JP2010516761A5 - - Google Patents
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- Publication number
- JP2010516761A5 JP2010516761A5 JP2009547189A JP2009547189A JP2010516761A5 JP 2010516761 A5 JP2010516761 A5 JP 2010516761A5 JP 2009547189 A JP2009547189 A JP 2009547189A JP 2009547189 A JP2009547189 A JP 2009547189A JP 2010516761 A5 JP2010516761 A5 JP 2010516761A5
- Authority
- JP
- Japan
- Prior art keywords
- combinations
- composition
- composition according
- pyrrolidone
- polyol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- 239000003200 antithyroid agent Substances 0.000 claims 4
- 229940043671 antithyroid preparations Drugs 0.000 claims 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- 150000004665 fatty acids Chemical class 0.000 claims 4
- 239000002798 polar solvent Substances 0.000 claims 4
- 229920005862 polyol Polymers 0.000 claims 4
- 150000003077 polyols Chemical class 0.000 claims 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 3
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical group O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 3
- XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 239000001087 glyceryl triacetate Substances 0.000 claims 2
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 229960002622 triacetin Drugs 0.000 claims 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 claims 1
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical compound COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 claims 1
- QCAHUFWKIQLBNB-UHFFFAOYSA-N 3-(3-methoxypropoxy)propan-1-ol Chemical compound COCCCOCCCO QCAHUFWKIQLBNB-UHFFFAOYSA-N 0.000 claims 1
- 239000004348 Glyceryl diacetate Substances 0.000 claims 1
- 206010020850 Hyperthyroidism Diseases 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 1
- 229940028356 diethylene glycol monobutyl ether Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000019443 glyceryl diacetate Nutrition 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 150000003505 terpenes Chemical class 0.000 claims 1
- 235000007586 terpenes Nutrition 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ552816A NZ552816A (en) | 2007-01-24 | 2007-01-24 | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
| PCT/NZ2008/000011 WO2008091167A1 (en) | 2007-01-24 | 2008-01-22 | Topical formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516761A JP2010516761A (ja) | 2010-05-20 |
| JP2010516761A5 true JP2010516761A5 (enExample) | 2011-02-10 |
Family
ID=39644688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547189A Pending JP2010516761A (ja) | 2007-01-24 | 2008-01-22 | 局所処方物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8748467B2 (enExample) |
| EP (1) | EP2124938A4 (enExample) |
| JP (1) | JP2010516761A (enExample) |
| AU (1) | AU2008208151B2 (enExample) |
| CA (1) | CA2713199C (enExample) |
| NZ (1) | NZ552816A (enExample) |
| WO (1) | WO2008091167A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ552816A (en) | 2007-01-24 | 2009-05-31 | Bomac Research Ltd | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
| JP5827954B2 (ja) * | 2010-09-30 | 2015-12-02 | 富山化学工業株式会社 | 経皮吸収製剤 |
| CA3186350A1 (en) * | 2013-02-27 | 2014-09-04 | Argenta Innovation Limited | Transdermal formulations |
| CN106714794B (zh) | 2014-05-13 | 2021-05-11 | 登卓药物有限公司 | 用于治疗甲状腺功能亢进的制剂 |
| WO2016198472A1 (en) | 2015-06-09 | 2016-12-15 | Hpf Ip Holding S.A. | Topical delivery system |
| WO2018195411A1 (en) * | 2017-04-21 | 2018-10-25 | Steven Hoffman | Compositions and methods for treating retinopathy |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5296222A (en) * | 1989-02-23 | 1994-03-22 | University Of Utah | Percutaneous drug delivery system |
| US5091182A (en) * | 1990-07-23 | 1992-02-25 | Syntex (U.S.A.) Inc. | Dispensing units for ketorolac topical gel formlations |
| EP0702554A1 (en) * | 1993-06-07 | 1996-03-27 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Use of an mhc class i suppressor drug for the treatment of autoimmune diseases and transplantation rejection |
| CN1046089C (zh) | 1993-07-24 | 1999-11-03 | 陈凌 | 外敷用抗甲状腺乳膏 |
| US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
| IL127189A0 (en) * | 1996-05-22 | 1999-09-22 | Diversified Pharmaceuticals In | Compositions methods and devices for the transdermal delivery of drugs |
| WO1998003641A1 (en) * | 1996-07-23 | 1998-01-29 | Crandall Wilson T | Transdermal transport of molecules |
| US5919436A (en) * | 1997-09-25 | 1999-07-06 | The Board Of Regents Of The University Of Oklahoma | Method of lightening skin |
| ES2237415T5 (es) * | 1999-01-14 | 2008-12-16 | Noven Pharmaceuticals, Inc. | Composiciones dermicas. |
| US20030170195A1 (en) | 2000-01-10 | 2003-09-11 | Noven Pharmaceuticals, Inc. | Compositions and methods for drug delivery |
| ATE290856T1 (de) * | 1999-12-16 | 2005-04-15 | Dermatrends Inc | Hydroxide freisetzende verbindungen zum verbessern der hautdurchlässigkeit |
| JP3962684B2 (ja) * | 2000-11-06 | 2007-08-22 | サムヤン コーポレイション | 改善された水分吸収能および接着性を有する経皮投与剤 |
| US8217157B2 (en) * | 2003-05-19 | 2012-07-10 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating and preventing heart tissue degeneration, and uses thereof |
| WO2005009510A2 (en) * | 2003-07-23 | 2005-02-03 | The Regents Of The University Of California | Penetration enhancer combinations for transdermal delivery |
| US20050209295A1 (en) * | 2004-03-16 | 2005-09-22 | Kohn Leonard D | Methimazole derivatives and tautomeric cyclic thiones to inhibit cell adhesion |
| FR2873883B1 (fr) * | 2004-07-28 | 2006-09-29 | Sagem | Procede de tramage d'une image |
| CN100406063C (zh) | 2005-05-18 | 2008-07-30 | 陈凌 | 外敷用抗甲状腺软膏及其制备方法 |
| CA2617934A1 (en) | 2005-08-05 | 2007-02-15 | Nuvo Research Inc. | Transdermal drug delivery formulation |
| NZ552816A (en) | 2007-01-24 | 2009-05-31 | Bomac Research Ltd | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
-
2007
- 2007-01-24 NZ NZ552816A patent/NZ552816A/en unknown
-
2008
- 2008-01-22 JP JP2009547189A patent/JP2010516761A/ja active Pending
- 2008-01-22 US US12/524,421 patent/US8748467B2/en active Active
- 2008-01-22 AU AU2008208151A patent/AU2008208151B2/en active Active
- 2008-01-22 WO PCT/NZ2008/000011 patent/WO2008091167A1/en not_active Ceased
- 2008-01-22 CA CA2713199A patent/CA2713199C/en not_active Expired - Fee Related
- 2008-01-22 EP EP08724001A patent/EP2124938A4/en not_active Withdrawn
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