JP2010513553A5 - - Google Patents
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- Publication number
- JP2010513553A5 JP2010513553A5 JP2009543062A JP2009543062A JP2010513553A5 JP 2010513553 A5 JP2010513553 A5 JP 2010513553A5 JP 2009543062 A JP2009543062 A JP 2009543062A JP 2009543062 A JP2009543062 A JP 2009543062A JP 2010513553 A5 JP2010513553 A5 JP 2010513553A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- aminomethyl
- hydrogen
- pharmacologically acceptable
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 N-ethyl-N-methyl-aminomethyl Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- LLAPDLPYIYKTGQ-UHFFFAOYSA-N 1-aminoethyl Chemical group C[CH]N LLAPDLPYIYKTGQ-UHFFFAOYSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010031096 Oropharyngeal cancer Diseases 0.000 claims 1
- 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 208000006359 hepatoblastoma Diseases 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000006958 oropharynx cancer Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 201000010106 skin squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87132206P | 2006-12-21 | 2006-12-21 | |
| PCT/US2007/087046 WO2008076705A1 (en) | 2006-12-21 | 2007-12-11 | Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010513553A JP2010513553A (ja) | 2010-04-30 |
| JP2010513553A5 true JP2010513553A5 (https=) | 2011-01-27 |
Family
ID=39185681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543062A Withdrawn JP2010513553A (ja) | 2006-12-21 | 2007-12-11 | 癌治療用イミダゾリジノニルアミノピリミジン化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8063212B2 (https=) |
| EP (1) | EP2125794B1 (https=) |
| JP (1) | JP2010513553A (https=) |
| KR (1) | KR101080594B1 (https=) |
| CN (1) | CN101568539B (https=) |
| AT (1) | ATE485291T1 (https=) |
| AU (1) | AU2007334040B2 (https=) |
| BR (1) | BRPI0720607A2 (https=) |
| CA (1) | CA2673564A1 (https=) |
| CY (1) | CY1110950T1 (https=) |
| DE (1) | DE602007010041D1 (https=) |
| DK (1) | DK2125794T3 (https=) |
| EA (1) | EA016178B1 (https=) |
| ES (1) | ES2351371T3 (https=) |
| HR (1) | HRP20100641T1 (https=) |
| MX (1) | MX2009006635A (https=) |
| PL (1) | PL2125794T3 (https=) |
| PT (1) | PT2125794E (https=) |
| RS (1) | RS51526B (https=) |
| SI (1) | SI2125794T1 (https=) |
| WO (1) | WO2008076705A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101563342B (zh) | 2006-12-21 | 2012-09-05 | 伊莱利利公司 | 用于治疗癌症的咪唑啉酮基氨基嘧啶化合物 |
| MX2009012228A (es) * | 2007-05-16 | 2009-12-01 | Lilly Co Eli | Compuesto de triazolil aminopirimidina. |
| IN2014MN02512A (https=) | 2012-06-14 | 2015-07-17 | Daiichi Sankyo Co Ltd | |
| EP2929883A1 (en) | 2014-04-08 | 2015-10-14 | Institut Pasteur | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors |
| KR102693614B1 (ko) | 2022-04-04 | 2024-08-08 | 경희대학교 산학협력단 | 나프탈렌-2-일알킬기가 치환된 이미다졸리움 유도체 및 이를 유효성분으로 포함하는 암 치료용 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4929726A (en) | 1988-02-09 | 1990-05-29 | Georgia State University Foundation, Inc. | Novel diazines and their method of preparation |
| WO2004063192A1 (en) * | 2003-01-10 | 2004-07-29 | Pharmacopeia Drug Discovery, Inc. | Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| US7786132B2 (en) * | 2004-12-17 | 2010-08-31 | Amgen Inc. | Aminopyrimidine compounds and methods of use |
| TW200800201A (en) | 2005-11-18 | 2008-01-01 | Lilly Co Eli | Pyrimidinyl benzothiophene compounds |
| JP5255559B2 (ja) * | 2006-03-31 | 2013-08-07 | アボット・ラボラトリーズ | インダゾール化合物 |
| CN101563342B (zh) | 2006-12-21 | 2012-09-05 | 伊莱利利公司 | 用于治疗癌症的咪唑啉酮基氨基嘧啶化合物 |
| MX2009012228A (es) | 2007-05-16 | 2009-12-01 | Lilly Co Eli | Compuesto de triazolil aminopirimidina. |
| AU2008254318B2 (en) | 2007-05-16 | 2012-04-05 | Eli Lilly And Company | Triazolyl aminopyrimidine compounds |
-
2007
- 2007-12-11 BR BRPI0720607-0A2A patent/BRPI0720607A2/pt not_active IP Right Cessation
- 2007-12-11 DK DK07855060.5T patent/DK2125794T3/da active
- 2007-12-11 KR KR1020097012768A patent/KR101080594B1/ko not_active Expired - Fee Related
- 2007-12-11 RS RSP-2010/0547A patent/RS51526B/sr unknown
- 2007-12-11 AU AU2007334040A patent/AU2007334040B2/en not_active Ceased
- 2007-12-11 US US12/516,251 patent/US8063212B2/en not_active Expired - Fee Related
- 2007-12-11 WO PCT/US2007/087046 patent/WO2008076705A1/en not_active Ceased
- 2007-12-11 ES ES07855060T patent/ES2351371T3/es active Active
- 2007-12-11 EP EP07855060A patent/EP2125794B1/en active Active
- 2007-12-11 HR HR20100641T patent/HRP20100641T1/hr unknown
- 2007-12-11 EA EA200970616A patent/EA016178B1/ru not_active IP Right Cessation
- 2007-12-11 DE DE602007010041T patent/DE602007010041D1/de active Active
- 2007-12-11 AT AT07855060T patent/ATE485291T1/de active
- 2007-12-11 MX MX2009006635A patent/MX2009006635A/es active IP Right Grant
- 2007-12-11 CA CA002673564A patent/CA2673564A1/en not_active Abandoned
- 2007-12-11 PT PT07855060T patent/PT2125794E/pt unknown
- 2007-12-11 CN CN2007800477447A patent/CN101568539B/zh not_active Expired - Fee Related
- 2007-12-11 PL PL07855060T patent/PL2125794T3/pl unknown
- 2007-12-11 SI SI200730463T patent/SI2125794T1/sl unknown
- 2007-12-11 JP JP2009543062A patent/JP2010513553A/ja not_active Withdrawn
-
2010
- 2010-11-26 CY CY20101101083T patent/CY1110950T1/el unknown
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