DE60221104D1 - Substituierte diarylharnstoffe als stimulatoren der fas-vermittelten apoptose - Google Patents

Substituierte diarylharnstoffe als stimulatoren der fas-vermittelten apoptose

Info

Publication number
DE60221104D1
DE60221104D1 DE60221104T DE60221104T DE60221104D1 DE 60221104 D1 DE60221104 D1 DE 60221104D1 DE 60221104 T DE60221104 T DE 60221104T DE 60221104 T DE60221104 T DE 60221104T DE 60221104 D1 DE60221104 D1 DE 60221104D1
Authority
DE
Germany
Prior art keywords
fas
mediated apoptosis
harves
stimulators
substituted diaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60221104T
Other languages
English (en)
Other versions
DE60221104T2 (de
Inventor
Louise Robinson
Hugo O Villar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/082,802 external-priority patent/US6525091B2/en
Application filed by Telik Inc filed Critical Telik Inc
Publication of DE60221104D1 publication Critical patent/DE60221104D1/de
Application granted granted Critical
Publication of DE60221104T2 publication Critical patent/DE60221104T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/42—Y being a hetero atom
DE60221104T 2001-03-07 2002-03-01 Substituierte diarylharnstoffe als stimulatoren der fas-vermittelten apoptose Expired - Fee Related DE60221104T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27398801P 2001-03-07 2001-03-07
US273988P 2001-03-07
US10/082,802 US6525091B2 (en) 2001-03-07 2002-02-22 Substituted diarylureas as stimulators for Fas-mediated apoptosis
US82802 2002-02-22
PCT/US2002/006217 WO2002076930A2 (en) 2001-03-07 2002-03-01 Substituted diarylureas as stimulators for fas-mediated apoptosis

Publications (2)

Publication Number Publication Date
DE60221104D1 true DE60221104D1 (de) 2007-08-23
DE60221104T2 DE60221104T2 (de) 2008-03-13

Family

ID=26767870

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60221104T Expired - Fee Related DE60221104T2 (de) 2001-03-07 2002-03-01 Substituierte diarylharnstoffe als stimulatoren der fas-vermittelten apoptose

Country Status (8)

Country Link
EP (1) EP1366021B1 (de)
JP (1) JP2004528311A (de)
AT (1) ATE366720T1 (de)
AU (1) AU2002306618B2 (de)
CA (1) CA2434020A1 (de)
DE (1) DE60221104T2 (de)
ES (1) ES2286267T3 (de)
WO (1) WO2002076930A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000041698A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP2324825A1 (de) 2002-02-11 2011-05-25 Bayer Healthcare LLC Arylharnstoffe mit Angiogenese hemmender Aktivität
US7645903B2 (en) 2002-10-31 2010-01-12 Ge Healthcare Bio-Sciences Ab Use of urea variants as affinity ligands
US8796250B2 (en) 2003-05-20 2014-08-05 Bayer Healthcare Llc Diaryl ureas for diseases mediated by PDGFR
BR122016015715B8 (pt) 2003-07-23 2021-05-25 Bayer Healthcare Llc composições farmacêuticas de metilamida de ácido 4[4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenóxi)-piridina-2-carboxílico

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3214468A (en) * 1959-08-14 1965-10-26 Geigy Ag J R Bis-(trifluoromethyl)-carbanilides
US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
RU2247109C9 (ru) * 1997-12-22 2005-06-20 Байер Копэрейшн Симметричные и несимметричные производные дифенилмочевины (варианты), фармацевтическая композиция, способ подавления роста опухолевых клеток, опосредованного киназой raf
EP1042305B1 (de) * 1997-12-22 2005-06-08 Bayer Pharmaceuticals Corp. HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN
ES2222705T3 (es) * 1998-04-17 2005-02-01 Parker Hughes Institute Inhibidores btk y metodos para su identificacion y uso.

Also Published As

Publication number Publication date
EP1366021B1 (de) 2007-07-11
WO2002076930A2 (en) 2002-10-03
JP2004528311A (ja) 2004-09-16
EP1366021A2 (de) 2003-12-03
CA2434020A1 (en) 2002-10-03
DE60221104T2 (de) 2008-03-13
ATE366720T1 (de) 2007-08-15
ES2286267T3 (es) 2007-12-01
WO2002076930A3 (en) 2003-01-16
AU2002306618B2 (en) 2006-11-09

Similar Documents

Publication Publication Date Title
NO20093464L (no) Nye medikamentblandinger basert pa anti-cholinergisk effektive forbindelser og beta-mimetika
ATE411022T1 (de) Pyridylpyrrol-derivate als wirksame kinase-hemmer
TNSN06034A1 (en) Pyridazine derivatives and their use as therapeutic agents
TNSN06032A1 (en) Pyridazine derivatives and their use as therapeutic agents
ATE408601T1 (de) Fredericamycin-derivate
DK1346041T3 (da) Terapeutiske midler og fremgangsmåder til anvendelse deraf til behandling af en amyloidogen sygdom
ATE538103T1 (de) Chinazolinonverbindungen als antikrebsmittel
EA200501849A1 (ru) Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ
IL175158A0 (en) Tocopherol-modified therapeutic drug compounds
BG108269A (en) Pyrazolopyrimidines as therapeutic agents
HK1095138A1 (en) Azabicyclic heterocycles as cannabinoid receptor modulators
IL189900A0 (en) Mek and methods of their use
ATE442142T1 (de) Fredericamycin-derivate als arzneimittel zur tumorbehandlung
MXPA04005156A (es) Antagonistas del receptor de adenosina a2a.
SE9900961D0 (sv) Novel compounds
ATE236147T1 (de) Derivate von flavonen, xanthonen und kumarinen
SE9802208D0 (sv) Novel compounds
HUP0103078A2 (hu) Készítmények és eljárások szürkehályog kezelésére
ATE357438T1 (de) 1,2,4-triaminobenzolderivate zur behandlung von erkrankungen des zentralnervensystems
ATE396986T1 (de) Pyrimidylpyrrolderivate, die als kinaseinhibitoren wirken
MXPA01008993A (es) Tratamiento de combinacion para depresion y ansiedad.
EP1453507A4 (de) Solubilisierte topoisomerase-gift-mittel
MXPA06007007A (es) Derivados de prolina usados como ingredientes farmaceuticos activos para el tratamiento de tumores.
DE60221104D1 (de) Substituierte diarylharnstoffe als stimulatoren der fas-vermittelten apoptose
SE9802209D0 (sv) Novel compounds

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee