JP2010515449A5 - - Google Patents
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- JP2010515449A5 JP2010515449A5 JP2009545253A JP2009545253A JP2010515449A5 JP 2010515449 A5 JP2010515449 A5 JP 2010515449A5 JP 2009545253 A JP2009545253 A JP 2009545253A JP 2009545253 A JP2009545253 A JP 2009545253A JP 2010515449 A5 JP2010515449 A5 JP 2010515449A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- dna
- interest
- sequences
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 29
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 20
- 239000002773 nucleotide Substances 0.000 claims 14
- 125000003729 nucleotide group Chemical group 0.000 claims 14
- 230000003993 interaction Effects 0.000 claims 11
- 108020004414 DNA Proteins 0.000 claims 9
- 238000012163 sequencing technique Methods 0.000 claims 8
- 108091008146 restriction endonucleases Proteins 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 239000003155 DNA primer Substances 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 3
- 210000000349 chromosome Anatomy 0.000 claims 3
- 238000012165 high-throughput sequencing Methods 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 239000013615 primer Substances 0.000 claims 3
- 230000008707 rearrangement Effects 0.000 claims 3
- 208000011580 syndromic disease Diseases 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- -1 silencer Substances 0.000 claims 2
- 230000005945 translocation Effects 0.000 claims 2
- 101000719121 Arabidopsis thaliana Protein MEI2-like 1 Proteins 0.000 claims 1
- 208000031404 Chromosome Aberrations Diseases 0.000 claims 1
- 101000933320 Homo sapiens Breakpoint cluster region protein Proteins 0.000 claims 1
- 101000958299 Homo sapiens Protein lyl-1 Proteins 0.000 claims 1
- 101001111742 Homo sapiens Rhombotin-2 Proteins 0.000 claims 1
- 101000857677 Homo sapiens Runt-related transcription factor 1 Proteins 0.000 claims 1
- 101000891113 Homo sapiens T-cell acute lymphocytic leukemia protein 1 Proteins 0.000 claims 1
- 101000625330 Homo sapiens T-cell acute lymphocytic leukemia protein 2 Proteins 0.000 claims 1
- 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 claims 1
- 238000012408 PCR amplification Methods 0.000 claims 1
- 102100038231 Protein lyl-1 Human genes 0.000 claims 1
- 102100023876 Rhombotin-2 Human genes 0.000 claims 1
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 claims 1
- 101000702553 Schistosoma mansoni Antigen Sm21.7 Proteins 0.000 claims 1
- 101000714192 Schistosoma mansoni Tegument antigen Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 102100040365 T-cell acute lymphocytic leukemia protein 1 Human genes 0.000 claims 1
- 102100025039 T-cell acute lymphocytic leukemia protein 2 Human genes 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 101100395211 Trichoderma harzianum his3 gene Proteins 0.000 claims 1
- 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 238000003491 array Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 210000002230 centromere Anatomy 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 231100000005 chromosome aberration Toxicity 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 238000001976 enzyme digestion Methods 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 239000012212 insulator Substances 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 238000007403 mPCR Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000003584 silencer Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 108091035539 telomere Proteins 0.000 claims 1
- 210000003411 telomere Anatomy 0.000 claims 1
- 102000055501 telomere Human genes 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99975007P | 2007-01-11 | 2007-01-11 | |
| US60/999,750 | 2007-01-11 | ||
| US97790007P | 2007-10-05 | 2007-10-05 | |
| US60/977,900 | 2007-10-05 | ||
| PCT/IB2008/000625 WO2008084405A2 (en) | 2007-01-11 | 2008-01-10 | Circular chromosome conformation capture (4c) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010515449A JP2010515449A (ja) | 2010-05-13 |
| JP2010515449A5 true JP2010515449A5 (enExample) | 2011-02-24 |
| JP5690068B2 JP5690068B2 (ja) | 2015-03-25 |
Family
ID=39609120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009545253A Active JP5690068B2 (ja) | 2007-01-11 | 2008-01-10 | 環状染色体コンホメーション捕捉（４ｃ） |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8642295B2 (enExample) |
| EP (1) | EP2121977B1 (enExample) |
| JP (1) | JP5690068B2 (enExample) |
| CN (1) | CN101688237A (enExample) |
| AU (1) | AU2008204338B2 (enExample) |
| BR (1) | BRPI0806565A2 (enExample) |
| DK (1) | DK2121977T3 (enExample) |
| ES (1) | ES2634266T3 (enExample) |
| PT (1) | PT2121977T (enExample) |
| WO (1) | WO2008084405A2 (enExample) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1899488B1 (en) * | 2005-07-04 | 2015-09-16 | Erasmus University Medical Center | Chromosome conformation capture-on-chip (4c) assay |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US9074244B2 (en) * | 2008-03-11 | 2015-07-07 | Affymetrix, Inc. | Array-based translocation and rearrangement assays |
| CN102712954A (zh) * | 2009-11-06 | 2012-10-03 | 小利兰·斯坦福大学托管委员会 | 器官移植患者移植排斥的非侵入性诊断 |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| CA2798758C (en) | 2010-05-18 | 2019-05-07 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| PT2591125T (pt) * | 2010-07-09 | 2018-05-09 | Cergentis B V | Estratégias 3-d de sequenciação de regiões genómicas de interesse |
| AU2012211957B2 (en) | 2011-02-04 | 2017-02-23 | The Trustees Of The University Of Pennsylvania | A method for detecting chromosome structure and gene expression simultaneously in single cells |
| CA2824387C (en) | 2011-02-09 | 2019-09-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| HK1199745A1 (en) | 2011-09-09 | 2015-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for obtaining a sequence |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US9411930B2 (en) | 2013-02-01 | 2016-08-09 | The Regents Of The University Of California | Methods for genome assembly and haplotype phasing |
| WO2014121091A1 (en) | 2013-02-01 | 2014-08-07 | The Regents Of The University Of California | Methods for genome assembly and haplotype phasing |
| EP2971278B1 (en) * | 2013-03-15 | 2022-08-10 | The Broad Institute, Inc. | Methods for determining multiple interactions between nucleic acids in a cell |
| KR101672531B1 (ko) * | 2013-04-18 | 2016-11-17 | 주식회사 젠큐릭스 | 조기 유방암 예후 예측 진단용 유전자 마커 및 이의 용도 |
| GB2517936B (en) * | 2013-09-05 | 2016-10-19 | Babraham Inst | Chromosome conformation capture method including selection and enrichment steps |
| EP3049557B1 (en) | 2013-09-27 | 2021-05-05 | University of Washington | Methods and systems for large scale scaffolding of genome assemblies |
| GB201320351D0 (en) * | 2013-11-18 | 2014-01-01 | Erasmus Universiteit Medisch Ct | Method |
| EP3561075A1 (en) | 2014-04-21 | 2019-10-30 | Natera, Inc. | Detecting mutations in tumour biopsies and cell-free samples |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| WO2016019360A1 (en) | 2014-08-01 | 2016-02-04 | Dovetail Genomics Llc | Tagging nucleic acids for sequence assembly |
| EP3201350B1 (en) | 2014-09-30 | 2020-12-02 | Global Life Sciences Solutions USA LLC | Method for nucleic acid analysis directly from an unpurified biological sample |
| WO2016094872A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Dead guides for crispr transcription factors |
| EP3985115A1 (en) | 2014-12-12 | 2022-04-20 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| CA2970370A1 (en) | 2014-12-24 | 2016-06-30 | Massachusetts Institute Of Technology | Crispr having or associated with destabilization domains |
| CA2976902A1 (en) | 2015-02-17 | 2016-08-25 | Dovetail Genomics Llc | Nucleic acid sequence assembly |
| WO2016154540A1 (en) | 2015-03-26 | 2016-09-29 | Dovetail Genomics Llc | Physical linkage preservation in dna storage |
| WO2016182893A1 (en) | 2015-05-08 | 2016-11-17 | Teh Broad Institute Inc. | Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof |
| EP4428863A3 (en) | 2015-05-11 | 2024-12-11 | Natera, Inc. | Methods and compositions for determining ploidy |
| EP3436575A1 (en) | 2015-06-18 | 2019-02-06 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| CA3012631A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| MY194686A (en) | 2015-06-24 | 2022-12-15 | Oxford BioDynamics PLC | Detection of chromosome interactions |
| WO2017061861A1 (en) * | 2015-10-05 | 2017-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Targeted locus amplification using cloning strategies |
| KR20180096586A (ko) | 2015-10-19 | 2018-08-29 | 더브테일 제노믹스 엘엘씨 | 게놈 어셈블리, 하플로타입 페이징 및 표적 독립적 핵산 검출을 위한 방법 |
| WO2017074788A1 (en) | 2015-10-27 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for targeting cancer-specific sequence variations |
| WO2017106657A1 (en) | 2015-12-18 | 2017-06-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| SG11201807117WA (en) | 2016-02-23 | 2018-09-27 | Dovetail Genomics Llc | Generation of phased read-sets for genome assembly and haplotype phasing |
| DK3443119T3 (da) | 2016-04-15 | 2022-05-23 | Natera Inc | Fremgangsmåde til bestemmelse af lunge cancer |
| KR102670601B1 (ko) | 2016-04-19 | 2024-05-29 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신규한 crispr 효소 및 시스템 |
| US11286478B2 (en) | 2016-04-19 | 2022-03-29 | The Broad Institute, Inc. | Cpf1 complexes with reduced indel activity |
| DK3455356T3 (da) | 2016-05-13 | 2021-11-01 | Dovetail Genomics Llc | Genfinding af langtrækkende bindingsinformation fra konserverede prøver |
| US20210222164A1 (en) | 2016-06-29 | 2021-07-22 | The Broad Institute, Inc. | Crispr-cas systems having destabilization domain |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| ES2971286T3 (es) * | 2016-12-01 | 2024-06-04 | Oxford BioDynamics PLC | Aplicación de interacciones cromosómicas epigenéticas en diagnóstico de cáncer |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| CA3047888C (en) | 2016-12-23 | 2025-05-27 | Oxford Biodynamics Ltd | METHOD FOR TYPING EPIGENETIC CHROMOSOME INTERACTIONS |
| CN107058484B (zh) * | 2016-12-26 | 2020-06-16 | 孙涛 | 一种应用于高通量测序同时检测t细胞和b细胞免疫组库的引物组合及试剂盒 |
| EP3612629A1 (en) | 2017-04-18 | 2020-02-26 | The Broad Institute, Inc. | Compositions for detecting secretion and methods of use |
| SG11202003233YA (en) * | 2017-11-03 | 2020-05-28 | Oxford BioDynamics PLC | Genetic regulation of immunoresponse by chromosome interactions |
| EP3714052A1 (en) | 2017-11-21 | 2020-09-30 | Arima Genomics, Inc. | Preserving spatial-proximal contiguity and molecular contiguity in nucleic acid templates |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| US12378592B2 (en) | 2018-01-31 | 2025-08-05 | Dovetail Genomics, Llc. | Sample prep for DNA linkage recovery |
| JP7573443B2 (ja) | 2018-04-14 | 2024-10-25 | ナテラ， インコーポレイテッド | 循環腫瘍ｄｎａの個別化された検出を用いる癌検出およびモニタリングの方法 |
| CN109033745A (zh) * | 2018-06-08 | 2018-12-18 | 中国农业科学院农业基因组研究所 | 一种消除三维基因组学技术噪音的方法及应用 |
| CN108804872A (zh) * | 2018-06-08 | 2018-11-13 | 中国农业科学院农业基因组研究所 | 利用外切酶组合消除三维基因组学技术噪音的方法及应用 |
| WO2020006370A1 (en) * | 2018-06-29 | 2020-01-02 | Grail, Inc. | Nucleic acid rearrangement and integration analysis |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| US12421507B2 (en) | 2018-08-20 | 2025-09-23 | The Broad Institute, Inc. | Methods and compositions for optochemical control of CRISPR-CAS9 |
| CN113272441A (zh) | 2018-11-20 | 2021-08-17 | 阿瑞玛基因组学公司 | 保留空间邻近连续性信息的制备核酸的方法和组合物 |
| CN109609611A (zh) * | 2018-12-26 | 2019-04-12 | 上海优甲医疗科技有限公司 | 一种基于高通量测序技术的基因定量测序方法 |
| EP3973073A1 (en) | 2019-05-20 | 2022-03-30 | Arima Genomics, Inc. | Methods and compositions for enhanced genome coverage and preservation of spatial proximal contiguity |
| US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
| EP3980559A1 (en) | 2019-06-06 | 2022-04-13 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| JP2023523002A (ja) | 2020-04-23 | 2023-06-01 | コーニンクレッカ ネーデルラントセ アカデミー ファン ヴェッテンシャッペン | 染色体近接実験における構造的変異検出 |
| GB202111194D0 (en) * | 2021-08-03 | 2021-09-15 | Cergentis B V | Method |
| WO2025117544A1 (en) | 2023-11-29 | 2025-06-05 | The Broad Institute, Inc. | Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) * | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) * | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) * | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) * | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) * | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4366241A (en) * | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| ES2155822T3 (es) | 1990-12-06 | 2001-06-01 | Affymetrix Inc | Compuestos y su utilizacion en una estrategia de sintesis binaria. |
| DE69233087T2 (de) | 1991-11-22 | 2003-12-24 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Verfahren zur Herstellung von Polymerarrays |
| WO1995011995A1 (en) | 1993-10-26 | 1995-05-04 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| US5837832A (en) * | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5571639A (en) * | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
| US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
| US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
| JP2000504575A (ja) | 1996-02-08 | 2000-04-18 | アフィメトリックス，インコーポレイテッド | 微生物のチップベースの種分化および表現型特徴付け |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| EP1483587A2 (en) * | 2002-03-08 | 2004-12-08 | The Babraham Institute | Tagging and recovery of elements associated with target molecules |
| EP1899488B1 (en) * | 2005-07-04 | 2015-09-16 | Erasmus University Medical Center | Chromosome conformation capture-on-chip (4c) assay |
-
2008
- 2008-01-10 EP EP08719319.9A patent/EP2121977B1/en active Active
- 2008-01-10 DK DK08719319.9T patent/DK2121977T3/en active
- 2008-01-10 ES ES08719319.9T patent/ES2634266T3/es active Active
- 2008-01-10 AU AU2008204338A patent/AU2008204338B2/en active Active
- 2008-01-10 BR BRPI0806565-9A patent/BRPI0806565A2/pt not_active Application Discontinuation
- 2008-01-10 CN CN200880008027A patent/CN101688237A/zh active Pending
- 2008-01-10 US US12/522,555 patent/US8642295B2/en active Active
- 2008-01-10 WO PCT/IB2008/000625 patent/WO2008084405A2/en not_active Ceased
- 2008-01-10 PT PT87193199T patent/PT2121977T/pt unknown
- 2008-01-10 JP JP2009545253A patent/JP5690068B2/ja active Active
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