JP2010516688A5 - - Google Patents
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- Publication number
- JP2010516688A5 JP2010516688A5 JP2009546483A JP2009546483A JP2010516688A5 JP 2010516688 A5 JP2010516688 A5 JP 2010516688A5 JP 2009546483 A JP2009546483 A JP 2009546483A JP 2009546483 A JP2009546483 A JP 2009546483A JP 2010516688 A5 JP2010516688 A5 JP 2010516688A5
- Authority
- JP
- Japan
- Prior art keywords
- contacting
- antimicrobial
- bacterium
- peptide
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 17
- 102000044503 Antimicrobial Peptides Human genes 0.000 claims description 13
- 108700042778 Antimicrobial Peptides Proteins 0.000 claims description 13
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
- 241000194019 Streptococcus mutans Species 0.000 claims description 5
- 230000002378 acidificating effect Effects 0.000 claims description 5
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 125000002091 cationic group Chemical group 0.000 claims description 3
- 208000002925 dental caries Diseases 0.000 claims description 3
- 230000007935 neutral effect Effects 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 2
- -1 Tboc Chemical group 0.000 claims 15
- 238000000034 method Methods 0.000 claims 9
- 241000894006 Bacteria Species 0.000 claims 8
- 210000002200 mouth mucosa Anatomy 0.000 claims 4
- 230000035755 proliferation Effects 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- WTKQMHWYSBWUBE-UHFFFAOYSA-N (3-nitropyridin-2-yl) thiohypochlorite Chemical group [O-][N+](=O)C1=CC=CN=C1SCl WTKQMHWYSBWUBE-UHFFFAOYSA-N 0.000 claims 2
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 2
- 125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 125000002933 cyclohexyloxy group Chemical group C1(CCCCC1)O* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000007937 lozenge Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002324 mouth wash Substances 0.000 claims 2
- 229940051866 mouthwash Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 229940034610 toothpaste Drugs 0.000 claims 2
- 239000000606 toothpaste Substances 0.000 claims 2
- 230000002087 whitening effect Effects 0.000 claims 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
- WSNDAYQNZRJGMJ-UHFFFAOYSA-N 2,2,2-trifluoroethanone Chemical compound FC(F)(F)[C]=O WSNDAYQNZRJGMJ-UHFFFAOYSA-N 0.000 claims 1
- CBEFMGJHEKAMNI-UHFFFAOYSA-N 9-oxofluorene-1-carboxylic acid Chemical group C12=CC=CC=C2C(=O)C2=C1C=CC=C2C(=O)O CBEFMGJHEKAMNI-UHFFFAOYSA-N 0.000 claims 1
- HTPXFGUCAUTOEL-UHFFFAOYSA-N 9h-fluorene-1-carboxylic acid Chemical group C1C2=CC=CC=C2C2=C1C(C(=O)O)=CC=C2 HTPXFGUCAUTOEL-UHFFFAOYSA-N 0.000 claims 1
- DNVJGJUGFFYUPT-UHFFFAOYSA-N 9h-fluorene-9-carboxylic acid Chemical group C1=CC=C2C(C(=O)O)C3=CC=CC=C3C2=C1 DNVJGJUGFFYUPT-UHFFFAOYSA-N 0.000 claims 1
- 235000010585 Ammi visnaga Nutrition 0.000 claims 1
- 244000153158 Ammi visnaga Species 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 241000628997 Flos Species 0.000 claims 1
- 241000194022 Streptococcus sp. Species 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000007922 nasal spray Substances 0.000 claims 1
- 239000000668 oral spray Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 238000009736 wetting Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 description 5
- 229920006227 ethylene-grafted-maleic anhydride Polymers 0.000 description 4
- 125000003345 AMP group Chemical group 0.000 description 3
- 239000012528 membrane Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 230000004913 activation Effects 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88078307P | 2007-01-16 | 2007-01-16 | |
| PCT/US2008/051101 WO2008140834A2 (en) | 2007-01-16 | 2008-01-15 | Novel antimicrobial peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516688A JP2010516688A (ja) | 2010-05-20 |
| JP2010516688A5 true JP2010516688A5 (https=) | 2013-05-23 |
Family
ID=40002852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546483A Pending JP2010516688A (ja) | 2007-01-16 | 2008-01-15 | 抗菌ペプチド |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7713927B2 (https=) |
| EP (1) | EP2118122B1 (https=) |
| JP (1) | JP2010516688A (https=) |
| CN (1) | CN101622271B (https=) |
| AU (1) | AU2008251748B2 (https=) |
| ES (1) | ES2548767T3 (https=) |
| IL (1) | IL199835A (https=) |
| WO (1) | WO2008140834A2 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007284801A1 (en) * | 2006-08-08 | 2008-02-21 | The Regents Of The University Of Californina | Salicylanilides enhance oral delivery of therapeutic peptides |
| CA2661634C (en) | 2006-09-06 | 2017-03-28 | The Regents Of The University Of California | Selectively targeted antimicrobial peptides and the use thereof |
| ES2548767T3 (es) * | 2007-01-16 | 2015-10-20 | The Regents Of The University Of California | Nuevos péptidos antimicrobianos |
| EP2168976A1 (en) * | 2008-09-24 | 2010-03-31 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Antimicrobial peptides |
| US20100184684A1 (en) * | 2009-01-06 | 2010-07-22 | C3 Jian, Inc. | Antibacterial and antifungal peptides |
| US20100202983A1 (en) * | 2009-02-09 | 2010-08-12 | Jernberg Gary R | Selectively targeted antimicrobials for the treatment of periodontal disease |
| US9987224B2 (en) * | 2011-02-04 | 2018-06-05 | Joseph E. Kovarik | Method and system for preventing migraine headaches, cluster headaches and dizziness |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US12533312B2 (en) | 2011-02-04 | 2026-01-27 | Seed Health, Inc. | Method and system for preventing sore throat in humans |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US11523934B2 (en) | 2011-02-04 | 2022-12-13 | Seed Health, Inc. | Method and system to facilitate the growth of desired bacteria in a human's mouth |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US10085938B2 (en) * | 2011-02-04 | 2018-10-02 | Joseph E. Kovarik | Method and system for preventing sore throat in humans |
| US10687975B2 (en) | 2011-02-04 | 2020-06-23 | Joseph E. Kovarik | Method and system to facilitate the growth of desired bacteria in a human's mouth |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US11357722B2 (en) | 2011-02-04 | 2022-06-14 | Seed Health, Inc. | Method and system for preventing sore throat in humans |
| US9320698B2 (en) * | 2011-05-11 | 2016-04-26 | Escape Therapeutics, Inc. | Peptide tyrosinase inhibitors and uses thereof |
| US12083158B2 (en) * | 2011-10-07 | 2024-09-10 | Morehouse School Of Medicine | Antibacterial compositions, methods of making and use thereof |
| US9028807B2 (en) | 2012-04-05 | 2015-05-12 | Ues, Inc. | Synthesis models for antimicrobial agents via the halogenation of organic/inorganic composites |
| CN103172701B (zh) * | 2013-03-18 | 2015-09-30 | 中国科学院过程工程研究所 | 一种新型穿膜肽及其应用 |
| JP2014218496A (ja) * | 2013-04-08 | 2014-11-20 | 和興フィルタテクノロジー株式会社 | 高保存性抗体溶液 |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| US12246043B2 (en) | 2013-12-20 | 2025-03-11 | Seed Health, Inc. | Topical application to treat acne vulgaris |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US12329783B2 (en) | 2013-12-20 | 2025-06-17 | Seed Health, Inc. | Method and system to improve the health of a person's skin microbiome |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| CN103830145B (zh) * | 2014-03-18 | 2015-10-28 | 林彤 | 一种含有生物肽与中药的牙膏 |
| CN106488929B (zh) * | 2014-05-09 | 2021-08-24 | 乌得勒支大学控股有限公司 | 新型cath2衍生物 |
| EP3180351B1 (en) * | 2014-08-14 | 2018-11-28 | Council of Scientific and Industrial Research | Novel synthetic antimicrobial peptides |
| CN106674329B (zh) * | 2015-11-05 | 2021-07-23 | 程家维 | 具备抗微生物、抗癌/促进伤口愈合活性的肽及其用途 |
| WO2017134661A1 (en) * | 2016-02-04 | 2017-08-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods for disrupting biofilms |
| CN107337713B (zh) * | 2016-05-03 | 2022-05-13 | 上海医药工业研究院 | 一组抑菌肽及其制备方法 |
| CN106390206B (zh) * | 2016-08-17 | 2019-06-28 | 广州宏柯源生物科技有限公司 | 一种多肽水凝胶、其制备方法及应用 |
| KR101899552B1 (ko) * | 2016-11-18 | 2018-09-17 | 군산대학교 산학협력단 | 전복에서 유래한 항균 펩타이드 유사체 및 이를 포함하는 항균용 약학 조성물 |
| US10111929B1 (en) * | 2017-04-07 | 2018-10-30 | Ez Ip, Llc | Growth hormone releasing factor analogs and uses |
| CN109232719B (zh) * | 2018-09-21 | 2021-06-29 | 中国科学院理化技术研究所 | 一种pH响应的抗菌肽及其制备方法和应用 |
| US20220053773A1 (en) * | 2018-10-01 | 2022-02-24 | Innate Immunity LLC | Compositions and methods for the treatment of pathogenic infections in plants |
| US20200102356A1 (en) * | 2018-10-01 | 2020-04-02 | NMC Inc. | Compositions and Methods for the Treatment of Huanglongbing (HLB) aka Citrus Greening in Citrus Plants |
| KR102170236B1 (ko) * | 2019-03-19 | 2020-10-29 | (주)노바셀테크놀로지 | 신규 다중 기능성 펩타이드 및 그의 용도 |
| WO2021042039A1 (en) * | 2019-08-29 | 2021-03-04 | Ajk Pharmaceutical Llc | Synthetic antimicrobial peptides |
| CA3166422A1 (en) * | 2019-12-30 | 2021-07-08 | Ohio State Innovation Foundation | Looped proteins comprising cell penetrating peptides |
| AU2021246017A1 (en) * | 2020-03-31 | 2022-11-10 | Innate Immunity LLC | Recombinant peptide to treat fire blight |
| KR102220323B1 (ko) * | 2020-05-15 | 2021-02-26 | (주)노바셀테크놀로지 | 신규 다중 기능성 펩타이드 및 그의 용도 |
| DE102020211387A1 (de) | 2020-09-10 | 2022-03-10 | Beiersdorf Aktiengesellschaft | Wirkstoffhaltige Wundverschlusszubereitung |
| CN113248572B (zh) * | 2021-04-30 | 2023-04-11 | 重庆理工大学 | 一种抗多重耐药菌环肽及其应用 |
| US20240287135A1 (en) * | 2021-09-03 | 2024-08-29 | Qc Bio-Technology (Shenzhen) Co., Ltd. | Antimicrobial peptide or peptide derivative, substitute, and composition thereof, and preparation method and application of composition |
| US20230134577A1 (en) * | 2021-09-20 | 2023-05-04 | The Procter & Gamble Company | Jammed Emulsion Toothpaste Compositions Comprising Fluoride |
| WO2025217869A1 (en) * | 2024-04-18 | 2025-10-23 | Jiangsu Protelight Pharmaceutical & Biotechnology Co., Ltd. | Antimicrobial peptides |
| WO2025259842A2 (en) * | 2024-06-12 | 2025-12-18 | Invaio Sciences, Inc. | Novel alpha-factor based peptides with antifungal activity |
| CN120289633B (zh) * | 2025-02-27 | 2025-11-28 | 黄冈师范学院 | 抗变形链球菌的多肽、核酸分子及在制备抗变形链球菌的药物应用 |
| CN120617172B (zh) * | 2025-06-25 | 2026-03-24 | 中国科学院南海海洋研究所 | 一种安全无防腐剂的海龙抗菌肽喷雾剂及其制备方法和应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2118939A1 (en) * | 1991-09-13 | 1993-04-01 | W. Lee Maloy | Biologically active amphiphilic peptide compositions and uses thereof |
| AUPN861496A0 (en) * | 1996-03-13 | 1996-04-04 | Commonwealth Scientific And Industrial Research Organisation | Lytic peptides |
| CA2294518A1 (en) * | 1997-07-15 | 1999-01-28 | Magainin Pharmaceuticals Inc. | Biologically active peptides with reduced toxicity in animals and a method for preparing same |
| CA2320429C (en) * | 1998-02-18 | 2011-04-19 | Harbor-Ucla Research And Education Institute | Antimicrobial peptides and derived metapeptides |
| US20040052814A1 (en) * | 1998-09-28 | 2004-03-18 | Wenyuan Shi | Fusion proteins for targeted delivery of antimicrobial peptides |
| US6610836B1 (en) * | 1999-01-29 | 2003-08-26 | Genome Therapeutics Corporation | Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics |
| US7569542B2 (en) * | 1999-08-20 | 2009-08-04 | The Regents Of The University Of California | Anti-microbial targeting chimeric pharmaceutical |
| US20020068066A1 (en) | 1999-08-20 | 2002-06-06 | Wenyuan Shi | Method for the treatment and prevention of dental caries |
| US20030143234A1 (en) * | 1999-08-20 | 2003-07-31 | Wenyuan Shi | Anti-microbial targeting chimeric pharmaceutical |
| WO2002014346A2 (en) * | 2000-08-15 | 2002-02-21 | North Carolina State University | Antimicrobial peptides isolated from fish |
| US6449760B1 (en) * | 2000-11-30 | 2002-09-10 | Lsi Logic Corporation | Pin placement method for integrated circuits |
| US6875744B2 (en) * | 2001-03-28 | 2005-04-05 | Helix Biomedix, Inc. | Short bioactive peptides |
| US7427408B2 (en) * | 2002-06-06 | 2008-09-23 | The Regents Of The University Of California | Quorum sensing and biofilm formation |
| US7087228B2 (en) * | 2002-07-03 | 2006-08-08 | University Of Southern California | Preventing tooth decay and infective endocarditis using natural oligopeptides |
| WO2004110341A2 (en) * | 2003-06-19 | 2004-12-23 | Yeda Research & Development Co. Ltd. | Antimicrobial and anticancer lipopeptides |
| US7875598B2 (en) * | 2004-03-04 | 2011-01-25 | The Regents Of The University Of California | Compositions useful for the treatment of microbial infections |
| US7452856B2 (en) * | 2004-07-06 | 2008-11-18 | Seikagaku Corporation | Antibacterial peptide |
| US7504381B2 (en) * | 2004-09-27 | 2009-03-17 | Technion Research & Development Foundation Ltd. | Antimicrobial agents |
| AU2006212922B2 (en) * | 2005-02-09 | 2011-04-21 | Helix Biomedix Inc. | Antimicrobial hexapeptides |
| EP2293064B1 (en) * | 2005-04-05 | 2012-04-04 | Allergan, Inc. | Lipophilic dye-based FRET assays for clostridial toxin activity |
| WO2007005635A2 (en) * | 2005-07-01 | 2007-01-11 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mitotic spindle protein aspm as a diagnostic marker for neoplasia and uses therefor |
| CA2620935A1 (en) | 2005-09-01 | 2007-03-08 | The Regents Of The University Of California | Method of using pore-forming peptides for genetic transformation, protein extraction, and transmembrane transport |
| CA2622915A1 (en) * | 2005-09-28 | 2007-04-05 | The Regents Of The University Of California | Calcium binding peptides |
| CA2660668C (en) * | 2006-08-21 | 2016-06-28 | The University Of British Columbia | Small cationic antimicrobial peptides |
| CA2661634C (en) * | 2006-09-06 | 2017-03-28 | The Regents Of The University Of California | Selectively targeted antimicrobial peptides and the use thereof |
| ES2548767T3 (es) | 2007-01-16 | 2015-10-20 | The Regents Of The University Of California | Nuevos péptidos antimicrobianos |
-
2008
- 2008-01-15 ES ES08795782.5T patent/ES2548767T3/es active Active
- 2008-01-15 WO PCT/US2008/051101 patent/WO2008140834A2/en not_active Ceased
- 2008-01-15 CN CN200880002256.9A patent/CN101622271B/zh not_active Expired - Fee Related
- 2008-01-15 EP EP08795782.5A patent/EP2118122B1/en active Active
- 2008-01-15 AU AU2008251748A patent/AU2008251748B2/en not_active Ceased
- 2008-01-15 US US12/014,634 patent/US7713927B2/en active Active
- 2008-01-15 JP JP2009546483A patent/JP2010516688A/ja active Pending
-
2009
- 2009-07-13 IL IL199835A patent/IL199835A/en active IP Right Grant
-
2010
- 2010-03-24 US US12/730,939 patent/US8609608B2/en not_active Expired - Fee Related
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