JP5470050B2 - アルツハイマー型老年認知症の治療方法 - Google Patents

アルツハイマー型老年認知症の治療方法 Download PDF

Info

Publication number
JP5470050B2
JP5470050B2 JP2009548551A JP2009548551A JP5470050B2 JP 5470050 B2 JP5470050 B2 JP 5470050B2 JP 2009548551 A JP2009548551 A JP 2009548551A JP 2009548551 A JP2009548551 A JP 2009548551A JP 5470050 B2 JP5470050 B2 JP 5470050B2
Authority
JP
Japan
Prior art keywords
acyl
alkyl
sdat
therapeutic agent
plasmenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009548551A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010518029A5 (enExample
JP2010518029A (ja
Inventor
ダイアン グッデノウェ
Original Assignee
フェノメノーム ディスカバリーズ インク
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フェノメノーム ディスカバリーズ インク filed Critical フェノメノーム ディスカバリーズ インク
Publication of JP2010518029A publication Critical patent/JP2010518029A/ja
Publication of JP2010518029A5 publication Critical patent/JP2010518029A5/ja
Application granted granted Critical
Publication of JP5470050B2 publication Critical patent/JP5470050B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
JP2009548551A 2007-02-08 2007-08-27 アルツハイマー型老年認知症の治療方法 Active JP5470050B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88888307P 2007-02-08 2007-02-08
US60/888,883 2007-02-08
PCT/CA2007/001472 WO2008095275A1 (en) 2007-02-08 2007-08-27 Methods for the treatment of senile dementia of the alzheimer's type

Publications (3)

Publication Number Publication Date
JP2010518029A JP2010518029A (ja) 2010-05-27
JP2010518029A5 JP2010518029A5 (enExample) 2010-10-21
JP5470050B2 true JP5470050B2 (ja) 2014-04-16

Family

ID=39537686

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009548551A Active JP5470050B2 (ja) 2007-02-08 2007-08-27 アルツハイマー型老年認知症の治療方法

Country Status (8)

Country Link
US (5) US9034923B2 (enExample)
EP (2) EP2117527B1 (enExample)
JP (1) JP5470050B2 (enExample)
AU (1) AU2007346587C1 (enExample)
CA (2) CA2695167C (enExample)
IL (1) IL200029A0 (enExample)
SG (1) SG173418A1 (enExample)
WO (1) WO2008095275A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007346587C1 (en) 2007-02-08 2015-01-22 Med-Life Discoveries Lp Methods for the treatment of Senile Dementia of the Alzheimer's Type
TWI475989B (zh) * 2008-12-22 2015-03-11 Phenomenome Discoveries Inc 縮醛磷脂類化合物,含彼之醫藥組成物以及治療老化疾病的方法
US10024857B2 (en) 2009-10-01 2018-07-17 Med-Life Discoveries Lp Serum-based biomarkers of pancreatic cancer and uses thereof for disease detection and diagnosis
US11723579B2 (en) 2017-09-19 2023-08-15 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US12280219B2 (en) 2017-12-31 2025-04-22 NeuroLight, Inc. Method and apparatus for neuroenhancement to enhance emotional response
US11478603B2 (en) 2017-12-31 2022-10-25 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
WO2020056418A1 (en) 2018-09-14 2020-03-19 Neuroenhancement Lab, LLC System and method of improving sleep
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
CN114236019B (zh) * 2022-02-24 2022-05-06 宝枫生物科技(北京)有限公司 脑白质病变的生物标志物的应用
CN118512461A (zh) * 2024-06-03 2024-08-20 东莞市第八人民医院(东莞市儿童医院) 一种母乳来源磷脂在防治支气管肺发育不良的应用
CN119876292B (zh) * 2025-03-27 2025-06-03 浙江省白马湖实验室有限公司 一种酰胺类缩醛磷脂化合物的制备方法及应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009371A1 (en) 1992-10-09 1994-04-28 Massachusetts Institute Of Technology Antemortem diagnostic test for alzheimer's disease
FR2736265B1 (fr) 1995-07-07 1997-09-26 Forgeot Marcel Nouvelles compositions a base de phosphoglycero ethers et leur utilisation dans le traitement des maladies neuro-degeneratives
US5731354A (en) 1996-05-06 1998-03-24 Clarion Pharmaceuticals Inc. Treatment for the inhibition of neuro-degenerative disease states
US6177476B1 (en) 1998-08-27 2001-01-23 Clarion Pharmaceuticals Inc. Nutritional supplements for replenishing plasmalogens
CA2298181C (en) 2000-02-02 2006-09-19 Dayan Burke Goodnough Non-targeted complex sample analysis
WO2001078652A2 (en) 2000-04-14 2001-10-25 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
WO2002021139A2 (en) 2000-09-08 2002-03-14 Oxford Glycosciences (Uk) Ltd. Automated identification of peptides
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
DE10291524D2 (de) 2001-04-06 2004-07-01 Anker Thorsten Verfahren zum Nachweis chronisch-demenzieller Erkrankungen, zugehörige Peptide und Nachweisreagenzien
DE10291986D2 (de) 2001-05-09 2004-04-15 Biovision Ag Verfahren zum Nachweis einer progredienten, chronisch-demenziellen Erkrankung, zugehörige Peptide und Nachweisreagenzien
WO2003081506A2 (en) 2002-03-22 2003-10-02 Phenomenome Discoveries Inc. Method of visualizing non-targeted metabolomic data generated from fourier transform ion cyclotron resonance mass spectrometers
JP2004026803A (ja) * 2002-03-29 2004-01-29 Nof Corp 神経細胞死予防剤
CA2746000C (en) 2002-08-23 2014-10-21 Bayer Schering Pharma Aktiengesellschaft Biomarkers for diagnosing alzheimer's disease
SE0203886D0 (sv) * 2002-12-27 2002-12-27 Ltp Lipid Technologies Provide Glycerolesterprodukt och dess användning
US20040191294A1 (en) * 2003-03-27 2004-09-30 Ramaprasad Talahalli Ravichandra Health composition
JPWO2004093910A1 (ja) 2003-04-22 2006-07-13 アステラス製薬株式会社 PPARδアゴニストによる脳神経変性疾患治療剤
US7794948B2 (en) 2003-11-07 2010-09-14 Vermilllion, Inc. Biomarkers for alzheimer's disease
WO2005085838A2 (en) 2004-03-02 2005-09-15 Vanderbilt University Computational analysis of mass spectroscopic lipid data
WO2005116659A2 (en) 2004-05-18 2005-12-08 Neurodx, Llc Compositions and methods relating to alzheimer’s disease
WO2007002285A2 (en) * 2005-06-21 2007-01-04 The Trustees Of The University Of Pennsylvania Methods for treating neurological and psychiatric conditions
JP4176749B2 (ja) 2005-07-29 2008-11-05 学校法人帝京大学 疾病検査法
CA2772688A1 (en) 2005-09-12 2007-03-22 Phenomenome Discoveries Inc. Methods for the diagnosis of colorectal cancer and ovarian cancer health states
US20090057553A1 (en) 2005-09-15 2009-03-05 Phenomenome Discoveries Inc. Method and apparatus for fourier transform ion cyclotron resonance mass spectrometry
CA2689848A1 (en) * 2006-02-28 2007-09-07 Phenomenome Discoveries Inc. Methods for the diagnosis of dementia and other neurological disorders
EP3231789A1 (en) 2006-05-26 2017-10-18 Phenomenome Discoveries Inc. Biomarkers for diagnosing multiple sclerosis, and methods thereof
WO2008093709A1 (ja) 2007-01-30 2008-08-07 Tohoku University アミロイド蛋白質の凝集抑制および分解促進によりアミロイドーシスと関連する疾患を予防または治療するための組成物
AU2007346587C1 (en) 2007-02-08 2015-01-22 Med-Life Discoveries Lp Methods for the treatment of Senile Dementia of the Alzheimer's Type
US8026099B2 (en) 2007-07-26 2011-09-27 Washington University Lipid profile as a biomarker for early detection of neurological disorders

Also Published As

Publication number Publication date
EP2620147B1 (en) 2020-06-03
US20120129934A1 (en) 2012-05-24
CA2620274A1 (en) 2008-06-20
EP2620147A3 (en) 2013-10-02
EP2117527A4 (en) 2012-09-12
US20150306057A1 (en) 2015-10-29
US9517222B2 (en) 2016-12-13
US20130046016A1 (en) 2013-02-21
EP2117527B1 (en) 2020-06-17
CA2620274C (en) 2011-10-04
AU2007346587A1 (en) 2008-08-14
US20160015673A1 (en) 2016-01-21
WO2008095275A1 (en) 2008-08-14
US9034923B2 (en) 2015-05-19
IL200029A0 (en) 2010-04-15
AU2007346587B2 (en) 2014-03-27
US20170056363A1 (en) 2017-03-02
CA2695167C (en) 2011-11-01
EP2117527A1 (en) 2009-11-18
US8993623B2 (en) 2015-03-31
JP2010518029A (ja) 2010-05-27
US10123989B2 (en) 2018-11-13
AU2007346587C1 (en) 2015-01-22
SG173418A1 (en) 2011-08-29
CA2695167A1 (en) 2008-06-20
EP2620147A2 (en) 2013-07-31

Similar Documents

Publication Publication Date Title
JP5470050B2 (ja) アルツハイマー型老年認知症の治療方法
Thomas et al. Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders
Corrigan et al. Abnormal content of n− 6 and n− 3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content
EP2493296B1 (en) Alleviating oxidative stress disorders with pufa derivatives
Senanayake et al. Plasmalogen deficiency and neuropathology in Alzheimer's disease: Causation or coincidence?
Lee et al. Identification of altered metabolic pathways during disease progression in EAE mice via metabolomics and lipidomics
Song et al. Effects of dietary glucocerebrosides from sea cucumber on the brain sphingolipid profiles of mouse models of Alzheimer's disease
Meletis Alkyl-acylglycerols and the important clinical ramifications of raising plasmalogens in dementia and Alzheimer’s disease
Nishiyama et al. Homostachydrine is a xenobiotic substrate of OCTN1/SLC22A4 and potentially sensitizes pentylenetetrazole-induced seizures in mice
Wood et al. Plasmalogen deficit: a new and testable hypothesis for the etiology of Alzheimer’s disease
Zhou et al. Effects of (S)-ketamine on depression-like behaviors in a chronic variable stress model: a role of brain lipidome
Zhang et al. Characterization of metabolites in a zebrafish model of alzheimer’s disease supplemented with mussel-derived plasmalogens by ultraperformance liquid chromatography q-exactive orbitrap mass spectrometry-based unbiased metabolomics
Slayo et al. The role of n-3-derived specialised pro-resolving mediators (SPMs) in microglial mitochondrial respiration and inflammation resolution in alzheimer’s disease
AU2014201707B2 (en) Methods for the treatment of Senile Dementia of the Alzheimer's Type
Sibomana et al. Influence of myo-inositol plus ethanolamine on plasmalogens and cell viability during oxidative stress
HK1182935A (en) Compounds for lowering cholesterol
HK1131348A (en) Compounds for use in the treatment of senile dementia of the alzheimer's type
HK1131348B (en) Compounds for use in the treatment of senile dementia of the alzheimer's type
HK1182935B (en) Compounds for lowering cholesterol
CN110621683A (zh) 环状缩醛磷脂酰乙醇胺
Saitoh et al. Changes in the amounts of myelin lipids and molecular species of plasmalogen PE in the brain of an autopsy case with d-bifunctional protein deficiency
Li et al. Influence of anesthesia on lipidomic biomarkers in elderly patients undergoing hip replacement surgery
Saunders Arachidonic acid and lipid metabolism following spinal cord injury
HK40013804A (en) Alleviating oxidative stress disorders with pufa derivatives
Giles Regulation of the brain lipidome in health and disease

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100827

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100827

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121018

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130115

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130122

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130218

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130507

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130801

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130808

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130903

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130910

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130927

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131004

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131107

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140127

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140203

R150 Certificate of patent or registration of utility model

Ref document number: 5470050

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250