CN101688237A - 环状染色体构象捕获(4c) - Google Patents
环状染色体构象捕获(4c) Download PDFInfo
- Publication number
- CN101688237A CN101688237A CN200880008027A CN200880008027A CN101688237A CN 101688237 A CN101688237 A CN 101688237A CN 200880008027 A CN200880008027 A CN 200880008027A CN 200880008027 A CN200880008027 A CN 200880008027A CN 101688237 A CN101688237 A CN 101688237A
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- China
- Prior art keywords
- dna
- sequence
- restriction enzyme
- target
- sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99975007P | 2007-01-11 | 2007-01-11 | |
| US60/999,750 | 2007-01-11 | ||
| US97790007P | 2007-10-05 | 2007-10-05 | |
| US60/977,900 | 2007-10-05 | ||
| PCT/IB2008/000625 WO2008084405A2 (en) | 2007-01-11 | 2008-01-10 | Circular chromosome conformation capture (4c) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101688237A true CN101688237A (zh) | 2010-03-31 |
Family
ID=39609120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880008027A Pending CN101688237A (zh) | 2007-01-11 | 2008-01-10 | 环状染色体构象捕获(4c) |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8642295B2 (enExample) |
| EP (1) | EP2121977B1 (enExample) |
| JP (1) | JP5690068B2 (enExample) |
| CN (1) | CN101688237A (enExample) |
| AU (1) | AU2008204338B2 (enExample) |
| BR (1) | BRPI0806565A2 (enExample) |
| DK (1) | DK2121977T3 (enExample) |
| ES (1) | ES2634266T3 (enExample) |
| PT (1) | PT2121977T (enExample) |
| WO (1) | WO2008084405A2 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103180459A (zh) * | 2010-07-09 | 2013-06-26 | 赛尔冉迪思股份有限公司 | 3-d目的基因组区域的测序策略 |
| CN104169433A (zh) * | 2011-02-04 | 2014-11-26 | 宾夕法尼亚大学董事会 | 在单细胞中同时检测染色体结构和基因表达的方法 |
| CN105658813A (zh) * | 2013-09-05 | 2016-06-08 | 巴布拉哈姆研究院 | 包括选择和富集步骤的染色体构象捕获方法 |
| CN105992825A (zh) * | 2013-11-18 | 2016-10-05 | 鹿特丹伊拉斯谟大学医疗中心 | 用于分析三维dna结构中的核苷酸序列相互作用的方法 |
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| NZ564262A (en) * | 2005-07-04 | 2010-02-26 | Univ Erasmus Medical Ct | Chromosome conformation capture-on-chip (4C) assay |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9074244B2 (en) * | 2008-03-11 | 2015-07-07 | Affymetrix, Inc. | Array-based translocation and rearrangement assays |
| JP2013509883A (ja) | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| CA3207599A1 (en) | 2010-05-18 | 2011-11-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| BR112013020220B1 (pt) | 2011-02-09 | 2020-03-17 | Natera, Inc. | Método para determinar o estado de ploidia de um cromossomo em um feto em gestação |
| US9249460B2 (en) | 2011-09-09 | 2016-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for obtaining a sequence |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| CA3209385A1 (en) | 2013-02-01 | 2014-08-07 | The Regents Of The University Of California | Methods for genome assembly and haplotype phasing |
| US9411930B2 (en) | 2013-02-01 | 2016-08-09 | The Regents Of The University Of California | Methods for genome assembly and haplotype phasing |
| EP2971278B1 (en) | 2013-03-15 | 2022-08-10 | The Broad Institute, Inc. | Methods for determining multiple interactions between nucleic acids in a cell |
| KR101672531B1 (ko) * | 2013-04-18 | 2016-11-17 | 주식회사 젠큐릭스 | 조기 유방암 예후 예측 진단용 유전자 마커 및 이의 용도 |
| US11694764B2 (en) | 2013-09-27 | 2023-07-04 | University Of Washington | Method for large scale scaffolding of genome assemblies |
| EP3134541B1 (en) | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| WO2016019360A1 (en) | 2014-08-01 | 2016-02-04 | Dovetail Genomics Llc | Tagging nucleic acids for sequence assembly |
| US11987836B2 (en) | 2014-09-30 | 2024-05-21 | Global Life Sciences Solutions Usa Llc | Method for nucleic acid analysis directly from an unpurified biological sample |
| WO2016094872A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Dead guides for crispr transcription factors |
| EP3889260A1 (en) | 2014-12-12 | 2021-10-06 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| EP3237615B2 (en) | 2014-12-24 | 2023-07-26 | The Broad Institute, Inc. | Crispr having or associated with destabilization domains |
| EP4030437A1 (en) | 2015-02-17 | 2022-07-20 | Dovetail Genomics, LLC | Nucleic acid sequence assembly |
| GB2554572B (en) | 2015-03-26 | 2021-06-23 | Dovetail Genomics Llc | Physical linkage preservation in DNA storage |
| WO2016182893A1 (en) | 2015-05-08 | 2016-11-17 | Teh Broad Institute Inc. | Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| CA3012631A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| AU2016279062A1 (en) | 2015-06-18 | 2019-03-28 | Omar O. Abudayyeh | Novel CRISPR enzymes and systems |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| JP2018518203A (ja) | 2015-06-24 | 2018-07-12 | オックスフォード バイオダイナミックス リミテッド | エピジェネティックな染色体相互作用 |
| US20180282799A1 (en) * | 2015-10-05 | 2018-10-04 | Koninklijke Nederlandse Akademie Van Wetenschappen | Targeted locus amplification using cloning strategies |
| EP3365445B1 (en) | 2015-10-19 | 2023-05-31 | Dovetail Genomics, LLC | Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection |
| EP3368687B1 (en) | 2015-10-27 | 2021-09-29 | The Broad Institute, Inc. | Compositions and methods for targeting cancer-specific sequence variations |
| US12110490B2 (en) | 2015-12-18 | 2024-10-08 | The Broad Institute, Inc. | CRISPR enzymes and systems |
| US10975417B2 (en) | 2016-02-23 | 2021-04-13 | Dovetail Genomics, Llc | Generation of phased read-sets for genome assembly and haplotype phasing |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| KR102424476B1 (ko) | 2016-04-19 | 2022-07-25 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신규한 crispr 효소 및 시스템 |
| US11286478B2 (en) | 2016-04-19 | 2022-03-29 | The Broad Institute, Inc. | Cpf1 complexes with reduced indel activity |
| EP3455356B1 (en) | 2016-05-13 | 2021-08-04 | Dovetail Genomics LLC | Recovering long-range linkage information from preserved samples |
| US20210222164A1 (en) | 2016-06-29 | 2021-07-22 | The Broad Institute, Inc. | Crispr-cas systems having destabilization domain |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| CA3045070A1 (en) | 2016-12-01 | 2018-06-07 | Oxford Biodynamics Limited | Application of epigenetic chromsomal interactions in cancer diagnostics |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| MY191260A (en) | 2016-12-23 | 2022-06-12 | Oxford BioDynamics PLC | Typing method |
| CN107058484B (zh) * | 2016-12-26 | 2020-06-16 | 孙涛 | 一种应用于高通量测序同时检测t细胞和b细胞免疫组库的引物组合及试剂盒 |
| WO2018195019A1 (en) | 2017-04-18 | 2018-10-25 | The Broad Institute Inc. | Compositions for detecting secretion and methods of use |
| HUE066292T2 (hu) * | 2017-11-03 | 2024-07-28 | Oxford BioDynamics PLC | Az immunválasz genetikai szabályozása kromoszóma-kölcsönhatások által |
| WO2019104034A1 (en) | 2017-11-21 | 2019-05-31 | Arima Genomics, Inc. | Preserving spatial-proximal contiguity and molecular contiguity in nucleic acid templates |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
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| CN108804872A (zh) * | 2018-06-08 | 2018-11-13 | 中国农业科学院农业基因组研究所 | 利用外切酶组合消除三维基因组学技术噪音的方法及应用 |
| CN109033745A (zh) * | 2018-06-08 | 2018-12-18 | 中国农业科学院农业基因组研究所 | 一种消除三维基因组学技术噪音的方法及应用 |
| TWI852936B (zh) * | 2018-06-29 | 2024-08-21 | 美商格瑞爾有限責任公司 | 核酸重組及整合分析 |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| WO2020041380A1 (en) | 2018-08-20 | 2020-02-27 | The Broad Institute, Inc. | Methods and compositions for optochemical control of crispr-cas9 |
| US11370810B2 (en) | 2018-11-20 | 2022-06-28 | Arima Genomics, Inc. | Methods and compositions for preparing nucleic acids that preserve spatial-proximal contiguity information |
| CN109609611A (zh) * | 2018-12-26 | 2019-04-12 | 上海优甲医疗科技有限公司 | 一种基于高通量测序技术的基因定量测序方法 |
| US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007004057A2 (en) * | 2005-07-04 | 2007-01-11 | Erasmus University Medical Center | Chromosome conformation capture-on-chip (4c) assay |
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| NL154598B (nl) * | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
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| US3996345A (en) * | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) * | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) * | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
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-
2008
- 2008-01-10 AU AU2008204338A patent/AU2008204338B2/en active Active
- 2008-01-10 PT PT87193199T patent/PT2121977T/pt unknown
- 2008-01-10 DK DK08719319.9T patent/DK2121977T3/en active
- 2008-01-10 EP EP08719319.9A patent/EP2121977B1/en active Active
- 2008-01-10 CN CN200880008027A patent/CN101688237A/zh active Pending
- 2008-01-10 BR BRPI0806565-9A patent/BRPI0806565A2/pt not_active Application Discontinuation
- 2008-01-10 WO PCT/IB2008/000625 patent/WO2008084405A2/en not_active Ceased
- 2008-01-10 ES ES08719319.9T patent/ES2634266T3/es active Active
- 2008-01-10 US US12/522,555 patent/US8642295B2/en active Active
- 2008-01-10 JP JP2009545253A patent/JP5690068B2/ja active Active
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| WO2007004057A2 (en) * | 2005-07-04 | 2007-01-11 | Erasmus University Medical Center | Chromosome conformation capture-on-chip (4c) assay |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103180459A (zh) * | 2010-07-09 | 2013-06-26 | 赛尔冉迪思股份有限公司 | 3-d目的基因组区域的测序策略 |
| CN103180459B (zh) * | 2010-07-09 | 2016-10-19 | 赛尔冉迪思股份有限公司 | 3-d目的基因组区域的测序策略 |
| US12006538B2 (en) | 2010-07-09 | 2024-06-11 | Cergentis Bv | 3-D genomic region of interest sequencing strategies |
| CN104169433A (zh) * | 2011-02-04 | 2014-11-26 | 宾夕法尼亚大学董事会 | 在单细胞中同时检测染色体结构和基因表达的方法 |
| CN105658813A (zh) * | 2013-09-05 | 2016-06-08 | 巴布拉哈姆研究院 | 包括选择和富集步骤的染色体构象捕获方法 |
| CN105658813B (zh) * | 2013-09-05 | 2021-01-05 | 巴布拉哈姆研究院 | 包括选择和富集步骤的染色体构象捕获方法 |
| CN105992825A (zh) * | 2013-11-18 | 2016-10-05 | 鹿特丹伊拉斯谟大学医疗中心 | 用于分析三维dna结构中的核苷酸序列相互作用的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| PT2121977T (pt) | 2017-08-18 |
| JP2010515449A (ja) | 2010-05-13 |
| EP2121977A2 (en) | 2009-11-25 |
| AU2008204338B2 (en) | 2014-03-06 |
| WO2008084405A2 (en) | 2008-07-17 |
| AU2008204338A8 (en) | 2009-08-06 |
| EP2121977B1 (en) | 2017-06-21 |
| DK2121977T3 (en) | 2017-09-18 |
| JP5690068B2 (ja) | 2015-03-25 |
| WO2008084405A3 (en) | 2009-01-29 |
| US20100062947A1 (en) | 2010-03-11 |
| US8642295B2 (en) | 2014-02-04 |
| ES2634266T3 (es) | 2017-09-27 |
| AU2008204338A1 (en) | 2008-07-17 |
| BRPI0806565A2 (pt) | 2014-05-06 |
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