JP2010521973A5 - - Google Patents
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- Publication number
- JP2010521973A5 JP2010521973A5 JP2009554750A JP2009554750A JP2010521973A5 JP 2010521973 A5 JP2010521973 A5 JP 2010521973A5 JP 2009554750 A JP2009554750 A JP 2009554750A JP 2009554750 A JP2009554750 A JP 2009554750A JP 2010521973 A5 JP2010521973 A5 JP 2010521973A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide
- target
- promoter
- expression
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003729 nucleotide group Chemical group 0.000 claims 40
- 239000002773 nucleotide Substances 0.000 claims 39
- 239000013598 vector Substances 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- 241000196324 Embryophyta Species 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 240000008042 Zea mays Species 0.000 claims 8
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 8
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 8
- 235000005822 corn Nutrition 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 5
- 230000001580 bacterial effect Effects 0.000 claims 5
- 241001133760 Acoelorraphe Species 0.000 claims 4
- 241000589158 Agrobacterium Species 0.000 claims 4
- 241000219194 Arabidopsis Species 0.000 claims 4
- 235000017060 Arachis glabrata Nutrition 0.000 claims 4
- 244000105624 Arachis hypogaea Species 0.000 claims 4
- 235000010777 Arachis hypogaea Nutrition 0.000 claims 4
- 235000018262 Arachis monticola Nutrition 0.000 claims 4
- 240000002791 Brassica napus Species 0.000 claims 4
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims 4
- 229920000742 Cotton Polymers 0.000 claims 4
- 244000068988 Glycine max Species 0.000 claims 4
- 235000010469 Glycine max Nutrition 0.000 claims 4
- 241000219146 Gossypium Species 0.000 claims 4
- 244000020551 Helianthus annuus Species 0.000 claims 4
- 235000003222 Helianthus annuus Nutrition 0.000 claims 4
- 244000061176 Nicotiana tabacum Species 0.000 claims 4
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 4
- 240000000111 Saccharum officinarum Species 0.000 claims 4
- 235000007201 Saccharum officinarum Nutrition 0.000 claims 4
- 240000006394 Sorghum bicolor Species 0.000 claims 4
- 235000011684 Sorghum saccharatum Nutrition 0.000 claims 4
- 241000209140 Triticum Species 0.000 claims 4
- 235000021307 Triticum Nutrition 0.000 claims 4
- 235000020232 peanut Nutrition 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 210000005260 human cell Anatomy 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- OUCUOMVLTQBZCY-BYPYZUCNSA-N (2s)-1-azaniumylpyrrolidine-2-carboxylate Chemical compound NN1CCC[C@H]1C(O)=O OUCUOMVLTQBZCY-BYPYZUCNSA-N 0.000 claims 1
- STGXGJRRAJKJRG-JDJSBBGDSA-N (3r,4r,5r)-5-(hydroxymethyl)-3-methoxyoxolane-2,4-diol Chemical group CO[C@H]1C(O)O[C@H](CO)[C@H]1O STGXGJRRAJKJRG-JDJSBBGDSA-N 0.000 claims 1
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
- PIINGYXNCHTJTF-UHFFFAOYSA-N 2-(2-azaniumylethylamino)acetate Chemical compound NCCNCC(O)=O PIINGYXNCHTJTF-UHFFFAOYSA-N 0.000 claims 1
- IVHVNMLJNASKHW-UHFFFAOYSA-M Chlorphonium chloride Chemical compound [Cl-].CCCC[P+](CCCC)(CCCC)CC1=CC=C(Cl)C=C1Cl IVHVNMLJNASKHW-UHFFFAOYSA-M 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 108091030071 RNAI Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- QCUXLGDVYYRCPI-UHFFFAOYSA-N [O-]P(O)(O)=[S+]N1CCOCC1 Chemical compound [O-]P(O)(O)=[S+]N1CCOCC1 QCUXLGDVYYRCPI-UHFFFAOYSA-N 0.000 claims 1
- 238000003491 array Methods 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89621207P | 2007-03-21 | 2007-03-21 | |
| US60/896,212 | 2007-03-21 | ||
| PCT/US2008/057704 WO2008116094A2 (en) | 2007-03-21 | 2008-03-20 | Combined hairpin-antisense compositions and methods for modulating expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010521973A JP2010521973A (ja) | 2010-07-01 |
| JP2010521973A5 true JP2010521973A5 (https=) | 2011-05-06 |
| JP5759673B2 JP5759673B2 (ja) | 2015-08-05 |
Family
ID=39766774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554750A Active JP5759673B2 (ja) | 2007-03-21 | 2008-03-20 | 組み合わされたヘアピン−アンチセンス組成物および発現を調節するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8796442B2 (https=) |
| EP (1) | EP2129680B1 (https=) |
| JP (1) | JP5759673B2 (https=) |
| AR (3) | AR066194A1 (https=) |
| AU (1) | AU2008228814B2 (https=) |
| BR (1) | BRPI0809130A8 (https=) |
| CA (1) | CA2681323A1 (https=) |
| DK (1) | DK2129680T3 (https=) |
| ES (1) | ES2538217T3 (https=) |
| HU (1) | HUE027018T2 (https=) |
| PL (1) | PL2129680T3 (https=) |
| PT (1) | PT2129680E (https=) |
| WO (1) | WO2008116094A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2129680B1 (en) | 2007-03-21 | 2015-05-06 | Brookhaven Science Associates, LLC | Combined hairpin-antisense compositions and methods for modulating expression |
| US10316352B2 (en) | 2008-05-13 | 2019-06-11 | Gen-Probe Incorporated | Methods of capturing a target nucleic acid for amplification and detection using an inactivatable target capture oligomer |
| US20130136727A1 (en) * | 2009-11-19 | 2013-05-30 | President And Fellows Of Harvard College | Angiogenin and Variants Thereof for Treatment of Neurodegenerative Diseases |
| EP2933333B1 (en) | 2010-07-08 | 2018-02-21 | Bonac Corporation | Single-strand nucleic acid molecule for controlling gene expression |
| EP2639307B1 (en) | 2010-08-03 | 2015-03-04 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
| WO2012074038A1 (ja) * | 2010-12-02 | 2012-06-07 | 第一三共株式会社 | 修飾１本鎖ポリヌクレオチド |
| WO2013180038A1 (ja) | 2012-05-26 | 2013-12-05 | 株式会社ボナック | デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子 |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途 |
| CN106068324B (zh) | 2013-12-27 | 2020-12-29 | 株式会社博纳克 | 控制基因表达的人工匹配型miRNA及其用途 |
| KR20170098914A (ko) | 2014-12-27 | 2017-08-30 | 가부시키가이샤 보낙 | 유전자 발현 제어를 위한 천연형 miRNA 및 그의 용도 |
| WO2016158809A1 (ja) | 2015-03-27 | 2016-10-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| EP4007813A4 (en) * | 2019-08-02 | 2023-08-30 | Commonwealth Scientific and Industrial Research Organisation | Rna molecules for modulating flowering in plants |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| WO1992003568A1 (en) | 1990-08-13 | 1992-03-05 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
| US6653458B1 (en) * | 1993-09-03 | 2003-11-25 | Isis Pharmaceuticals, Inc. | Modified oligonucleotides |
| GB9710475D0 (en) | 1997-05-21 | 1997-07-16 | Zeneca Ltd | Gene silencing |
| US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
| AR013269A1 (es) | 1997-08-04 | 2000-12-13 | Scras | Producto que contiene por lo menos un rna de doble filamento combinado con por lo menos un agente anti-viral, para la utilizacion terapeutica en eltratamiento de una enfermedad viral, en especial de la hepatitis viral |
| US5952657A (en) | 1997-08-22 | 1999-09-14 | Thermo Microscopes, Corp. | Atomic force microscope with integrated optics for attachment to optical microscope |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| CN101818145A (zh) | 1998-03-20 | 2010-09-01 | 联邦科学和工业研究组织 | 控制基因表达 |
| CN1202246C (zh) | 1998-04-08 | 2005-05-18 | 联邦科学和工业研究组织 | 获得修饰表型的方法和措施 |
| US6106982A (en) | 1998-05-11 | 2000-08-22 | Avery Dennison Corporation | Imaged receptor laminate and process for making same |
| AR020078A1 (es) | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| GB9827152D0 (en) | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| CA2361201A1 (en) | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US6160215A (en) | 1999-03-26 | 2000-12-12 | Curtin; Lawrence F. | Method of making photovoltaic device |
| KR20070118315A (ko) | 1999-04-21 | 2007-12-14 | 와이어쓰 | 폴리뉴클레오티드 서열의 기능을 억제하기 위한 조성물 |
| BR0012325A (pt) | 1999-07-09 | 2002-05-21 | American Home Prod | Métodos e composições para prevenção da formação de rna anormal durante a transcrição de uma sequência de plasmìdeo |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| WO2001038551A1 (en) | 1999-11-29 | 2001-05-31 | Cold Spring Harbor Laboratory | Regulation of polycomb group gene expression for increasing seed size in plants |
| RU2164944C1 (ru) | 1999-12-09 | 2001-04-10 | Институт молекулярной биологии им. В.А. Энгельгардта РАН | Способ изменения генетических свойств организма |
| IT1316982B1 (it) | 2000-01-17 | 2003-05-26 | Univ Roma | Isolamento e caratterizzazione di un gene per il silenziamento genicoda n.crassa e suoi usi. |
| EP1272630A2 (en) | 2000-03-16 | 2003-01-08 | Genetica, Inc. | Methods and compositions for rna interference |
| KR20020097198A (ko) | 2000-03-17 | 2002-12-31 | 베니텍 오스트레일리아 리미티드 | 유전자 사일런싱 |
| WO2001070944A2 (de) | 2000-03-22 | 2001-09-27 | Aventis Pharma Deutschland Gmbh | Nematoden als modellorganismen zur untersuchung neurodegenerativer erkrankungen und insbesonder der parkinsonschen erkrankung, verwendungen und verfahren zum auffinden von substanzen und genen, die bei der behandlung solcher erfrankungen eingesetz werden können, sowie identifizierung eines nematodengens. |
| GB0007268D0 (en) | 2000-03-24 | 2000-05-17 | Cyclacel Ltd | Cell cycle progression proteins |
| WO2001092513A1 (en) | 2000-05-30 | 2001-12-06 | Johnson & Johnson Research Pty Limited | METHODS FOR MEDIATING GENE SUPPRESION BY USING FACTORS THAT ENHANCE RNAi |
| DE60135482D1 (de) | 2000-11-09 | 2008-10-02 | Cenix Bioscience Gmbh | Eukaryontische zellteilungsgene und deren verwendung in der diagnostik sowie in der behandlung von proliferativen erkrankungen |
| CA2429814C (en) | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20030130186A1 (en) | 2001-07-20 | 2003-07-10 | Chandra Vargeese | Conjugates and compositions for cellular delivery |
| US6566524B2 (en) | 2001-12-21 | 2003-05-20 | The Procter & Gamble Co. | Methods for synthesis of amino-tetrahydroisoquinoline-sulfonamide hydroxamic acids |
| CA2478904A1 (en) * | 2002-03-14 | 2003-09-18 | Commonwealth Scientific And Industrial Research Organisation | Modified gene-silencing rna and uses thereof |
| EP1348943A3 (en) | 2002-03-25 | 2003-12-17 | Sysmex Corporation | Sheath liquid for particle analyzer |
| US20040053876A1 (en) * | 2002-03-26 | 2004-03-18 | The Regents Of The University Of Michigan | siRNAs and uses therof |
| US7387896B2 (en) * | 2003-03-26 | 2008-06-17 | The Regents Of The University Of Michigan | MicroRNA vectors |
| EP2129680B1 (en) | 2007-03-21 | 2015-05-06 | Brookhaven Science Associates, LLC | Combined hairpin-antisense compositions and methods for modulating expression |
-
2008
- 2008-03-20 EP EP20080732595 patent/EP2129680B1/en active Active
- 2008-03-20 HU HUE08732595A patent/HUE027018T2/en unknown
- 2008-03-20 JP JP2009554750A patent/JP5759673B2/ja active Active
- 2008-03-20 CA CA002681323A patent/CA2681323A1/en not_active Abandoned
- 2008-03-20 ES ES08732595.7T patent/ES2538217T3/es active Active
- 2008-03-20 AU AU2008228814A patent/AU2008228814B2/en active Active
- 2008-03-20 US US12/052,658 patent/US8796442B2/en active Active
- 2008-03-20 WO PCT/US2008/057704 patent/WO2008116094A2/en not_active Ceased
- 2008-03-20 BR BRPI0809130A patent/BRPI0809130A8/pt not_active Application Discontinuation
- 2008-03-20 PT PT87325957T patent/PT2129680E/pt unknown
- 2008-03-20 DK DK08732595.7T patent/DK2129680T3/en active
- 2008-03-20 PL PL08732595T patent/PL2129680T3/pl unknown
- 2008-03-25 AR ARP080101204A patent/AR066194A1/es unknown
-
2011
- 2011-03-23 AR ARP110100994A patent/AR080722A2/es unknown
-
2014
- 2014-08-05 US US14/452,049 patent/US9193972B2/en active Active
- 2014-10-21 AR ARP140103952A patent/AR098140A2/es active IP Right Grant
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