JP2011505867A5 - - Google Patents
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- Publication number
- JP2011505867A5 JP2011505867A5 JP2010538953A JP2010538953A JP2011505867A5 JP 2011505867 A5 JP2011505867 A5 JP 2011505867A5 JP 2010538953 A JP2010538953 A JP 2010538953A JP 2010538953 A JP2010538953 A JP 2010538953A JP 2011505867 A5 JP2011505867 A5 JP 2011505867A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding fragment
- humanized antibody
- hepatitis
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 24
- 239000000427 antigen Substances 0.000 claims 20
- 102000036639 antigens Human genes 0.000 claims 20
- 108091007433 antigens Proteins 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 241000711549 Hepacivirus C Species 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 101710125507 Integrase/recombinase Proteins 0.000 claims 1
- 208000037621 acute hepatitis C virus infection Diseases 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 208000020403 chronic hepatitis C virus infection Diseases 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000013610 patient sample Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US606607P | 2007-12-17 | 2007-12-17 | |
| US61/006,066 | 2007-12-17 | ||
| PCT/IB2008/003952 WO2009081285A2 (en) | 2007-12-17 | 2008-12-17 | Hepatitis c virus antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011505867A JP2011505867A (ja) | 2011-03-03 |
| JP2011505867A5 true JP2011505867A5 (cg-RX-API-DMAC7.html) | 2014-05-22 |
| JP5763344B2 JP5763344B2 (ja) | 2015-08-12 |
Family
ID=40801628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538953A Expired - Fee Related JP5763344B2 (ja) | 2007-12-17 | 2008-12-17 | Ｃ型肝炎ウイルス抗体 |
Country Status (18)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| CA2985229C (en) | 2004-10-07 | 2023-02-07 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| US9457179B2 (en) | 2007-03-20 | 2016-10-04 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
| US9814230B2 (en) | 2008-01-31 | 2017-11-14 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
| MX2011006516A (es) * | 2008-12-17 | 2011-08-04 | Genentech Inc | Terapia de combinacion de virus de hepatitis c. |
| WO2012142487A1 (en) | 2011-04-14 | 2012-10-18 | Transmedics, Inc. | Organ care solution for ex-vivo machine perfusion of donor lungs |
| JP6158171B2 (ja) * | 2011-05-02 | 2017-07-05 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 合成ｃ型肝炎ゲノム、並びに、その製造方法及びその使用 |
| US20130084301A1 (en) * | 2011-08-30 | 2013-04-04 | Steven Foung | Cluster of Neutralizing Antibodies to Hepatitis C Virus |
| US10215457B2 (en) * | 2011-12-09 | 2019-02-26 | Applied Materials, Inc. | Heat exchanger for cooling a heating tube and method thereof |
| ITFI20120122A1 (it) * | 2012-06-15 | 2013-12-16 | Kedrion S P A 50 | Anticorpi monoclonali capaci di legare la proteina virale e2 loro preparazione ed uso. |
| CN102928595A (zh) * | 2012-10-12 | 2013-02-13 | 武汉康苑生物医药科技有限公司 | 丙型肝炎病毒抗原抗体时间分辨免疫荧光分析法联合检测及检测试剂盒 |
| WO2014116749A1 (en) | 2013-01-23 | 2014-07-31 | Genentech, Inc. | Anti-hcv antibodies and methods of using thereof |
| SG10201802194WA (en) * | 2013-09-19 | 2018-05-30 | Novavax Inc | Immunogenic middle east respiratory syndrome coronavirus (mers-cov) compositions and methods |
| RU2539770C1 (ru) * | 2013-12-27 | 2015-01-27 | Татьяна Николаевна Власик | Способ нейтрализации вируса гепатита с, полностью человеческое моноклональное антитело против вируса гепатита с (варианты), композиция полностью человеческих моноклональных антител против вируса гепатита с и гибридная мышь/человек клеточная линия - продуцент полностью человеческих моноклональных антител против вируса гепатита с (варианты) |
| EP3151663B1 (en) | 2014-06-02 | 2020-09-23 | Transmedics, Inc. | Ex vivo organ care system |
| GB201415714D0 (en) * | 2014-09-05 | 2014-10-22 | Medical Res Council | Antibodies and antigen binding fragments thereof |
| BR112017010520B1 (pt) | 2014-12-12 | 2022-08-30 | Tevosol, Inc | Aparelho e método para perfusão de órgãos |
| CA2997267A1 (en) | 2015-09-09 | 2017-03-16 | Transmedics, Inc. | Aortic cannula for ex vivo organ care system |
| CN105177017B (zh) * | 2015-10-30 | 2020-06-02 | 中国人民解放军第三军医大学第一附属医院 | 抗多亚基因型hcv抗体基因r4-85及其应用 |
| CN105219780B (zh) * | 2015-10-30 | 2020-06-02 | 中国人民解放军第三军医大学第一附属医院 | 抗多亚基因型hcv抗体基因r3-19及其应用 |
| KR102640157B1 (ko) * | 2016-03-22 | 2024-02-27 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 인간화 항-클라우딘-1 항체 및 이의 용도 |
| DK3462861T5 (da) | 2016-05-30 | 2024-01-08 | Transmedics Inc | Fremgangsmåde til ex vivo-lungeventilati on med et varierende udvendigt tryk |
| US11236171B2 (en) | 2016-12-21 | 2022-02-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies specific for FLT3 and uses thereof |
| US10953089B1 (en) | 2020-01-27 | 2021-03-23 | Novavax, Inc. | Coronavirus vaccine formulations |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2272443B (en) * | 1991-06-10 | 1995-10-25 | Lucky Ltd | Nucleotide and amino acid sequences of Korean hepatitis C virus |
| ITPN960013A1 (it) * | 1996-02-26 | 1997-08-26 | Marcello Piazza | Farmaco atto a proteggere l'individuo dal contagio di epatite virale, ecc. |
| US20060188511A1 (en) | 1998-11-05 | 2006-08-24 | Foung Steven K | Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes |
| AU2002243259B2 (en) * | 2000-12-01 | 2008-02-07 | The Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Monoclonal antibodies specific for the E2 glycoprotein of hepatitis C virus and their use in the diagnosis, treatment, and prevention of hepatitis C |
| ITRM20020049A1 (it) * | 2002-01-30 | 2003-07-30 | Biostrands S R L | Frammenti fab di anticorpi monoclonali umani diretti contro la glicoproteina e2 di hcv e dotati di potere neutralizzante in vitro. |
| CA2601400A1 (en) * | 2005-03-19 | 2006-09-28 | Medical Research Council | Improvements in or relating to treatment and prevention of viral infections |
-
2008
- 2008-12-17 EP EP08865543.6A patent/EP2231704B1/en not_active Not-in-force
- 2008-12-17 KR KR1020107015856A patent/KR20100102163A/ko not_active Ceased
- 2008-12-17 CN CN200880125928.5A patent/CN101939334B/zh not_active Expired - Fee Related
- 2008-12-17 BR BRPI0821252-0A patent/BRPI0821252A2/pt not_active IP Right Cessation
- 2008-12-17 US US12/809,050 patent/US9193781B2/en not_active Expired - Fee Related
- 2008-12-17 MX MX2010006767A patent/MX2010006767A/es not_active Application Discontinuation
- 2008-12-17 CA CA2708740A patent/CA2708740C/en not_active Expired - Fee Related
- 2008-12-17 AU AU2008341542A patent/AU2008341542B2/en not_active Ceased
- 2008-12-17 WO PCT/IB2008/003952 patent/WO2009081285A2/en not_active Ceased
- 2008-12-17 JP JP2010538953A patent/JP5763344B2/ja not_active Expired - Fee Related
- 2008-12-17 RU RU2010129429/10A patent/RU2462475C2/ru not_active IP Right Cessation
- 2008-12-17 PE PE2008002086A patent/PE20091109A1/es not_active Application Discontinuation
- 2008-12-17 NZ NZ585622A patent/NZ585622A/xx not_active IP Right Cessation
- 2008-12-17 CL CL2008003784A patent/CL2008003784A1/es unknown
- 2008-12-17 TW TW097149206A patent/TW200940090A/zh unknown
- 2008-12-18 AR ARP080105506A patent/AR072039A1/es not_active Application Discontinuation
-
2010
- 2010-05-16 IL IL205795A patent/IL205795A0/en unknown
- 2010-05-18 ZA ZA2010/03509A patent/ZA201003509B/en unknown