CA2620274C - Methods for the treatment of senile dementia of the alzheimer's type - Google Patents
Methods for the treatment of senile dementia of the alzheimer's type Download PDFInfo
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- CA2620274C CA2620274C CA2620274A CA2620274A CA2620274C CA 2620274 C CA2620274 C CA 2620274C CA 2620274 A CA2620274 A CA 2620274A CA 2620274 A CA2620274 A CA 2620274A CA 2620274 C CA2620274 C CA 2620274C
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- Neurology (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
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| EP2117527B1 (en) | 2007-02-08 | 2020-06-17 | Med-Life Discoveries LP | Compounds for use in the treatment of senile dementia of the alzheimer's type |
| TWI475989B (zh) | 2008-12-22 | 2015-03-11 | Phenomenome Discoveries Inc | 縮醛磷脂類化合物，含彼之醫藥組成物以及治療老化疾病的方法 |
| CA2774869C (en) | 2009-10-01 | 2017-10-24 | Phenomenome Discoveries Inc. | Serum-based biomarkers of pancreatic cancer and uses thereof for disease detection and diagnosis |
| US11723579B2 (en) | 2017-09-19 | 2023-08-15 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US11318277B2 (en) | 2017-12-31 | 2022-05-03 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| WO2020056418A1 (en) | 2018-09-14 | 2020-03-19 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| CN114236019B (zh) * | 2022-02-24 | 2022-05-06 | 宝枫生物科技（北京）有限公司 | 脑白质病变的生物标志物的应用 |
| CN118512461A (zh) * | 2024-06-03 | 2024-08-20 | 东莞市第八人民医院（东莞市儿童医院） | 一种母乳来源磷脂在防治支气管肺发育不良的应用 |
| CN119876292B (zh) * | 2025-03-27 | 2025-06-03 | 浙江省白马湖实验室有限公司 | 一种酰胺类缩醛磷脂化合物的制备方法及应用 |
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| WO1994009371A1 (en) | 1992-10-09 | 1994-04-28 | Massachusetts Institute Of Technology | Antemortem diagnostic test for alzheimer's disease |
| FR2736265B1 (fr) | 1995-07-07 | 1997-09-26 | Forgeot Marcel | Nouvelles compositions a base de phosphoglycero ethers et leur utilisation dans le traitement des maladies neuro-degeneratives |
| US5731354A (en) | 1996-05-06 | 1998-03-24 | Clarion Pharmaceuticals Inc. | Treatment for the inhibition of neuro-degenerative disease states |
| US6177476B1 (en) | 1998-08-27 | 2001-01-23 | Clarion Pharmaceuticals Inc. | Nutritional supplements for replenishing plasmalogens |
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| CA2443806A1 (en) | 2000-04-14 | 2002-10-25 | Metabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
| WO2002021139A2 (en) | 2000-09-08 | 2002-03-14 | Oxford Glycosciences (Uk) Ltd. | Automated identification of peptides |
| US6838452B2 (en) * | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| DE10291524D2 (de) | 2001-04-06 | 2004-07-01 | Anker Thorsten | Verfahren zum Nachweis chronisch-demenzieller Erkrankungen, zugehörige Peptide und Nachweisreagenzien |
| AU2002341488A1 (en) | 2001-05-09 | 2002-11-18 | Biovision Ag | Method for detecting progredient chronic dementia, and associated peptides and detection reagents |
| CA2476412C (en) | 2002-03-22 | 2008-02-19 | Phenomenome Discoveries Inc. | Method of visualizing non-targeted metabolomic data generated from fourier transform ion cyclotron resonance mass spectrometers |
| JP2004026803A (ja) * | 2002-03-29 | 2004-01-29 | Nof Corp | 神経細胞死予防剤 |
| DE60333608D1 (de) | 2002-08-23 | 2010-09-09 | Bayer Schering Pharma Ag | Biomarker zur Diagnose von Alzheimer |
| SE0203886D0 (sv) * | 2002-12-27 | 2002-12-27 | Ltp Lipid Technologies Provide | Glycerolesterprodukt och dess användning |
| US20040191294A1 (en) * | 2003-03-27 | 2004-09-30 | Ramaprasad Talahalli Ravichandra | Health composition |
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| EP1694816B1 (en) | 2003-11-07 | 2013-08-28 | Ciphergen Biosystems, Inc. | Biomarkers for alzheimer's disease |
| WO2005085838A2 (en) | 2004-03-02 | 2005-09-15 | Vanderbilt University | Computational analysis of mass spectroscopic lipid data |
| WO2005116659A2 (en) | 2004-05-18 | 2005-12-08 | Neurodx, Llc | Compositions and methods relating to alzheimer’s disease |
| WO2007002285A2 (en) * | 2005-06-21 | 2007-01-04 | The Trustees Of The University Of Pennsylvania | Methods for treating neurological and psychiatric conditions |
| JP4176749B2 (ja) | 2005-07-29 | 2008-11-05 | 学校法人帝京大学 | 疾病検査法 |
| CA2619732C (en) | 2005-09-12 | 2012-06-12 | Phenomenome Discoveries Inc. | Methods for the diagnosis of colorectal cancer and ovarian cancer health states |
| WO2007030948A1 (en) | 2005-09-15 | 2007-03-22 | Phenomenome Discoveries Inc. | Method and apparatus for fourier transform ion cyclotron resonance mass spectrometry |
| EP2851369A3 (en) | 2006-02-28 | 2015-06-17 | Phenomenome Discoveries Inc. | Methods for the diagnosis of dementia and other neurological disorders |
| US20100062472A1 (en) | 2006-05-26 | 2010-03-11 | Phenomenome Discoveries Inc. | Biomarkers for diagnosing multiple sclerosis, and methods thereof |
| JPWO2008093709A1 (ja) * | 2007-01-30 | 2010-05-20 | 株式会社プロジェクト・エム | アミロイド蛋白質の凝集抑制および分解促進によりアミロイドーシスと関連する疾患を予防または治療するための組成物 |
| EP2117527B1 (en) | 2007-02-08 | 2020-06-17 | Med-Life Discoveries LP | Compounds for use in the treatment of senile dementia of the alzheimer's type |
| US8026099B2 (en) | 2007-07-26 | 2011-09-27 | Washington University | Lipid profile as a biomarker for early detection of neurological disorders |
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| US10123989B2 (en) | 2018-11-13 |
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| AU2007346587A1 (en) | 2008-08-14 |
| CA2695167C (en) | 2011-11-01 |
| IL200029A0 (en) | 2010-04-15 |
| CA2695167A1 (en) | 2008-06-20 |
| US9034923B2 (en) | 2015-05-19 |
| WO2008095275A1 (en) | 2008-08-14 |
| EP2620147B1 (en) | 2020-06-03 |
| EP2620147A2 (en) | 2013-07-31 |
| US20120129934A1 (en) | 2012-05-24 |
| US20170056363A1 (en) | 2017-03-02 |
| CA2620274A1 (en) | 2008-06-20 |
| US20130046016A1 (en) | 2013-02-21 |
| US20150306057A1 (en) | 2015-10-29 |
| EP2117527A1 (en) | 2009-11-18 |
| US8993623B2 (en) | 2015-03-31 |
| US20160015673A1 (en) | 2016-01-21 |
| AU2007346587B2 (en) | 2014-03-27 |
| US9517222B2 (en) | 2016-12-13 |
| AU2007346587C1 (en) | 2015-01-22 |
| EP2620147A3 (en) | 2013-10-02 |
| SG173418A1 (en) | 2011-08-29 |
| JP2010518029A (ja) | 2010-05-27 |
| EP2117527B1 (en) | 2020-06-17 |
| JP5470050B2 (ja) | 2014-04-16 |
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