PL2129680T3 - Łączone kompozycje cząsteczek antysensownych o strukturze spinki do włosów oraz sposoby modulacji ekspresji - Google Patents
Łączone kompozycje cząsteczek antysensownych o strukturze spinki do włosów oraz sposoby modulacji ekspresjiInfo
- Publication number
- PL2129680T3 PL2129680T3 PL08732595T PL08732595T PL2129680T3 PL 2129680 T3 PL2129680 T3 PL 2129680T3 PL 08732595 T PL08732595 T PL 08732595T PL 08732595 T PL08732595 T PL 08732595T PL 2129680 T3 PL2129680 T3 PL 2129680T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- modulating expression
- antisense compositions
- hairpin
- combined
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89621207P | 2007-03-21 | 2007-03-21 | |
| PCT/US2008/057704 WO2008116094A2 (en) | 2007-03-21 | 2008-03-20 | Combined hairpin-antisense compositions and methods for modulating expression |
| EP20080732595 EP2129680B1 (en) | 2007-03-21 | 2008-03-20 | Combined hairpin-antisense compositions and methods for modulating expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2129680T3 true PL2129680T3 (pl) | 2015-10-30 |
Family
ID=39766774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08732595T PL2129680T3 (pl) | 2007-03-21 | 2008-03-20 | Łączone kompozycje cząsteczek antysensownych o strukturze spinki do włosów oraz sposoby modulacji ekspresji |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8796442B2 (https=) |
| EP (1) | EP2129680B1 (https=) |
| JP (1) | JP5759673B2 (https=) |
| AR (3) | AR066194A1 (https=) |
| AU (1) | AU2008228814B2 (https=) |
| BR (1) | BRPI0809130A8 (https=) |
| CA (1) | CA2681323A1 (https=) |
| DK (1) | DK2129680T3 (https=) |
| ES (1) | ES2538217T3 (https=) |
| HU (1) | HUE027018T2 (https=) |
| PL (1) | PL2129680T3 (https=) |
| PT (1) | PT2129680E (https=) |
| WO (1) | WO2008116094A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2129680T3 (pl) | 2007-03-21 | 2015-10-30 | Brookhaven Science Ass Llc | Łączone kompozycje cząsteczek antysensownych o strukturze spinki do włosów oraz sposoby modulacji ekspresji |
| AU2009246363B2 (en) | 2008-05-13 | 2013-10-24 | Gen-Probe Incorporated | Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences |
| WO2011062762A2 (en) * | 2009-11-19 | 2011-05-26 | President And Fellows Of Harvard College | Angiogenin and variants thereof for treatment of neurodegenerative diseases |
| US8785121B2 (en) | 2010-07-08 | 2014-07-22 | Bonac Corporation | Single-stranded nucleic acid molecule for controlling gene expression |
| US8691782B2 (en) | 2010-08-03 | 2014-04-08 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
| ES2527660T3 (es) * | 2010-08-03 | 2015-01-28 | Bonac Corporation | Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno |
| AU2011337658A1 (en) * | 2010-12-02 | 2013-07-04 | Daiichi Sankyo Company, Limited | Modified single-strand polynucleotide |
| CN109810977A (zh) | 2012-05-26 | 2019-05-28 | 株式会社博纳克 | 具有递送功能的基因表达调控用单链核酸分子 |
| CN105899663B (zh) | 2013-12-26 | 2019-07-26 | 学校法人东京医科大学 | 用于基因表达控制的人工模拟miRNA及其用途 |
| SG10201913570XA (en) | 2013-12-27 | 2020-03-30 | Bonac Corp | Artificial match-type mirna for controlling gene expression and use therefor |
| SG11201705223XA (en) | 2014-12-27 | 2017-07-28 | Bonac Corp | NATURALLY OCCURING miRNA FOR CONTROLLING GENE EXPRESSION, AND USE OF SAME |
| JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| MX2022001439A (es) * | 2019-08-02 | 2022-05-06 | Commw Scient Ind Res Org | Moléculas de arn para modular el florecimiento en plantas. |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| JPH0813274B2 (ja) * | 1990-08-13 | 1996-02-14 | アイシス・ファーマシューティカルス・インコーポレーテッド | 遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド |
| US6653458B1 (en) * | 1993-09-03 | 2003-11-25 | Isis Pharmaceuticals, Inc. | Modified oligonucleotides |
| GB9710475D0 (en) | 1997-05-21 | 1997-07-16 | Zeneca Ltd | Gene silencing |
| US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
| TW589189B (en) | 1997-08-04 | 2004-06-01 | Scras | Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis |
| US5952657A (en) | 1997-08-22 | 1999-09-14 | Thermo Microscopes, Corp. | Atomic force microscope with integrated optics for attachment to optical microscope |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| WO1999049029A1 (en) | 1998-03-20 | 1999-09-30 | Benitec Australia Ltd | Control of gene expression |
| NZ507093A (en) | 1998-04-08 | 2003-08-29 | Commw Scient Ind Res Org | Methods and means for reducing the phenotypic expression of a nucleic acid of interest in a plant |
| US6106982A (en) | 1998-05-11 | 2000-08-22 | Avery Dennison Corporation | Imaged receptor laminate and process for making same |
| AR020078A1 (es) | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| GB9827152D0 (en) | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| EP2314700A1 (en) | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US6160215A (en) | 1999-03-26 | 2000-12-12 | Curtin; Lawrence F. | Method of making photovoltaic device |
| WO2000063364A2 (en) | 1999-04-21 | 2000-10-26 | American Home Products Corporation | Methods and compositions for inhibiting the function of polynucleotide sequences |
| IL147026A0 (en) | 1999-07-09 | 2002-08-14 | American Home Prod | Method and compositions for preventing the formation of aberrant rna during transcripting of a plasmid sequence |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| WO2001038551A1 (en) | 1999-11-29 | 2001-05-31 | Cold Spring Harbor Laboratory | Regulation of polycomb group gene expression for increasing seed size in plants |
| RU2164944C1 (ru) | 1999-12-09 | 2001-04-10 | Институт молекулярной биологии им. В.А. Энгельгардта РАН | Способ изменения генетических свойств организма |
| IT1316982B1 (it) | 2000-01-17 | 2003-05-26 | Univ Roma | Isolamento e caratterizzazione di un gene per il silenziamento genicoda n.crassa e suoi usi. |
| EP1272630A2 (en) | 2000-03-16 | 2003-01-08 | Genetica, Inc. | Methods and compositions for rna interference |
| MXPA02009069A (es) | 2000-03-17 | 2004-04-05 | Benitec Australia Ltd | Silenciamiento genetico. |
| WO2001070944A2 (de) | 2000-03-22 | 2001-09-27 | Aventis Pharma Deutschland Gmbh | Nematoden als modellorganismen zur untersuchung neurodegenerativer erkrankungen und insbesonder der parkinsonschen erkrankung, verwendungen und verfahren zum auffinden von substanzen und genen, die bei der behandlung solcher erfrankungen eingesetz werden können, sowie identifizierung eines nematodengens. |
| GB0007268D0 (en) | 2000-03-24 | 2000-05-17 | Cyclacel Ltd | Cell cycle progression proteins |
| ATE513910T1 (de) | 2000-05-30 | 2011-07-15 | Johnson & Johnson Res Pty Ltd | Methoden zur gensuppression mithilfe von rnai verstärkenden faktoren |
| AU2002224838B9 (en) | 2000-11-09 | 2007-02-08 | Cenix Bioscience Gmbh | Eukaryotic cell division genes and their use in diagnosis and treatment of proliferative diseases |
| US20040259247A1 (en) | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20030130186A1 (en) | 2001-07-20 | 2003-07-10 | Chandra Vargeese | Conjugates and compositions for cellular delivery |
| US6566524B2 (en) | 2001-12-21 | 2003-05-20 | The Procter & Gamble Co. | Methods for synthesis of amino-tetrahydroisoquinoline-sulfonamide hydroxamic acids |
| EP1487980A4 (en) * | 2002-03-14 | 2005-08-10 | Commw Scient Ind Res Org | MODIFIED GENE ALDE GENE RNA AND USES THEREOF |
| EP1348943A3 (en) | 2002-03-25 | 2003-12-17 | Sysmex Corporation | Sheath liquid for particle analyzer |
| US20040053876A1 (en) * | 2002-03-26 | 2004-03-18 | The Regents Of The University Of Michigan | siRNAs and uses therof |
| US7387896B2 (en) * | 2003-03-26 | 2008-06-17 | The Regents Of The University Of Michigan | MicroRNA vectors |
| PL2129680T3 (pl) | 2007-03-21 | 2015-10-30 | Brookhaven Science Ass Llc | Łączone kompozycje cząsteczek antysensownych o strukturze spinki do włosów oraz sposoby modulacji ekspresji |
-
2008
- 2008-03-20 PL PL08732595T patent/PL2129680T3/pl unknown
- 2008-03-20 DK DK08732595.7T patent/DK2129680T3/en active
- 2008-03-20 ES ES08732595.7T patent/ES2538217T3/es active Active
- 2008-03-20 US US12/052,658 patent/US8796442B2/en active Active
- 2008-03-20 PT PT87325957T patent/PT2129680E/pt unknown
- 2008-03-20 EP EP20080732595 patent/EP2129680B1/en active Active
- 2008-03-20 HU HUE08732595A patent/HUE027018T2/en unknown
- 2008-03-20 WO PCT/US2008/057704 patent/WO2008116094A2/en not_active Ceased
- 2008-03-20 BR BRPI0809130A patent/BRPI0809130A8/pt not_active Application Discontinuation
- 2008-03-20 AU AU2008228814A patent/AU2008228814B2/en active Active
- 2008-03-20 JP JP2009554750A patent/JP5759673B2/ja active Active
- 2008-03-20 CA CA002681323A patent/CA2681323A1/en not_active Abandoned
- 2008-03-25 AR ARP080101204A patent/AR066194A1/es unknown
-
2011
- 2011-03-23 AR ARP110100994A patent/AR080722A2/es unknown
-
2014
- 2014-08-05 US US14/452,049 patent/US9193972B2/en active Active
- 2014-10-21 AR ARP140103952A patent/AR098140A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US9193972B2 (en) | 2015-11-24 |
| AR098140A2 (es) | 2016-05-04 |
| AR080722A2 (es) | 2012-05-02 |
| JP5759673B2 (ja) | 2015-08-05 |
| AU2008228814B2 (en) | 2014-03-06 |
| HUE027018T2 (en) | 2016-08-29 |
| EP2129680A4 (en) | 2010-10-20 |
| ES2538217T3 (es) | 2015-06-18 |
| US20080311658A1 (en) | 2008-12-18 |
| US20140342453A1 (en) | 2014-11-20 |
| EP2129680A2 (en) | 2009-12-09 |
| JP2010521973A (ja) | 2010-07-01 |
| AR066194A1 (es) | 2009-08-05 |
| CA2681323A1 (en) | 2008-09-25 |
| DK2129680T3 (en) | 2015-08-10 |
| US8796442B2 (en) | 2014-08-05 |
| BRPI0809130A2 (pt) | 2014-08-26 |
| AU2008228814A1 (en) | 2008-09-25 |
| WO2008116094A2 (en) | 2008-09-25 |
| BRPI0809130A8 (pt) | 2021-11-03 |
| PT2129680E (pt) | 2015-08-28 |
| EP2129680B1 (en) | 2015-05-06 |
| WO2008116094A3 (en) | 2008-11-20 |
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