemical compound N1=CC(CNCCOC)=CC=C1C1=CC2=NC=CC(OC=3C(=CC(NC(=S)NC(=O)CC=4C=CC(F)=CC=4)=CC=3)F)=C2S1 YRCHYHRCBXNYNU-UHFFFAOYSA-N 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 2
- 238000002428 photodynamic therapy Methods 0.000 claims 2
- 229950003647 semaxanib Drugs 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 229950005976 tivantinib Drugs 0.000 claims 2
- 238000011277 treatment modality Methods 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 101150022655 HGF gene Proteins 0.000 claims 1
- 102000038030 PI3Ks Human genes 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000033077 cellular process Effects 0.000 claims 1
- 230000008859 change Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 229960001972 panitumumab Drugs 0.000 claims 1
- 230000008569 process Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92338407P | 2007-04-13 | 2007-04-13 | |
| US60/923,384 | 2007-04-13 | ||
| PCT/US2008/004804 WO2008127710A2 (en) | 2007-04-13 | 2008-04-11 | Methods for treating cancer resistant to erbb therapeutics |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014097474A Division JP2014141530A (ja) | 2007-04-13 | 2014-05-09 | ＥｒｂＢ療法に耐性である癌を治療するための方法 |
| JP2016039191A Division JP2016121176A (ja) | 2007-04-13 | 2016-03-01 | ＥｒｂＢ療法に耐性である癌を治療するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523680A JP2010523680A (ja) | 2010-07-15 |
| JP2010523680A5 true JP2010523680A5 (cg-RX-API-DMAC7.html) | 2011-11-04 |
| JP5926487B2 JP5926487B2 (ja) | 2016-05-25 |
Family
ID=39561970
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503084A Active JP5926487B2 (ja) | 2007-04-13 | 2008-04-11 | ＥｒｂＢ療法に耐性である癌を治療するための方法 |
| JP2014097474A Pending JP2014141530A (ja) | 2007-04-13 | 2014-05-09 | ＥｒｂＢ療法に耐性である癌を治療するための方法 |
| JP2016039191A Withdrawn JP2016121176A (ja) | 2007-04-13 | 2016-03-01 | ＥｒｂＢ療法に耐性である癌を治療するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014097474A Pending JP2014141530A (ja) | 2007-04-13 | 2014-05-09 | ＥｒｂＢ療法に耐性である癌を治療するための方法 |
| JP2016039191A Withdrawn JP2016121176A (ja) | 2007-04-13 | 2016-03-01 | ＥｒｂＢ療法に耐性である癌を治療するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8715665B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2076289B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5926487B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008239594B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2683559C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2076289T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2529790T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008127710A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (56)
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| NZ556673A (en) | 2005-02-03 | 2010-03-26 | Gen Hospital Corp | Method for treating gefitinib and/or erlotinib resistant cancer with an EGFR inhibitor |
| EP3488866A1 (en) | 2005-11-04 | 2019-05-29 | Wyeth LLC | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
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| CA2683559C (en) * | 2007-04-13 | 2019-09-24 | Dana Farber Cancer Institute, Inc. | Methods for treating cancer resistant to erbb therapeutics |
| US20090042906A1 (en) * | 2007-04-26 | 2009-02-12 | Massachusetts Institute Of Technology | Methods for treating cancers associated with constitutive egfr signaling |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| SG188802A1 (en) * | 2008-03-06 | 2013-04-30 | Genentech Inc | Combination therapy with c-met and egfr antagonists |
| UY31800A (es) * | 2008-05-05 | 2009-11-10 | Smithkline Beckman Corp | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb |
| ES2531322T3 (es) | 2008-06-17 | 2015-03-13 | Wyeth Llc | Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina |
| EP3175853B1 (en) | 2008-08-04 | 2023-11-01 | Wyeth LLC | Antineoplastic combinations of neratinib and capecitabine |
| KR20110044905A (ko) * | 2008-08-15 | 2011-05-02 | 메리맥 파마슈티컬즈, 인크. | 치료제에 대한 세포의 반응을 예측하는 방법 및 시스템 |
| WO2010022017A2 (en) * | 2008-08-19 | 2010-02-25 | Hartmut Geiger | Method and composition for enhancing hematopoietic stem cell mobilization |
| AU2009300328A1 (en) * | 2008-10-01 | 2010-04-08 | Ludwig Institute For Cancer Research | Methods for the treatment of cancer |
| CA2752232C (en) | 2009-02-12 | 2016-11-22 | Arqule, Inc. | A composition comprising (-)-trans-3-(5,6-dihydro-4h-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1h-indol-3-yl) pyrrolidine-2, 5-dione in combination with a second anti-proliferative agent |
| PT3000467T (pt) | 2009-04-06 | 2023-03-30 | Wyeth Llc | Regime de tratamento utilizando neratinib para o cancro de mama |
| AU2015201262B2 (en) * | 2009-11-13 | 2017-04-27 | Amgen Inc. | Material and methods for treating or preventing her-3 associated diseases |
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| US8895001B2 (en) | 2010-03-11 | 2014-11-25 | Merrimack Pharmaceuticals, Inc. | Use of ErbB3 inhibitors in the treatment of triple negative and basal-like breast cancers |
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| CN108424456B (zh) | 2011-11-23 | 2022-04-26 | 医学免疫有限责任公司 | 特异于her3的结合分子及其用途 |
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| US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
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| KR102373193B1 (ko) | 2012-11-21 | 2022-03-10 | 얀센 바이오테크 인코포레이티드 | 이중특이성 EGFR/c-Met 항체 |
| WO2014110577A1 (en) | 2013-01-14 | 2014-07-17 | Dcb-Usa Llc | Dnazyme for silencing the expression of egfr |
| WO2014182521A1 (en) * | 2013-05-06 | 2014-11-13 | Medimmune, Llc | Diagnostic methods and treatments for cancer |
| US11305012B2 (en) | 2013-09-24 | 2022-04-19 | Medimmune, Llc | Binding molecules specific for HER3 and uses thereof |
| US10196446B2 (en) | 2013-10-14 | 2019-02-05 | Janssen Biotech, Inc. | Cysteine engineered fibronectin type III domain binding molecules |
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| US10745490B2 (en) | 2014-04-11 | 2020-08-18 | Celldex Therapeutics, Inc. | Anti-ErbB antibodies and methods of use thereof |
| KR101751371B1 (ko) * | 2014-06-25 | 2017-06-27 | 연세대학교 원주산학협력단 | 3,4,5-트리하이드록시벤조산, 이의 유도체 또는 이의 염을 유효성분으로 포함하는 수용체 티로신 키나아제 저해제 내성 항암제 조성물 |
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| KR102568559B1 (ko) | 2016-12-14 | 2023-08-18 | 얀센 바이오테크 인코포레이티드 | Cd8a-결합 섬유결합소 iii형 도메인 |
| CN111867586A (zh) * | 2018-03-13 | 2020-10-30 | 得克萨斯州大学系统董事会 | 用于治疗具有egfr激活突变的癌症的方法 |
| MX2021010265A (es) | 2019-02-26 | 2021-09-23 | Janssen Biotech Inc | Terapias de combinacion y estratificacion de pacientes con anticuerpos anti-egfr/c-met biespecificos. |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
| MY208668A (en) | 2019-05-14 | 2025-05-23 | Janssen Biotech Inc | Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors |
| WO2021076543A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Epcam binding fibronectin type iii domains |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| CN114786682B (zh) | 2019-10-14 | 2024-07-16 | Aro生物疗法公司 | 结合cd71的纤维粘连蛋白iii型结构域 |
| BR112022015140A2 (pt) | 2020-02-12 | 2022-10-11 | Janssen Biotech Inc | Tratamento de pacientes que têm mutações de salto do éxon 14 de c-met |
| JP2024517610A (ja) | 2021-04-14 | 2024-04-23 | アロ・バイオセラピューティクス・カンパニー | Ｃｄ７１に結合するフィブロネクチンｉｉｉ型ドメイン |
| KR20240031947A (ko) | 2021-04-14 | 2024-03-08 | 에이알오 바이오테라퓨틱스 컴패니 | Fn3 도메인-시르나 접합체 및 이의 용도 |
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-
2008
- 2008-04-11 CA CA2683559A patent/CA2683559C/en active Active
- 2008-04-11 WO PCT/US2008/004804 patent/WO2008127710A2/en not_active Ceased
- 2008-04-11 JP JP2010503084A patent/JP5926487B2/ja active Active
- 2008-04-11 US US12/450,826 patent/US8715665B2/en active Active
- 2008-04-11 ES ES08742861.1T patent/ES2529790T3/es active Active
- 2008-04-11 EP EP08742861.1A patent/EP2076289B1/en active Active
- 2008-04-11 EP EP14189064.0A patent/EP2851091B1/en active Active
- 2008-04-11 AU AU2008239594A patent/AU2008239594B2/en active Active
- 2008-04-11 DK DK08742861.1T patent/DK2076289T3/da active
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2014
- 2014-04-18 US US14/256,418 patent/US20140296100A1/en not_active Abandoned
- 2014-05-09 JP JP2014097474A patent/JP2014141530A/ja active Pending
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2015
- 2015-12-11 US US14/965,923 patent/US11008620B2/en active Active
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2016
- 2016-03-01 JP JP2016039191A patent/JP2016121176A/ja not_active Withdrawn
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