JP2010518854A5 - - Google Patents

Info

Publication number

JP2010518854A5

JP2010518854A5 JP2009550888A JP2009550888A JP2010518854A5 JP 2010518854 A5 JP2010518854 A5 JP 2010518854A5 JP 2009550888 A JP2009550888 A JP 2009550888A JP 2009550888 A JP2009550888 A JP 2009550888A JP 2010518854 A5 JP2010518854 A5 JP 2010518854A5

Authority

JP

Japan

Prior art keywords

seq

variable region

chain variable

antibody

antigen

Prior art date

2008-02-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 102000036639 antigens Human genes 0.000 claims description 67
• 108091007433 antigens Proteins 0.000 claims description 67
• 238000000034 method Methods 0.000 claims description 19
• SHFKGANKURXVMY-LCWPZEQJSA-N hcv e2 protein Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)CC1=CC=CC=C1 SHFKGANKURXVMY-LCWPZEQJSA-N 0.000 claims description 15
• 239000012634 fragment Substances 0.000 claims description 14
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• 241000124008 Mammalia Species 0.000 claims description 10
• 101710125507 Integrase/recombinase Proteins 0.000 claims description 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
• 230000001404 mediated effect Effects 0.000 claims description 5
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• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
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• 239000003053 toxin Substances 0.000 claims description 2
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• 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 6
• 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 6
• 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 6
• 238000001514 detection method Methods 0.000 claims 1
• 241000711549 Hepacivirus C Species 0.000 description 34
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 12
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• 108091035707 Consensus sequence Proteins 0.000 description 4
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• 238000011830 transgenic mouse model Methods 0.000 description 1