JP2010519289A5 - - Google Patents
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- JP2010519289A5 JP2010519289A5 JP2009550773A JP2009550773A JP2010519289A5 JP 2010519289 A5 JP2010519289 A5 JP 2010519289A5 JP 2009550773 A JP2009550773 A JP 2009550773A JP 2009550773 A JP2009550773 A JP 2009550773A JP 2010519289 A5 JP2010519289 A5 JP 2010519289A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- independently
- group
- metalloprotein
- antibody according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004965 antibodies Human genes 0.000 claims 10
- 108090001123 antibodies Proteins 0.000 claims 10
- 102000010750 Metalloproteins Human genes 0.000 claims 4
- 108010063312 Metalloproteins Proteins 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- 108010006035 Metalloproteases Proteins 0.000 claims 2
- 102000005741 Metalloproteases Human genes 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000038129 antigens Human genes 0.000 claims 2
- 108091007172 antigens Proteins 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 102100014894 MMP2 Human genes 0.000 claims 1
- 101700060512 MMP2 Proteins 0.000 claims 1
- 102100006844 MMP9 Human genes 0.000 claims 1
- 101700067851 MMP9 Proteins 0.000 claims 1
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Claims (12)
- 一般式（Ｉ）を有する化合物：
式中、
ｍおよびｎはそれぞれが独立して、１〜６の整数である；
Ｘ１〜Ｘ３およびＹ１〜Ｙ３はそれぞれが独立して、ＯまたはＳである；
Ｒ１〜Ｒ３はそれぞれが独立して、水素、アルキルおよびシクロアルキルからなる群から選択される；および
Ｒは（ＣＨ２）ｘ−Ｃ（＝Ｏ）ＮＲ’−（ＣＨ２）ｙ−ＮＲ’Ｒ”であり、
ただし：
ｘおよびｙはそれぞれが独立して、１〜６の整数である；および
Ｒ’およびＲ”はそれぞれが独立して、水素、アルキルおよびシクロアルキルからなる群から選択される。 - 式（ＩＩ）を有する請求項１に記載の化合物：
式中、Ｒ＝−ＣＨ２−Ｃ（＝Ｏ）ＮＨ−ＣＨ２−ＣＨ２−ＮＨ２。 - 請求項１または２に記載の化合物と特異的に結合することができる抗原認識領域を含む抗体。
- 配列番号７、８、９、１０、１１および１２に規定されるＣＤＲアミノ酸配列を含む抗原認識領域を含む抗体。
- 前記ＣＤＲアミノ酸配列は、配列番号１３、１４、１５、１６、１７および１８からなる群から選択される核酸配列によってコードされる、請求項４に記載の抗体。
- 金属タンパク質の活性を阻害することができる、請求項３または４に記載の抗体。
- 前記金属タンパク質は、ＭＭＰ−２およびＭＭＰ−９からなる群から選択される、請求項６に記載の抗体。
- 金属タンパク質阻害剤を製造する方法であって、請求項１または２に記載の化合物に向けられた抗体を作製し、それにより、金属タンパク質阻害剤を製造することを含む方法。
- 請求項３または４に記載の抗体と医薬的に許容され得る担体とを含む医薬組成物。
- マトリックスメタロプロテアーゼ活性を細胞において阻害する方法であって、細胞を請求項３または４に記載される抗体のいずれか１つとインビトロで接触させ、それにより、マトリックスメタロプロテアーゼ活性を細胞において阻害することを含む方法。
- 固体支持体に付着される、請求項３または４に記載の抗体。
- 請求項３または４に記載の抗体と緩衝剤を含むキット。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90285407P | 2007-02-23 | 2007-02-23 | |
| US60/902,854 | 2007-02-23 | ||
| PCT/IL2008/000230 WO2008102359A1 (en) | 2007-02-23 | 2008-02-21 | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013150040A Division JP5792231B2 (ja) | 2007-02-23 | 2013-07-19 | 金属タンパク質の活性を阻害するために有用な抗体および該抗体を含有する医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519289A JP2010519289A (ja) | 2010-06-03 |
| JP2010519289A5 true JP2010519289A5 (ja) | 2011-01-20 |
| JP5513130B2 JP5513130B2 (ja) | 2014-06-04 |
Family
ID=39534848
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009550773A Expired - Fee Related JP5513130B2 (ja) | 2007-02-23 | 2008-02-21 | 金属タンパク質の活性を阻害するために有用な抗体および該抗体を含有する医薬組成物 |
| JP2013150040A Expired - Fee Related JP5792231B2 (ja) | 2007-02-23 | 2013-07-19 | 金属タンパク質の活性を阻害するために有用な抗体および該抗体を含有する医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013150040A Expired - Fee Related JP5792231B2 (ja) | 2007-02-23 | 2013-07-19 | 金属タンパク質の活性を阻害するために有用な抗体および該抗体を含有する医薬組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US8324355B2 (ja) |
| EP (1) | EP2155691B1 (ja) |
| JP (2) | JP5513130B2 (ja) |
| KR (1) | KR20090113908A (ja) |
| CN (1) | CN101702906B (ja) |
| BR (1) | BRPI0807256A2 (ja) |
| CA (1) | CA2678304A1 (ja) |
| IL (2) | IL224120A (ja) |
| MX (1) | MX2009008914A (ja) |
| RU (1) | RU2503682C2 (ja) |
| WO (1) | WO2008102359A1 (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5513130B2 (ja) | 2007-02-23 | 2014-06-04 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | 金属タンパク質の活性を阻害するために有用な抗体および該抗体を含有する医薬組成物 |
| AU2008338421A1 (en) | 2007-12-17 | 2009-06-25 | Dyax Corp. | Compositions and methods for treating osteolytic disorders comprising MMP-14 binding proteins |
| JP2011517320A (ja) * | 2008-03-03 | 2011-06-02 | ダイアックス コーポレーション | メタロプロテアーゼ９結合タンパク質およびメタロプロテアーゼ２結合タンパク質 |
| US8673267B2 (en) * | 2009-03-02 | 2014-03-18 | Massachusetts Institute Of Technology | Methods and products for in vivo enzyme profiling |
| AU2011210362B2 (en) * | 2010-01-27 | 2015-09-10 | Yeda Research And Development Co. Ltd. | Antibodies that inhibit metalloproteins |
| JP5878538B2 (ja) | 2010-08-27 | 2016-03-08 | ギリアド バイオロジクス, インク.Gilead Biologics, Inc. | マトリクスメタロプロティナーゼ９に対する抗体 |
| EP2632956B1 (en) | 2010-10-28 | 2018-06-20 | Yeda Research and Development Co. Ltd. | Methods of generating antibodies to metalloenzymes |
| US10314909B2 (en) | 2011-10-21 | 2019-06-11 | Dyax Corp. | Combination therapy comprising an MMP-14 binding protein |
| US9732156B2 (en) | 2012-02-29 | 2017-08-15 | Gilead Biologics, Inc. | Methods of treating rheumatoid arthritis using antibodies to matrix metalloproteinase 9 |
| CN105452481A (zh) | 2013-06-07 | 2016-03-30 | 麻省理工学院 | 基于亲和力检测配体编码的合成性生物标记物 |
| WO2015150510A1 (en) | 2014-04-03 | 2015-10-08 | Csl Behring Ag | Nebulization of immunoglobulin |
| US11452121B2 (en) | 2014-05-19 | 2022-09-20 | Qualcomm Incorporated | Apparatus and method for synchronous multiplexing and multiple access for different latency targets utilizing thin control |
| US11019620B2 (en) | 2014-05-19 | 2021-05-25 | Qualcomm Incorporated | Apparatus and method for inter-band pairing of carriers for time division duplex transmit- and receive-switching and its application to multiplexing of different transmission time intervals |
| EP2985296A1 (en) * | 2014-08-13 | 2016-02-17 | Calypso Biotech SA | Antibodies specific for MMP9 |
| WO2017176017A1 (en) * | 2016-04-04 | 2017-10-12 | Samsung Electronics Co., Ltd. | Method and apparatus for transmitting and receiving feedback in wireless communication system |
| WO2018148595A1 (en) * | 2017-02-10 | 2018-08-16 | Washington University | Antibodies to tip1 and methods of use thereof |
| CN111051339A (zh) | 2017-07-18 | 2020-04-21 | 第一三共株式会社 | 活性mmp-9-结合肽 |
| EP3911753A1 (en) | 2019-01-17 | 2021-11-24 | Massachusetts Institute of Technology | Sensors for detecting and imaging of cancer metastasis |
| IL264768A (en) | 2019-02-10 | 2020-08-31 | Sagi Irit | ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use |
| US11332546B2 (en) | 2019-05-21 | 2022-05-17 | The Regents Of The University Of California | Protease inhibitory antibodies and methods of use thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595700A (en) | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| US5525629A (en) | 1992-04-07 | 1996-06-11 | British Bio-Technology Limited | Inhibition of cytokine production |
| GB9320660D0 (en) | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| AU2361295A (en) | 1994-04-28 | 1995-11-29 | Merck & Co., Inc. | N-carboxyalkyl derivatives as antidegenerative active agents |
| WO1995029892A1 (en) | 1994-04-28 | 1995-11-09 | The Du Pont Merck Pharmaceutical Company | Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents |
| GB9416897D0 (en) | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
| PT757984E (pt) | 1995-08-08 | 2003-02-28 | Ono Pharmaceutical Co | Derivados de acido hidroxamico uteis para inibir a gelatinase |
| IL116126A0 (en) * | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
| ATE225343T1 (de) | 1995-12-20 | 2002-10-15 | Hoffmann La Roche | Matrix-metalloprotease inhibitoren |
| EP0871439B1 (en) | 1996-01-02 | 2004-03-31 | Aventis Pharmaceuticals Inc. | Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds |
| KR20000022532A (ko) | 1996-06-27 | 2000-04-25 | 오노 야꾸힝 고교 가부시키가이샤 | 아릴(설파이드, 설폭시드 및 설폰)유도체 및 이를 활성 성분으로 함유하는 약물 |
| US6174915B1 (en) | 1997-03-25 | 2001-01-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| AU758619B2 (en) | 1998-07-30 | 2003-03-27 | Warner-Lambert Company | Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases |
| IL132105A0 (en) * | 1998-12-24 | 2001-03-19 | Yeda Res & Dev | Caspase-8 interacting proteins |
| ATE517926T1 (de) * | 2003-04-04 | 2011-08-15 | Yeda Res & Dev | Antikörper zur hemmung der aktivität von mmp-2 und mmp-9 |
| JP5513130B2 (ja) * | 2007-02-23 | 2014-06-04 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | 金属タンパク質の活性を阻害するために有用な抗体および該抗体を含有する医薬組成物 |
| AU2011210362B2 (en) | 2010-01-27 | 2015-09-10 | Yeda Research And Development Co. Ltd. | Antibodies that inhibit metalloproteins |
-
2008
- 2008-02-21 JP JP2009550773A patent/JP5513130B2/ja not_active Expired - Fee Related
- 2008-02-21 BR BRPI0807256-6A2A patent/BRPI0807256A2/pt not_active IP Right Cessation
- 2008-02-21 WO PCT/IL2008/000230 patent/WO2008102359A1/en active Application Filing
- 2008-02-21 US US12/449,728 patent/US8324355B2/en active Active
- 2008-02-21 CN CN200880012673.1A patent/CN101702906B/zh not_active Expired - Fee Related
- 2008-02-21 RU RU2009132006/04A patent/RU2503682C2/ru not_active IP Right Cessation
- 2008-02-21 EP EP08710230.7A patent/EP2155691B1/en active Active
- 2008-02-21 KR KR1020097019866A patent/KR20090113908A/ko not_active Application Discontinuation
- 2008-02-21 MX MX2009008914A patent/MX2009008914A/es not_active Application Discontinuation
- 2008-02-21 CA CA002678304A patent/CA2678304A1/en not_active Abandoned
-
2012
- 2012-08-28 US US13/596,090 patent/US8486653B2/en active Active
-
2013
- 2013-01-06 IL IL224120A patent/IL224120A/en active IP Right Grant
- 2013-01-06 IL IL224121A patent/IL224121A/en active IP Right Grant
- 2013-04-29 US US13/872,265 patent/US9416195B2/en active Active
- 2013-07-19 JP JP2013150040A patent/JP5792231B2/ja not_active Expired - Fee Related
-
2016
- 2016-05-23 US US15/161,375 patent/US9902783B2/en active Active
-
2018
- 2018-01-09 US US15/865,479 patent/US20180134808A1/en not_active Abandoned
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