JP2010513440A - Ｂ２アドレナリン受容体活性の調節用４−ヒドロキシ−２−オキソ−２，３−ジヒドロ−１，３−ベンゾチアゾール−イル化合物 - Google Patents
Ｂ２アドレナリン受容体活性の調節用４−ヒドロキシ−２−オキソ−２，３−ジヒドロ−１，３−ベンゾチアゾール−イル化合物 Download PDFInfo
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- JP2010513440A JP2010513440A JP2009542202A JP2009542202A JP2010513440A JP 2010513440 A JP2010513440 A JP 2010513440A JP 2009542202 A JP2009542202 A JP 2009542202A JP 2009542202 A JP2009542202 A JP 2009542202A JP 2010513440 A JP2010513440 A JP 2010513440A
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- ethyl
- hydroxy
- dihydro
- oxo
- amino
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- -1 4-Hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-yl compounds Chemical class 0.000 title claims description 351
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- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 103
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 103
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
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| US91004507P | 2007-04-04 | 2007-04-04 | |
| US95198007P | 2007-07-26 | 2007-07-26 | |
| PCT/GB2007/004861 WO2008075026A1 (en) | 2006-12-20 | 2007-12-19 | 4-hydr0xy-2-0x0-2, 3 -dihydro- 1, 3-benzothiazol- 7yl compounds for modulation of b2-adrenoreceptor activity |
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| JP2010513440A true JP2010513440A (ja) | 2010-04-30 |
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| JP (1) | JP2010513440A (https=) |
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| AT (1) | ATE517879T1 (https=) |
| AU (1) | AU2007336075B2 (https=) |
| BR (1) | BRPI0722096A2 (https=) |
| CA (1) | CA2672811A1 (https=) |
| CL (1) | CL2007003765A1 (https=) |
| CO (1) | CO6190554A2 (https=) |
| EC (1) | ECSP099426A (https=) |
| IL (1) | IL199014A0 (https=) |
| MX (1) | MX2009006009A (https=) |
| NO (1) | NO20092691L (https=) |
| PE (1) | PE20081544A1 (https=) |
| SA (1) | SA07280728B1 (https=) |
| TW (1) | TW200833670A (https=) |
| UY (1) | UY30808A1 (https=) |
| WO (1) | WO2008075026A1 (https=) |
Cited By (1)
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| JP2014525472A (ja) * | 2011-09-06 | 2014-09-29 | ノバルティス アーゲー | ベンゾチアゾロン化合物 |
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| TW200738658A (en) * | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200738659A (en) * | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200745067A (en) * | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| GB0702458D0 (en) * | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| BRPI0912657A2 (pt) * | 2008-05-13 | 2016-01-26 | Astrazeneca Ab | produto farmacêutico compreendendo um antagonista de receptor muscarínico e um agonista beta2-adrenorreceptor |
| EA017627B1 (ru) | 2008-05-13 | 2013-01-30 | Астразенека Аб | Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора |
| UY31905A (es) | 2008-06-18 | 2010-01-29 | Astrazeneca Ab | Derivados de benzoxazinona, procesos de preparación, composiciones farmacéuticas conteniéndolos y aplicaciones. |
| KR20110022611A (ko) * | 2008-06-20 | 2011-03-07 | 아스트라제네카 아베 | 베타２－아드레날린수용체 활성의 조절을 위한, ４－히드록시－２－옥소－２,３－디히드로－１,３－벤조티아졸－７－일 화합물을 포함하는 제약 조성물 |
| GB0814728D0 (en) * | 2008-08-12 | 2008-09-17 | Argenta Discovery Ltd | New combination |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| US9353078B2 (en) * | 2013-10-01 | 2016-05-31 | New York University | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06502635A (ja) * | 1990-11-20 | 1994-03-24 | アストラゼネカ・アクチエボラーグ | 生物学的に活性なアミン |
| JPH11512422A (ja) * | 1995-09-15 | 1999-10-26 | アストラ・フアーマシユウテイカルズ・リミテツド | ベンゾチアゾロン誘導体 |
| JP2005539027A (ja) * | 2002-08-09 | 2005-12-22 | ノバルティス アクチエンゲゼルシャフト | ベータ−２−アドレノレセプターアゴニスト活性を有するベンゾチアゾール誘導体 |
| JP4522474B2 (ja) * | 2005-08-09 | 2010-08-11 | アストラゼネカ・アクチエボラーグ | 新規なベンゾチアゾロン誘導体 |
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| US2653977A (en) | 1953-09-29 | Chxnx | ||
| US3775477A (en) | 1971-03-10 | 1973-11-27 | Sterling Drug Inc | N,n'-bis(2-aryl-2-(hydroxy or oxo)-ethyl)-bridged-bis-carboxamides |
| US4460581A (en) | 1982-10-12 | 1984-07-17 | Boehringer Ingelheim Kg | (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones |
| DE3571808D1 (en) | 1984-04-17 | 1989-08-31 | Glaxo Group Ltd | Ethanolamine compounds |
| US4554284A (en) | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones |
| US4554287A (en) | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones |
| GB8525483D0 (en) | 1985-10-16 | 1985-11-20 | Glaxo Group Ltd | Chemical compounds |
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2007
- 2007-12-07 TW TW096146813A patent/TW200833670A/zh unknown
- 2007-12-19 AT AT07848598T patent/ATE517879T1/de not_active IP Right Cessation
- 2007-12-19 US US11/959,679 patent/US7700782B2/en not_active Expired - Fee Related
- 2007-12-19 KR KR1020097015062A patent/KR20090091342A/ko not_active Withdrawn
- 2007-12-19 AU AU2007336075A patent/AU2007336075B2/en not_active Ceased
- 2007-12-19 EP EP07848598A patent/EP2121642B1/en active Active
- 2007-12-19 BR BRPI0722096-0A2A patent/BRPI0722096A2/pt not_active IP Right Cessation
- 2007-12-19 MX MX2009006009A patent/MX2009006009A/es active IP Right Grant
- 2007-12-19 JP JP2009542202A patent/JP2010513440A/ja active Pending
- 2007-12-19 US US12/519,552 patent/US20100022491A1/en not_active Abandoned
- 2007-12-19 WO PCT/GB2007/004861 patent/WO2008075026A1/en not_active Ceased
- 2007-12-19 UY UY30808A patent/UY30808A1/es unknown
- 2007-12-19 CA CA002672811A patent/CA2672811A1/en not_active Abandoned
- 2007-12-20 AR ARP070105801A patent/AR064635A1/es not_active Application Discontinuation
- 2007-12-20 CL CL200703765A patent/CL2007003765A1/es unknown
- 2007-12-29 SA SA7280728A patent/SA07280728B1/ar unknown
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- 2008-01-02 PE PE2008000009A patent/PE20081544A1/es not_active Application Discontinuation
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- 2009-05-27 IL IL199014A patent/IL199014A0/en unknown
- 2009-05-27 CO CO09054440A patent/CO6190554A2/es not_active Application Discontinuation
- 2009-06-15 EC EC2009009426A patent/ECSP099426A/es unknown
- 2009-07-15 NO NO20092691A patent/NO20092691L/no not_active Application Discontinuation
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2014525472A (ja) * | 2011-09-06 | 2014-09-29 | ノバルティス アーゲー | ベンゾチアゾロン化合物 |
| JP2017132781A (ja) * | 2011-09-06 | 2017-08-03 | ノバルティス アーゲー | ベンゾチアゾロン化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20100249200A1 (en) | 2010-09-30 |
| US20080207698A1 (en) | 2008-08-28 |
| CL2007003765A1 (es) | 2008-08-22 |
| US7700782B2 (en) | 2010-04-20 |
| WO2008075026A1 (en) | 2008-06-26 |
| ATE517879T1 (de) | 2011-08-15 |
| KR20090091342A (ko) | 2009-08-27 |
| UY30808A1 (es) | 2008-07-31 |
| IL199014A0 (en) | 2010-02-17 |
| EP2121642B1 (en) | 2011-07-27 |
| HK1136572A1 (en) | 2010-07-02 |
| CA2672811A1 (en) | 2008-06-26 |
| PE20081544A1 (es) | 2009-01-11 |
| ECSP099426A (es) | 2009-07-31 |
| US20100022491A1 (en) | 2010-01-28 |
| NO20092691L (no) | 2009-09-16 |
| TW200833670A (en) | 2008-08-16 |
| AR064635A1 (es) | 2009-04-15 |
| AU2007336075A1 (en) | 2008-06-26 |
| BRPI0722096A2 (pt) | 2014-04-01 |
| CO6190554A2 (es) | 2010-08-19 |
| AU2007336075B2 (en) | 2011-10-27 |
| EP2121642A1 (en) | 2009-11-25 |
| SA07280728B1 (ar) | 2010-12-01 |
| MX2009006009A (es) | 2009-06-16 |
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