JP2010518154A5 - - Google Patents
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- Publication number
- JP2010518154A5 JP2010518154A5 JP2009549466A JP2009549466A JP2010518154A5 JP 2010518154 A5 JP2010518154 A5 JP 2010518154A5 JP 2009549466 A JP2009549466 A JP 2009549466A JP 2009549466 A JP2009549466 A JP 2009549466A JP 2010518154 A5 JP2010518154 A5 JP 2010518154A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- active ingredient
- disease
- tamoxifen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 239000004480 active ingredient Substances 0.000 claims 17
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 229960001603 tamoxifen Drugs 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 230000007423 decrease Effects 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical group CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 4
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 claims 4
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 4
- 229960003009 clopidogrel Drugs 0.000 claims 4
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 208000019553 vascular disease Diseases 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- 206010059245 Angiopathy Diseases 0.000 claims 3
- 229940127218 antiplatelet drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010002388 Angina unstable Diseases 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims 2
- 206010051787 Multiple organ transplant rejection Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 208000007814 Unstable Angina Diseases 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000003111 delayed effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 230000023750 transforming growth factor beta production Effects 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- ZQZFYGIXNQKOAV-OCEACIFDSA-N Droloxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C(O)C=CC=1)\C1=CC=C(OCCN(C)C)C=C1 ZQZFYGIXNQKOAV-OCEACIFDSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- JJKOTMDDZAJTGQ-DQSJHHFOSA-N Idoxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN2CCCC2)=CC=1)/C1=CC=C(I)C=C1 JJKOTMDDZAJTGQ-DQSJHHFOSA-N 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- BXBJCCCIFADZBU-UHFFFAOYSA-J copper aspirinate Chemical compound [Cu+2].[Cu+2].CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O BXBJCCCIFADZBU-UHFFFAOYSA-J 0.000 claims 1
- 229950004203 droloxifene Drugs 0.000 claims 1
- 229960001123 epoprostenol Drugs 0.000 claims 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229950002248 idoxifene Drugs 0.000 claims 1
- 229960002240 iloprost Drugs 0.000 claims 1
- HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 claims 1
- 239000003055 low molecular weight heparin Substances 0.000 claims 1
- 229940127215 low-molecular weight heparin Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 claims 1
- 229960004622 raloxifene Drugs 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical group C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 229960003425 tirofiban Drugs 0.000 claims 1
- COKMIXFXJJXBQG-NRFANRHFSA-N tirofiban Chemical compound C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 COKMIXFXJJXBQG-NRFANRHFSA-N 0.000 claims 1
- 229960005026 toremifene Drugs 0.000 claims 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0702871.5A GB0702871D0 (en) | 2007-02-14 | 2007-02-14 | Improved compositions and combinations 1 |
| PCT/GB2008/000451 WO2008099144A2 (en) | 2007-02-14 | 2008-02-07 | Tgf-beta stimulant and further agent to reduce side effects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518154A JP2010518154A (ja) | 2010-05-27 |
| JP2010518154A5 true JP2010518154A5 (enExample) | 2011-03-31 |
Family
ID=37908631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549466A Pending JP2010518154A (ja) | 2007-02-14 | 2008-02-07 | 副作用を減少させる、ｔｇｆ−ベータ刺激因子及び追加の剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100099642A1 (enExample) |
| EP (1) | EP2121020A2 (enExample) |
| JP (1) | JP2010518154A (enExample) |
| CN (1) | CN101668543A (enExample) |
| CA (1) | CA2678127A1 (enExample) |
| GB (1) | GB0702871D0 (enExample) |
| RU (1) | RU2009134039A (enExample) |
| WO (1) | WO2008099144A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2939314A1 (fr) * | 2008-12-04 | 2010-06-11 | Univ Victor Segalen Bordeaux 2 | Nouvelles compositions et methodes pour la potentialisation des signaux d'apoptose dans les cellules tumorales |
| GB2475907A (en) * | 2009-12-04 | 2011-06-08 | Tcp Innovations Ltd | Composition comprising a mixture of clopidogrel and droloxifene |
| US20110136858A1 (en) * | 2009-12-04 | 2011-06-09 | Grainger David J | Preferred Combination Therapy |
| WO2015103355A1 (en) | 2014-01-01 | 2015-07-09 | Medivation Technologies, Inc. | Compounds and methods of use |
| CN104211778A (zh) * | 2014-09-28 | 2014-12-17 | 苏州普罗达生物科技有限公司 | 一种转化生长因子β1激动剂多肽及其制备方法、应用 |
| CN104311631A (zh) * | 2014-09-28 | 2015-01-28 | 苏州普罗达生物科技有限公司 | 转化生长因子β1激动剂多肽及其制备方法、应用 |
| WO2020097317A1 (en) * | 2018-11-07 | 2020-05-14 | Health Research, Inc. | Exploiting estrogen receptor beta and tp53 interaction as a new therapeutic strategy for cancer |
| CN116152157A (zh) * | 2022-11-28 | 2023-05-23 | 苏州大学 | 基于肿瘤组织灌注影像学特征的生物标志物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6251920B1 (en) * | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6117911A (en) * | 1997-04-11 | 2000-09-12 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
-
2007
- 2007-02-14 GB GBGB0702871.5A patent/GB0702871D0/en not_active Ceased
-
2008
- 2008-02-07 WO PCT/GB2008/000451 patent/WO2008099144A2/en not_active Ceased
- 2008-02-07 US US12/527,337 patent/US20100099642A1/en not_active Abandoned
- 2008-02-07 CN CN200880009702A patent/CN101668543A/zh active Pending
- 2008-02-07 EP EP08709352A patent/EP2121020A2/en not_active Withdrawn
- 2008-02-07 RU RU2009134039/15A patent/RU2009134039A/ru not_active Application Discontinuation
- 2008-02-07 JP JP2009549466A patent/JP2010518154A/ja active Pending
- 2008-02-07 CA CA002678127A patent/CA2678127A1/en not_active Abandoned
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