ES2286267T3 - Diarilureas sustituidas como estimuladoras de mediada por fas. - Google Patents

Diarilureas sustituidas como estimuladoras de mediada por fas. Download PDF

Info

Publication number
ES2286267T3
ES2286267T3 ES02753691T ES02753691T ES2286267T3 ES 2286267 T3 ES2286267 T3 ES 2286267T3 ES 02753691 T ES02753691 T ES 02753691T ES 02753691 T ES02753691 T ES 02753691T ES 2286267 T3 ES2286267 T3 ES 2286267T3
Authority
ES
Spain
Prior art keywords
compound
fas
optionally substituted
compound according
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02753691T
Other languages
English (en)
Spanish (es)
Inventor
Louise Robinson
Hugo O. Villar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/082,802 external-priority patent/US6525091B2/en
Application filed by Telik Inc filed Critical Telik Inc
Application granted granted Critical
Publication of ES2286267T3 publication Critical patent/ES2286267T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/42—Y being a hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES02753691T 2001-03-07 2002-03-01 Diarilureas sustituidas como estimuladoras de mediada por fas. Expired - Lifetime ES2286267T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US27398801P 2001-03-07 2001-03-07
US273988P 2001-03-07
US10/082,802 US6525091B2 (en) 2001-03-07 2002-02-22 Substituted diarylureas as stimulators for Fas-mediated apoptosis
US82802 2002-02-22

Publications (1)

Publication Number Publication Date
ES2286267T3 true ES2286267T3 (es) 2007-12-01

Family

ID=26767870

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02753691T Expired - Lifetime ES2286267T3 (es) 2001-03-07 2002-03-01 Diarilureas sustituidas como estimuladoras de mediada por fas.

Country Status (8)

Country Link
EP (1) EP1366021B1 (enExample)
JP (1) JP2004528311A (enExample)
AT (1) ATE366720T1 (enExample)
AU (1) AU2002306618B2 (enExample)
CA (1) CA2434020A1 (enExample)
DE (1) DE60221104T2 (enExample)
ES (1) ES2286267T3 (enExample)
WO (1) WO2002076930A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2298311B1 (en) 1999-01-13 2012-05-09 Bayer HealthCare LLC w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
DK1478358T3 (da) 2002-02-11 2013-10-07 Bayer Healthcare Llc Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
WO2004039765A1 (en) * 2002-10-31 2004-05-13 Amersham Biosciences Ab Use of urea variants as affinity ligands
EP1636585B2 (en) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl ureas with kinase inhibiting activity
PL1663978T3 (pl) 2003-07-23 2008-04-30 Bayer Healthcare Llc Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów
US12098117B2 (en) * 2018-12-11 2024-09-24 Duke University Compositions and methods for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3214468A (en) * 1959-08-14 1965-10-26 Geigy Ag J R Bis-(trifluoromethyl)-carbanilides
US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
ATE291011T1 (de) * 1997-12-22 2005-04-15 Bayer Pharmaceuticals Corp Hemmung der raf-kinase unter verwendung von symmetrisch und unsymmetrisch substituierten harnstoffen
DE69830513T2 (de) * 1997-12-22 2006-03-16 Bayer Pharmaceuticals Corp., West Haven HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN
AU3653099A (en) * 1998-04-17 1999-11-08 Parker Hughes Institute Btk inhibitors and methods for their identification and use

Also Published As

Publication number Publication date
WO2002076930A3 (en) 2003-01-16
CA2434020A1 (en) 2002-10-03
JP2004528311A (ja) 2004-09-16
DE60221104D1 (de) 2007-08-23
AU2002306618B2 (en) 2006-11-09
EP1366021B1 (en) 2007-07-11
DE60221104T2 (de) 2008-03-13
WO2002076930A2 (en) 2002-10-03
ATE366720T1 (de) 2007-08-15
EP1366021A2 (en) 2003-12-03

Similar Documents

Publication Publication Date Title
US6525091B2 (en) Substituted diarylureas as stimulators for Fas-mediated apoptosis
ES2991366T3 (es) Inhibidores de NEK7 cinasa
JP3476203B2 (ja) カルシトニン擬似体
TW202134216A (zh) HIF-2α抑制劑
TW202508563A (zh) Ｋａｒｓ調節化合物
TW202519526A (zh) 二醯基甘油激酶調節化合物
KR102287207B1 (ko) Nhe3-결합 화합물 및 포스페이트 수송을 저해하는 방법
US20190389844A1 (en) 2-arylsulfonamido-n-arylacetamide derivatized stat3 inhibitors
JP7498108B2 (ja) 医学的障害の予防および治療のための化合物およびその使用
BR112019023722A2 (pt) Compostos para a prevenção e tratamento de doenças e o uso dos mesmos
CN111356675A (zh) 用于治疗病症的cxcr-2抑制剂
US6372719B1 (en) ανβ3 integrin antagonists in combination with chemotherapeutic agents
TW201320997A (zh) 含ｓｒｃ同源區２蛋白酪胺酸磷酸酶－１增效劑及其治療方法
CN101932565B (zh) 作为akt蛋白激酶抑制剂的羟基化嘧啶基环戊烷
RU2418584C2 (ru) Новые производные флороглюцина, обладающие активностью в отношении лиганда селектина
WO2018031579A1 (en) Momelotinib for treating of acvr1 -mediated diseases
WO2012022780A1 (en) 18-beta-glycyrrhetinic acid derivatives with anti-tumor activity
ES2800162T3 (es) Uso terapéutico de moduladores funcionales negativos de la eritropoyetina
EP1366021B1 (en) Substituted diarylureas as stimulators for fas-mediated apoptosis
AU2002306618A1 (en) Substituted diarylureas as stimulators for Fas-mediated apoptosis
JP2022502378A (ja) ２’−ハロゲン化−４’−チオ−２’−デオキシ−５−アザシチジンアナログおよびその使用
RU2434006C2 (ru) Новые полициклические соединения
WO2005089068A2 (en) Pharmaceutical compositions comprising anti-inflammatory quinazolinecarboxamide derivatives
JP2005516052A (ja) 非鎮静性バルビツール酸誘導体
WO2002072096A1 (en) Acridines as stimulators for fas-mediated apoptosis