JP2010521973A5 - - Google Patents
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- Publication number
- JP2010521973A5 JP2010521973A5 JP2009554750A JP2009554750A JP2010521973A5 JP 2010521973 A5 JP2010521973 A5 JP 2010521973A5 JP 2009554750 A JP2009554750 A JP 2009554750A JP 2009554750 A JP2009554750 A JP 2009554750A JP 2010521973 A5 JP2010521973 A5 JP 2010521973A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide
- target
- promoter
- expression
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003729 nucleotide group Chemical group 0.000 claims 40
- 239000002773 nucleotide Substances 0.000 claims 39
- 239000013598 vector Substances 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- 241000196324 Embryophyta Species 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 240000008042 Zea mays Species 0.000 claims 8
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 8
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 8
- 235000005822 corn Nutrition 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 5
- 230000001580 bacterial effect Effects 0.000 claims 5
- 241001133760 Acoelorraphe Species 0.000 claims 4
- 241000589158 Agrobacterium Species 0.000 claims 4
- 241000219194 Arabidopsis Species 0.000 claims 4
- 235000017060 Arachis glabrata Nutrition 0.000 claims 4
- 244000105624 Arachis hypogaea Species 0.000 claims 4
- 235000010777 Arachis hypogaea Nutrition 0.000 claims 4
- 235000018262 Arachis monticola Nutrition 0.000 claims 4
- 240000002791 Brassica napus Species 0.000 claims 4
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims 4
- 229920000742 Cotton Polymers 0.000 claims 4
- 244000068988 Glycine max Species 0.000 claims 4
- 235000010469 Glycine max Nutrition 0.000 claims 4
- 241000219146 Gossypium Species 0.000 claims 4
- 244000020551 Helianthus annuus Species 0.000 claims 4
- 235000003222 Helianthus annuus Nutrition 0.000 claims 4
- 244000061176 Nicotiana tabacum Species 0.000 claims 4
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 4
- 240000000111 Saccharum officinarum Species 0.000 claims 4
- 235000007201 Saccharum officinarum Nutrition 0.000 claims 4
- 240000006394 Sorghum bicolor Species 0.000 claims 4
- 235000011684 Sorghum saccharatum Nutrition 0.000 claims 4
- 241000209140 Triticum Species 0.000 claims 4
- 235000021307 Triticum Nutrition 0.000 claims 4
- 235000020232 peanut Nutrition 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 210000005260 human cell Anatomy 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- OUCUOMVLTQBZCY-BYPYZUCNSA-N (2s)-1-azaniumylpyrrolidine-2-carboxylate Chemical compound NN1CCC[C@H]1C(O)=O OUCUOMVLTQBZCY-BYPYZUCNSA-N 0.000 claims 1
- STGXGJRRAJKJRG-JDJSBBGDSA-N (3r,4r,5r)-5-(hydroxymethyl)-3-methoxyoxolane-2,4-diol Chemical group CO[C@H]1C(O)O[C@H](CO)[C@H]1O STGXGJRRAJKJRG-JDJSBBGDSA-N 0.000 claims 1
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
- PIINGYXNCHTJTF-UHFFFAOYSA-N 2-(2-azaniumylethylamino)acetate Chemical compound NCCNCC(O)=O PIINGYXNCHTJTF-UHFFFAOYSA-N 0.000 claims 1
- IVHVNMLJNASKHW-UHFFFAOYSA-M Chlorphonium chloride Chemical compound [Cl-].CCCC[P+](CCCC)(CCCC)CC1=CC=C(Cl)C=C1Cl IVHVNMLJNASKHW-UHFFFAOYSA-M 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 108091030071 RNAI Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- QCUXLGDVYYRCPI-UHFFFAOYSA-N [O-]P(O)(O)=[S+]N1CCOCC1 Chemical compound [O-]P(O)(O)=[S+]N1CCOCC1 QCUXLGDVYYRCPI-UHFFFAOYSA-N 0.000 claims 1
- 238000003491 array Methods 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89621207P | 2007-03-21 | 2007-03-21 | |
| US60/896,212 | 2007-03-21 | ||
| PCT/US2008/057704 WO2008116094A2 (en) | 2007-03-21 | 2008-03-20 | Combined hairpin-antisense compositions and methods for modulating expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010521973A JP2010521973A (ja) | 2010-07-01 |
| JP2010521973A5 true JP2010521973A5 (https=) | 2011-05-06 |
| JP5759673B2 JP5759673B2 (ja) | 2015-08-05 |
Family
ID=39766774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554750A Active JP5759673B2 (ja) | 2007-03-21 | 2008-03-20 | 組み合わされたヘアピン−アンチセンス組成物および発現を調節するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8796442B2 (https=) |
| EP (1) | EP2129680B1 (https=) |
| JP (1) | JP5759673B2 (https=) |
| AR (3) | AR066194A1 (https=) |
| AU (1) | AU2008228814B2 (https=) |
| BR (1) | BRPI0809130A8 (https=) |
| CA (1) | CA2681323A1 (https=) |
| DK (1) | DK2129680T3 (https=) |
| ES (1) | ES2538217T3 (https=) |
| HU (1) | HUE027018T2 (https=) |
| PL (1) | PL2129680T3 (https=) |
| PT (1) | PT2129680E (https=) |
| WO (1) | WO2008116094A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2129680T3 (pl) | 2007-03-21 | 2015-10-30 | Brookhaven Science Ass Llc | Łączone kompozycje cząsteczek antysensownych o strukturze spinki do włosów oraz sposoby modulacji ekspresji |
| AU2009246363B2 (en) | 2008-05-13 | 2013-10-24 | Gen-Probe Incorporated | Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences |
| WO2011062762A2 (en) * | 2009-11-19 | 2011-05-26 | President And Fellows Of Harvard College | Angiogenin and variants thereof for treatment of neurodegenerative diseases |
| US8785121B2 (en) | 2010-07-08 | 2014-07-22 | Bonac Corporation | Single-stranded nucleic acid molecule for controlling gene expression |
| US8691782B2 (en) | 2010-08-03 | 2014-04-08 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
| ES2527660T3 (es) * | 2010-08-03 | 2015-01-28 | Bonac Corporation | Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno |
| AU2011337658A1 (en) * | 2010-12-02 | 2013-07-04 | Daiichi Sankyo Company, Limited | Modified single-strand polynucleotide |
| CN109810977A (zh) | 2012-05-26 | 2019-05-28 | 株式会社博纳克 | 具有递送功能的基因表达调控用单链核酸分子 |
| CN105899663B (zh) | 2013-12-26 | 2019-07-26 | 学校法人东京医科大学 | 用于基因表达控制的人工模拟miRNA及其用途 |
| SG10201913570XA (en) | 2013-12-27 | 2020-03-30 | Bonac Corp | Artificial match-type mirna for controlling gene expression and use therefor |
| SG11201705223XA (en) | 2014-12-27 | 2017-07-28 | Bonac Corp | NATURALLY OCCURING miRNA FOR CONTROLLING GENE EXPRESSION, AND USE OF SAME |
| JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| MX2022001439A (es) * | 2019-08-02 | 2022-05-06 | Commw Scient Ind Res Org | Moléculas de arn para modular el florecimiento en plantas. |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| JPH0813274B2 (ja) * | 1990-08-13 | 1996-02-14 | アイシス・ファーマシューティカルス・インコーポレーテッド | 遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド |
| US6653458B1 (en) * | 1993-09-03 | 2003-11-25 | Isis Pharmaceuticals, Inc. | Modified oligonucleotides |
| GB9710475D0 (en) | 1997-05-21 | 1997-07-16 | Zeneca Ltd | Gene silencing |
| US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
| TW589189B (en) | 1997-08-04 | 2004-06-01 | Scras | Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis |
| US5952657A (en) | 1997-08-22 | 1999-09-14 | Thermo Microscopes, Corp. | Atomic force microscope with integrated optics for attachment to optical microscope |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| WO1999049029A1 (en) | 1998-03-20 | 1999-09-30 | Benitec Australia Ltd | Control of gene expression |
| NZ507093A (en) | 1998-04-08 | 2003-08-29 | Commw Scient Ind Res Org | Methods and means for reducing the phenotypic expression of a nucleic acid of interest in a plant |
| US6106982A (en) | 1998-05-11 | 2000-08-22 | Avery Dennison Corporation | Imaged receptor laminate and process for making same |
| AR020078A1 (es) | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| GB9827152D0 (en) | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| EP2314700A1 (en) | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US6160215A (en) | 1999-03-26 | 2000-12-12 | Curtin; Lawrence F. | Method of making photovoltaic device |
| WO2000063364A2 (en) | 1999-04-21 | 2000-10-26 | American Home Products Corporation | Methods and compositions for inhibiting the function of polynucleotide sequences |
| IL147026A0 (en) | 1999-07-09 | 2002-08-14 | American Home Prod | Method and compositions for preventing the formation of aberrant rna during transcripting of a plasmid sequence |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| WO2001038551A1 (en) | 1999-11-29 | 2001-05-31 | Cold Spring Harbor Laboratory | Regulation of polycomb group gene expression for increasing seed size in plants |
| RU2164944C1 (ru) | 1999-12-09 | 2001-04-10 | Институт молекулярной биологии им. В.А. Энгельгардта РАН | Способ изменения генетических свойств организма |
| IT1316982B1 (it) | 2000-01-17 | 2003-05-26 | Univ Roma | Isolamento e caratterizzazione di un gene per il silenziamento genicoda n.crassa e suoi usi. |
| EP1272630A2 (en) | 2000-03-16 | 2003-01-08 | Genetica, Inc. | Methods and compositions for rna interference |
| MXPA02009069A (es) | 2000-03-17 | 2004-04-05 | Benitec Australia Ltd | Silenciamiento genetico. |
| WO2001070944A2 (de) | 2000-03-22 | 2001-09-27 | Aventis Pharma Deutschland Gmbh | Nematoden als modellorganismen zur untersuchung neurodegenerativer erkrankungen und insbesonder der parkinsonschen erkrankung, verwendungen und verfahren zum auffinden von substanzen und genen, die bei der behandlung solcher erfrankungen eingesetz werden können, sowie identifizierung eines nematodengens. |
| GB0007268D0 (en) | 2000-03-24 | 2000-05-17 | Cyclacel Ltd | Cell cycle progression proteins |
| ATE513910T1 (de) | 2000-05-30 | 2011-07-15 | Johnson & Johnson Res Pty Ltd | Methoden zur gensuppression mithilfe von rnai verstärkenden faktoren |
| AU2002224838B9 (en) | 2000-11-09 | 2007-02-08 | Cenix Bioscience Gmbh | Eukaryotic cell division genes and their use in diagnosis and treatment of proliferative diseases |
| US20040259247A1 (en) | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20030130186A1 (en) | 2001-07-20 | 2003-07-10 | Chandra Vargeese | Conjugates and compositions for cellular delivery |
| US6566524B2 (en) | 2001-12-21 | 2003-05-20 | The Procter & Gamble Co. | Methods for synthesis of amino-tetrahydroisoquinoline-sulfonamide hydroxamic acids |
| EP1487980A4 (en) * | 2002-03-14 | 2005-08-10 | Commw Scient Ind Res Org | MODIFIED GENE ALDE GENE RNA AND USES THEREOF |
| EP1348943A3 (en) | 2002-03-25 | 2003-12-17 | Sysmex Corporation | Sheath liquid for particle analyzer |
| US20040053876A1 (en) * | 2002-03-26 | 2004-03-18 | The Regents Of The University Of Michigan | siRNAs and uses therof |
| US7387896B2 (en) * | 2003-03-26 | 2008-06-17 | The Regents Of The University Of Michigan | MicroRNA vectors |
| PL2129680T3 (pl) | 2007-03-21 | 2015-10-30 | Brookhaven Science Ass Llc | Łączone kompozycje cząsteczek antysensownych o strukturze spinki do włosów oraz sposoby modulacji ekspresji |
-
2008
- 2008-03-20 PL PL08732595T patent/PL2129680T3/pl unknown
- 2008-03-20 DK DK08732595.7T patent/DK2129680T3/en active
- 2008-03-20 ES ES08732595.7T patent/ES2538217T3/es active Active
- 2008-03-20 US US12/052,658 patent/US8796442B2/en active Active
- 2008-03-20 PT PT87325957T patent/PT2129680E/pt unknown
- 2008-03-20 EP EP20080732595 patent/EP2129680B1/en active Active
- 2008-03-20 HU HUE08732595A patent/HUE027018T2/en unknown
- 2008-03-20 WO PCT/US2008/057704 patent/WO2008116094A2/en not_active Ceased
- 2008-03-20 BR BRPI0809130A patent/BRPI0809130A8/pt not_active Application Discontinuation
- 2008-03-20 AU AU2008228814A patent/AU2008228814B2/en active Active
- 2008-03-20 JP JP2009554750A patent/JP5759673B2/ja active Active
- 2008-03-20 CA CA002681323A patent/CA2681323A1/en not_active Abandoned
- 2008-03-25 AR ARP080101204A patent/AR066194A1/es unknown
-
2011
- 2011-03-23 AR ARP110100994A patent/AR080722A2/es unknown
-
2014
- 2014-08-05 US US14/452,049 patent/US9193972B2/en active Active
- 2014-10-21 AR ARP140103952A patent/AR098140A2/es active IP Right Grant
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