JP2011520424A5 - - Google Patents
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- Publication number
- JP2011520424A5 JP2011520424A5 JP2011505154A JP2011505154A JP2011520424A5 JP 2011520424 A5 JP2011520424 A5 JP 2011520424A5 JP 2011505154 A JP2011505154 A JP 2011505154A JP 2011505154 A JP2011505154 A JP 2011505154A JP 2011520424 A5 JP2011520424 A5 JP 2011520424A5
- Authority
- JP
- Japan
- Prior art keywords
- targeting polypeptide
- complex
- seq
- cell
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4508808P | 2008-04-15 | 2008-04-15 | |
| US61/045,088 | 2008-04-15 | ||
| PCT/US2009/040607 WO2009129281A2 (en) | 2008-04-15 | 2009-04-15 | Compositions and methods for delivering inhibitory oligonucleotides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014250963A Division JP2015096073A (ja) | 2008-04-15 | 2014-12-11 | 阻害性オリゴヌクレオチドを送達するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011520424A JP2011520424A (ja) | 2011-07-21 |
| JP2011520424A5 true JP2011520424A5 (https=) | 2012-06-07 |
| JP5667043B2 JP5667043B2 (ja) | 2015-02-12 |
Family
ID=41172206
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011505154A Expired - Fee Related JP5667043B2 (ja) | 2008-04-15 | 2009-04-15 | 阻害性オリゴヌクレオチドを送達するための組成物および方法 |
| JP2014250963A Pending JP2015096073A (ja) | 2008-04-15 | 2014-12-11 | 阻害性オリゴヌクレオチドを送達するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014250963A Pending JP2015096073A (ja) | 2008-04-15 | 2014-12-11 | 阻害性オリゴヌクレオチドを送達するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8703921B2 (https=) |
| EP (1) | EP2276511A2 (https=) |
| JP (2) | JP5667043B2 (https=) |
| AU (1) | AU2009236270B2 (https=) |
| CA (1) | CA2720363A1 (https=) |
| WO (1) | WO2009129281A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5667043B2 (ja) | 2008-04-15 | 2015-02-12 | アメリカ合衆国ＧＯＶＥＲＮＭＥＮＴ ＯＦ ＴＨＥ ＵＮＩＴＥＤ ＳＴＡＴＥＳ ＯＦ ＡＭＥＲＩＣＡ， ａｓ ｒｅｐｒｅｓｅｎｔｅｄ ｂｙ ＴＨＥ ＳＥＣＲＥＴＡＲＹ， ＤＥＰＡＲＴＭＥＮＴ ＯＦ ＨＥＡＬＴＨＡＮＤ ＨＵＭＡＮ ＳＥＲＶＩＣＥＳ | 阻害性オリゴヌクレオチドを送達するための組成物および方法 |
| US10485879B2 (en) | 2008-04-15 | 2019-11-26 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Plasma cell cytokine vehicle containing fusion proteins for targeted introduction of siRNA into cells and tissues |
| JP2019513371A (ja) | 2016-04-01 | 2019-05-30 | アビディティー バイオサイエンシーズ エルエルシー | 核酸ポリペプチド組成物とその使用 |
| WO2018094195A1 (en) | 2016-11-21 | 2018-05-24 | Tribiotica Llc | Methods for directed folding assembly or dimerization of proteins by templated assembly reactions |
| US11186839B2 (en) | 2016-11-21 | 2021-11-30 | Tribiotica Llc | Methods for preventing titration of bimolecular templated assembly reactions by structurally-determined differential hybridizations |
| JP6661797B2 (ja) * | 2016-11-22 | 2020-03-11 | 株式会社東芝 | 核酸凝縮ペプチド、核酸凝縮ペプチドセット、核酸送達キャリア、核酸送達方法、細胞作製方法、細胞検出方法及びキット |
| JP7506601B2 (ja) | 2017-12-06 | 2024-06-26 | アビディティー バイオサイエンシーズ，インク． | 筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法 |
| US11555190B2 (en) | 2020-03-19 | 2023-01-17 | Avidity Biosciences, Inc. | Compositions and methods of treating Facioscapulohumeral muscular dystrophy |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| US6172208B1 (en) | 1992-07-06 | 2001-01-09 | Genzyme Corporation | Oligonucleotides modified with conjugate groups |
| DE614989T1 (de) | 1993-02-17 | 1995-09-28 | Morphosys Proteinoptimierung | Verfahren für in vivo Selektion von Ligandenbindende Proteine. |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5753613A (en) | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
| JP3659261B2 (ja) | 1994-10-20 | 2005-06-15 | モルフォシス・アクチェンゲゼルシャフト | 組換体タンパク質の多機能性複合体への標的化ヘテロ結合 |
| US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| CA2297070A1 (en) | 1997-08-01 | 1999-02-11 | Morphosys Ag | Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| JP2003528024A (ja) | 1997-12-16 | 2003-09-24 | バレンティス・インコーポレーテッド | 製剤化された核酸分子の無針注入 |
| AR020078A1 (es) | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| DE60040274D1 (de) | 1999-03-10 | 2008-10-30 | Phogen Ltd | Verabreichung von nukleinsäuren und proteinen an zellen |
| ATE482275T1 (de) | 1999-07-02 | 2010-10-15 | Morphosys Ag | Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden |
| ES2327382T3 (es) | 1999-07-20 | 2009-10-29 | Morphosys Ag | Metodos para presentar (poli)peptidos/proteinas en particulas de bacteriofagos a traves de enlaces disulfuro. |
| US20070042983A1 (en) | 2001-05-18 | 2007-02-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
| KR20040008526A (ko) | 2002-07-18 | 2004-01-31 | 주식회사 하이닉스반도체 | 플래시 메모리 셀의 소거 방법 |
| AU2003256857A1 (en) | 2002-08-08 | 2004-02-25 | Dharmacon, Inc. | Short interfering rnas having a hairpin structure containing a non-nucleotide loop |
| EP1635832A2 (en) | 2003-06-06 | 2006-03-22 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes |
| WO2006023491A2 (en) * | 2004-08-16 | 2006-03-02 | The Cbr Institute For Biomedical Research, Inc. | Method of delivering rna interference and uses thereof |
| CA2624662A1 (en) | 2005-09-30 | 2007-04-12 | The Government Of The United States Of America, As Represented By The Se Cretary Of Health And Human Services | Methods and compositions for modulating immune tolerance |
| US20070231392A1 (en) | 2006-01-23 | 2007-10-04 | Ernst Wagner | CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY |
| US20130129752A1 (en) | 2006-04-25 | 2013-05-23 | Immune Disease Institute, Inc. | Targeted delivery to leukocytes using protein carriers |
| EP2121929B1 (en) * | 2007-01-26 | 2011-11-23 | Industry-University Cooperation Foundation Hanyang University | Targeted delivery of sirna |
| JP5667043B2 (ja) | 2008-04-15 | 2015-02-12 | アメリカ合衆国ＧＯＶＥＲＮＭＥＮＴ ＯＦ ＴＨＥ ＵＮＩＴＥＤ ＳＴＡＴＥＳ ＯＦ ＡＭＥＲＩＣＡ， ａｓ ｒｅｐｒｅｓｅｎｔｅｄ ｂｙ ＴＨＥ ＳＥＣＲＥＴＡＲＹ， ＤＥＰＡＲＴＭＥＮＴ ＯＦ ＨＥＡＬＴＨＡＮＤ ＨＵＭＡＮ ＳＥＲＶＩＣＥＳ | 阻害性オリゴヌクレオチドを送達するための組成物および方法 |
-
2009
- 2009-04-15 JP JP2011505154A patent/JP5667043B2/ja not_active Expired - Fee Related
- 2009-04-15 EP EP09733166A patent/EP2276511A2/en not_active Withdrawn
- 2009-04-15 AU AU2009236270A patent/AU2009236270B2/en not_active Ceased
- 2009-04-15 CA CA2720363A patent/CA2720363A1/en not_active Abandoned
- 2009-04-15 WO PCT/US2009/040607 patent/WO2009129281A2/en not_active Ceased
- 2009-04-15 US US12/988,148 patent/US8703921B2/en active Active
-
2014
- 2014-03-20 US US14/220,726 patent/US9415116B2/en active Active
- 2014-12-11 JP JP2014250963A patent/JP2015096073A/ja active Pending
-
2016
- 2016-07-07 US US15/204,789 patent/US10765694B2/en active Active
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