JP2010516761A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010516761A5 JP2010516761A5 JP2009547189A JP2009547189A JP2010516761A5 JP 2010516761 A5 JP2010516761 A5 JP 2010516761A5 JP 2009547189 A JP2009547189 A JP 2009547189A JP 2009547189 A JP2009547189 A JP 2009547189A JP 2010516761 A5 JP2010516761 A5 JP 2010516761A5
- Authority
- JP
- Japan
- Prior art keywords
- combinations
- composition
- composition according
- pyrrolidone
- polyol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- 239000003200 antithyroid agent Substances 0.000 claims 4
- 229940043671 antithyroid preparations Drugs 0.000 claims 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- 150000004665 fatty acids Chemical class 0.000 claims 4
- 239000002798 polar solvent Substances 0.000 claims 4
- 229920005862 polyol Polymers 0.000 claims 4
- 150000003077 polyols Chemical class 0.000 claims 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 3
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical group O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 3
- XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 239000001087 glyceryl triacetate Substances 0.000 claims 2
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 229960002622 triacetin Drugs 0.000 claims 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 claims 1
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical compound COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 claims 1
- QCAHUFWKIQLBNB-UHFFFAOYSA-N 3-(3-methoxypropoxy)propan-1-ol Chemical compound COCCCOCCCO QCAHUFWKIQLBNB-UHFFFAOYSA-N 0.000 claims 1
- 239000004348 Glyceryl diacetate Substances 0.000 claims 1
- 206010020850 Hyperthyroidism Diseases 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 1
- 229940028356 diethylene glycol monobutyl ether Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000019443 glyceryl diacetate Nutrition 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 150000003505 terpenes Chemical class 0.000 claims 1
- 235000007586 terpenes Nutrition 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ552816A NZ552816A (en) | 2007-01-24 | 2007-01-24 | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
| PCT/NZ2008/000011 WO2008091167A1 (en) | 2007-01-24 | 2008-01-22 | Topical formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516761A JP2010516761A (ja) | 2010-05-20 |
| JP2010516761A5 true JP2010516761A5 (enExample) | 2011-02-10 |
Family
ID=39644688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547189A Pending JP2010516761A (ja) | 2007-01-24 | 2008-01-22 | 局所処方物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8748467B2 (enExample) |
| EP (1) | EP2124938A4 (enExample) |
| JP (1) | JP2010516761A (enExample) |
| AU (1) | AU2008208151B2 (enExample) |
| CA (1) | CA2713199C (enExample) |
| NZ (1) | NZ552816A (enExample) |
| WO (1) | WO2008091167A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ552816A (en) | 2007-01-24 | 2009-05-31 | Bomac Research Ltd | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
| TWI544924B (zh) * | 2010-09-30 | 2016-08-11 | 富山化學工業股份有限公司 | 經皮吸收製劑 |
| US20160008471A1 (en) * | 2013-02-27 | 2016-01-14 | Laurie Robert Batt | Transdermal formulations |
| US10369135B2 (en) | 2014-05-13 | 2019-08-06 | Dendropharm Gmbh | Formulations for treatment of hyperthyroidism |
| WO2016198472A1 (en) | 2015-06-09 | 2016-12-15 | Hpf Ip Holding S.A. | Topical delivery system |
| EP3612225A1 (en) * | 2017-04-21 | 2020-02-26 | Steven Hoffman | Compositions and methods for treating retinopathy |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5296222A (en) * | 1989-02-23 | 1994-03-22 | University Of Utah | Percutaneous drug delivery system |
| US5091182A (en) * | 1990-07-23 | 1992-02-25 | Syntex (U.S.A.) Inc. | Dispensing units for ketorolac topical gel formlations |
| AU695120B2 (en) * | 1993-06-07 | 1998-08-06 | Baylor College Of Medicine | Use of an MHC class I suppressor drug for the treatment of autoimmune diseases and transplantation rejection |
| CN1046089C (zh) * | 1993-07-24 | 1999-11-03 | 陈凌 | 外敷用抗甲状腺乳膏 |
| US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
| CA2256365A1 (en) * | 1996-05-22 | 1997-11-27 | Diversified Pharmaceuticals, Inc. | Compositions, methods and devices for the transdermal delivery of drugs |
| CA2262009A1 (en) * | 1996-07-23 | 1998-01-29 | Wilson T. Crandall | Transdermal transport of molecules |
| US5919436A (en) * | 1997-09-25 | 1999-07-06 | The Board Of Regents Of The University Of Oklahoma | Method of lightening skin |
| PT1061900E (pt) | 1999-01-14 | 2005-04-29 | Noven Pharma | Composicoes e metodos para libertacao de uma droga |
| US20030170195A1 (en) | 2000-01-10 | 2003-09-11 | Noven Pharmaceuticals, Inc. | Compositions and methods for drug delivery |
| CN100482216C (zh) * | 1999-12-16 | 2009-04-29 | 德马全兹股份有限公司 | 氢氧根释放剂增强透皮渗透的用途 |
| CN100340237C (zh) * | 2000-11-06 | 2007-10-03 | 株式会社三养社 | 吸水性和粘附性能改善的经皮给药系统 |
| US8217157B2 (en) * | 2003-05-19 | 2012-07-10 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating and preventing heart tissue degeneration, and uses thereof |
| US20070269379A1 (en) * | 2003-07-23 | 2007-11-22 | Samir Mitragotri | Penetration Enhancer Combinations for Transdermal Delivery |
| US20050209295A1 (en) * | 2004-03-16 | 2005-09-22 | Kohn Leonard D | Methimazole derivatives and tautomeric cyclic thiones to inhibit cell adhesion |
| FR2873883B1 (fr) * | 2004-07-28 | 2006-09-29 | Sagem | Procede de tramage d'une image |
| CN100406063C (zh) | 2005-05-18 | 2008-07-30 | 陈凌 | 外敷用抗甲状腺软膏及其制备方法 |
| CN101296691B (zh) | 2005-08-05 | 2011-07-27 | 努沃研究公司 | 透皮释药剂型 |
| NZ552816A (en) | 2007-01-24 | 2009-05-31 | Bomac Research Ltd | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
-
2007
- 2007-01-24 NZ NZ552816A patent/NZ552816A/en unknown
-
2008
- 2008-01-22 AU AU2008208151A patent/AU2008208151B2/en active Active
- 2008-01-22 US US12/524,421 patent/US8748467B2/en active Active
- 2008-01-22 EP EP08724001A patent/EP2124938A4/en not_active Withdrawn
- 2008-01-22 WO PCT/NZ2008/000011 patent/WO2008091167A1/en not_active Ceased
- 2008-01-22 JP JP2009547189A patent/JP2010516761A/ja active Pending
- 2008-01-22 CA CA2713199A patent/CA2713199C/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010516761A5 (enExample) | ||
| JP2012530719A5 (enExample) | ||
| JP5576693B2 (ja) | 経皮吸収促進剤、および該経皮吸収促進剤を含有する経皮製剤 | |
| JP2008533007A5 (enExample) | ||
| JP2011506330A5 (enExample) | ||
| MX2010010647A (es) | Proceso para preparar formulaciones de dabigatran para administracion oral. | |
| JP2015511638A5 (enExample) | ||
| JP5542053B2 (ja) | ピルフェニドンを含有するゲル | |
| EA032938B1 (ru) | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения | |
| JP2013537530A5 (enExample) | ||
| JP2010513500A5 (enExample) | ||
| WO2008082507A3 (en) | Pharmaceutical compositions and method for treating inflammation in cattle and other animals | |
| JP2015516496A5 (enExample) | ||
| BR0309990A (pt) | Processo para produzir um hidrato de um sal de adição de ácido de um composto, hidrato de um sal de adição de ácido de um composto, composição farmacêutica ou veterinária, uso de um hidrato agente para o uso como um inibidor ou p-glicoproteìna, e, métodos para modular a mdr modulada pela p-gp no tratamento de tumores, para potencializar a citotoxicidade de um agente citotóxico para uma célula de tumor, para tratar uma doença em que o patógeno responsável exibe resistência a múltiplos medicamentos, e para realçar uma caracterìstica de um agente terapêutico | |
| JP2010526827A5 (enExample) | ||
| CN1227005C (zh) | 含尼美舒利的局部药用组合物 | |
| WO2015038552A3 (en) | Aspirin formulation for increased efficacy | |
| WO2010020799A3 (en) | Compositions for the treatment of neoplastic diseases | |
| CA2474246A1 (en) | Alkylammonium salts of omeprazole and esomeprazole | |
| JP2006523723A5 (enExample) | ||
| JP2017514875A5 (enExample) | ||
| JP2008532967A5 (enExample) | ||
| WO2011063774A3 (en) | Pectin complexes of steroids and pharmaceutical compositions based thereon | |
| CN104173321A (zh) | 制备通过外用贴剂给药的、具有消炎镇痛活性的药物组合物的方法，及以此获得的组合物 | |
| CN101909653A (zh) | 具有高渗透活性并显示出抗微生物作用、消炎作用和再生作用的组合物 |