JP2010517529A5 - - Google Patents
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- JP2010517529A5 JP2010517529A5 JP2009548312A JP2009548312A JP2010517529A5 JP 2010517529 A5 JP2010517529 A5 JP 2010517529A5 JP 2009548312 A JP2009548312 A JP 2009548312A JP 2009548312 A JP2009548312 A JP 2009548312A JP 2010517529 A5 JP2010517529 A5 JP 2010517529A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 60
- 108090000765 processed proteins & peptides Proteins 0.000 claims 53
- 229920001184 polypeptide Polymers 0.000 claims 46
- 102000004196 processed proteins & peptides Human genes 0.000 claims 46
- 235000001014 amino acid Nutrition 0.000 claims 43
- 150000001413 amino acids Chemical class 0.000 claims 40
- 101001021253 Homo sapiens Hepcidin Proteins 0.000 claims 38
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 32
- 239000000203 mixture Substances 0.000 claims 30
- 238000000034 method Methods 0.000 claims 27
- XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims 19
- 108060003558 hepcidin Proteins 0.000 claims 16
- 229910052742 iron Inorganic materials 0.000 claims 16
- 208000007502 anemia Diseases 0.000 claims 14
- 230000027455 binding Effects 0.000 claims 13
- 102000018511 hepcidin Human genes 0.000 claims 12
- 229940066919 hepcidin Drugs 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 230000010437 erythropoiesis Effects 0.000 claims 8
- 238000003018 immunoassay Methods 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 230000013632 homeostatic process Effects 0.000 claims 7
- 208000020832 chronic kidney disease Diseases 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 206010061218 Inflammation Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 230000004054 inflammatory process Effects 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 102000003951 Erythropoietin Human genes 0.000 claims 4
- 108090000394 Erythropoietin Proteins 0.000 claims 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
- 210000003743 erythrocyte Anatomy 0.000 claims 4
- 229940105423 erythropoietin Drugs 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical group [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 4
- 210000001995 reticulocyte Anatomy 0.000 claims 4
- 206010003210 Arteriosclerosis Diseases 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 3
- 206010019280 Heart failures Diseases 0.000 claims 3
- 208000018565 Hemochromatosis Diseases 0.000 claims 3
- 102000001554 Hemoglobins Human genes 0.000 claims 3
- 108010054147 Hemoglobins Proteins 0.000 claims 3
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims 3
- 108091006976 SLC40A1 Proteins 0.000 claims 3
- 206010040047 Sepsis Diseases 0.000 claims 3
- 206010047115 Vasculitis Diseases 0.000 claims 3
- 230000002159 abnormal effect Effects 0.000 claims 3
- 238000007792 addition Methods 0.000 claims 3
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 3
- 230000004071 biological effect Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 208000028208 end stage renal disease Diseases 0.000 claims 3
- 201000000523 end stage renal failure Diseases 0.000 claims 3
- 201000000388 hemochromatosis type 4 Diseases 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 230000004936 stimulating effect Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 3
- 238000002965 ELISA Methods 0.000 claims 2
- 102000008857 Ferritin Human genes 0.000 claims 2
- 238000008416 Ferritin Methods 0.000 claims 2
- 108050000784 Ferritin Proteins 0.000 claims 2
- 238000004820 blood count Methods 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 208000019501 erythrocyte disease Diseases 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 238000007910 systemic administration Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- -1 Ab43 Chemical compound 0.000 claims 1
- 241001385733 Aesculus indica Species 0.000 claims 1
- 208000020459 Anaemia of malignant disease Diseases 0.000 claims 1
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 claims 1
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000018434 Iron-Regulatory Proteins Human genes 0.000 claims 1
- 108010066420 Iron-Regulatory Proteins Proteins 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 210000000628 antibody-producing cell Anatomy 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000005534 hematocrit Methods 0.000 claims 1
- 102000044890 human EPO Human genes 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000012004 kinetic exclusion assay Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000012360 testing method Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88805907P | 2007-02-02 | 2007-02-02 | |
| US1513807P | 2007-12-19 | 2007-12-19 | |
| PCT/US2008/001325 WO2008097461A2 (en) | 2007-02-02 | 2008-01-30 | Hepcidin and hepcidin antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014119334A Division JP2014221763A (ja) | 2007-02-02 | 2014-06-10 | ヘプシジン及びヘプシジン抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010517529A JP2010517529A (ja) | 2010-05-27 |
| JP2010517529A5 true JP2010517529A5 (https=) | 2012-06-14 |
Family
ID=39682290
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548312A Withdrawn JP2010517529A (ja) | 2007-02-02 | 2008-01-30 | ヘプシジン及びヘプシジン抗体 |
| JP2014119334A Withdrawn JP2014221763A (ja) | 2007-02-02 | 2014-06-10 | ヘプシジン及びヘプシジン抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014119334A Withdrawn JP2014221763A (ja) | 2007-02-02 | 2014-06-10 | ヘプシジン及びヘプシジン抗体 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8629250B2 (https=) |
| EP (1) | EP2111412A2 (https=) |
| JP (2) | JP2010517529A (https=) |
| AR (2) | AR065083A1 (https=) |
| AU (1) | AU2008214386B2 (https=) |
| CA (1) | CA2676036A1 (https=) |
| CL (1) | CL2008000278A1 (https=) |
| MX (1) | MX2009008104A (https=) |
| PE (2) | PE20090722A1 (https=) |
| TW (3) | TW201307390A (https=) |
| WO (1) | WO2008097461A2 (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1392345B2 (en) | 2001-05-25 | 2018-02-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis |
| EP2066687A4 (en) | 2006-09-21 | 2010-12-08 | Alnylam Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF HAMP GENE |
| ATE553778T1 (de) | 2007-10-02 | 2012-05-15 | Inst Nat Sante Rech Med | Für humanes hepcidin spezifische antikörper |
| AR069062A1 (es) | 2007-11-02 | 2009-12-23 | Lilly Co Eli | Anticuerpo anti-hepcidina |
| WO2009094551A1 (en) * | 2008-01-25 | 2009-07-30 | Amgen Inc. | Ferroportin antibodies and methods of use |
| US9315577B2 (en) * | 2008-05-01 | 2016-04-19 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
| EP2328931B1 (en) | 2008-08-06 | 2013-08-14 | Eli Lilly And Company | Anti-hepcidin-25 selective antibodies and uses thereof |
| EP2157432A1 (en) * | 2008-08-15 | 2010-02-24 | Qiagen GmbH | Method for analysing a complex sample by mass spectrometry |
| US8183346B2 (en) | 2008-12-05 | 2012-05-22 | Eli Lilly And Company | Anti-ferroportin 1 monoclonal antibodies and uses thereof |
| US8435941B2 (en) | 2008-12-05 | 2013-05-07 | The Regents Of The University Of California | Mini-hepcidin peptides and methods of using thereof |
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- 2008-01-30 PE PE2008000218A patent/PE20090722A1/es not_active Application Discontinuation
- 2008-01-30 AU AU2008214386A patent/AU2008214386B2/en not_active Ceased
- 2008-01-30 PE PE2012001627A patent/PE20130588A1/es not_active Application Discontinuation
- 2008-01-30 CL CL200800278A patent/CL2008000278A1/es unknown
- 2008-01-30 EP EP08725041A patent/EP2111412A2/en not_active Withdrawn
- 2008-01-30 CA CA002676036A patent/CA2676036A1/en not_active Abandoned
- 2008-01-30 AR ARP080100364A patent/AR065083A1/es unknown
- 2008-01-30 MX MX2009008104A patent/MX2009008104A/es active IP Right Grant
- 2008-01-30 JP JP2009548312A patent/JP2010517529A/ja not_active Withdrawn
- 2008-01-30 TW TW100141324A patent/TW201206954A/zh unknown
- 2008-01-30 US US12/022,515 patent/US8629250B2/en active Active
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2011
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-
2012
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2013
- 2013-12-11 US US14/103,351 patent/US20140286953A1/en not_active Abandoned
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2014
- 2014-06-10 JP JP2014119334A patent/JP2014221763A/ja not_active Withdrawn
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