JP5690068B2 - 環状染色体コンホメーション捕捉(4c) - Google Patents

環状染色体コンホメーション捕捉(4c) Download PDF

Info

Publication number
JP5690068B2
JP5690068B2 JP2009545253A JP2009545253A JP5690068B2 JP 5690068 B2 JP5690068 B2 JP 5690068B2 JP 2009545253 A JP2009545253 A JP 2009545253A JP 2009545253 A JP2009545253 A JP 2009545253A JP 5690068 B2 JP5690068 B2 JP 5690068B2
Authority
JP
Japan
Prior art keywords
dna
sequence
sequences
nucleotide sequence
target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009545253A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010515449A (ja
JP2010515449A5 (enExample
Inventor
ラート,ウーター デ
ラート,ウーター デ
グロスヴェルド,フランク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Erasmus University Medical Center
Original Assignee
Erasmus University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erasmus University Medical Center filed Critical Erasmus University Medical Center
Publication of JP2010515449A publication Critical patent/JP2010515449A/ja
Publication of JP2010515449A5 publication Critical patent/JP2010515449A5/ja
Application granted granted Critical
Publication of JP5690068B2 publication Critical patent/JP5690068B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2009545253A 2007-01-11 2008-01-10 環状染色体コンホメーション捕捉(4c) Active JP5690068B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99975007P 2007-01-11 2007-01-11
US60/999,750 2007-01-11
US97790007P 2007-10-05 2007-10-05
US60/977,900 2007-10-05
PCT/IB2008/000625 WO2008084405A2 (en) 2007-01-11 2008-01-10 Circular chromosome conformation capture (4c)

Publications (3)

Publication Number Publication Date
JP2010515449A JP2010515449A (ja) 2010-05-13
JP2010515449A5 JP2010515449A5 (enExample) 2011-02-24
JP5690068B2 true JP5690068B2 (ja) 2015-03-25

Family

ID=39609120

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009545253A Active JP5690068B2 (ja) 2007-01-11 2008-01-10 環状染色体コンホメーション捕捉(4c)

Country Status (10)

Country Link
US (1) US8642295B2 (enExample)
EP (1) EP2121977B1 (enExample)
JP (1) JP5690068B2 (enExample)
CN (1) CN101688237A (enExample)
AU (1) AU2008204338B2 (enExample)
BR (1) BRPI0806565A2 (enExample)
DK (1) DK2121977T3 (enExample)
ES (1) ES2634266T3 (enExample)
PT (1) PT2121977T (enExample)
WO (1) WO2008084405A2 (enExample)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1899488B1 (en) * 2005-07-04 2015-09-16 Erasmus University Medical Center Chromosome conformation capture-on-chip (4c) assay
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US9074244B2 (en) * 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
CN102712954A (zh) * 2009-11-06 2012-10-03 小利兰·斯坦福大学托管委员会 器官移植患者移植排斥的非侵入性诊断
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
CA2798758C (en) 2010-05-18 2019-05-07 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
PT2591125T (pt) * 2010-07-09 2018-05-09 Cergentis B V Estratégias 3-d de sequenciação de regiões genómicas de interesse
AU2012211957B2 (en) 2011-02-04 2017-02-23 The Trustees Of The University Of Pennsylvania A method for detecting chromosome structure and gene expression simultaneously in single cells
CA2824387C (en) 2011-02-09 2019-09-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
HK1199745A1 (en) 2011-09-09 2015-07-17 The Board Of Trustees Of The Leland Stanford Junior University Methods for obtaining a sequence
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US9411930B2 (en) 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
WO2014121091A1 (en) 2013-02-01 2014-08-07 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
EP2971278B1 (en) * 2013-03-15 2022-08-10 The Broad Institute, Inc. Methods for determining multiple interactions between nucleic acids in a cell
KR101672531B1 (ko) * 2013-04-18 2016-11-17 주식회사 젠큐릭스 조기 유방암 예후 예측 진단용 유전자 마커 및 이의 용도
GB2517936B (en) * 2013-09-05 2016-10-19 Babraham Inst Chromosome conformation capture method including selection and enrichment steps
EP3049557B1 (en) 2013-09-27 2021-05-05 University of Washington Methods and systems for large scale scaffolding of genome assemblies
GB201320351D0 (en) * 2013-11-18 2014-01-01 Erasmus Universiteit Medisch Ct Method
EP3561075A1 (en) 2014-04-21 2019-10-30 Natera, Inc. Detecting mutations in tumour biopsies and cell-free samples
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
WO2016019360A1 (en) 2014-08-01 2016-02-04 Dovetail Genomics Llc Tagging nucleic acids for sequence assembly
EP3201350B1 (en) 2014-09-30 2020-12-02 Global Life Sciences Solutions USA LLC Method for nucleic acid analysis directly from an unpurified biological sample
WO2016094872A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Dead guides for crispr transcription factors
EP3985115A1 (en) 2014-12-12 2022-04-20 The Broad Institute, Inc. Protected guide rnas (pgrnas)
WO2016094874A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Escorted and functionalized guides for crispr-cas systems
CA2970370A1 (en) 2014-12-24 2016-06-30 Massachusetts Institute Of Technology Crispr having or associated with destabilization domains
CA2976902A1 (en) 2015-02-17 2016-08-25 Dovetail Genomics Llc Nucleic acid sequence assembly
WO2016154540A1 (en) 2015-03-26 2016-09-29 Dovetail Genomics Llc Physical linkage preservation in dna storage
WO2016182893A1 (en) 2015-05-08 2016-11-17 Teh Broad Institute Inc. Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
EP4428863A3 (en) 2015-05-11 2024-12-11 Natera, Inc. Methods and compositions for determining ploidy
EP3436575A1 (en) 2015-06-18 2019-02-06 The Broad Institute Inc. Novel crispr enzymes and systems
CA3012631A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
MY194686A (en) 2015-06-24 2022-12-15 Oxford BioDynamics PLC Detection of chromosome interactions
WO2017061861A1 (en) * 2015-10-05 2017-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Targeted locus amplification using cloning strategies
KR20180096586A (ko) 2015-10-19 2018-08-29 더브테일 제노믹스 엘엘씨 게놈 어셈블리, 하플로타입 페이징 및 표적 독립적 핵산 검출을 위한 방법
WO2017074788A1 (en) 2015-10-27 2017-05-04 The Broad Institute Inc. Compositions and methods for targeting cancer-specific sequence variations
WO2017106657A1 (en) 2015-12-18 2017-06-22 The Broad Institute Inc. Novel crispr enzymes and systems
SG11201807117WA (en) 2016-02-23 2018-09-27 Dovetail Genomics Llc Generation of phased read-sets for genome assembly and haplotype phasing
DK3443119T3 (da) 2016-04-15 2022-05-23 Natera Inc Fremgangsmåde til bestemmelse af lunge cancer
KR102670601B1 (ko) 2016-04-19 2024-05-29 더 브로드 인스티튜트, 인코퍼레이티드 신규한 crispr 효소 및 시스템
US11286478B2 (en) 2016-04-19 2022-03-29 The Broad Institute, Inc. Cpf1 complexes with reduced indel activity
DK3455356T3 (da) 2016-05-13 2021-11-01 Dovetail Genomics Llc Genfinding af langtrækkende bindingsinformation fra konserverede prøver
US20210222164A1 (en) 2016-06-29 2021-07-22 The Broad Institute, Inc. Crispr-cas systems having destabilization domain
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
ES2971286T3 (es) * 2016-12-01 2024-06-04 Oxford BioDynamics PLC Aplicación de interacciones cromosómicas epigenéticas en diagnóstico de cáncer
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CA3047888C (en) 2016-12-23 2025-05-27 Oxford Biodynamics Ltd METHOD FOR TYPING EPIGENETIC CHROMOSOME INTERACTIONS
CN107058484B (zh) * 2016-12-26 2020-06-16 孙涛 一种应用于高通量测序同时检测t细胞和b细胞免疫组库的引物组合及试剂盒
EP3612629A1 (en) 2017-04-18 2020-02-26 The Broad Institute, Inc. Compositions for detecting secretion and methods of use
SG11202003233YA (en) * 2017-11-03 2020-05-28 Oxford BioDynamics PLC Genetic regulation of immunoresponse by chromosome interactions
EP3714052A1 (en) 2017-11-21 2020-09-30 Arima Genomics, Inc. Preserving spatial-proximal contiguity and molecular contiguity in nucleic acid templates
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
US12378592B2 (en) 2018-01-31 2025-08-05 Dovetail Genomics, Llc. Sample prep for DNA linkage recovery
JP7573443B2 (ja) 2018-04-14 2024-10-25 ナテラ, インコーポレイテッド 循環腫瘍dnaの個別化された検出を用いる癌検出およびモニタリングの方法
CN109033745A (zh) * 2018-06-08 2018-12-18 中国农业科学院农业基因组研究所 一种消除三维基因组学技术噪音的方法及应用
CN108804872A (zh) * 2018-06-08 2018-11-13 中国农业科学院农业基因组研究所 利用外切酶组合消除三维基因组学技术噪音的方法及应用
WO2020006370A1 (en) * 2018-06-29 2020-01-02 Grail, Inc. Nucleic acid rearrangement and integration analysis
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
US12421507B2 (en) 2018-08-20 2025-09-23 The Broad Institute, Inc. Methods and compositions for optochemical control of CRISPR-CAS9
CN113272441A (zh) 2018-11-20 2021-08-17 阿瑞玛基因组学公司 保留空间邻近连续性信息的制备核酸的方法和组合物
CN109609611A (zh) * 2018-12-26 2019-04-12 上海优甲医疗科技有限公司 一种基于高通量测序技术的基因定量测序方法
EP3973073A1 (en) 2019-05-20 2022-03-30 Arima Genomics, Inc. Methods and compositions for enhanced genome coverage and preservation of spatial proximal contiguity
US20220235340A1 (en) 2019-05-20 2022-07-28 The Broad Institute, Inc. Novel crispr-cas systems and uses thereof
EP3980559A1 (en) 2019-06-06 2022-04-13 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
JP2023523002A (ja) 2020-04-23 2023-06-01 コーニンクレッカ ネーデルラントセ アカデミー ファン ヴェッテンシャッペン 染色体近接実験における構造的変異検出
GB202111194D0 (en) * 2021-08-03 2021-09-15 Cergentis B V Method
WO2025117544A1 (en) 2023-11-29 2025-06-05 The Broad Institute, Inc. Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
ES2155822T3 (es) 1990-12-06 2001-06-01 Affymetrix Inc Compuestos y su utilizacion en una estrategia de sintesis binaria.
DE69233087T2 (de) 1991-11-22 2003-12-24 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verfahren zur Herstellung von Polymerarrays
WO1995011995A1 (en) 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5571639A (en) * 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
JP2000504575A (ja) 1996-02-08 2000-04-18 アフィメトリックス,インコーポレイテッド 微生物のチップベースの種分化および表現型特徴付け
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
EP1483587A2 (en) * 2002-03-08 2004-12-08 The Babraham Institute Tagging and recovery of elements associated with target molecules
EP1899488B1 (en) * 2005-07-04 2015-09-16 Erasmus University Medical Center Chromosome conformation capture-on-chip (4c) assay

Also Published As

Publication number Publication date
WO2008084405A3 (en) 2009-01-29
WO2008084405A2 (en) 2008-07-17
AU2008204338A8 (en) 2009-08-06
BRPI0806565A2 (pt) 2014-05-06
PT2121977T (pt) 2017-08-18
EP2121977A2 (en) 2009-11-25
ES2634266T3 (es) 2017-09-27
AU2008204338A1 (en) 2008-07-17
DK2121977T3 (en) 2017-09-18
US8642295B2 (en) 2014-02-04
CN101688237A (zh) 2010-03-31
JP2010515449A (ja) 2010-05-13
AU2008204338B2 (en) 2014-03-06
EP2121977B1 (en) 2017-06-21
US20100062947A1 (en) 2010-03-11

Similar Documents

Publication Publication Date Title
JP5690068B2 (ja) 環状染色体コンホメーション捕捉(4c)
DK1899488T3 (en) CHROMOSOM CONFORMATIONS "CAPTURE-ON-CHIP" (4C) -ASSAY
KR102592367B1 (ko) 게놈 및 치료학적 적용을 위한 핵산 분자의 클론 복제 및 증폭을 위한 시스템 및 방법
CN102482719B (zh) 使用阵列比较基因组杂交技术分析核酸突变的方法
CA2661640A1 (en) Mapping of genomic interactions
JP2004511236A (ja) 核酸差異を含有するポリヌクレオチドを同定かつ単離する方法
JP2016537029A (ja) 三次元dna構造におけるヌクレオチド配列の相互作用を分析する方法
WO2000053806A1 (en) Method of identifying gene transcription patterns
US20070003929A1 (en) Method for identifying, analyzing and/or cloning nucleic acid isoforms
US20060228714A1 (en) Nucleic acid representations utilizing type IIB restriction endonuclease cleavage products
Class et al. Patent application title: CIRCULAR CHROMOSOME CONFORMATION CAPTURE (4C) Inventors: Wouter De Laat (Rotterdam, NL) Frank Grosveld (Rotterdam, NL) Assignees: Erasmus University Medical Center
CN101238225B (zh) 染色体构象芯片捕获(4c)测定
HK1118870A (en) Chromosome conformation capture-on-chip (4c) assay
HK1118870B (en) Chromosome conformation capture-on-chip (4c) assay
CN101238225A (zh) 染色体构象芯片捕获(4c)测定

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110106

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110106

RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7426

Effective date: 20110209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20110209

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130528

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130828

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140422

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140822

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20141014

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150106

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150130

R150 Certificate of patent or registration of utility model

Ref document number: 5690068

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250