JP2010514681A5 - - Google Patents
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- Publication number
- JP2010514681A5 JP2010514681A5 JP2009543158A JP2009543158A JP2010514681A5 JP 2010514681 A5 JP2010514681 A5 JP 2010514681A5 JP 2009543158 A JP2009543158 A JP 2009543158A JP 2009543158 A JP2009543158 A JP 2009543158A JP 2010514681 A5 JP2010514681 A5 JP 2010514681A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- phenyl
- ring
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- AVBPTIYKXNVKNJ-UHFFFAOYSA-N Cc(cc1)cc(C=CN2)c1C2=O Chemical compound Cc(cc1)cc(C=CN2)c1C2=O AVBPTIYKXNVKNJ-UHFFFAOYSA-N 0.000 description 1
- APPHSAIPZPYEGB-UHFFFAOYSA-N Cc(cc1)cc(N=CN2)c1C2=O Chemical compound Cc(cc1)cc(N=CN2)c1C2=O APPHSAIPZPYEGB-UHFFFAOYSA-N 0.000 description 1
- MKVWWULERWAKBU-UHFFFAOYSA-N Cc1cc(C=CNC2=O)c2nc1 Chemical compound Cc1cc(C=CNC2=O)c2nc1 MKVWWULERWAKBU-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87086406P | 2006-12-20 | 2006-12-20 | |
| US98446007P | 2007-11-01 | 2007-11-01 | |
| PCT/US2007/088032 WO2008079836A2 (en) | 2006-12-20 | 2007-12-19 | Macrocyclic factor viia inhibitors useful as anticoagulants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010514681A JP2010514681A (ja) | 2010-05-06 |
| JP2010514681A5 true JP2010514681A5 (en:Method) | 2010-09-16 |
Family
ID=39430763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543158A Withdrawn JP2010514681A (ja) | 2006-12-20 | 2007-12-19 | 抗凝血剤として有用な大環状第ｖｉｉａ因子阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8420830B2 (en:Method) |
| EP (1) | EP2102176A2 (en:Method) |
| JP (1) | JP2010514681A (en:Method) |
| AR (1) | AR064471A1 (en:Method) |
| AU (1) | AU2007337025A1 (en:Method) |
| CA (1) | CA2673598A1 (en:Method) |
| CL (1) | CL2007003718A1 (en:Method) |
| MX (1) | MX2009006689A (en:Method) |
| NO (1) | NO20092279L (en:Method) |
| PE (1) | PE20081775A1 (en:Method) |
| TW (1) | TW200836735A (en:Method) |
| WO (1) | WO2008079836A2 (en:Method) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008079759A1 (en) | 2006-12-20 | 2008-07-03 | Bristol-Myers Squibb Company | Bicyclic lactam factor viia inhibitors useful as anticoagulants |
| WO2011071730A1 (en) * | 2009-12-08 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds |
| CA2789622C (en) * | 2010-02-11 | 2018-04-03 | Bristol-Myers Squibb Company | Macrocycles as factor xia inhibitors |
| CN102993065B (zh) * | 2011-09-13 | 2015-07-29 | 中国科学院上海药物研究所 | 含手性叔丁基亚磺酰基的α-芳基氨基酸酯类化合物、其制备方法及用途 |
| SI2766346T1 (sl) | 2011-10-14 | 2017-05-31 | Bristol-Myers Squibb Company | Substituirane tetrahidroizokinolinske spojine kot faktor xia inhibitorji |
| KR101795562B1 (ko) * | 2011-12-27 | 2017-11-08 | (주)바이오팜솔루션즈 | 뇌졸중의 치료 또는 예방에 사용되는 페닐카바메이트 화합물 |
| US9174974B2 (en) * | 2012-06-08 | 2015-11-03 | Bristol-Myers Squibb Company | Macrocyclic factor VIIa inhibitors |
| PT2880026T (pt) | 2012-08-03 | 2017-05-03 | Bristol Myers Squibb Co | Dihidropiridona p1 como inibidores de fator xia |
| LT2882734T (lt) * | 2012-08-03 | 2016-12-12 | Bristol-Myers Squibb Company | Dihidropiridonai, kaip xia faktoriaus slopikliai |
| US9315519B2 (en) | 2012-10-12 | 2016-04-19 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors |
| WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| EP2906551B1 (en) | 2012-10-12 | 2018-02-28 | Bristol-Myers Squibb Company | Crystalline forms of a factor xia inhibitor |
| EP2978751B1 (en) | 2013-03-25 | 2018-12-05 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
| US9657006B2 (en) | 2013-06-13 | 2017-05-23 | Bristol-Myers Squibb Company | Macrocyclic factor VIIa inhibitors |
| NO2760821T3 (en:Method) | 2014-01-31 | 2018-03-10 | ||
| KR20240017118A (ko) | 2014-01-31 | 2024-02-06 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 XIa 억제제로서의 헤테로시클릭 P2' 기를 갖는 마크로사이클 |
| EP3189047B1 (en) | 2014-09-04 | 2018-12-26 | Bristol-Myers Squibb Company | Diamide macrocycles that are fxia inhibitors |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| EP3072943B1 (en) | 2015-03-26 | 2018-05-02 | Idemitsu Kosan Co., Ltd. | Dibenzofuran/carbazole-substituted benzonitriles |
| US10676477B2 (en) * | 2015-07-29 | 2020-06-09 | Bristol-Myers Squibb Company | Factor XIa macrocycle inhibitors bearing a non-aromatic P2' group |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0028489B1 (en) | 1979-11-05 | 1983-10-05 | Beecham Group Plc | Enzyme derivatives, and their preparation |
| US5023236A (en) | 1988-04-07 | 1991-06-11 | Corvas, Inc. | Factor VII/VIIA active site inhibitors |
| US5843442A (en) | 1990-10-22 | 1998-12-01 | Corvas International, Inc. | Blood coagulation protein antagonists and uses therefor |
| US5866542A (en) | 1994-10-18 | 1999-02-02 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
| PE121699A1 (es) | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| ZA985247B (en) | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
| WO2000077027A2 (en) | 1999-06-14 | 2000-12-21 | Tularik Limited | Serine protease inhibitors |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| CA2428191A1 (en) | 2000-11-07 | 2002-05-30 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
| AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| WO2003011222A2 (en) * | 2001-07-27 | 2003-02-13 | Merck & Co., Inc. | Thrombin inhibitors |
| EP1427415B1 (en) | 2001-09-21 | 2009-08-12 | Brystol-Myers Squibb Company | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
| EP1594845A4 (en) | 2003-02-11 | 2008-05-21 | Bristol Myers Squibb Co | BENZENE ACETAMIDE COMPOUNDS USEFUL AS SERINE PROTEASE INHIBITORS |
| EP1594505A4 (en) | 2003-02-11 | 2008-08-13 | Bristol Myers Squibb Co | PHENYLGLYCIN DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS |
| ATE479676T1 (de) | 2005-01-10 | 2010-09-15 | Bristol Myers Squibb Co | Als antikoagulanzien verwendbare phenylglycinamid-derivate |
| US20090131474A1 (en) * | 2005-03-03 | 2009-05-21 | Martino Forino | Screening methods for protein kinase b inhibitors employing virtual docking approaches and compounds and compositions discovered thereby |
| US7456195B2 (en) | 2005-06-24 | 2008-11-25 | Bristol-Myers Squibb Company | Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants |
| PE20071132A1 (es) | 2005-12-23 | 2007-12-14 | Bristol Myers Squibb Co | Compuestos macrociclicos como inhibidores del factor viia |
| US8044242B2 (en) | 2006-03-09 | 2011-10-25 | Bristol-Myers Squibb Company | 2-(aryloxy) acetamide factor VIIa inhibitors useful as anticoagulants |
| WO2008079759A1 (en) | 2006-12-20 | 2008-07-03 | Bristol-Myers Squibb Company | Bicyclic lactam factor viia inhibitors useful as anticoagulants |
-
2007
- 2007-12-14 PE PE2007001814A patent/PE20081775A1/es not_active Application Discontinuation
- 2007-12-19 MX MX2009006689A patent/MX2009006689A/es not_active Application Discontinuation
- 2007-12-19 WO PCT/US2007/088032 patent/WO2008079836A2/en not_active Ceased
- 2007-12-19 CA CA002673598A patent/CA2673598A1/en not_active Abandoned
- 2007-12-19 TW TW096148731A patent/TW200836735A/zh unknown
- 2007-12-19 US US12/519,376 patent/US8420830B2/en active Active
- 2007-12-19 JP JP2009543158A patent/JP2010514681A/ja not_active Withdrawn
- 2007-12-19 AR ARP070105750A patent/AR064471A1/es not_active Application Discontinuation
- 2007-12-19 AU AU2007337025A patent/AU2007337025A1/en not_active Abandoned
- 2007-12-19 CL CL200703718A patent/CL2007003718A1/es unknown
- 2007-12-19 EP EP07869479A patent/EP2102176A2/en not_active Withdrawn
-
2009
- 2009-06-12 NO NO20092279A patent/NO20092279L/no not_active Application Discontinuation
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