JP2004528311A5 - - Google Patents
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- Publication number
- JP2004528311A5 JP2004528311A5 JP2002576193A JP2002576193A JP2004528311A5 JP 2004528311 A5 JP2004528311 A5 JP 2004528311A5 JP 2002576193 A JP2002576193 A JP 2002576193A JP 2002576193 A JP2002576193 A JP 2002576193A JP 2004528311 A5 JP2004528311 A5 JP 2004528311A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- optionally substituted
- formula
- independently selected
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims description 20
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 9
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 9
- 125000003107 substituted aryl group Chemical group 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- SHNYEQQLGGRSGF-UHFFFAOYSA-N 1,3-bis(4-chloro-3-nitrophenyl)urea Chemical compound C1=C(Cl)C([N+](=O)[O-])=CC(NC(=O)NC=2C=C(C(Cl)=CC=2)[N+]([O-])=O)=C1 SHNYEQQLGGRSGF-UHFFFAOYSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 229940121357 antivirals Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27398801P | 2001-03-07 | 2001-03-07 | |
| US10/082,802 US6525091B2 (en) | 2001-03-07 | 2002-02-22 | Substituted diarylureas as stimulators for Fas-mediated apoptosis |
| PCT/US2002/006217 WO2002076930A2 (en) | 2001-03-07 | 2002-03-01 | Substituted diarylureas as stimulators for fas-mediated apoptosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528311A JP2004528311A (ja) | 2004-09-16 |
| JP2004528311A5 true JP2004528311A5 (enExample) | 2006-01-05 |
Family
ID=26767870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576193A Withdrawn JP2004528311A (ja) | 2001-03-07 | 2002-03-01 | Ｆａｓ媒介アポトーシスの刺激剤としての置換ジアリールウレア |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1366021B1 (enExample) |
| JP (1) | JP2004528311A (enExample) |
| AT (1) | ATE366720T1 (enExample) |
| AU (1) | AU2002306618B2 (enExample) |
| CA (1) | CA2434020A1 (enExample) |
| DE (1) | DE60221104T2 (enExample) |
| ES (1) | ES2286267T3 (enExample) |
| WO (1) | WO2002076930A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
| WO2004039765A1 (en) * | 2002-10-31 | 2004-05-13 | Amersham Biosciences Ab | Use of urea variants as affinity ligands |
| EP1626714B1 (en) | 2003-05-20 | 2007-07-04 | Bayer Pharmaceuticals Corporation | Diaryl ureas for diseases mediated by pdgfr |
| EP1663978B1 (en) | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
| US12098117B2 (en) * | 2018-12-11 | 2024-09-24 | Duke University | Compositions and methods for the treatment of cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3214468A (en) * | 1959-08-14 | 1965-10-26 | Geigy Ag J R | Bis-(trifluoromethyl)-carbanilides |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| CA2315715C (en) * | 1997-12-22 | 2010-06-22 | Bayer Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| CN1213022C (zh) * | 1997-12-22 | 2005-08-03 | 拜尔有限公司 | 用对称和不对称的取代二苯脲抑制raf激酶 |
| ATE269295T1 (de) * | 1998-04-17 | 2004-07-15 | Parker Hughes Inst | Btk inhibitoren und verfahren zur identifizierung und verwendung |
-
2002
- 2002-03-01 WO PCT/US2002/006217 patent/WO2002076930A2/en not_active Ceased
- 2002-03-01 AT AT02753691T patent/ATE366720T1/de not_active IP Right Cessation
- 2002-03-01 EP EP02753691A patent/EP1366021B1/en not_active Expired - Lifetime
- 2002-03-01 CA CA002434020A patent/CA2434020A1/en not_active Abandoned
- 2002-03-01 DE DE60221104T patent/DE60221104T2/de not_active Expired - Fee Related
- 2002-03-01 AU AU2002306618A patent/AU2002306618B2/en not_active Ceased
- 2002-03-01 JP JP2002576193A patent/JP2004528311A/ja not_active Withdrawn
- 2002-03-01 ES ES02753691T patent/ES2286267T3/es not_active Expired - Lifetime
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