JP2010516761A - 局所処方物 - Google Patents
局所処方物 Download PDFInfo
- Publication number
- JP2010516761A JP2010516761A JP2009547189A JP2009547189A JP2010516761A JP 2010516761 A JP2010516761 A JP 2010516761A JP 2009547189 A JP2009547189 A JP 2009547189A JP 2009547189 A JP2009547189 A JP 2009547189A JP 2010516761 A JP2010516761 A JP 2010516761A
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- JP
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- Prior art keywords
- composition
- combinations
- animal
- glycol
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000012049 topical pharmaceutical composition Substances 0.000 title description 2
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- 241001465754 Metazoa Species 0.000 claims abstract description 34
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- 229940043671 antithyroid preparations Drugs 0.000 claims abstract description 30
- 238000011282 treatment Methods 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 42
- CFOYWRHIYXMDOT-UHFFFAOYSA-N carbimazole Chemical compound CCOC(=O)N1C=CN(C)C1=S CFOYWRHIYXMDOT-UHFFFAOYSA-N 0.000 claims description 29
- 229960001704 carbimazole Drugs 0.000 claims description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- PMRYVIKBURPHAH-UHFFFAOYSA-N methimazole Chemical compound CN1C=CNC1=S PMRYVIKBURPHAH-UHFFFAOYSA-N 0.000 claims description 24
- 229960002178 thiamazole Drugs 0.000 claims description 24
- 206010020850 Hyperthyroidism Diseases 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 18
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 16
- 239000003961 penetration enhancing agent Substances 0.000 claims description 16
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- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 12
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- 229960002622 triacetin Drugs 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
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- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 claims description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 229940028356 diethylene glycol monobutyl ether Drugs 0.000 claims description 3
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 claims description 3
- 125000000545 (4R)-limonene group Chemical group 0.000 claims description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims description 2
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- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 2
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- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- HWGBHCRJGXAGEU-UHFFFAOYSA-N Methylthiouracil Chemical compound CC1=CC(=O)NC(=S)N1 HWGBHCRJGXAGEU-UHFFFAOYSA-N 0.000 description 1
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- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ552816A NZ552816A (en) | 2007-01-24 | 2007-01-24 | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
| PCT/NZ2008/000011 WO2008091167A1 (en) | 2007-01-24 | 2008-01-22 | Topical formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516761A true JP2010516761A (ja) | 2010-05-20 |
| JP2010516761A5 JP2010516761A5 (enExample) | 2011-02-10 |
Family
ID=39644688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547189A Pending JP2010516761A (ja) | 2007-01-24 | 2008-01-22 | 局所処方物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8748467B2 (enExample) |
| EP (1) | EP2124938A4 (enExample) |
| JP (1) | JP2010516761A (enExample) |
| AU (1) | AU2008208151B2 (enExample) |
| CA (1) | CA2713199C (enExample) |
| NZ (1) | NZ552816A (enExample) |
| WO (1) | WO2008091167A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020517663A (ja) * | 2017-04-21 | 2020-06-18 | スティーブン・ホフマン | 網膜症を治療するための組成物及び方法 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ552816A (en) | 2007-01-24 | 2009-05-31 | Bomac Research Ltd | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
| JP5827954B2 (ja) * | 2010-09-30 | 2015-12-02 | 富山化学工業株式会社 | 経皮吸収製剤 |
| CA3186350A1 (en) * | 2013-02-27 | 2014-09-04 | Argenta Innovation Limited | Transdermal formulations |
| CN106714794B (zh) | 2014-05-13 | 2021-05-11 | 登卓药物有限公司 | 用于治疗甲状腺功能亢进的制剂 |
| WO2016198472A1 (en) | 2015-06-09 | 2016-12-15 | Hpf Ip Holding S.A. | Topical delivery system |
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| JP2001039865A (ja) * | 1995-04-26 | 2001-02-13 | Theratech Inc | 経皮的投与のためのマトリックスパッチ |
| JP2004500360A (ja) * | 1999-12-16 | 2004-01-08 | ダーマトレンズ， インコーポレイテッド | 皮膚浸透促進剤としての水酸化物放出剤 |
| JP2004512356A (ja) * | 2000-11-06 | 2004-04-22 | サムヤン コーポレイション | 改善された水分吸収能および接着性を有する経皮投与剤 |
| WO2006018554A1 (fr) * | 2004-07-28 | 2006-02-23 | Sagem Communication | Procédé de tramage d'une d'image |
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| US5296222A (en) * | 1989-02-23 | 1994-03-22 | University Of Utah | Percutaneous drug delivery system |
| US5091182A (en) * | 1990-07-23 | 1992-02-25 | Syntex (U.S.A.) Inc. | Dispensing units for ketorolac topical gel formlations |
| EP0702554A1 (en) * | 1993-06-07 | 1996-03-27 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Use of an mhc class i suppressor drug for the treatment of autoimmune diseases and transplantation rejection |
| CN1046089C (zh) | 1993-07-24 | 1999-11-03 | 陈凌 | 外敷用抗甲状腺乳膏 |
| IL127189A0 (en) * | 1996-05-22 | 1999-09-22 | Diversified Pharmaceuticals In | Compositions methods and devices for the transdermal delivery of drugs |
| WO1998003641A1 (en) * | 1996-07-23 | 1998-01-29 | Crandall Wilson T | Transdermal transport of molecules |
| US5919436A (en) * | 1997-09-25 | 1999-07-06 | The Board Of Regents Of The University Of Oklahoma | Method of lightening skin |
| ES2237415T5 (es) * | 1999-01-14 | 2008-12-16 | Noven Pharmaceuticals, Inc. | Composiciones dermicas. |
| US20030170195A1 (en) | 2000-01-10 | 2003-09-11 | Noven Pharmaceuticals, Inc. | Compositions and methods for drug delivery |
| US8217157B2 (en) * | 2003-05-19 | 2012-07-10 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating and preventing heart tissue degeneration, and uses thereof |
| WO2005009510A2 (en) * | 2003-07-23 | 2005-02-03 | The Regents Of The University Of California | Penetration enhancer combinations for transdermal delivery |
| US20050209295A1 (en) * | 2004-03-16 | 2005-09-22 | Kohn Leonard D | Methimazole derivatives and tautomeric cyclic thiones to inhibit cell adhesion |
| CN100406063C (zh) | 2005-05-18 | 2008-07-30 | 陈凌 | 外敷用抗甲状腺软膏及其制备方法 |
| CA2617934A1 (en) | 2005-08-05 | 2007-02-15 | Nuvo Research Inc. | Transdermal drug delivery formulation |
| NZ552816A (en) | 2007-01-24 | 2009-05-31 | Bomac Research Ltd | Formulation for transdermal administration of antihyperthyroid drug comprising a penetration enhancer selected from oleic acid, d-limonene, pyrrolidones, a C2-C8 alcohol, glycol ethers, triacetin and combinations thereof |
-
2007
- 2007-01-24 NZ NZ552816A patent/NZ552816A/en unknown
-
2008
- 2008-01-22 JP JP2009547189A patent/JP2010516761A/ja active Pending
- 2008-01-22 US US12/524,421 patent/US8748467B2/en active Active
- 2008-01-22 AU AU2008208151A patent/AU2008208151B2/en active Active
- 2008-01-22 WO PCT/NZ2008/000011 patent/WO2008091167A1/en not_active Ceased
- 2008-01-22 CA CA2713199A patent/CA2713199C/en not_active Expired - Fee Related
- 2008-01-22 EP EP08724001A patent/EP2124938A4/en not_active Withdrawn
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| JP2001039865A (ja) * | 1995-04-26 | 2001-02-13 | Theratech Inc | 経皮的投与のためのマトリックスパッチ |
| JP2004500360A (ja) * | 1999-12-16 | 2004-01-08 | ダーマトレンズ， インコーポレイテッド | 皮膚浸透促進剤としての水酸化物放出剤 |
| JP2004512356A (ja) * | 2000-11-06 | 2004-04-22 | サムヤン コーポレイション | 改善された水分吸収能および接着性を有する経皮投与剤 |
| WO2006018554A1 (fr) * | 2004-07-28 | 2006-02-23 | Sagem Communication | Procédé de tramage d'une d'image |
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| JPN6012054628; Ｍａｇｎｕｓｓｏｎ ＢＭ ｅｔ ａｌ．: 'Ｖｅｔｅｒｉｎａｒｙ ｄｒｕｇ ｄｅｌｉｖｅｒｙ： ｐｏｔｅｎｔｉａｌ ｆｏｒ ｓｋｉｎ ｐｅｎｅｔｒａｔｉｏｎ ｅｎｈａｎｃｅｍｅｎｔ．' Ａｄｖ Ｄｒｕｇ Ｄｅｌｉｖ Ｒｅｖ． Ｖｏｌ．５０ Ｎｏ．３, 20010901, ｐｐ．２０５-２２７ * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020517663A (ja) * | 2017-04-21 | 2020-06-18 | スティーブン・ホフマン | 網膜症を治療するための組成物及び方法 |
| JP7171611B2 (ja) | 2017-04-21 | 2022-11-15 | スティーブン・ホフマン | 網膜症を治療するための組成物及び方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2713199A1 (en) | 2008-07-31 |
| EP2124938A1 (en) | 2009-12-02 |
| CA2713199C (en) | 2015-05-19 |
| NZ552816A (en) | 2009-05-31 |
| AU2008208151A1 (en) | 2008-07-31 |
| US8748467B2 (en) | 2014-06-10 |
| WO2008091167A1 (en) | 2008-07-31 |
| US20100137389A1 (en) | 2010-06-03 |
| EP2124938A4 (en) | 2010-04-14 |
| AU2008208151B2 (en) | 2014-02-20 |
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