AR066194A1 - Composiciones antisentido en horquilla combinadas y metodos para modular la expresion de un gen blanco en celulas - Google Patents
Composiciones antisentido en horquilla combinadas y metodos para modular la expresion de un gen blanco en celulasInfo
- Publication number
- AR066194A1 AR066194A1 ARP080101204A ARP080101204A AR066194A1 AR 066194 A1 AR066194 A1 AR 066194A1 AR P080101204 A ARP080101204 A AR P080101204A AR P080101204 A ARP080101204 A AR P080101204A AR 066194 A1 AR066194 A1 AR 066194A1
- Authority
- AR
- Argentina
- Prior art keywords
- expression
- target
- nucleotide sequence
- modulates
- methods
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 11
- 125000003729 nucleotide group Chemical group 0.000 abstract 11
- 210000004027 cell Anatomy 0.000 abstract 3
- 241000589158 Agrobacterium Species 0.000 abstract 1
- 108091030071 RNAI Proteins 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000009368 gene silencing by RNA Effects 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89621207P | 2007-03-21 | 2007-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR066194A1 true AR066194A1 (es) | 2009-08-05 |
Family
ID=39766774
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101204A AR066194A1 (es) | 2007-03-21 | 2008-03-25 | Composiciones antisentido en horquilla combinadas y metodos para modular la expresion de un gen blanco en celulas |
| ARP110100994A AR080722A2 (es) | 2007-03-21 | 2011-03-23 | Metodo para regular la expresion de un blanco con una construccion de nucleotidos y para tratar un acondicion patologica |
| ARP140103952A AR098140A2 (es) | 2007-03-21 | 2014-10-21 | Método para regular la expresión de un blanco con una construcción de nucleótidos y para tratar una condición patológica; método para preparar dicha construcción composición médica y célula que la contiene |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110100994A AR080722A2 (es) | 2007-03-21 | 2011-03-23 | Metodo para regular la expresion de un blanco con una construccion de nucleotidos y para tratar un acondicion patologica |
| ARP140103952A AR098140A2 (es) | 2007-03-21 | 2014-10-21 | Método para regular la expresión de un blanco con una construcción de nucleótidos y para tratar una condición patológica; método para preparar dicha construcción composición médica y célula que la contiene |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8796442B2 (https=) |
| EP (1) | EP2129680B1 (https=) |
| JP (1) | JP5759673B2 (https=) |
| AR (3) | AR066194A1 (https=) |
| AU (1) | AU2008228814B2 (https=) |
| BR (1) | BRPI0809130A8 (https=) |
| CA (1) | CA2681323A1 (https=) |
| DK (1) | DK2129680T3 (https=) |
| ES (1) | ES2538217T3 (https=) |
| HU (1) | HUE027018T2 (https=) |
| PL (1) | PL2129680T3 (https=) |
| PT (1) | PT2129680E (https=) |
| WO (1) | WO2008116094A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2129680B1 (en) | 2007-03-21 | 2015-05-06 | Brookhaven Science Associates, LLC | Combined hairpin-antisense compositions and methods for modulating expression |
| US10316352B2 (en) | 2008-05-13 | 2019-06-11 | Gen-Probe Incorporated | Methods of capturing a target nucleic acid for amplification and detection using an inactivatable target capture oligomer |
| US20130136727A1 (en) * | 2009-11-19 | 2013-05-30 | President And Fellows Of Harvard College | Angiogenin and Variants Thereof for Treatment of Neurodegenerative Diseases |
| EP2933333B1 (en) | 2010-07-08 | 2018-02-21 | Bonac Corporation | Single-strand nucleic acid molecule for controlling gene expression |
| EP2639307B1 (en) | 2010-08-03 | 2015-03-04 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
| WO2012074038A1 (ja) * | 2010-12-02 | 2012-06-07 | 第一三共株式会社 | 修飾１本鎖ポリヌクレオチド |
| WO2013180038A1 (ja) | 2012-05-26 | 2013-12-05 | 株式会社ボナック | デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子 |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途 |
| CN106068324B (zh) | 2013-12-27 | 2020-12-29 | 株式会社博纳克 | 控制基因表达的人工匹配型miRNA及其用途 |
| KR20170098914A (ko) | 2014-12-27 | 2017-08-30 | 가부시키가이샤 보낙 | 유전자 발현 제어를 위한 천연형 miRNA 및 그의 용도 |
| WO2016158809A1 (ja) | 2015-03-27 | 2016-10-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| EP4007813A4 (en) * | 2019-08-02 | 2023-08-30 | Commonwealth Scientific and Industrial Research Organisation | Rna molecules for modulating flowering in plants |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| WO1992003568A1 (en) | 1990-08-13 | 1992-03-05 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
| US6653458B1 (en) * | 1993-09-03 | 2003-11-25 | Isis Pharmaceuticals, Inc. | Modified oligonucleotides |
| GB9710475D0 (en) | 1997-05-21 | 1997-07-16 | Zeneca Ltd | Gene silencing |
| US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
| AR013269A1 (es) | 1997-08-04 | 2000-12-13 | Scras | Producto que contiene por lo menos un rna de doble filamento combinado con por lo menos un agente anti-viral, para la utilizacion terapeutica en eltratamiento de una enfermedad viral, en especial de la hepatitis viral |
| US5952657A (en) | 1997-08-22 | 1999-09-14 | Thermo Microscopes, Corp. | Atomic force microscope with integrated optics for attachment to optical microscope |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| CN101818145A (zh) | 1998-03-20 | 2010-09-01 | 联邦科学和工业研究组织 | 控制基因表达 |
| CN1202246C (zh) | 1998-04-08 | 2005-05-18 | 联邦科学和工业研究组织 | 获得修饰表型的方法和措施 |
| US6106982A (en) | 1998-05-11 | 2000-08-22 | Avery Dennison Corporation | Imaged receptor laminate and process for making same |
| AR020078A1 (es) | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| GB9827152D0 (en) | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| CA2361201A1 (en) | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US6160215A (en) | 1999-03-26 | 2000-12-12 | Curtin; Lawrence F. | Method of making photovoltaic device |
| KR20070118315A (ko) | 1999-04-21 | 2007-12-14 | 와이어쓰 | 폴리뉴클레오티드 서열의 기능을 억제하기 위한 조성물 |
| BR0012325A (pt) | 1999-07-09 | 2002-05-21 | American Home Prod | Métodos e composições para prevenção da formação de rna anormal durante a transcrição de uma sequência de plasmìdeo |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| WO2001038551A1 (en) | 1999-11-29 | 2001-05-31 | Cold Spring Harbor Laboratory | Regulation of polycomb group gene expression for increasing seed size in plants |
| RU2164944C1 (ru) | 1999-12-09 | 2001-04-10 | Институт молекулярной биологии им. В.А. Энгельгардта РАН | Способ изменения генетических свойств организма |
| IT1316982B1 (it) | 2000-01-17 | 2003-05-26 | Univ Roma | Isolamento e caratterizzazione di un gene per il silenziamento genicoda n.crassa e suoi usi. |
| EP1272630A2 (en) | 2000-03-16 | 2003-01-08 | Genetica, Inc. | Methods and compositions for rna interference |
| KR20020097198A (ko) | 2000-03-17 | 2002-12-31 | 베니텍 오스트레일리아 리미티드 | 유전자 사일런싱 |
| WO2001070944A2 (de) | 2000-03-22 | 2001-09-27 | Aventis Pharma Deutschland Gmbh | Nematoden als modellorganismen zur untersuchung neurodegenerativer erkrankungen und insbesonder der parkinsonschen erkrankung, verwendungen und verfahren zum auffinden von substanzen und genen, die bei der behandlung solcher erfrankungen eingesetz werden können, sowie identifizierung eines nematodengens. |
| GB0007268D0 (en) | 2000-03-24 | 2000-05-17 | Cyclacel Ltd | Cell cycle progression proteins |
| WO2001092513A1 (en) | 2000-05-30 | 2001-12-06 | Johnson & Johnson Research Pty Limited | METHODS FOR MEDIATING GENE SUPPRESION BY USING FACTORS THAT ENHANCE RNAi |
| DE60135482D1 (de) | 2000-11-09 | 2008-10-02 | Cenix Bioscience Gmbh | Eukaryontische zellteilungsgene und deren verwendung in der diagnostik sowie in der behandlung von proliferativen erkrankungen |
| CA2429814C (en) | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20030130186A1 (en) | 2001-07-20 | 2003-07-10 | Chandra Vargeese | Conjugates and compositions for cellular delivery |
| US6566524B2 (en) | 2001-12-21 | 2003-05-20 | The Procter & Gamble Co. | Methods for synthesis of amino-tetrahydroisoquinoline-sulfonamide hydroxamic acids |
| CA2478904A1 (en) * | 2002-03-14 | 2003-09-18 | Commonwealth Scientific And Industrial Research Organisation | Modified gene-silencing rna and uses thereof |
| EP1348943A3 (en) | 2002-03-25 | 2003-12-17 | Sysmex Corporation | Sheath liquid for particle analyzer |
| US20040053876A1 (en) * | 2002-03-26 | 2004-03-18 | The Regents Of The University Of Michigan | siRNAs and uses therof |
| US7387896B2 (en) * | 2003-03-26 | 2008-06-17 | The Regents Of The University Of Michigan | MicroRNA vectors |
| EP2129680B1 (en) | 2007-03-21 | 2015-05-06 | Brookhaven Science Associates, LLC | Combined hairpin-antisense compositions and methods for modulating expression |
-
2008
- 2008-03-20 EP EP20080732595 patent/EP2129680B1/en active Active
- 2008-03-20 HU HUE08732595A patent/HUE027018T2/en unknown
- 2008-03-20 JP JP2009554750A patent/JP5759673B2/ja active Active
- 2008-03-20 CA CA002681323A patent/CA2681323A1/en not_active Abandoned
- 2008-03-20 ES ES08732595.7T patent/ES2538217T3/es active Active
- 2008-03-20 AU AU2008228814A patent/AU2008228814B2/en active Active
- 2008-03-20 US US12/052,658 patent/US8796442B2/en active Active
- 2008-03-20 WO PCT/US2008/057704 patent/WO2008116094A2/en not_active Ceased
- 2008-03-20 BR BRPI0809130A patent/BRPI0809130A8/pt not_active Application Discontinuation
- 2008-03-20 PT PT87325957T patent/PT2129680E/pt unknown
- 2008-03-20 DK DK08732595.7T patent/DK2129680T3/en active
- 2008-03-20 PL PL08732595T patent/PL2129680T3/pl unknown
- 2008-03-25 AR ARP080101204A patent/AR066194A1/es unknown
-
2011
- 2011-03-23 AR ARP110100994A patent/AR080722A2/es unknown
-
2014
- 2014-08-05 US US14/452,049 patent/US9193972B2/en active Active
- 2014-10-21 AR ARP140103952A patent/AR098140A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PL2129680T3 (pl) | 2015-10-30 |
| US20140342453A1 (en) | 2014-11-20 |
| ES2538217T3 (es) | 2015-06-18 |
| AR080722A2 (es) | 2012-05-02 |
| PT2129680E (pt) | 2015-08-28 |
| WO2008116094A3 (en) | 2008-11-20 |
| WO2008116094A2 (en) | 2008-09-25 |
| EP2129680A2 (en) | 2009-12-09 |
| HUE027018T2 (en) | 2016-08-29 |
| JP2010521973A (ja) | 2010-07-01 |
| EP2129680B1 (en) | 2015-05-06 |
| US9193972B2 (en) | 2015-11-24 |
| AU2008228814A1 (en) | 2008-09-25 |
| JP5759673B2 (ja) | 2015-08-05 |
| CA2681323A1 (en) | 2008-09-25 |
| AR098140A2 (es) | 2016-05-04 |
| DK2129680T3 (en) | 2015-08-10 |
| EP2129680A4 (en) | 2010-10-20 |
| BRPI0809130A8 (pt) | 2021-11-03 |
| BRPI0809130A2 (pt) | 2014-08-26 |
| US20080311658A1 (en) | 2008-12-18 |
| AU2008228814B2 (en) | 2014-03-06 |
| US8796442B2 (en) | 2014-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR066194A1 (es) | Composiciones antisentido en horquilla combinadas y metodos para modular la expresion de un gen blanco en celulas | |
| Bassetto | Forward guidance: Communication, commitment, or both? | |
| BR112012005296A2 (pt) | microorganismos e métodos para a coprodução de isopropanol com alcoóis primários, diós e ácidos. | |
| MY176922A (en) | Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis | |
| PE20190844A1 (es) | Modulacion de transcripcion con arn de direccion a adn generico | |
| MY159971A (en) | Multipotent/pluripotent cells and methods | |
| MX2012004291A (es) | Microorganismos para la produccion de 1,4-butanoidol, 4-hidroxibutanal, 4-hidroxibutiril-coa, putrescina y compuestos y metodos relacionados con los mismos. | |
| BR112012014062A2 (pt) | organismo microbiano que não ocorre naturalmente e método para produzir 1,3 bdo | |
| MX2016017317A (es) | Metodos y composiciones para modificaciones geneticas dirigidas y metodos de uso. | |
| CL2012002474A1 (es) | Metodo para regular la expresion de un gen endogeno objetivo en una planta u organos vegetales en crecimiento que comprende al menos un polinucleotido que tiene una secuencia esencialmente identica a una secuencia de 18 o mas nucleotidos contiguos en dicho gen endogeno o en el arn mensajero transcrito a partir de dicho gen | |
| MX349350B (es) | Gen r4 restaurador de esterilidad macho citoplasmico (cms) tipo c de maiz, marcadores moleculares y su uso. | |
| MY160595A (en) | Energetic modulation of nerves | |
| BRPI0507934A (pt) | plantas modificadas com mini-cromossomas | |
| WO2019236672A8 (en) | Microbial consortia producing dipicolinic acid and methods for selecting microbes for co-formulation with carriers | |
| PE20121533A1 (es) | Metodo para producir l-aminoacido | |
| BR112021026002A2 (pt) | Regeneração e transformação melhorada de plantas com a ajuda de um gene de reforço grf1 | |
| WO2022016166A3 (en) | Differentiation of trophectoderm lineage cells from pluripotent stem cells | |
| WO2021231263A3 (en) | Nucleic acid amplification methods | |
| WO2021216778A3 (en) | Artificial expression constructs for selectively modulating gene expression in neocortical layer 5 glutamatergic neurons | |
| MX382997B (es) | Composiciones y metodos para mejorar la expresion genetica de pklr. | |
| CA3198027A1 (en) | Cells, tissues, organs, and animals having one or more modified genes for enhanced xenograft survival and tolerance | |
| MX2021003219A (es) | Biomaterial que comprende celulas germinales derivadas de tejido adiposo y gelatina y metodo para producir el mismo. | |
| WO2023213983A3 (en) | Expression construct | |
| CL2021000423A1 (es) | Métodos para liberar fósforo desde materia orgánica | |
| ATE438726T1 (de) | Modulation der anzahl von pflanzenzellen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |