JP2010516814A5 - - Google Patents
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- Publication number
- JP2010516814A5 JP2010516814A5 JP2009548305A JP2009548305A JP2010516814A5 JP 2010516814 A5 JP2010516814 A5 JP 2010516814A5 JP 2009548305 A JP2009548305 A JP 2009548305A JP 2009548305 A JP2009548305 A JP 2009548305A JP 2010516814 A5 JP2010516814 A5 JP 2010516814A5
- Authority
- JP
- Japan
- Prior art keywords
- chitosan
- composition
- mixtures
- agent
- molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001661 Chitosan Polymers 0.000 claims 37
- 239000000203 mixture Substances 0.000 claims 35
- 239000003795 chemical substances by application Substances 0.000 claims 16
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 11
- 125000000524 functional group Chemical group 0.000 claims 8
- 239000003246 corticosteroid Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 5
- 239000008177 pharmaceutical agent Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 229960001334 corticosteroids Drugs 0.000 claims 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 4
- 150000003180 prostaglandins Chemical class 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 239000003755 preservative agent Substances 0.000 claims 3
- 208000002111 Eye Abnormalities Diseases 0.000 claims 2
- 229920002413 Polyhexanide Polymers 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 claims 1
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 1
- 239000008351 acetate buffer Substances 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims 1
- 229960002470 bimatoprost Drugs 0.000 claims 1
- 229960003260 chlorhexidine Drugs 0.000 claims 1
- 229910001919 chlorite Inorganic materials 0.000 claims 1
- 229910052619 chlorite group Inorganic materials 0.000 claims 1
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims 1
- 239000007979 citrate buffer Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims 1
- 229960004867 hexetidine Drugs 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88755907P | 2007-01-31 | 2007-01-31 | |
| US60/887,559 | 2007-01-31 | ||
| PCT/US2008/001301 WO2008094659A2 (en) | 2007-01-31 | 2008-01-31 | Novel biomaterials for ocular drug delivery and a method for making and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014044210A Division JP2014129408A (ja) | 2007-01-31 | 2014-03-06 | 眼薬物送達用の新規生体材料ならびにその製造および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010516814A JP2010516814A (ja) | 2010-05-20 |
| JP2010516814A5 true JP2010516814A5 (https=) | 2011-03-24 |
| JP5541926B2 JP5541926B2 (ja) | 2014-07-09 |
Family
ID=39409833
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548305A Expired - Fee Related JP5541926B2 (ja) | 2007-01-31 | 2008-01-31 | 眼薬物送達用の新規生体材料ならびにその製造および使用方法 |
| JP2014044210A Pending JP2014129408A (ja) | 2007-01-31 | 2014-03-06 | 眼薬物送達用の新規生体材料ならびにその製造および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014044210A Pending JP2014129408A (ja) | 2007-01-31 | 2014-03-06 | 眼薬物送達用の新規生体材料ならびにその製造および使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US8252771B2 (https=) |
| EP (2) | EP2114370B1 (https=) |
| JP (2) | JP5541926B2 (https=) |
| KR (1) | KR20090108723A (https=) |
| AU (1) | AU2008211083B2 (https=) |
| BR (1) | BRPI0807065A2 (https=) |
| CA (1) | CA2676919C (https=) |
| MX (1) | MX2009008170A (https=) |
| WO (2) | WO2008094659A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007257436B2 (en) | 2006-06-02 | 2013-05-02 | Synedgen, Inc. | Chitosan-derivative compounds and methods of controlling microbial populations |
| US20080248508A1 (en) * | 2006-08-17 | 2008-10-09 | Shenda Baker | Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials |
| KR20090108723A (ko) * | 2007-01-31 | 2009-10-16 | 알러간, 인코포레이티드 | 안 약물 송달을 위한 신규한 생체적합물질 및 이의 제조방법 및 용도 |
| US8871247B2 (en) | 2007-02-19 | 2014-10-28 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
| US20100009009A1 (en) * | 2008-07-10 | 2010-01-14 | Micropure, Inc. | Method and composition for prevention and treatment of oral fungal infections |
| CN101780105B (zh) * | 2009-01-20 | 2011-09-28 | 沈阳兴齐制药有限公司 | 小牛血去蛋白提取物的滴眼液 |
| US20100233101A1 (en) | 2009-02-13 | 2010-09-16 | Micropure, Inc. | Composition and method for the oxidative consumption of salivary biomolecules |
| EP2477617B1 (en) | 2009-09-18 | 2018-01-31 | Bioinspire Technologies Inc. | Free-standing biodegradable patch |
| US9271925B2 (en) | 2013-03-11 | 2016-03-01 | Bioinspire Technologies, Inc. | Multi-layer biodegradable device having adjustable drug release profile |
| CN101695583B (zh) * | 2009-10-29 | 2012-12-26 | 中国人民解放军第三军医大学第一附属医院 | 一种用于组织修复的颗粒状生物材料及其制备方法 |
| WO2011130646A1 (en) | 2010-04-15 | 2011-10-20 | Marine Polymer Technologies, Inc. | Anti-bacterial applications of poly -n-acetylglucosamine nanofibers |
| WO2012061803A2 (en) * | 2010-11-06 | 2012-05-10 | Marine Polymer Technologies, Inc. | Compositions and methods for nanopolymer-based nucleic acid delivery |
| BR112013020719B1 (pt) | 2011-02-14 | 2018-04-17 | Allergan, Inc. | Composições de derivados de bimatoprost tipo éster e métodos |
| NZ732118A (en) | 2011-04-15 | 2018-11-30 | Marine Polymer Tech Inc | Treatment of disease with poly-n-acetylglucosamine nanofibers |
| US9962401B2 (en) * | 2011-09-27 | 2018-05-08 | Purdue Research Foundation | Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles |
| US20150010634A1 (en) * | 2011-10-12 | 2015-01-08 | Ascendis Pharma Ophthamology Division A/S | Prevention and treatment of ocular conditions |
| US8968790B2 (en) * | 2011-12-09 | 2015-03-03 | Shaker A. Mousa | Nanoformulation of vitamin D derivatives and/or vitamin D metabolites |
| US9956291B2 (en) * | 2012-07-10 | 2018-05-01 | Shaker A. Mousa | Nanoformulation and methods of use of thyroid receptor beta1 agonists for liver targeting |
| AU2013353985B2 (en) * | 2012-12-07 | 2017-07-13 | Ascendis Pharma A/S | Carrier-linked prostanoid prodrugs |
| TWI485189B (zh) | 2012-12-28 | 2015-05-21 | Ind Tech Res Inst | 固體製劑及其製造方法 |
| WO2014152796A2 (en) | 2013-03-14 | 2014-09-25 | Hemcon Medical Technologies, Inc. | Biocompatible and bioabsorbable derivatized chitosan compositions |
| GB201309788D0 (en) * | 2013-05-31 | 2013-07-17 | Medtrade Products Ltd | Process for the removal of contamination from a raw material |
| CN106456536B (zh) | 2014-05-07 | 2020-05-12 | 克罗马药品股份有限公司 | 水性眼用溶液和治疗干眼综合征的方法 |
| US10449272B2 (en) | 2015-10-16 | 2019-10-22 | Industrial Technology Research Institute | Hydrogel composition and method for using the same |
| WO2017072236A1 (en) | 2015-10-30 | 2017-05-04 | Croma-Pharma Gesellschaft M.B.H. | Therapeutic use of a sterile aqueous ophthalmic solution |
| JP2018532753A (ja) | 2015-10-30 | 2018-11-08 | クロマ−ファーマ ゲゼルシャフト エム．ベー．ハー． | 滅菌水性点眼液の治療的使用 |
| BR112018013105A2 (pt) * | 2015-12-28 | 2018-12-11 | Alumend Llc | composições e métodos para reduzir a irritação da pele |
| AU2017311636B2 (en) | 2016-08-19 | 2023-08-10 | Orasis Pharmaceuticals Ltd. | Ophthalmic pharmaceutical compositions and uses relating thereto |
| CA3020197C (en) | 2017-09-01 | 2024-06-04 | Micropure, Inc. | Aliphatic anionic compounds and oxidative compounds with improved stability and efficacy for use in pharmaceutical compositions |
| CN110343263A (zh) * | 2018-04-02 | 2019-10-18 | 中国海洋大学 | 一种基于氢氧化钾和低温溶解壳聚糖的方法 |
| US11344507B2 (en) | 2019-01-08 | 2022-05-31 | Alumend, Llc | Topical compositions containing low molecular weight chitosan derivatives |
| KR20220100850A (ko) | 2019-07-26 | 2022-07-18 | 판도럼 테크놀로지스 프라이뱃 리미티드 | 생체공학적 제형, 이의 제조 및 구현 공정 |
| KR102119693B1 (ko) | 2019-10-31 | 2020-06-05 | 경희대학교 산학협력단 | 숙신화 콜라겐-피브리노겐 하이드로겔의 제조방법 |
| US20240000704A1 (en) * | 2020-04-03 | 2024-01-04 | Tissuetech, Inc. | Methods of using umbilical cord products for treatment of ocular surface disorders |
| US12023276B2 (en) | 2021-02-24 | 2024-07-02 | Ocular Therapeutix, Inc. | Intracanalicular depot inserter device |
| CN113440643B (zh) * | 2021-06-10 | 2022-04-29 | 武汉大学 | 一种可吸收外科材料的表面抗菌处理方法 |
| CN113881070B (zh) * | 2021-11-09 | 2022-11-15 | 中北大学 | 具有光-应力双重响应的碳量子点/壳聚糖衍生物水凝胶的制备方法及应用 |
| WO2025090805A1 (en) * | 2023-10-25 | 2025-05-01 | The Board Of Trustees Of The Leland Stanford Junior University | Antimicrobial irrigation solutions for endourological procedures |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2053333T3 (es) * | 1990-07-26 | 1994-07-16 | Searle & Co | Sistema polimerico para la administracion de farmacos. |
| FR2707878A1 (fr) | 1993-07-21 | 1995-01-27 | Imedex | Nouvelles compositions adhésives à usage chirurgical. |
| US5422116A (en) * | 1994-02-18 | 1995-06-06 | Ciba-Geigy Corporation | Liquid ophthalmic sustained release delivery system |
| US5510102A (en) * | 1995-01-23 | 1996-04-23 | The Regents Of The University Of California | Plasma and polymer containing surgical hemostatic adhesives |
| TW389694B (en) * | 1995-08-17 | 2000-05-11 | Novartis Ag | Compositions including o-carboxyalkyl chitosan and methods of use in ophthalmics |
| US6015474A (en) | 1997-06-20 | 2000-01-18 | Protein Polymer Technologies | Methods of using primer molecules for enhancing the mechanical performance of tissue adhesives and sealants |
| US6200595B1 (en) | 1998-04-24 | 2001-03-13 | Kuraray Co., Ltd. | Medical adhesive |
| JP2000288079A (ja) * | 1999-04-07 | 2000-10-17 | Toyobo Co Ltd | 生体組織用接着剤 |
| KR100698559B1 (ko) * | 1999-06-11 | 2007-03-21 | 넥타르 테라퓨틱스 에이엘, 코포레이션 | 키토산 및 폴리(에틸렌 글리콜) 또는 관련 폴리머로부터유래되는 하이드로겔 |
| US6310188B1 (en) * | 2000-01-24 | 2001-10-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method for producing chitin or chitosan |
| US6991652B2 (en) * | 2000-06-13 | 2006-01-31 | Burg Karen J L | Tissue engineering composite |
| US20040047892A1 (en) * | 2000-11-15 | 2004-03-11 | Desrosiers Eric Andre | Filler composition for soft tissue augmentation and reconstructive surgery |
| US6756363B1 (en) * | 2000-11-17 | 2004-06-29 | Wound Healing Of Oklahoma, Inc. | Solutions and films of glycated chitosan |
| KR100507968B1 (ko) * | 2001-08-18 | 2005-08-17 | 한국과학기술연구원 | 자기집합체를 형성하는 항암제-키토산 복합체 및 그의제조방법 |
| ATA13842001A (de) * | 2001-08-31 | 2002-10-15 | Mucobiomer Biotechnologische F | Chitosan-thio-alkyl-amidin konjugate und deren kosmetische sowie pharmazeutische verwendung |
| ATE506079T1 (de) | 2003-11-05 | 2011-05-15 | Photobiomed Corp | Verbindungsgewebe und vernetzungsproteine mit naphthalimid-verbindungen |
| WO2005113608A1 (en) * | 2004-05-20 | 2005-12-01 | Mentor Corporation | Method of covalently linking hyaluronan and chitosan |
| US20050283004A1 (en) * | 2004-06-18 | 2005-12-22 | Hopax Chemicals Manufacturing Co., Ltd. | Alkylsulfonated polyaminosaccharides |
| KR100578382B1 (ko) * | 2004-07-16 | 2006-05-11 | 나재운 | 항암제의 전달체용 수용성 키토산 나노입자 및 그 제조방법 |
| EP1929996B1 (en) * | 2004-11-09 | 2011-02-16 | Novagali Pharma S.A. | Ophthalmic emulsions containing an immunosuppressive agent |
| GB0615834D0 (en) * | 2006-08-09 | 2006-09-20 | Univ Glasgow | Polymeric micellar clusters and their uses in formulating drugs |
| KR20090108723A (ko) * | 2007-01-31 | 2009-10-16 | 알러간, 인코포레이티드 | 안 약물 송달을 위한 신규한 생체적합물질 및 이의 제조방법 및 용도 |
-
2008
- 2008-01-31 KR KR1020097018022A patent/KR20090108723A/ko not_active Withdrawn
- 2008-01-31 CA CA2676919A patent/CA2676919C/en not_active Expired - Fee Related
- 2008-01-31 EP EP08725018A patent/EP2114370B1/en not_active Not-in-force
- 2008-01-31 EP EP11191300.0A patent/EP2425816A3/en not_active Withdrawn
- 2008-01-31 WO PCT/US2008/001301 patent/WO2008094659A2/en not_active Ceased
- 2008-01-31 US US12/023,977 patent/US8252771B2/en not_active Expired - Fee Related
- 2008-01-31 MX MX2009008170A patent/MX2009008170A/es active IP Right Grant
- 2008-01-31 JP JP2009548305A patent/JP5541926B2/ja not_active Expired - Fee Related
- 2008-01-31 AU AU2008211083A patent/AU2008211083B2/en not_active Ceased
- 2008-01-31 WO PCT/US2008/001332 patent/WO2008094675A2/en not_active Ceased
- 2008-01-31 BR BRPI0807065A patent/BRPI0807065A2/pt not_active IP Right Cessation
- 2008-01-31 US US12/023,963 patent/US9855337B2/en active Active
-
2014
- 2014-03-06 JP JP2014044210A patent/JP2014129408A/ja active Pending
-
2015
- 2015-12-22 US US14/978,512 patent/US9884121B2/en active Active
-
2017
- 2017-12-29 US US15/858,315 patent/US20180344858A1/en not_active Abandoned
-
2018
- 2018-02-05 US US15/888,586 patent/US20180344859A1/en not_active Abandoned
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