JP2010517529A5 - - Google Patents
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- JP2010517529A5 JP2010517529A5 JP2009548312A JP2009548312A JP2010517529A5 JP 2010517529 A5 JP2010517529 A5 JP 2010517529A5 JP 2009548312 A JP2009548312 A JP 2009548312A JP 2009548312 A JP2009548312 A JP 2009548312A JP 2010517529 A5 JP2010517529 A5 JP 2010517529A5
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- seq
- amino acid
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- acid sequence
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 60
- 108090000765 processed proteins & peptides Proteins 0.000 claims 53
- 229920001184 polypeptide Polymers 0.000 claims 46
- 102000004196 processed proteins & peptides Human genes 0.000 claims 46
- 235000001014 amino acid Nutrition 0.000 claims 43
- 150000001413 amino acids Chemical class 0.000 claims 40
- 101001021253 Homo sapiens Hepcidin Proteins 0.000 claims 38
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 32
- 239000000203 mixture Substances 0.000 claims 30
- 238000000034 method Methods 0.000 claims 27
- XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims 19
- 108060003558 hepcidin Proteins 0.000 claims 16
- 229910052742 iron Inorganic materials 0.000 claims 16
- 208000007502 anemia Diseases 0.000 claims 14
- 230000027455 binding Effects 0.000 claims 13
- 102000018511 hepcidin Human genes 0.000 claims 12
- 229940066919 hepcidin Drugs 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 230000010437 erythropoiesis Effects 0.000 claims 8
- 238000003018 immunoassay Methods 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 230000013632 homeostatic process Effects 0.000 claims 7
- 208000020832 chronic kidney disease Diseases 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 206010061218 Inflammation Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 230000004054 inflammatory process Effects 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 102000003951 Erythropoietin Human genes 0.000 claims 4
- 108090000394 Erythropoietin Proteins 0.000 claims 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
- 210000003743 erythrocyte Anatomy 0.000 claims 4
- 229940105423 erythropoietin Drugs 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical group [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 4
- 210000001995 reticulocyte Anatomy 0.000 claims 4
- 206010003210 Arteriosclerosis Diseases 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 3
- 206010019280 Heart failures Diseases 0.000 claims 3
- 208000018565 Hemochromatosis Diseases 0.000 claims 3
- 102000001554 Hemoglobins Human genes 0.000 claims 3
- 108010054147 Hemoglobins Proteins 0.000 claims 3
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims 3
- 108091006976 SLC40A1 Proteins 0.000 claims 3
- 206010040047 Sepsis Diseases 0.000 claims 3
- 206010047115 Vasculitis Diseases 0.000 claims 3
- 230000002159 abnormal effect Effects 0.000 claims 3
- 238000007792 addition Methods 0.000 claims 3
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 3
- 230000004071 biological effect Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 208000028208 end stage renal disease Diseases 0.000 claims 3
- 201000000523 end stage renal failure Diseases 0.000 claims 3
- 201000000388 hemochromatosis type 4 Diseases 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 230000004936 stimulating effect Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 3
- 238000002965 ELISA Methods 0.000 claims 2
- 102000008857 Ferritin Human genes 0.000 claims 2
- 238000008416 Ferritin Methods 0.000 claims 2
- 108050000784 Ferritin Proteins 0.000 claims 2
- 238000004820 blood count Methods 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 208000019501 erythrocyte disease Diseases 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 238000007910 systemic administration Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- -1 Ab43 Chemical compound 0.000 claims 1
- 241001385733 Aesculus indica Species 0.000 claims 1
- 208000020459 Anaemia of malignant disease Diseases 0.000 claims 1
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 claims 1
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000018434 Iron-Regulatory Proteins Human genes 0.000 claims 1
- 108010066420 Iron-Regulatory Proteins Proteins 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 210000000628 antibody-producing cell Anatomy 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000005534 hematocrit Methods 0.000 claims 1
- 102000044890 human EPO Human genes 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000012004 kinetic exclusion assay Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000012360 testing method Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88805907P | 2007-02-02 | 2007-02-02 | |
| US1513807P | 2007-12-19 | 2007-12-19 | |
| PCT/US2008/001325 WO2008097461A2 (en) | 2007-02-02 | 2008-01-30 | Hepcidin and hepcidin antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014119334A Division JP2014221763A (ja) | 2007-02-02 | 2014-06-10 | ヘプシジン及びヘプシジン抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010517529A JP2010517529A (ja) | 2010-05-27 |
| JP2010517529A5 true JP2010517529A5 (https=) | 2012-06-14 |
Family
ID=39682290
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548312A Withdrawn JP2010517529A (ja) | 2007-02-02 | 2008-01-30 | ヘプシジン及びヘプシジン抗体 |
| JP2014119334A Withdrawn JP2014221763A (ja) | 2007-02-02 | 2014-06-10 | ヘプシジン及びヘプシジン抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014119334A Withdrawn JP2014221763A (ja) | 2007-02-02 | 2014-06-10 | ヘプシジン及びヘプシジン抗体 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8629250B2 (https=) |
| EP (1) | EP2111412A2 (https=) |
| JP (2) | JP2010517529A (https=) |
| AR (2) | AR065083A1 (https=) |
| AU (1) | AU2008214386B2 (https=) |
| CA (1) | CA2676036A1 (https=) |
| CL (1) | CL2008000278A1 (https=) |
| MX (1) | MX2009008104A (https=) |
| PE (2) | PE20090722A1 (https=) |
| TW (3) | TW201307390A (https=) |
| WO (1) | WO2008097461A2 (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4944360B2 (ja) † | 2001-05-25 | 2012-05-30 | アンスティテュ ナシオナル ド ラ サント エ ド ラ ルシュルシェ メディカル（アンセルム） | 鉄ホメオスタシスの障害を治療するための医薬品を製造するためのヘプシジンの使用 |
| AU2007299629C1 (en) | 2006-09-21 | 2012-05-10 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the HAMP gene |
| WO2009044284A1 (en) | 2007-10-02 | 2009-04-09 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Antibodies specific for human hepcidin |
| PE20091261A1 (es) * | 2007-11-02 | 2009-08-17 | Lilly Co Eli | Anticuerpos anti-hepcidina |
| ES2500066T3 (es) * | 2008-01-25 | 2014-09-30 | Amgen, Inc | Anticuerpos frente a ferroportina y métodos de uso |
| CA2722600C (en) * | 2008-05-01 | 2014-01-21 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
| EA201170312A1 (ru) | 2008-08-06 | 2012-03-30 | Эли Лилли Энд Компани | Селективные антитела к гепцидину-25 и их применение |
| EP2157432A1 (en) * | 2008-08-15 | 2010-02-24 | Qiagen GmbH | Method for analysing a complex sample by mass spectrometry |
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- 2008-01-30 WO PCT/US2008/001325 patent/WO2008097461A2/en not_active Ceased
- 2008-01-30 PE PE2008000218A patent/PE20090722A1/es not_active Application Discontinuation
- 2008-01-30 EP EP08725041A patent/EP2111412A2/en not_active Withdrawn
- 2008-01-30 CL CL200800278A patent/CL2008000278A1/es unknown
- 2008-01-30 TW TW100141324A patent/TW201206954A/zh unknown
- 2008-01-30 CA CA002676036A patent/CA2676036A1/en not_active Abandoned
- 2008-01-30 AR ARP080100364A patent/AR065083A1/es unknown
- 2008-01-30 PE PE2012001627A patent/PE20130588A1/es not_active Application Discontinuation
- 2008-01-30 JP JP2009548312A patent/JP2010517529A/ja not_active Withdrawn
- 2008-01-30 US US12/022,515 patent/US8629250B2/en active Active
- 2008-01-30 MX MX2009008104A patent/MX2009008104A/es active IP Right Grant
- 2008-01-30 TW TW097103507A patent/TW200900420A/zh unknown
-
2011
- 2011-07-15 AR ARP110102562A patent/AR082235A2/es not_active Application Discontinuation
-
2012
- 2012-09-14 US US13/620,007 patent/US20130018176A1/en not_active Abandoned
-
2013
- 2013-12-11 US US14/103,351 patent/US20140286953A1/en not_active Abandoned
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2014
- 2014-06-10 JP JP2014119334A patent/JP2014221763A/ja not_active Withdrawn
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