|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4510245A
(en)
|
1982-11-18 |
1985-04-09 |
Chiron Corporation |
Adenovirus promoter system
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
|
US4968615A
(en)
|
1985-12-18 |
1990-11-06 |
Ciba-Geigy Corporation |
Deoxyribonucleic acid segment from a virus
|
|
GB8823869D0
(en)
*
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5811523A
(en)
|
1988-11-10 |
1998-09-22 |
Trinchieri; Giorgio |
Antibodies to natural killer stimulatory factor
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DK0494955T3
(da)
|
1989-10-05 |
1998-10-26 |
Optein Inc |
Cellefri syntese og isolering af hidtil ukendte gener og polypeptider
|
|
US6683046B1
(en)
|
1989-12-22 |
2004-01-27 |
Hoffmann-La Roche Inc. |
Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
|
|
US6150584A
(en)
*
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6673986B1
(en)
*
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
|
AU665190B2
(en)
|
1990-07-10 |
1995-12-21 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5633425A
(en)
*
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
WO1994025585A1
(en)
|
1993-04-26 |
1994-11-10 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5814318A
(en)
*
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US7084260B1
(en)
*
|
1996-10-10 |
2006-08-01 |
Genpharm International, Inc. |
High affinity human antibodies and human antibodies against human antigens
|
|
US6255458B1
(en)
*
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US5789650A
(en)
*
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
DK0546073T3
(da)
*
|
1990-08-29 |
1998-02-02 |
Genpharm Int |
Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
|
|
US5545806A
(en)
*
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
*
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
*
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
US5656272A
(en)
*
|
1991-03-18 |
1997-08-12 |
New York University Medical Center |
Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
|
|
US5698195A
(en)
*
|
1991-03-18 |
1997-12-16 |
New York University Medical Center |
Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies
|
|
US5919452A
(en)
*
|
1991-03-18 |
1999-07-06 |
New York University |
Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
|
|
US6284471B1
(en)
*
|
1991-03-18 |
2001-09-04 |
New York University Medical Center |
Anti-TNFa antibodies and assays employing anti-TNFa antibodies
|
|
US6277969B1
(en)
*
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
|
ATE269401T1
(de)
|
1991-04-10 |
2004-07-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
DE69229477T2
(de)
|
1991-09-23 |
1999-12-09 |
Cambridge Antibody Technology Ltd., Melbourn |
Methoden zur Herstellung humanisierter Antikörper
|
|
GB9122820D0
(en)
|
1991-10-28 |
1991-12-11 |
Wellcome Found |
Stabilised antibodies
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
EP0652950B1
(en)
|
1992-07-24 |
2007-12-19 |
Amgen Fremont Inc. |
Generation of xenogeneic antibodies
|
|
US5652138A
(en)
*
|
1992-09-30 |
1997-07-29 |
The Scripps Research Institute |
Human neutralizing monoclonal antibodies to human immunodeficiency virus
|
|
ES2159529T5
(es)
*
|
1993-03-05 |
2011-03-09 |
Bayer Corporation |
Anticuerpos monoclonales humanos anti-tnf alfa.
|
|
US5654168A
(en)
|
1994-07-01 |
1997-08-05 |
Basf Aktiengesellschaft |
Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units
|
|
US5464758A
(en)
|
1993-06-14 |
1995-11-07 |
Gossen; Manfred |
Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
|
|
CA2125763C
(en)
|
1993-07-02 |
2007-08-28 |
Maurice Kent Gately |
P40 homodimer of interleukin-12
|
|
EP0638644A1
(en)
|
1993-07-19 |
1995-02-15 |
F. Hoffmann-La Roche Ag |
Receptors of interleukin-12 and antibodies
|
|
EP0659766A1
(en)
|
1993-11-23 |
1995-06-28 |
Schering-Plough |
Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
|
|
ZA95960B
(en)
*
|
1994-03-14 |
1995-10-10 |
Genetics Inst |
Use of interleukin-12 antagonists in the treatment of autoimmune diseases
|
|
US5910486A
(en)
|
1994-09-06 |
1999-06-08 |
Uab Research Foundation |
Methods for modulating protein function in cells using, intracellular antibody homologues
|
|
WO1996012436A1
(en)
*
|
1994-10-20 |
1996-05-02 |
Instent, Inc. |
Cystoscope delivery system
|
|
JP2758154B2
(ja)
|
1995-04-06 |
1998-05-28 |
エフ・ホフマン−ラ ロシユ アーゲー |
インターフェロンを含む液体製剤
|
|
DE69637481T2
(de)
|
1995-04-27 |
2009-04-09 |
Amgen Fremont Inc. |
Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
US6685940B2
(en)
*
|
1995-07-27 |
2004-02-03 |
Genentech, Inc. |
Protein formulation
|
|
ES2434840T3
(es)
|
1995-07-27 |
2013-12-17 |
Genentech, Inc. |
Formulación de proteína liofilizada isotónica estable
|
|
US5853697A
(en)
|
1995-10-25 |
1998-12-29 |
The United States Of America, As Represented By The Department Of Health & Human Services |
Methods of treating established colitis using antibodies against IL-12
|
|
US6297395B1
(en)
*
|
1995-11-10 |
2001-10-02 |
The Secretary Of State For Defence In Her Brittanic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland |
Calixarenes and their use for sequestration of metals
|
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
|
KR100317188B1
(ko)
*
|
1996-02-09 |
2002-02-19 |
스타르크, 카르크 |
사람TNFα와결합하는사람항체
|
|
AU7257696A
(en)
|
1996-10-11 |
1998-05-11 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Methods for enhancing oral tolerance and treating autoimmune disease using inhibitors of interleukin-12
|
|
AU4959997A
(en)
|
1996-11-15 |
1998-06-10 |
Kennedy Institute Of Rheumatology, The |
Suppression of tnf alpha and il-12 in therapy
|
|
CA2616914C
(en)
|
1996-12-03 |
2012-05-29 |
Abgenix, Inc. |
Egfr-binding antibody
|
|
US6054487A
(en)
*
|
1997-03-18 |
2000-04-25 |
Basf Aktiengesellschaft |
Methods and compositions for modulating responsiveness to corticosteroids
|
|
BR9810409A
(pt)
|
1997-03-18 |
2000-08-22 |
Basf Ag |
Métodos e composições para a modulação de responsividade a corticosteróides
|
|
US6183744B1
(en)
|
1997-03-24 |
2001-02-06 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
JP3919235B2
(ja)
|
1997-06-13 |
2007-05-23 |
ジェネンテク，インコーポレイテッド |
抗体製剤
|
|
WO1999009055A2
(en)
|
1997-08-18 |
1999-02-25 |
Innogenetics N.V. |
Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
|
|
AU744302B2
(en)
|
1997-10-31 |
2002-02-21 |
Beth Israel Deaconess Medical Center |
Use of anti-IL-12 antibodies in transplantation rejection
|
|
PT1049717E
(pt)
*
|
1998-01-23 |
2007-05-31 |
Hoffmann La Roche |
Anticorpos contra a il-12 humana.
|
|
US20020161199A1
(en)
*
|
1998-04-08 |
2002-10-31 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
EP0953639A1
(en)
|
1998-04-30 |
1999-11-03 |
Boehringer Ingelheim International GmbH |
FAPalpha-specific antibody with improved producibility
|
|
CA2353520C
(en)
|
1998-12-09 |
2006-04-25 |
Protein Design Labs, Inc. |
Animal model for psoriasis for the prevention and treatment of psoriasis in humans
|
|
NZ596723A
(en)
*
|
1999-03-25 |
2013-07-26 |
Abbott Gmbh & Co Kg |
Human antibodies that bind human il-12 and methods for producing
|
|
US6914128B1
(en)
*
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
US7883704B2
(en)
*
|
1999-03-25 |
2011-02-08 |
Abbott Gmbh & Co. Kg |
Methods for inhibiting the activity of the P40 subunit of human IL-12
|
|
ATE316982T1
(de)
|
1999-08-09 |
2006-02-15 |
Lexigen Pharm Corp |
Mehrere zytokin-antikörper komplexen
|
|
US6902734B2
(en)
*
|
2000-08-07 |
2005-06-07 |
Centocor, Inc. |
Anti-IL-12 antibodies and compositions thereof
|
|
IL156618A0
(en)
|
2000-12-28 |
2004-01-04 |
Altus Biologics Inc |
Crystals of whole antibodies and fragments thereof, methods for the preparation thereof and diagnostic kits utilizing the same
|
|
WO2002098445A1
(fr)
*
|
2001-05-30 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preparation de proteines
|
|
AU2002314825A1
(en)
|
2001-05-30 |
2002-12-09 |
Centocor, Inc. |
Anti-p40 immunoglobulin derived proteins, compositions, methods and uses
|
|
EP1539212A4
(en)
*
|
2002-07-12 |
2007-05-02 |
Medarex Inc |
METHOD AND COMPOSITIONS FOR PREVENTING OXIDATIVE DEGRADATION OF PROTEINS
|
|
US20090280065A1
(en)
*
|
2006-04-10 |
2009-11-12 |
Willian Mary K |
Uses and Compositions for Treatment of Psoriasis
|
|
US7608260B2
(en)
*
|
2003-01-06 |
2009-10-27 |
Medimmune, Llc |
Stabilized immunoglobulins
|
|
US7354584B2
(en)
|
2003-04-11 |
2008-04-08 |
Medimmune, Inc. |
Recombinant IL-9 antibodies
|
|
CA2525184C
(en)
*
|
2003-05-09 |
2012-10-30 |
Centocor, Inc. |
Il-23p40 specific immunoglobulin derived proteins, compositions, methods and uses
|
|
PT1698640E
(pt)
*
|
2003-10-01 |
2016-03-31 |
Kyowa Hakko Kirin Co Ltd |
Processo para estabilizar um anticorpo e composição sob a forma de solução estabilizada contendo o anticorpo
|
|
AU2004298393A1
(en)
*
|
2003-12-19 |
2005-06-30 |
Protemix Corporation Limited |
Copper antagonist compounds
|
|
CN1898264A
(zh)
|
2003-12-23 |
2007-01-17 |
泰勒公司 |
用新的抗il13单克隆抗体治疗癌症
|
|
BRPI0507608A
(pt)
*
|
2004-02-12 |
2007-07-03 |
Merck Patent Gmbh |
formulações de anticorpos anti-egfr lìquidas altamente concentradas
|
|
RU2292215C2
(ru)
|
2004-05-21 |
2007-01-27 |
Дмитрий Васильевич Николенко |
Комплекс для лечения псориаза и способ лечения
|
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
|
BRPI0513601A
(pt)
|
2004-07-23 |
2008-05-13 |
Genentech Inc |
métodos de produção de cristais de anticorpo ou seu fragmento, composições, formulação, cristal de anticorpo ou seu fragmento, método de tratamento e métodos de produção de cristais e de gel de proteìna de anticorpo ou seu fragmento
|
|
EA016022B1
(ru)
|
2004-12-21 |
2012-01-30 |
Сентокор, Инк. |
Выделенное антитело млекопитающего против il-12 и способ изменения его активности
|
|
CN101252951B
(zh)
|
2005-06-30 |
2011-12-21 |
森托科尔公司 |
抗il-23抗体、组合物、方法和用途
|
|
KR20080098504A
(ko)
*
|
2006-02-03 |
2008-11-10 |
메디뮨 엘엘씨 |
단백질 제제
|
|
US7993833B2
(en)
*
|
2006-09-11 |
2011-08-09 |
Celera Corporation |
Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof
|
|
EP2087102B1
(en)
|
2006-10-13 |
2014-03-26 |
Janssen Biotech, Inc. |
Enhancement of hybridoma fusion efficiencies through cell synchronization
|
|
MX2009007570A
(es)
|
2007-01-16 |
2009-07-22 |
Abbott Lab |
Metodos para tratar la psoriasis.
|
|
RU2476442C2
(ru)
*
|
2007-03-29 |
2013-02-27 |
Эббот Лэборетриз |
Кристаллические антитела против il-12 человека
|
|
JP2011515404A
(ja)
*
|
2008-03-18 |
2011-05-19 |
アボット・ラボラトリーズ |
乾癬を治療するための方法
|
|
US20120225080A1
(en)
*
|
2008-03-18 |
2012-09-06 |
Abbott Laboratories |
Human antibodies that bind the p40 subunit of human il-12/il-23 and uses therefor
|
|
EP2145898A1
(en)
*
|
2008-07-15 |
2010-01-20 |
CHIESI FARMACEUTICI S.p.A. |
Anti-amyloid immunogenic compositions, methods and uses
|
|
KR20110096553A
(ko)
*
|
2008-11-28 |
2011-08-30 |
아보트 러보러터리즈 |
안정한 항체 조성물 및 이의 안정화 방법
|
|
WO2011032148A1
(en)
*
|
2009-09-14 |
2011-03-17 |
Abbott Laboratories |
Methods for treating psoriasis
|
|
MX2013003920A
(es)
*
|
2010-10-06 |
2013-06-03 |
Abbvie Inc |
Metodos para el tratamiento de la psoriasis.
|
|
SG191874A1
(en)
*
|
2011-01-07 |
2013-08-30 |
Abbvie Inc |
Anti-il-12/il-23 antibodies and uses thereof
|