JP2010518029A5 - - Google Patents
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- Publication number
- JP2010518029A5 JP2010518029A5 JP2009548551A JP2009548551A JP2010518029A5 JP 2010518029 A5 JP2010518029 A5 JP 2010518029A5 JP 2009548551 A JP2009548551 A JP 2009548551A JP 2009548551 A JP2009548551 A JP 2009548551A JP 2010518029 A5 JP2010518029 A5 JP 2010518029A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- alkyl
- acyl
- plasmenyl
- glycerol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 46
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 44
- 229940124597 therapeutic agent Drugs 0.000 claims 44
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 34
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims 20
- 208000010877 cognitive disease Diseases 0.000 claims 20
- 208000028698 Cognitive impairment Diseases 0.000 claims 19
- 235000012000 cholesterol Nutrition 0.000 claims 17
- 235000014113 dietary fatty acids Nutrition 0.000 claims 17
- 229930195729 fatty acid Natural products 0.000 claims 17
- 239000000194 fatty acid Substances 0.000 claims 17
- 150000004665 fatty acids Chemical class 0.000 claims 17
- 230000000069 prophylactic effect Effects 0.000 claims 10
- GNGACRATGGDKBX-UHFFFAOYSA-N dihydroxyacetone phosphate Chemical compound OCC(=O)COP(O)(O)=O GNGACRATGGDKBX-UHFFFAOYSA-N 0.000 claims 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 8
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 230000003449 preventive effect Effects 0.000 claims 5
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 4
- SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical class NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 claims 4
- 229910019142 PO4 Inorganic materials 0.000 claims 4
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 4
- 229960000541 cetyl alcohol Drugs 0.000 claims 4
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 4
- 229940055577 oleyl alcohol Drugs 0.000 claims 4
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims 4
- KLAKIAVEMQMVBT-UHFFFAOYSA-N p-hydroxy-phenacyl alcohol Natural products OCC(=O)C1=CC=C(O)C=C1 KLAKIAVEMQMVBT-UHFFFAOYSA-N 0.000 claims 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical class [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 4
- 239000010452 phosphate Chemical class 0.000 claims 4
- 229940012831 stearyl alcohol Drugs 0.000 claims 4
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 229940126033 PPAR agonist Drugs 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 150000001982 diacylglycerols Chemical class 0.000 claims 2
- 238000004949 mass spectrometry Methods 0.000 claims 2
- 230000003557 neuropsychological effect Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 101100424823 Arabidopsis thaliana TDT gene Proteins 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 150000004668 long chain fatty acids Chemical class 0.000 claims 1
- 230000006996 mental state Effects 0.000 claims 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88888307P | 2007-02-08 | 2007-02-08 | |
| US60/888,883 | 2007-02-08 | ||
| PCT/CA2007/001472 WO2008095275A1 (en) | 2007-02-08 | 2007-08-27 | Methods for the treatment of senile dementia of the alzheimer's type |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518029A JP2010518029A (ja) | 2010-05-27 |
| JP2010518029A5 true JP2010518029A5 (enExample) | 2010-10-21 |
| JP5470050B2 JP5470050B2 (ja) | 2014-04-16 |
Family
ID=39537686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548551A Active JP5470050B2 (ja) | 2007-02-08 | 2007-08-27 | アルツハイマー型老年認知症の治療方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US9034923B2 (enExample) |
| EP (2) | EP2117527B1 (enExample) |
| JP (1) | JP5470050B2 (enExample) |
| AU (1) | AU2007346587C1 (enExample) |
| CA (2) | CA2620274C (enExample) |
| IL (1) | IL200029A0 (enExample) |
| SG (1) | SG173418A1 (enExample) |
| WO (1) | WO2008095275A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2117527B1 (en) | 2007-02-08 | 2020-06-17 | Med-Life Discoveries LP | Compounds for use in the treatment of senile dementia of the alzheimer's type |
| TWI475989B (zh) * | 2008-12-22 | 2015-03-11 | Phenomenome Discoveries Inc | 縮醛磷脂類化合物，含彼之醫藥組成物以及治療老化疾病的方法 |
| CA2774869C (en) | 2009-10-01 | 2017-10-24 | Phenomenome Discoveries Inc. | Serum-based biomarkers of pancreatic cancer and uses thereof for disease detection and diagnosis |
| WO2019060298A1 (en) | 2017-09-19 | 2019-03-28 | Neuroenhancement Lab, LLC | METHOD AND APPARATUS FOR NEURO-ACTIVATION |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US11318277B2 (en) | 2017-12-31 | 2022-05-03 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| CA3112564A1 (en) | 2018-09-14 | 2020-03-19 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| CN114236019B (zh) * | 2022-02-24 | 2022-05-06 | 宝枫生物科技（北京）有限公司 | 脑白质病变的生物标志物的应用 |
| CN118512461A (zh) * | 2024-06-03 | 2024-08-20 | 东莞市第八人民医院（东莞市儿童医院） | 一种母乳来源磷脂在防治支气管肺发育不良的应用 |
| CN119876292B (zh) * | 2025-03-27 | 2025-06-03 | 浙江省白马湖实验室有限公司 | 一种酰胺类缩醛磷脂化合物的制备方法及应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994009371A1 (en) | 1992-10-09 | 1994-04-28 | Massachusetts Institute Of Technology | Antemortem diagnostic test for alzheimer's disease |
| FR2736265B1 (fr) | 1995-07-07 | 1997-09-26 | Forgeot Marcel | Nouvelles compositions a base de phosphoglycero ethers et leur utilisation dans le traitement des maladies neuro-degeneratives |
| US5731354A (en) | 1996-05-06 | 1998-03-24 | Clarion Pharmaceuticals Inc. | Treatment for the inhibition of neuro-degenerative disease states |
| US6177476B1 (en) | 1998-08-27 | 2001-01-23 | Clarion Pharmaceuticals Inc. | Nutritional supplements for replenishing plasmalogens |
| CA2298181C (en) | 2000-02-02 | 2006-09-19 | Dayan Burke Goodnough | Non-targeted complex sample analysis |
| EP1285092A4 (en) | 2000-04-14 | 2003-07-16 | Metabolon Inc | METHOD FOR DISCOVERY OF MEDICINES, DISEASE TREATMENT AND DIAGNOSIS USE THE METABOLOMICS |
| US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
| WO2002021139A2 (en) | 2000-09-08 | 2002-03-14 | Oxford Glycosciences (Uk) Ltd. | Automated identification of peptides |
| US6838452B2 (en) * | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| AU2002338348A1 (en) | 2001-04-06 | 2002-10-21 | Biovision Ag | Method for detecting chronic dementia diseases, and corresponding peptides and detection reagents |
| EP1389306A2 (de) | 2001-05-09 | 2004-02-18 | BioVisioN AG | Verfahren zum nachweis einer progedienten, chronisch-demenziellen erkrankung, zugehörige peptide und nachweisreagenzien |
| NZ534751A (en) | 2002-03-22 | 2007-05-31 | Phenomenome Discoveries Inc | Method of visualizing non-targeted metabolomic data generated from fourier transform ion cyclotron resonance mass spectrometers |
| JP2004026803A (ja) * | 2002-03-29 | 2004-01-29 | Nof Corp | 神経細胞死予防剤 |
| ES2311751T3 (es) | 2002-08-23 | 2009-02-16 | Bayer Healthcare Ag | Biomarcadores de polipeptidos para la diagnosis de la enfermedad de alzheimer. |
| SE0203886D0 (sv) * | 2002-12-27 | 2002-12-27 | Ltp Lipid Technologies Provide | Glycerolesterprodukt och dess användning |
| US20040191294A1 (en) * | 2003-03-27 | 2004-09-30 | Ramaprasad Talahalli Ravichandra | Health composition |
| EP1637161A4 (en) * | 2003-04-22 | 2007-06-27 | Astellas Pharma Inc | MEANS FOR THE TREATMENT OF NEURODEGENERATIVE ILLNESSES OF THE BRAIN WITH PPAR [delta] AGONIST |
| EP1694816B1 (en) | 2003-11-07 | 2013-08-28 | Ciphergen Biosystems, Inc. | Biomarkers for alzheimer's disease |
| WO2005085838A2 (en) | 2004-03-02 | 2005-09-15 | Vanderbilt University | Computational analysis of mass spectroscopic lipid data |
| WO2005116659A2 (en) | 2004-05-18 | 2005-12-08 | Neurodx, Llc | Compositions and methods relating to alzheimer’s disease |
| WO2007002285A2 (en) * | 2005-06-21 | 2007-01-04 | The Trustees Of The University Of Pennsylvania | Methods for treating neurological and psychiatric conditions |
| JP4176749B2 (ja) | 2005-07-29 | 2008-11-05 | 学校法人帝京大学 | 疾病検査法 |
| CA2772688A1 (en) | 2005-09-12 | 2007-03-22 | Phenomenome Discoveries Inc. | Methods for the diagnosis of colorectal cancer and ovarian cancer health states |
| EP1932164B1 (en) | 2005-09-15 | 2013-04-24 | Phenomenome Discoveries Inc. | Method and apparatus for fourier transform ion cyclotron resonance mass spectrometry |
| KR20080104350A (ko) | 2006-02-28 | 2008-12-02 | 페노미넘 디스커버리스 인코포레이티드 | 치매 및 다른 신경 장애의 진단을 위한 방법 |
| JP2009538416A (ja) | 2006-05-26 | 2009-11-05 | フェノメノーム ディスカバリーズ インク | 多発性硬化症を診断するための生物マーカー、及びその方法 |
| JPWO2008093709A1 (ja) | 2007-01-30 | 2010-05-20 | 株式会社プロジェクト・エム | アミロイド蛋白質の凝集抑制および分解促進によりアミロイドーシスと関連する疾患を予防または治療するための組成物 |
| EP2117527B1 (en) | 2007-02-08 | 2020-06-17 | Med-Life Discoveries LP | Compounds for use in the treatment of senile dementia of the alzheimer's type |
| US8026099B2 (en) | 2007-07-26 | 2011-09-27 | Washington University | Lipid profile as a biomarker for early detection of neurological disorders |
-
2007
- 2007-08-27 EP EP07800499.1A patent/EP2117527B1/en active Active
- 2007-08-27 AU AU2007346587A patent/AU2007346587C1/en active Active
- 2007-08-27 SG SG2011053717A patent/SG173418A1/en unknown
- 2007-08-27 WO PCT/CA2007/001472 patent/WO2008095275A1/en not_active Ceased
- 2007-08-27 CA CA2620274A patent/CA2620274C/en active Active
- 2007-08-27 EP EP13160192.4A patent/EP2620147B1/en active Active
- 2007-08-27 CA CA2695167A patent/CA2695167C/en active Active
- 2007-08-27 US US12/090,342 patent/US9034923B2/en active Active
- 2007-08-27 JP JP2009548551A patent/JP5470050B2/ja active Active
-
2009
- 2009-07-23 IL IL200029A patent/IL200029A0/en unknown
-
2012
- 2012-06-18 US US13/526,197 patent/US8993623B2/en active Active
-
2015
- 2015-03-19 US US14/663,440 patent/US20160015673A1/en not_active Abandoned
- 2015-03-31 US US14/674,705 patent/US9517222B2/en active Active
-
2016
- 2016-11-11 US US15/349,831 patent/US10123989B2/en active Active
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