JP2010522765A5 - - Google Patents

Download PDF

Info

Publication number
JP2010522765A5
JP2010522765A5 JP2010501214A JP2010501214A JP2010522765A5 JP 2010522765 A5 JP2010522765 A5 JP 2010522765A5 JP 2010501214 A JP2010501214 A JP 2010501214A JP 2010501214 A JP2010501214 A JP 2010501214A JP 2010522765 A5 JP2010522765 A5 JP 2010522765A5
Authority
JP
Japan
Prior art keywords
alkyl
compound
formula
independently
hetar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010501214A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010522765A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/058385 external-priority patent/WO2008121687A2/en
Publication of JP2010522765A publication Critical patent/JP2010522765A/ja
Publication of JP2010522765A5 publication Critical patent/JP2010522765A5/ja
Pending legal-status Critical Current

Links

JP2010501214A 2007-03-28 2008-03-27 受容体チロシンキナーゼとしてのイミダゾ［１，２−ａ］ピリジン化合物 Pending JP2010522765A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90855607P 2007-03-28 2007-03-28
PCT/US2008/058385 WO2008121687A2 (en) 2007-03-28 2008-03-27 Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2010522765A JP2010522765A (ja) 2010-07-08
JP2010522765A5 true JP2010522765A5 (en:Method) 2012-03-22

Family

ID=39731287

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010501214A Pending JP2010522765A (ja) 2007-03-28 2008-03-27 受容体チロシンキナーゼとしてのイミダゾ［１，２−ａ］ピリジン化合物

Country Status (7)

Country Link
US (1) US20100144751A1 (en:Method)
EP (1) EP2139888A2 (en:Method)
JP (1) JP2010522765A (en:Method)
CN (1) CN101679422A (en:Method)
CA (1) CA2682231A1 (en:Method)
TW (1) TW200843757A (en:Method)
WO (1) WO2008121687A2 (en:Method)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2467008C2 (ru) * 2007-04-03 2012-11-20 Эррэй Биофарма Инк. СОЕДИНЕНИЯ ИМИДАЗО[1,2-a]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ РЕЦЕПТОРНЫХ ТИРОЗИНКИНАЗ
CN101835787A (zh) 2007-11-30 2010-09-15 诺瓦提斯公司 C2-c5-烷基-咪唑-二膦酸盐
US8987251B2 (en) 2008-08-19 2015-03-24 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
WO2010022081A1 (en) 2008-08-19 2010-02-25 Array Biopharma Inc. Triazolopyridine compounds as pim kinase inhibitors
TWI496779B (zh) 2008-08-19 2015-08-21 Array Biopharma Inc 作為ｐｉｍ激酶抑制劑之三唑吡啶化合物
US8895550B2 (en) 2008-08-19 2014-11-25 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
CA2749837C (en) 2009-01-21 2017-07-11 Rigel Pharmaceuticals, Inc. Derivatives of n2-(3-pyridil or phenyl)-n4-(4-piperidyl)-2,4-pyrimidinediamine useful in the treatment of inflammatory, autoimmune or proliferative diseases
SG175995A1 (en) 2009-06-05 2011-12-29 Pfizer L- ( piperidin-4-yl) -pyrazole derivatives as gpr 119 modulators
WO2011051342A1 (en) 2009-10-30 2011-05-05 Janssen Pharmaceutica Nv IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
EP2332917B1 (en) * 2009-11-11 2012-08-01 Sygnis Bioscience GmbH & Co. KG Compounds for PIM kinase inhibition and for treating malignancy
FR2952934B1 (fr) * 2009-11-23 2012-06-22 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
CN103221392B (zh) 2010-11-17 2015-06-03 埃科特莱茵药品有限公司 桥联螺[2.4]庚酯衍生物
SI2678329T1 (sl) * 2011-02-25 2016-05-31 Array Biopharma Inc. Triazolopiridinske spojine kot inhibitorji kinaze pim
EP2524915A1 (en) 2011-05-20 2012-11-21 Sanofi 2-Amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors
CA2838645C (en) 2011-06-27 2020-03-10 Janssen Pharmaceutica Nv 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
WO2013007768A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
CN104066730B (zh) 2011-10-14 2017-03-08 埃姆比特生物科学公司 杂环化合物及其作为iii型受体酪氨酸激酶调节剂的用途
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
US9669035B2 (en) 2012-06-26 2017-06-06 Janssen Pharmaceutica Nv Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl-[1,2,4]triazolo-[4,3-A]]quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological of metabolic disorders
WO2014009305A1 (en) 2012-07-09 2014-01-16 Janssen Pharmaceutica Nv Inhibitors of phosphodiesterase 10 enzyme
EP2900238B1 (en) 2012-09-28 2017-12-06 Vanderbilt University Fused heterocyclic compounds as selective bmp inhibitors
ES2649156T3 (es) 2013-01-14 2018-01-10 Incyte Holdings Corporation Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
JP6554037B2 (ja) 2013-01-15 2019-07-31 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用なチアゾールカルボキサミドおよびピリジンカルボキサミド化合物
AR097431A1 (es) 2013-08-23 2016-03-16 Incyte Corp Compuestos de carboxamida de furo y tienopiridina útiles como inhibidores de quinasas pim
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
CN104597194B (zh) * 2015-01-15 2016-07-06 武汉轻工大学 3-氯-1，2-丙二醇的高效液相色谱-荧光检测方法
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
US9920032B2 (en) 2015-10-02 2018-03-20 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
RU2764243C2 (ru) 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Гетероциклические соединения в качестве ингибиторов PAD
CA3076476A1 (en) 2017-10-18 2019-04-25 Jubilant Epipad LLC Imidazo-pyridine compounds as pad inhibitors
WO2019087214A1 (en) 2017-11-06 2019-05-09 Jubilant Biosys Limited Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
PL3704120T3 (pl) 2017-11-24 2024-09-16 Jubilant Episcribe Llc Związki heterocykliczne jako inhibitory prmt5
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
BR112020018610A2 (pt) 2018-03-13 2020-12-29 Jubilant Prodel LLC Compostos de fórmula i, fórmula ii, fórmula iii, fórmula iv, fórmula v, fórmula vi, ou seus polimorfos, estereoisômeros, tautômeros, profármacos, solvatos e sais farmaceuticamente aceitáveis dos mesmos e uso dos mesmos; processo de preparação; composição farmacêutica; e método para o tratamento e/ou prevenção de várias doenças, que incluem câncer e doenças infecciosas
WO2019178383A1 (en) 2018-03-14 2019-09-19 Vanderbilt University Inhibition of bmp signaling, compounds, compositions and uses thereof
CN110833556A (zh) * 2018-08-15 2020-02-25 广西梧州制药（集团）股份有限公司 吡唑并嘧啶衍生物在治疗肝纤维化的用途
US20240025892A1 (en) * 2020-08-05 2024-01-25 The General Hospital Corporation Salt inducible kinase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA75055C2 (uk) * 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
WO2003092595A2 (en) * 2002-05-02 2003-11-13 Merck & Co., Inc Tyrosine kinase inhibitors
SG145748A1 (en) * 2003-08-15 2008-09-29 Irm Llc 6-substituted anilino purines as rtk inhibitors
US20050256309A1 (en) * 2004-05-12 2005-11-17 Altenbach Robert J Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands

Similar Documents

Publication Publication Date Title
JP2010522765A5 (en:Method)
AU2021326209B2 (en) EFGR inhibitor, preparation method therefor, and application thereof
AU2018282363B2 (en) Compounds and methods of use
CA2868958C (en) Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
JP5064024B2 (ja) イマチニブの製造方法、及び該方法により製造されたイマチニブ
CN104125957B (zh) 取代的苄基吡唑
TWI690525B (zh) 具有四氫吡喃基甲基之吡啶酮衍生物及其用途
CN104203242B (zh) 取代的喹啉类作为布鲁顿酪氨酸激酶抑制剂
JP2016523973A5 (en:Method)
JP2013544846A5 (en:Method)
CA3142069A1 (en) Aurora kinase inhibitor and use thereof
JP2014503574A5 (en:Method)
JP2011509302A5 (en:Method)
WO2013173254A1 (en) Bicyclic compounds as kinases inhibitors
RU2012151012A (ru) Циклопропиловые дикарбоксамиды и аналоги, обладающие противораковым и антипролиферативным действием
JP2011509301A5 (en:Method)
JP2010528021A5 (en:Method)
CN106986822A (zh) 用于治疗 nk‑1 受体相关疾病的取代的 4‑苯基吡啶
CN105530938A (zh) 用于治疗由逆转录病毒引起的疾病的化合物
JP2010526096A5 (ja) キナーゼ阻害剤として有用なチアゾールおよびピラゾール
JP2017525757A5 (en:Method)
TW201240986A (en) Novel kinase inhibitors
TW202317532A (zh) Aak1抑制劑及其用途
JP2015500884A5 (en:Method)
KR20180028456A (ko) 1,4-디치환 이미다졸 유도체