JP2010513879A5 - - Google Patents
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- JP2010513879A5 JP2010513879A5 JP2009541760A JP2009541760A JP2010513879A5 JP 2010513879 A5 JP2010513879 A5 JP 2010513879A5 JP 2009541760 A JP2009541760 A JP 2009541760A JP 2009541760 A JP2009541760 A JP 2009541760A JP 2010513879 A5 JP2010513879 A5 JP 2010513879A5
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- 238000000034 method Methods 0.000 claims description 43
- 239000003550 marker Substances 0.000 claims description 36
- 201000010099 disease Diseases 0.000 claims description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 230000000747 cardiac effect Effects 0.000 claims description 18
- 238000013517 stratification Methods 0.000 claims description 17
- 230000004064 dysfunction Effects 0.000 claims description 16
- 208000015181 infectious disease Diseases 0.000 claims description 15
- 239000012634 fragment Substances 0.000 claims description 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 14
- 230000004054 inflammatory process Effects 0.000 claims description 12
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 11
- 238000003745 diagnosis Methods 0.000 claims description 11
- 238000000338 in vitro Methods 0.000 claims description 11
- 238000005259 measurement Methods 0.000 claims description 10
- 206010061218 Inflammation Diseases 0.000 claims description 9
- 210000004072 lung Anatomy 0.000 claims description 9
- 206010024119 Left ventricular failure Diseases 0.000 claims description 8
- 102100034296 Natriuretic peptides A Human genes 0.000 claims description 8
- 108010074051 C-Reactive Protein Proteins 0.000 claims description 6
- 102100032752 C-reactive protein Human genes 0.000 claims description 6
- 206010020772 Hypertension Diseases 0.000 claims description 6
- 208000002193 Pain Diseases 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 6
- 206010057190 Respiratory tract infections Diseases 0.000 claims description 5
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 claims description 4
- 102400000667 Brain natriuretic peptide 32 Human genes 0.000 claims description 4
- 101800002247 Brain natriuretic peptide 45 Proteins 0.000 claims description 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 4
- -1 NT-proANP Proteins 0.000 claims description 4
- 102400001263 NT-proBNP Human genes 0.000 claims description 4
- 101710187800 Natriuretic peptides A Proteins 0.000 claims description 4
- 102100036836 Natriuretic peptides B Human genes 0.000 claims description 4
- 101710187802 Natriuretic peptides B Proteins 0.000 claims description 4
- 206010039163 Right ventricular failure Diseases 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 4
- 239000002934 diuretic Substances 0.000 claims description 4
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 4
- 230000002757 inflammatory effect Effects 0.000 claims description 4
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims description 4
- 230000000302 ischemic effect Effects 0.000 claims description 4
- 230000001452 natriuretic effect Effects 0.000 claims description 4
- 230000002644 neurohormonal effect Effects 0.000 claims description 4
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 206010068956 Respiratory tract inflammation Diseases 0.000 claims description 3
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 2
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims description 2
- 206010002383 Angina Pectoris Diseases 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 101800000285 Big gastrin Proteins 0.000 claims description 2
- 206010006417 Bronchial carcinoma Diseases 0.000 claims description 2
- 102400000060 Copeptin Human genes 0.000 claims description 2
- 101800000115 Copeptin Proteins 0.000 claims description 2
- 102000004420 Creatine Kinase Human genes 0.000 claims description 2
- 108010042126 Creatine kinase Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- 102000004862 Gastrin releasing peptide Human genes 0.000 claims description 2
- 108090001005 Interleukin-6 Proteins 0.000 claims description 2
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- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 claims description 2
- 108010092277 Leptin Proteins 0.000 claims description 2
- 102000016267 Leptin Human genes 0.000 claims description 2
- 206010024971 Lower respiratory tract infections Diseases 0.000 claims description 2
- 102400000569 Myeloperoxidase Human genes 0.000 claims description 2
- 108090000235 Myeloperoxidases Proteins 0.000 claims description 2
- 208000009525 Myocarditis Diseases 0.000 claims description 2
- 102000036675 Myoglobin Human genes 0.000 claims description 2
- 108010062374 Myoglobin Proteins 0.000 claims description 2
- 108090000189 Neuropeptides Proteins 0.000 claims description 2
- 102000003797 Neuropeptides Human genes 0.000 claims description 2
- 206010029538 Non-cardiogenic pulmonary oedema Diseases 0.000 claims description 2
- 206010035664 Pneumonia Diseases 0.000 claims description 2
- 102100028427 Pro-neuropeptide Y Human genes 0.000 claims description 2
- 108010048233 Procalcitonin Proteins 0.000 claims description 2
- 102000001253 Protein Kinase Human genes 0.000 claims description 2
- 102000004903 Troponin Human genes 0.000 claims description 2
- 108090001027 Troponin Proteins 0.000 claims description 2
- 102000013394 Troponin I Human genes 0.000 claims description 2
- 108010065729 Troponin I Proteins 0.000 claims description 2
- 102000004987 Troponin T Human genes 0.000 claims description 2
- 108090001108 Troponin T Proteins 0.000 claims description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
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- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 2
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- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 208000029078 coronary artery disease Diseases 0.000 claims description 2
- 238000013399 early diagnosis Methods 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 230000001631 hypertensive effect Effects 0.000 claims description 2
- 208000015210 hypertensive heart disease Diseases 0.000 claims description 2
- 229940047122 interleukins Drugs 0.000 claims description 2
- 229940039781 leptin Drugs 0.000 claims description 2
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 244000045947 parasite Species 0.000 claims description 2
- 239000013610 patient sample Substances 0.000 claims description 2
- RZIMNEGTIDYAGZ-HNSJZBNRSA-N pro-gastrin Chemical compound N([C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C(=O)[C@@H]1CCC(=O)N1 RZIMNEGTIDYAGZ-HNSJZBNRSA-N 0.000 claims description 2
- CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 claims description 2
- 108010072272 proendothelin 1 Proteins 0.000 claims description 2
- 238000004393 prognosis Methods 0.000 claims description 2
- 108010088603 proneuropeptide Y Proteins 0.000 claims description 2
- 108010001670 prosomatostatin Proteins 0.000 claims description 2
- GGYTXJNZMFRSLX-UHFFFAOYSA-N prosomatostatin Chemical compound C1CCC(C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NCC(=O)NC2C(NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C4=CC=CC=C4NC=3)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(C(=O)NC(CO)C(=O)NC(CSSC2)C(O)=O)C(C)O)C(C)O)=O)N1C(=O)C(C)NC(=O)C(CCSC)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(C)NC(=O)C(N)CO GGYTXJNZMFRSLX-UHFFFAOYSA-N 0.000 claims description 2
- 108060006633 protein kinase Proteins 0.000 claims description 2
- 201000000306 sarcoidosis Diseases 0.000 claims description 2
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 238000003748 differential diagnosis Methods 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 230000005986 heart dysfunction Effects 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108010069820 Pro-Opiomelanocortin Proteins 0.000 description 1
- 239000000683 Pro-Opiomelanocortin Substances 0.000 description 1
- 102100027467 Pro-opiomelanocortin Human genes 0.000 description 1
- 210000004900 c-terminal fragment Anatomy 0.000 description 1
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- 108010012004 proadrenomedullin Proteins 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006060112A DE102006060112A1 (de) | 2006-12-20 | 2006-12-20 | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| DE102006060112.2 | 2006-12-20 | ||
| PCT/DE2007/002300 WO2008074315A2 (de) | 2006-12-20 | 2007-12-20 | Diagnose und risikostratifizierung mittels dem neuen marker ct-proadm |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513879A JP2010513879A (ja) | 2010-04-30 |
| JP2010513879A5 true JP2010513879A5 (enExample) | 2011-11-24 |
| JP5379018B2 JP5379018B2 (ja) | 2013-12-25 |
Family
ID=39431425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541760A Active JP5379018B2 (ja) | 2006-12-20 | 2007-12-20 | 新規な診断マーカーであるｃｔ−プロａｄｍによる診断および危険性の層化 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8436135B2 (enExample) |
| EP (1) | EP2111552B1 (enExample) |
| JP (1) | JP5379018B2 (enExample) |
| CN (2) | CN103884841B (enExample) |
| AT (1) | ATE552504T1 (enExample) |
| DE (1) | DE102006060112A1 (enExample) |
| ES (1) | ES2383711T3 (enExample) |
| WO (1) | WO2008074315A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1628136A1 (en) * | 2004-08-19 | 2006-02-22 | B.R.A.H.M.S. Aktiengesellschaft | Method of diagnosis of disease using copeptin |
| US8906857B2 (en) * | 2005-12-01 | 2014-12-09 | B.R.A.H.M.S. Gmbh | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| DE102006060112A1 (de) * | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| DE102007009751A1 (de) | 2007-02-28 | 2008-09-04 | B.R.A.H.M.S Aktiengesellschaft | Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens |
| ES2795003T3 (es) * | 2008-10-07 | 2020-11-20 | Brahms Gmbh | Biomarcador para la predicción de los primeros eventos adversos |
| JP5584695B2 (ja) * | 2008-11-11 | 2014-09-03 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ａｄｍ及びｂｎｐのレベルを決定することによる心疾患に罹患した患者の予後診断及びリスク評価 |
| CN102428368B (zh) * | 2009-05-05 | 2015-04-22 | B.R.A.H.M.S有限公司 | 患有内皮功能/功能障碍相关疾病的患者的基于血管活性激素的分层 |
| CA2785592A1 (en) * | 2010-01-08 | 2011-07-14 | Cavadis B.V. | Determination of exosomel biomarkers for predicting cardiovascular events |
| US9709565B2 (en) | 2010-04-21 | 2017-07-18 | Memed Diagnostics Ltd. | Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof |
| BR112012032389A2 (pt) * | 2010-06-18 | 2016-10-25 | Brahms Gmbh | biomarcadores para a previsão de câncer incidente |
| RU2017110678A (ru) * | 2010-11-01 | 2019-01-24 | Б.Р.А.Х.М.С Гмбх | Оценка прогноза и риска пациентов с неспецифическими жалобами |
| ES2886979T3 (es) | 2012-02-09 | 2021-12-21 | Memed Diagnostics Ltd | Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos |
| EP2637023A1 (en) * | 2012-03-08 | 2013-09-11 | B.R.A.H.M.S GmbH | Prediction of outcome in patients with chronic obstructive pulmonary disease |
| EP2976646B1 (en) * | 2013-03-20 | 2020-08-19 | sphingotec GmbH | Adrenomedullin to guide therapy of blood pressure decline |
| EP3180621B1 (en) | 2014-08-14 | 2020-04-01 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
| WO2016059636A1 (en) | 2014-10-14 | 2016-04-21 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof |
| CN111624345A (zh) | 2014-12-11 | 2020-09-04 | 米密德诊断学有限公司 | 用于诊断多种感染的标记组合及其使用方法 |
| CN104655849B (zh) * | 2015-02-15 | 2016-08-24 | 河北博海生物工程开发有限公司 | 一种肿瘤靶标的筛选方法 |
| CA3015046A1 (en) | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Rna determinants for distinguishing between bacterial and viral infections |
| IL287757B (en) | 2016-03-03 | 2022-07-01 | Memed Diagnostics Ltd | Analyzing rna for diagnosing infection type |
| RU2019103403A (ru) | 2016-07-08 | 2020-08-10 | Сфинготек Гмбх | Адреномедуллин для оценки застоя у индивидуума с острой сердечной недостаточностью |
| CN109804245B (zh) | 2016-07-10 | 2022-10-25 | 米密德诊断学有限公司 | 感染的早期诊断 |
| EP4141448A1 (en) | 2016-07-10 | 2023-03-01 | MeMed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| EP3279667A1 (en) * | 2016-08-02 | 2018-02-07 | Abbott Laboratories | Cardiac troponin i and copeptin as biomarkers for short-term mortality in acute exacerbation of chronic obstructive pulmonary disease (aecopd) |
| WO2018060999A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of risk assessment and disease classification |
| WO2018060998A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
| JP6855118B2 (ja) * | 2017-03-14 | 2021-04-07 | 東ソー株式会社 | 全身状態の良不良を評価するための情報を提供する方法及び測定試薬 |
| US10209260B2 (en) | 2017-07-05 | 2019-02-19 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| EP3438668A1 (en) | 2017-08-04 | 2019-02-06 | B.R.A.H.M.S GmbH | Diagnosis and risk stratification of fungal infections |
| EP3682247B1 (en) | 2017-09-13 | 2022-02-09 | B.R.A.H.M.S GmbH | Proadrenomedullin as a marker for abnormal platelet levels |
| CN111480076A (zh) * | 2017-10-18 | 2020-07-31 | 艾德里诺医药公司 | 抗肾上腺髓质素（adm）结合剂治疗下的疗法监测 |
| EP3502706A1 (en) | 2017-12-20 | 2019-06-26 | B.R.A.H.M.S GmbH | Workflow for risk assessment and patient management using procalcitonin and midregional-proadrenomedullin |
| WO2019154900A1 (en) | 2018-02-08 | 2019-08-15 | Sphingotec Gmbh | Adrenomedullin (adm) for diagnosis and/or prediction of dementia and anti-adrenomedullin binder for use in therapy or prevention of dementia |
| EP3803396B1 (en) * | 2018-06-01 | 2023-03-01 | B.R.A.H.M.S GmbH | Biomarkers for the diagnosis of invasive fungal infections |
| US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
| US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
| US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
| US12322100B2 (en) | 2018-12-11 | 2025-06-03 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity |
| US12400762B2 (en) | 2018-12-11 | 2025-08-26 | Eko.Ai Pte. Ltd. | Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy |
| US20220196678A1 (en) * | 2019-02-21 | 2022-06-23 | B.R.A.H.M.S. Gmbh | Method for the diagnosis of macce in patients who underwent gastrointestinal surgery |
| JP2022521390A (ja) * | 2019-02-21 | 2022-04-07 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 術後有害事象の診断または予後 |
| JP7575400B2 (ja) | 2019-03-29 | 2024-10-29 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | バイオマーカーに基づく遠隔患者管理の処方 |
| EP3715851A1 (en) | 2019-03-29 | 2020-09-30 | B.R.A.H.M.S GmbH | Prescription of remote patient management based on biomarkers |
| CA3148275A1 (en) | 2019-08-30 | 2021-03-04 | 4TEEN4 Pharmaceuticals GmbH | Therapy guidance and/or therapy monitoring for treatment of shock |
| EP4023218A1 (en) | 2020-12-02 | 2022-07-06 | S-Form Pharma | Combination therapy for patients having acute and/or persistent dyspnea |
| EP4345109A1 (en) | 2022-09-30 | 2024-04-03 | AdrenoMed AG | Anti-adrenomedullin (adm) binder for use in therapy of pediatric patients with congenital heart disease |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2774769B2 (ja) | 1993-04-26 | 1998-07-09 | 賢治 寒川 | アドレノメデュリン |
| DE19847690A1 (de) | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
| AUPR005600A0 (en) * | 2000-09-12 | 2000-10-05 | University Of Sydney, The | Diagnostic assay |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| DE10316583A1 (de) | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| GB0401730D0 (en) * | 2004-01-27 | 2004-03-03 | Bioxell Spa | Diagnosis method |
| DE102005036094A1 (de) * | 2005-08-01 | 2007-02-08 | B.R.A.H.M.S Ag | In vitro Verfahren zur Diagnose von neurodegenerativen Erkrankungen |
| US8906857B2 (en) * | 2005-12-01 | 2014-12-09 | B.R.A.H.M.S. Gmbh | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| JP4423426B2 (ja) * | 2006-05-29 | 2010-03-03 | 国立大学法人 宮崎大学 | アドレノメデュリン前駆体ｃ末端ペプチドの濃度の上昇を循環器疾患又は炎症性疾患の指標とする方法 |
| DE102006046996A1 (de) * | 2006-10-01 | 2008-04-03 | Brahms Aktiengesellschaft | Diagnose von Infektionen oder Entzündungserkrankungen der Atemwege und Lunge assoziiert mit Herzinsuffizienz |
| US9012151B2 (en) * | 2006-11-09 | 2015-04-21 | B.R.A.H.M.S. Gmbh | Methods of diagnosis and risk stratification of adverse events in post myocardial infarction patients using pro-adrenomedullin |
| DE102006060112A1 (de) * | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| DE102007021443A1 (de) * | 2007-05-08 | 2008-11-13 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels NT-proET-1 |
| EP2180322A1 (en) * | 2008-10-22 | 2010-04-28 | BRAHMS Aktiengesellschaft | Prognostic biomarkers for the progression of primary chronic kidney disease |
| JP5785086B2 (ja) * | 2008-10-31 | 2015-09-24 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病の予測バイオマーカーとしてのアルギニンバソプレシンプロホルモン |
| WO2011000020A1 (en) * | 2009-06-12 | 2011-01-06 | Sbc Research Pty Ltd | Enhanced method of detection |
| CN102472752B (zh) * | 2009-08-28 | 2015-08-19 | B.R.A.H.M.S有限公司 | 用于不良事件的预后的降钙素原 |
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2006
- 2006-12-20 DE DE102006060112A patent/DE102006060112A1/de not_active Withdrawn
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2007
- 2007-12-20 US US12/520,159 patent/US8436135B2/en not_active Expired - Fee Related
- 2007-12-20 AT AT07856143T patent/ATE552504T1/de active
- 2007-12-20 CN CN201410026248.5A patent/CN103884841B/zh active Active
- 2007-12-20 WO PCT/DE2007/002300 patent/WO2008074315A2/de not_active Ceased
- 2007-12-20 ES ES07856143T patent/ES2383711T3/es active Active
- 2007-12-20 CN CN200780047509.XA patent/CN101611314B/zh active Active
- 2007-12-20 EP EP07856143A patent/EP2111552B1/de active Active
- 2007-12-20 JP JP2009541760A patent/JP5379018B2/ja active Active
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2013
- 2013-03-01 US US13/782,027 patent/US8853355B2/en active Active
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2014
- 2014-09-05 US US14/478,639 patent/US9726675B2/en active Active
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