JP2010540657A5 - - Google Patents

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Publication number
JP2010540657A5
JP2010540657A5 JP2010528161A JP2010528161A JP2010540657A5 JP 2010540657 A5 JP2010540657 A5 JP 2010540657A5 JP 2010528161 A JP2010528161 A JP 2010528161A JP 2010528161 A JP2010528161 A JP 2010528161A JP 2010540657 A5 JP2010540657 A5 JP 2010540657A5
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JP
Japan
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patient
antigen
antibody
psma
binding fragment
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JP2010528161A
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English (en)
Japanese (ja)
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JP2010540657A (ja
JP5951929B2 (ja
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Priority claimed from PCT/US2008/078742 external-priority patent/WO2009046294A2/en
Publication of JP2010540657A publication Critical patent/JP2010540657A/ja
Publication of JP2010540657A5 publication Critical patent/JP2010540657A5/ja
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JP2010528161A 2007-10-03 2008-10-03 Ｐｓｍａ抗体を用いる増殖性障害の治療 Active JP5951929B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97736407P 2007-10-03 2007-10-03
US60/977,364 2007-10-03
PCT/US2008/078742 WO2009046294A2 (en) 2007-10-03 2008-10-03 Treatment of proliferative disorders using antibodies to psma

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013207386A Division JP5969446B2 (ja) 2007-10-03 2013-10-02 Ｐｓｍａ抗体を用いる増殖性障害の治療
JP2016005363A Division JP6054557B2 (ja) 2007-10-03 2016-01-14 Ｐｓｍａ抗体を用いる増殖性障害の治療

Publications (3)

Publication Number Publication Date
JP2010540657A JP2010540657A (ja) 2010-12-24
JP2010540657A5 true JP2010540657A5 (enExample) 2011-11-24
JP5951929B2 JP5951929B2 (ja) 2016-07-13

Family

ID=40404317

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010528161A Active JP5951929B2 (ja) 2007-10-03 2008-10-03 Ｐｓｍａ抗体を用いる増殖性障害の治療
JP2013207386A Active JP5969446B2 (ja) 2007-10-03 2013-10-02 Ｐｓｍａ抗体を用いる増殖性障害の治療
JP2016005363A Active JP6054557B2 (ja) 2007-10-03 2016-01-14 Ｐｓｍａ抗体を用いる増殖性障害の治療

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013207386A Active JP5969446B2 (ja) 2007-10-03 2013-10-02 Ｐｓｍａ抗体を用いる増殖性障害の治療
JP2016005363A Active JP6054557B2 (ja) 2007-10-03 2016-01-14 Ｐｓｍａ抗体を用いる増殖性障害の治療

Country Status (5)

Country Link
US (4) US20100291113A1 (enExample)
EP (3) EP2209498A2 (enExample)
JP (3) JP5951929B2 (enExample)
CA (1) CA2700410C (enExample)
WO (1) WO2009046294A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201290020A1 (ru) 2009-05-19 2013-10-30 ЭйАйСи БЛЭБ КОМПАНИ Композитный токоприемник и способы его изготовления
HK1205788A1 (en) * 2012-02-24 2015-12-24 Cornell University Elevated psma identifies lethal prostate cancers
US20130315830A1 (en) * 2012-02-28 2013-11-28 Cornell University PSMA as a BioMarker for Androgen Activity in Prostate Cancer
CA2887047A1 (en) * 2012-10-05 2014-04-10 Cornell University Androgen suppression, prostate-specific membrane antigen and the concept of conditionally enhanced vulnerability
MA41046A (fr) * 2014-10-10 2017-08-15 Memorial Sloan Kettering Cancer Center Thérapies liées au psma
WO2016130819A2 (en) * 2015-02-11 2016-08-18 Emergent Product Development Seattle Llc Compositions and methods for combination therapy with prostate-specific membrane antigen binding proteins
HK1251480A1 (zh) 2015-09-21 2019-02-01 Aptevo Research And Development Llc Cd3结合多肽
EP3609544B1 (en) * 2017-04-11 2025-04-09 The Johns Hopkins University Prodrugs of 2-pmpa for healthy tissue protection during psma-targeted cancer imaging or radiotherapy
WO2021076543A1 (en) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Epcam binding fibronectin type iii domains
AU2021266735A1 (en) * 2020-05-05 2022-12-22 Aro Biotherapeutics Company Prostate specific membrane antigen binding fibronectin type III domains and cells comprising the same
CA3188601A1 (en) 2020-07-08 2022-01-13 LAVA Therapeutics N.V. Antibodies that bind psma and gamma-delta t cell receptors
EP4323409A4 (en) 2021-04-14 2025-04-16 ARO Biotherapeutics Company CD71-BINDING FIBRONECTIN TYPE III DOMAINS
US12239710B2 (en) 2021-04-14 2025-03-04 Aro Biotherapeutics Company FN3 domain-siRNA conjugates and uses thereof

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5869620A (en) * 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US5869053A (en) * 1988-03-04 1999-02-09 Cancer Research Campaign Technology, Ltd. 5T4 antigen from human trophoblasts
US4892824A (en) * 1988-03-15 1990-01-09 Synbiotics Corporation Fast track method for producing monoclonal bi-specific immunoglobulins
US6010902A (en) * 1988-04-04 2000-01-04 Bristol-Meyers Squibb Company Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
US5162504A (en) 1988-06-03 1992-11-10 Cytogen Corporation Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE3920358A1 (de) * 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
WO1991000906A1 (en) 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
DE69133557D1 (de) 1990-08-29 2007-03-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
DK0546073T3 (da) 1990-08-29 1998-02-02 Genpharm Int Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US6197298B1 (en) * 1991-04-19 2001-03-06 Tanox, Inc. Modified binding molecules specific for T lymphocytes and their use as in vivo immune modulators in animals
DE4140142A1 (de) * 1991-12-05 1993-06-09 Boehringer Mannheim Gmbh, 6800 Mannheim, De Multivalentes dextranreagenz zum einsatz in praezipitationstests
US5965132A (en) * 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
CA2076465C (en) 1992-03-25 2002-11-26 Ravi V. J. Chari Cell binding agent conjugates of analogues and derivatives of cc-1065
US6096289A (en) * 1992-05-06 2000-08-01 Immunomedics, Inc. Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy
WO1994013806A1 (en) * 1992-12-11 1994-06-23 The Dow Chemical Company Multivalent single chain antibodies
US5861156A (en) * 1993-01-08 1999-01-19 Creative Biomolecules Methods of delivering agents to target cells
US5705614A (en) * 1993-04-09 1998-01-06 Chiron Corporation Methods of producing antigen forks
US5869049A (en) * 1993-09-02 1999-02-09 Trustees Of Dartmouth College Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists
US6569432B1 (en) * 1995-02-24 2003-05-27 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof
GB9324807D0 (en) * 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US7037647B1 (en) * 1995-02-24 2006-05-02 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof
GB9504344D0 (en) * 1995-03-03 1995-04-19 Unilever Plc Antibody fragment production
US5747035A (en) * 1995-04-14 1998-05-05 Genentech, Inc. Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor
US6150508A (en) 1996-03-25 2000-11-21 Northwest Biotherapeutics, Inc. Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6107090A (en) 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
GB9712818D0 (en) * 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
US5922845A (en) * 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
WO1998045419A1 (en) * 1997-04-03 1998-10-15 Universite Laval Transgenic expression in genital tract and sexual accessory glands
WO1998052976A1 (en) 1997-05-21 1998-11-26 Biovation Limited Method for the production of non-immunogenic proteins
US6368596B1 (en) * 1997-07-08 2002-04-09 Board Of Regents, The University Of Texas System Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
US6994851B1 (en) * 1997-07-10 2006-02-07 Mannkind Corporation Method of inducing a CTL response
US6977074B2 (en) * 1997-07-10 2005-12-20 Mannkind Corporation Method of inducing a CTL response
US6030792A (en) * 1997-11-13 2000-02-29 Pfizer Inc Assays for measurement of protein fragments in biological media
US5981209A (en) 1997-12-04 1999-11-09 Guilford Pharmaceuticals Inc. Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia
US6709844B1 (en) * 2000-11-16 2004-03-23 Mannkind Corporation Avoidance of undesirable replication intermediates in plasmid propagation
AU3657899A (en) * 1998-04-20 1999-11-08 James E. Bailey Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
US6200765B1 (en) * 1998-05-04 2001-03-13 Pacific Northwest Cancer Foundation Non-invasive methods to detect prostate cancer
ATE437947T1 (de) * 1998-06-01 2009-08-15 Agensys Inc Serpentintransmembranantigene exprimiert in menschlichem krebs und deren verwendungen
US6833438B1 (en) * 1999-06-01 2004-12-21 Agensys, Inc. Serpentine transmembrane antigens expressed in human cancers and uses thereof
US20030149531A1 (en) * 2000-12-06 2003-08-07 Hubert Rene S. Serpentine transmembrane antigens expressed in human cancers and uses thereof
US6361774B1 (en) * 1999-09-17 2002-03-26 Immunomedics, Inc. Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug
CA2342967A1 (en) 1998-12-08 2000-06-15 Biovation Limited Modifying protein immunogenicity
EP1171468B1 (en) * 1999-04-09 2008-07-02 Universität Zürich Method for the Stabilization of Chimeric Immunoglobulins or Immunoglobulin Fragments, and Stabilized Anti-EGP-2-scFv Fragment
EP1185559A2 (en) * 1999-04-28 2002-03-13 Board Of Regents, The University Of Texas System Compositions and methods for cancer treatment by selectively inhibiting vegf
US6342587B1 (en) * 1999-10-22 2002-01-29 Ludwig Institute For Cancer Research A33 antigen specific immunoglobulin products and uses thereof
DE60032633T2 (de) * 1999-11-24 2007-10-04 Immunogen Inc., Cambridge Zytotoxische mittel, die taxane enthalten und ihre therapeutische anwendung
WO2001071005A2 (en) * 2000-03-24 2001-09-27 Micromet Ag Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex
JP2003531588A (ja) * 2000-04-11 2003-10-28 ジェネンテック・インコーポレーテッド 多価抗体とその用途
US6861234B1 (en) * 2000-04-28 2005-03-01 Mannkind Corporation Method of epitope discovery
US6375991B1 (en) * 2000-09-08 2002-04-23 Albemarle Corporation Production of concentrated biocidal solutions
DE10045591A1 (de) * 2000-09-15 2002-04-04 Klaus Pfizenmaier Ortsspezifische, antikörpervermittelte Aktivierung proapoptotischer Zytokine - AMAIZe (Antibody-Mediated Apoptosis Inducing Zytokine)
AU2002256505B2 (en) 2001-05-11 2008-06-26 Eisai Inc. Hydroxamic acids and acyl hydroxamines as naaladase inhibitors
US20090226429A1 (en) * 2001-05-25 2009-09-10 Human Genome Sciences, Inc. Antibodies That Immunospecifically Bind to TRAIL Receptors
US7666414B2 (en) 2001-06-01 2010-02-23 Cornell Research Foundation, Inc. Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen
EP1392360B1 (en) * 2001-06-01 2011-11-30 Cornell Research Foundation, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
US7514078B2 (en) * 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US7494646B2 (en) * 2001-09-06 2009-02-24 Agensys, Inc. Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
JP2005505271A (ja) * 2001-09-06 2005-02-24 アジェンシス， インコーポレイテッド 癌の処置および検出において有用なｓｔｅａｐ−１と名称が与えられる核酸および対応するタンパク質
IL159422A0 (en) * 2001-09-20 2004-06-01 Cornell Res Foundation Inc Methods and compositions for treating or preventing skin disorders using binding agents specific for prostate-specific membrane antigen
EP1448588A4 (en) * 2001-10-23 2006-10-25 Psma Dev Company L L C ANTIBODIES AND MULTIMERS OF PSMA PROTEINS
MXPA04003798A (es) * 2001-10-25 2004-07-30 Genentech Inc Composiciones de glicoproteina.
US20040018519A1 (en) * 2001-11-16 2004-01-29 Wright ,Jr. George L Methods and devices for quantitative detection of prostate specific membrane antigen and other prostatic markers
JP4460302B2 (ja) * 2002-02-05 2010-05-12 ジェネンテック インコーポレイテッド タンパク質精製法
AU2003265235A1 (en) * 2002-04-26 2003-12-19 Genetech, Inc. Non-affinity purification of proteins
JP2004000045A (ja) * 2002-05-31 2004-01-08 Kyowa Hakko Kogyo Co Ltd 前立腺特異的膜抗原に対する抗体
WO2004001004A2 (en) * 2002-06-21 2003-12-31 Johns Hopkins University School Of Medicine Membrane associated tumor endothelium markers
US20050026178A1 (en) * 2003-03-28 2005-02-03 Marit Nilsen-Hamilton Allosteric probes and methods
US20050163782A1 (en) * 2003-06-27 2005-07-28 Biogen Idec Ma Inc. Modified binding molecules comprising connecting peptides
JP4599355B2 (ja) * 2003-07-28 2010-12-15 ジェネンテック， インコーポレイテッド プロテインａアフィニティークロマトグラフィーの間のプロテインａの浸出の低減
US7524813B2 (en) * 2003-10-10 2009-04-28 Novo Nordisk Health Care Ag Selectively conjugated peptides and methods of making the same
MXPA06004035A (es) * 2003-10-16 2006-08-31 Micromet Ag Aglutinantes cd3 de-inmunizados multi-especificos.
PL2489364T3 (pl) * 2003-11-06 2015-06-30 Seattle Genetics Inc Związki monometylowaliny zdolne do sprzęgania do przeciwciał
EP1704228B1 (en) * 2004-01-16 2012-04-11 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Immunokinases
EP1718667B1 (en) * 2004-02-23 2013-01-09 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
WO2005094882A1 (en) * 2004-03-03 2005-10-13 Millennium Pharmaceuticals, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
WO2005101017A1 (en) * 2004-04-07 2005-10-27 Genentech, Inc. Mass spectrometry of antibody conjugates
PL1742966T3 (pl) * 2004-04-22 2014-04-30 Agensys Inc Przeciwciała i pochodzące z nich cząsteczki, które wiążą się z białkami STEAP-1
NZ552745A (en) * 2004-07-16 2009-01-31 Micromet Ag Expression-enhanced polypeptides
US20100111856A1 (en) * 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
BRPI0516284A (pt) * 2004-09-23 2008-09-02 Genentech Inc anticorpo construìdo com cisteìna, método de selecionar anticorpos, compostos conjugados de droga-anticorpo, composição farmacêutica, método para matar ou inibir a proliferação de células de tumor, métodos de inibir a proliferação celular e o crescimento de células de tumor, artigo manufaturado e método para produzir um composto
EP1851251A2 (en) * 2005-02-18 2007-11-07 Medarex, Inc. Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues
NZ606294A (en) * 2005-07-25 2014-09-26 Emergent Product Dev Seattle B-cell reduction using cd37-specific and cd20-specific binding molecules
US7612181B2 (en) * 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
CA2682605A1 (en) * 2007-04-18 2008-10-30 Zymogenetics, Inc. Single chain fc, methods of making and methods of treatment
JP5669581B2 (ja) * 2007-10-18 2015-02-12 バヴァリアン・ノルディック・インコーポレイテッド 前立腺癌を処置するためのｍｖａの使用
ES2547552T3 (es) * 2008-02-01 2015-10-07 Genentech, Inc. Metabolito de nemorrubicina y reactivos análogos, conjugados anticuerpo-fármaco y métodos
JP6067222B2 (ja) * 2008-07-15 2017-01-25 ジェネンテック， インコーポレイテッド アントラサイクリン誘導体コンジュゲート、その調製方法及び抗腫瘍化合物としてのその用途
US20100069616A1 (en) * 2008-08-06 2010-03-18 The Regents Of The University Of California Engineered antibody-nanoparticle conjugates
WO2010027629A2 (en) * 2008-09-08 2010-03-11 Conocophillips Company System for incondensable component separation in a liquefied natural gas facility
EP2358912B1 (en) * 2008-10-30 2016-10-12 Caris Life Sciences Switzerland Holdings GmbH Methods for assessing rna patterns
JP2012508577A (ja) * 2008-11-12 2012-04-12 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 表現型を決定するためのエキソソームの使用方法およびそのシステム
SG171764A1 (en) * 2008-12-16 2011-07-28 Millipore Corp Purification of proteins
US8424854B2 (en) * 2008-12-25 2013-04-23 Tokai Rubber Industries, Ltd. Fluid-filled type vibration damping device
US9067986B2 (en) * 2009-04-27 2015-06-30 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
US8416206B2 (en) * 2009-07-08 2013-04-09 Smart Technologies Ulc Method for manipulating a graphic widget in a three-dimensional environment displayed on a touch panel of an interactive input system
TWM383852U (en) * 2009-07-13 2010-07-01 Speedtech Corp An improvement of the universal serial bus connector
WO2011043061A1 (ja) * 2009-10-05 2011-04-14 キヤノン株式会社 光音響イメージング用造影剤、及び、それを用いた光音響イメージング方法

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