JP2010520758A5 - - Google Patents
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- Publication number
- JP2010520758A5 JP2010520758A5 JP2009552983A JP2009552983A JP2010520758A5 JP 2010520758 A5 JP2010520758 A5 JP 2010520758A5 JP 2009552983 A JP2009552983 A JP 2009552983A JP 2009552983 A JP2009552983 A JP 2009552983A JP 2010520758 A5 JP2010520758 A5 JP 2010520758A5
- Authority
- JP
- Japan
- Prior art keywords
- reovirus
- nucleic acid
- residue
- polypeptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000702263 Reovirus sp. Species 0.000 claims 69
- 229920001184 polypeptide Polymers 0.000 claims 39
- 102000004196 processed proteins & peptides Human genes 0.000 claims 39
- 108090000765 processed proteins & peptides Proteins 0.000 claims 39
- 150000007523 nucleic acids Chemical class 0.000 claims 38
- 230000004048 modification Effects 0.000 claims 35
- 238000012986 modification Methods 0.000 claims 35
- 108020004707 nucleic acids Proteins 0.000 claims 29
- 102000039446 nucleic acids Human genes 0.000 claims 29
- 230000001965 increasing effect Effects 0.000 claims 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 150000001413 amino acids Chemical class 0.000 claims 16
- 238000000034 method Methods 0.000 claims 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 9
- 102100037651 AP-2 complex subunit sigma Human genes 0.000 claims 4
- 101000806914 Homo sapiens AP-2 complex subunit sigma Proteins 0.000 claims 4
- 108700034660 Reovirus lambda3 Proteins 0.000 claims 4
- 230000006037 cell lysis Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000035945 sensitivity Effects 0.000 claims 4
- 238000001959 radiotherapy Methods 0.000 claims 3
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 241000725641 Reovirus S4 Species 0.000 claims 2
- 108700018523 Reovirus mu2 Proteins 0.000 claims 2
- 108700023681 Reovirus sigma NS Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 230000004900 autophagic degradation Effects 0.000 claims 2
- 230000008901 benefit Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000030833 cell death Effects 0.000 claims 2
- 230000008406 drug-drug interaction Effects 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 230000005847 immunogenicity Effects 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000017074 necrotic cell death Effects 0.000 claims 2
- 238000004806 packaging method and process Methods 0.000 claims 2
- 230000007505 plaque formation Effects 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 231100000419 toxicity Toxicity 0.000 claims 2
- 230000001988 toxicity Effects 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 241000702244 Orthoreovirus Species 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 238000002650 immunosuppressive therapy Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000002703 mutagenesis Methods 0.000 claims 1
- 231100000350 mutagenesis Toxicity 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 238000002741 site-directed mutagenesis Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89442507P | 2007-03-12 | 2007-03-12 | |
| US60/894,425 | 2007-03-12 | ||
| US98956807P | 2007-11-21 | 2007-11-21 | |
| US60/989,568 | 2007-11-21 | ||
| PCT/CA2008/000483 WO2008110004A1 (en) | 2007-03-12 | 2008-03-11 | Reoviruses having modified sequences |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010520758A JP2010520758A (ja) | 2010-06-17 |
| JP2010520758A5 true JP2010520758A5 (enExample) | 2011-04-28 |
| JP5577103B2 JP5577103B2 (ja) | 2014-08-20 |
Family
ID=39758956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009552983A Active JP5577103B2 (ja) | 2007-03-12 | 2008-03-11 | 改変配列を有するレオウイルス |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7803385B2 (enExample) |
| EP (2) | EP2952583A1 (enExample) |
| JP (1) | JP5577103B2 (enExample) |
| KR (1) | KR101647843B1 (enExample) |
| CN (1) | CN103710359A (enExample) |
| AR (1) | AR066395A1 (enExample) |
| AU (1) | AU2008226291B2 (enExample) |
| CA (1) | CA2678721C (enExample) |
| DK (1) | DK2132315T3 (enExample) |
| ES (1) | ES2548442T3 (enExample) |
| IL (4) | IL200353A (enExample) |
| MX (2) | MX2009009598A (enExample) |
| SG (1) | SG191602A1 (enExample) |
| TW (1) | TW200904979A (enExample) |
| WO (1) | WO2008110004A1 (enExample) |
| ZA (1) | ZA200905951B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6110461A (en) * | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| US6136307A (en) * | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
| DK2132315T3 (en) | 2007-03-12 | 2015-10-19 | Oncolytics Biotech Inc | Reoviruses with modified sequences |
| MX2010003556A (es) * | 2007-10-22 | 2010-04-21 | Oncolytics Biotech Inc | Regimen de tratamiento para trastornos proliferantes. |
| EP2296678A4 (en) * | 2008-05-27 | 2012-03-21 | Oncolytics Biotech Inc | MODULATION OF INTERSTITIAL PRESSURE AND ONCOLYTIC VIRUS RELIEF AND DISTRIBUTION |
| US8470312B2 (en) * | 2008-05-27 | 2013-06-25 | Oncolytics Biotech, Inc. | Abrogating proinflammatory cytokine production during oncolytic reovirus therapy |
| MX2010014555A (es) * | 2008-06-26 | 2011-04-27 | Ceva Sante Animale Sa | Reoviridae aviar unico. |
| FR2939807B1 (fr) * | 2008-12-11 | 2010-12-17 | Biomerieux Sa | Nouveau reovirus isole, procedes et kits de detection |
| EP2482824B1 (en) | 2009-10-02 | 2016-11-30 | The Trustees of Columbia University in the City of New York | Piscine reovirus immunogenic compositions |
| JP6034798B2 (ja) * | 2010-12-02 | 2016-11-30 | オンコリティクス バイオテク，インコーポレーテッド | 液体ウイルス製剤 |
| KR102023207B1 (ko) * | 2010-12-02 | 2019-11-25 | 온콜리틱스 바이오테크 인코포레이티드 | 동결건조 바이러스 제형 |
| TW201307561A (zh) * | 2011-04-29 | 2013-02-16 | 腫瘤防治生化科技公司 | 使用凝膠滲透層析法純化病毒之方法 |
| WO2015070323A1 (en) | 2013-11-15 | 2015-05-21 | Oncolytics Biotech Inc. | Oncolytic viruses and increased cancer treatment regimens |
| US9660989B1 (en) | 2014-01-31 | 2017-05-23 | Google Inc. | Internet-wide identity management widget |
| EP3417866B1 (en) | 2016-02-16 | 2020-12-23 | Osaka University | Medicinal composition for treating fibrosis |
| WO2019237063A1 (en) * | 2018-06-07 | 2019-12-12 | Emory University | Modified reoviruses, particles, and uses in treating proliferative disorders |
| KR102401077B1 (ko) | 2019-01-25 | 2022-05-24 | 바이로큐어 주식회사 | 다람쥐 섬유종 바이러스 및 리오바이러스를 포함하는 암 예방 또는 치료용 약학적 조성물 |
| WO2020227245A1 (en) * | 2019-05-03 | 2020-11-12 | Kansas State University Research Foundation | Immunogenic compositions for novel reassortant mammalian ortheovirus from pigs |
| JP2024500164A (ja) * | 2020-12-22 | 2024-01-04 | バイロキュア インコーポレイテッド | 新規な改変レオウイルス及びその用途 |
| CN116917468A (zh) * | 2020-12-22 | 2023-10-20 | 百洛克株式会社 | 新型修饰的呼肠孤病毒及其用途 |
| WO2023048532A1 (ko) * | 2021-09-24 | 2023-03-30 | 바이로큐어 주식회사 | 레오바이러스 기반 신규한 백신플랫폼 및 이의 용도 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US6136307A (en) * | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
| US6110461A (en) | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| US6565831B1 (en) * | 1999-02-24 | 2003-05-20 | Oncolytics Biotech Inc. | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders |
| TWI289158B (en) | 2000-08-10 | 2007-11-01 | Oncolytics Biotech Inc | Method of producing infectious reovirus |
| ATE472733T1 (de) | 2000-11-09 | 2010-07-15 | Oncolytics Biotech Inc | Verfahren zur beurteilung von zellulären proliferativen erkrankungen |
| WO2002043647A2 (en) | 2000-12-01 | 2002-06-06 | University Of Ottawa | Oncolytic virus |
| ES2500645T3 (es) | 2001-03-16 | 2014-09-30 | Oncolytics Biotech Inc. | Método para extracción de virus de un cultivo celular |
| US7163678B2 (en) * | 2002-11-07 | 2007-01-16 | Oncolytics Biotech Inc. | Reovirus for the treatment of ral-mediated cellular proliferative disorders |
| WO2005111200A1 (en) * | 2004-05-17 | 2005-11-24 | Universite De Montreal | Novel strains of reoviruses and methods of uses thereof |
| EP1775343A4 (en) * | 2004-06-24 | 2007-11-14 | Dnavec Research Inc | ANTITUM-AGENT WITH DENDRITIC CELL WITH THE TRANSFECTED RNA VIRUS |
| CA2617600A1 (en) * | 2005-08-01 | 2007-09-07 | University Technologies International, Inc. | Attenuated reovirus |
| US20100086522A1 (en) | 2006-07-18 | 2010-04-08 | Ottawa Health Research Institute | Disparate suicide carrier cells for tumor targeting of promiscuous oncolytic viruses |
| DK2132315T3 (en) | 2007-03-12 | 2015-10-19 | Oncolytics Biotech Inc | Reoviruses with modified sequences |
| US8470312B2 (en) * | 2008-05-27 | 2013-06-25 | Oncolytics Biotech, Inc. | Abrogating proinflammatory cytokine production during oncolytic reovirus therapy |
| KR102023207B1 (ko) * | 2010-12-02 | 2019-11-25 | 온콜리틱스 바이오테크 인코포레이티드 | 동결건조 바이러스 제형 |
| JP6034798B2 (ja) * | 2010-12-02 | 2016-11-30 | オンコリティクス バイオテク，インコーポレーテッド | 液体ウイルス製剤 |
-
2008
- 2008-03-11 DK DK08733587.3T patent/DK2132315T3/en active
- 2008-03-11 SG SG2013040027A patent/SG191602A1/en unknown
- 2008-03-11 JP JP2009552983A patent/JP5577103B2/ja active Active
- 2008-03-11 US US12/046,095 patent/US7803385B2/en active Active
- 2008-03-11 CN CN201310353609.2A patent/CN103710359A/zh active Pending
- 2008-03-11 ES ES08733587.3T patent/ES2548442T3/es active Active
- 2008-03-11 EP EP15176066.7A patent/EP2952583A1/en not_active Withdrawn
- 2008-03-11 MX MX2009009598A patent/MX2009009598A/es active IP Right Grant
- 2008-03-11 KR KR1020097019418A patent/KR101647843B1/ko active Active
- 2008-03-11 WO PCT/CA2008/000483 patent/WO2008110004A1/en not_active Ceased
- 2008-03-11 EP EP08733587.3A patent/EP2132315B1/en active Active
- 2008-03-11 CA CA2678721A patent/CA2678721C/en active Active
- 2008-03-12 AR ARP080101017A patent/AR066395A1/es unknown
- 2008-03-12 TW TW097108636A patent/TW200904979A/zh unknown
- 2008-03-14 AU AU2008226291A patent/AU2008226291B2/en active Active
-
2009
- 2009-08-12 IL IL200353A patent/IL200353A/en active IP Right Grant
- 2009-08-27 ZA ZA2009/05951A patent/ZA200905951B/en unknown
- 2009-09-08 MX MX2013013938A patent/MX346950B/es unknown
-
2010
- 2010-08-02 US US12/848,684 patent/US8691241B2/en active Active
-
2012
- 2012-08-30 IL IL221700A patent/IL221700A0/en unknown
- 2012-08-30 IL IL221702A patent/IL221702A0/en unknown
- 2012-08-30 IL IL221701A patent/IL221701A0/en unknown
-
2014
- 2014-02-13 US US14/179,840 patent/US10039827B2/en active Active
-
2018
- 2018-07-03 US US16/027,206 patent/US10596260B2/en active Active
-
2020
- 2020-02-13 US US16/790,114 patent/US11246930B2/en active Active
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