CO6190554A2 - Compuestos de 4-hidroxi-2-oxo-2, 3-dihidro-1, 3-benzotiazol-7il para la modulacion de la actividad del adrenoreceptor beta2 - Google Patents
Compuestos de 4-hidroxi-2-oxo-2, 3-dihidro-1, 3-benzotiazol-7il para la modulacion de la actividad del adrenoreceptor beta2Info
- Publication number
- CO6190554A2 CO6190554A2 CO09054440A CO09054440A CO6190554A2 CO 6190554 A2 CO6190554 A2 CO 6190554A2 CO 09054440 A CO09054440 A CO 09054440A CO 09054440 A CO09054440 A CO 09054440A CO 6190554 A2 CO6190554 A2 CO 6190554A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- halogen
- optionally substituted
- cycloalkyl
- alkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
1.- Un compuesto de la fórmuladonde Ra y Rb son, independientemente, hidrógeno o C1-3 alquil; o Ra y Rb, junto con el carbono al cual están unidos, forman un anillo ciclopropil o ciclobutil; R1 es: un C3-12 alquil a- o ß-ramificado (opcionalmente sustituido por halógeno, C1-6 alcoxi, C1-6 alquiltio, C1-6 alquilS(O), C1-6 alquilS(O)2, C1-6 haloalcoxi, hidroxi, NR26R27, OC(O)(C1-6alquil), C3-12 cicloalquil o R28), CH2(C3-12 cicloalquil) (el anillo cicloalquil es opcionalmente sustituido por halógeno, C1-6 alquil, C1-6 alcoxi, C1-6 alquiltio, C1-6 alquilS(O), C1-6 alquilS(O)2, C1-6 haloalcoxi, hidroxi, NR26R27, OC(O)(C1-6 alquil), C3-12 cicloalquil o R28), C3-12 cicloalquil (opcionalmente sustituido por halógeno, C1-6 alquil, C1-6 alcoxi, C1-6 alquiltio, C1-6 alquilS(O), C1-6 alquilS(O)2, C1-6 haloalcoxi, hidroxi, NR26R27, OC(O)(C1-6alquil), C3-12 cicloalquil o R28) o R28;R6 es un sistema de anillos aromáticos o heteroaromáticos de 5 a 14 miembros el cual es opcionalmente sustituido por halógeno, hidroxi, carboxil, C1-6 alquil (opcionalmente sustituido por halógeno o -NR7R8), C1-6 alcoxi (opcionalmente sustituido por halógeno o -NR9R10), C3-6 cicloalquil, C1-6 alcoxicarbonil, -NR11R12, C1-6 alquilcarbonilamino, C1-6 alquilsulfonilamino, fenilsulfonilamino, -C(O)NHR13, -SO2NHR14, C1-6 alquilS(O)p (opcionalmente sustituido por halógeno), C2-4 alquenil, C2-4 alquinil, ciano o C0-6 alquil-R15, o un fenil o un anillo heteroaromático de 5 ó 6 miembros (cada uno de los cuales es opcionalmente sustituido por halógeno, trifluorometil, hidroxi, C1-6 alquil, C1-6 alcoxi o -NR16R17); R6 puede también ser C1-6 haloalquil; p es 0, 1 ó 2; R13 es hidrógeno, C1-6 alquil, fenil-C0-6 alquil o C2-6 alquileno-NR18R19; ambos R18 y R19 son, independientemente, hidrógeno o C1-6 alquil, o R18 y R19 junto con el átomo de nitrógeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 6 miembros que comprende opcionalmente un heteroátomo del anillo adicional seleccionado de nitrógeno y oxígeno; R14 es hidrógeno, C1-6 alquil, fenil-C0-6 alquil o C2-6 alquileno-NR20R21; R15 es un anillo que contiene nitrógeno de 5 ó 6 miembros saturado; ...
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87092206P | 2006-12-20 | 2006-12-20 | |
| US91004507P | 2007-04-04 | 2007-04-04 | |
| US95198007P | 2007-07-26 | 2007-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6190554A2 true CO6190554A2 (es) | 2010-08-19 |
Family
ID=39167020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09054440A CO6190554A2 (es) | 2006-12-20 | 2009-05-27 | Compuestos de 4-hidroxi-2-oxo-2, 3-dihidro-1, 3-benzotiazol-7il para la modulacion de la actividad del adrenoreceptor beta2 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7700782B2 (es) |
| EP (1) | EP2121642B1 (es) |
| JP (1) | JP2010513440A (es) |
| KR (1) | KR20090091342A (es) |
| AR (1) | AR064635A1 (es) |
| AT (1) | ATE517879T1 (es) |
| AU (1) | AU2007336075B2 (es) |
| BR (1) | BRPI0722096A2 (es) |
| CA (1) | CA2672811A1 (es) |
| CL (1) | CL2007003765A1 (es) |
| CO (1) | CO6190554A2 (es) |
| EC (1) | ECSP099426A (es) |
| HK (1) | HK1136572A1 (es) |
| IL (1) | IL199014A0 (es) |
| MX (1) | MX2009006009A (es) |
| NO (1) | NO20092691L (es) |
| PE (1) | PE20081544A1 (es) |
| SA (1) | SA07280728B1 (es) |
| TW (1) | TW200833670A (es) |
| UY (1) | UY30808A1 (es) |
| WO (1) | WO2008075026A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200738658A (en) | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200738659A (en) * | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200745067A (en) | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| TW200833670A (en) * | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| BRPI0912657A2 (pt) * | 2008-05-13 | 2016-01-26 | Astrazeneca Ab | produto farmacêutico compreendendo um antagonista de receptor muscarínico e um agonista beta2-adrenorreceptor |
| EA017627B1 (ru) | 2008-05-13 | 2013-01-30 | Астразенека Аб | Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора |
| AU2009260899B2 (en) | 2008-06-18 | 2012-02-23 | Astrazeneca Ab | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
| KR20110022611A (ko) * | 2008-06-20 | 2011-03-07 | 아스트라제네카 아베 | 베타２－아드레날린수용체 활성의 조절을 위한, ４－히드록시－２－옥소－２,３－디히드로－１,３－벤조티아졸－７－일 화합물을 포함하는 제약 조성물 |
| GB0814728D0 (en) * | 2008-08-12 | 2008-09-17 | Argenta Discovery Ltd | New combination |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| JO3192B1 (ar) * | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| US9353078B2 (en) * | 2013-10-01 | 2016-05-31 | New York University | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof |
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| TW200833670A (en) * | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| GB0702457D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination 666 |
| GB0702459D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 669 |
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| GB0703999D0 (en) | 2007-03-01 | 2007-04-11 | Astrazeneca Ab | New combination 667 |
| WO2009037503A2 (en) | 2007-09-18 | 2009-03-26 | Astrazeneca Ab | New combination - 012 for the treatment of respiratory diseases |
| JP2011507593A (ja) * | 2007-12-20 | 2011-03-10 | アストラゼネカ・アクチエボラーグ | 粉末８５４を脱凝集解体する装置ならびに方法 |
| KR20110022611A (ko) * | 2008-06-20 | 2011-03-07 | 아스트라제네카 아베 | 베타２－아드레날린수용체 활성의 조절을 위한, ４－히드록시－２－옥소－２,３－디히드로－１,３－벤조티아졸－７－일 화합물을 포함하는 제약 조성물 |
-
2007
- 2007-12-07 TW TW096146813A patent/TW200833670A/zh unknown
- 2007-12-19 US US11/959,679 patent/US7700782B2/en not_active Expired - Fee Related
- 2007-12-19 WO PCT/GB2007/004861 patent/WO2008075026A1/en active Application Filing
- 2007-12-19 JP JP2009542202A patent/JP2010513440A/ja active Pending
- 2007-12-19 EP EP07848598A patent/EP2121642B1/en active Active
- 2007-12-19 CA CA002672811A patent/CA2672811A1/en not_active Abandoned
- 2007-12-19 MX MX2009006009A patent/MX2009006009A/es active IP Right Grant
- 2007-12-19 KR KR1020097015062A patent/KR20090091342A/ko not_active Application Discontinuation
- 2007-12-19 BR BRPI0722096-0A2A patent/BRPI0722096A2/pt not_active IP Right Cessation
- 2007-12-19 AT AT07848598T patent/ATE517879T1/de not_active IP Right Cessation
- 2007-12-19 UY UY30808A patent/UY30808A1/es unknown
- 2007-12-19 AU AU2007336075A patent/AU2007336075B2/en not_active Ceased
- 2007-12-19 US US12/519,552 patent/US20100022491A1/en not_active Abandoned
- 2007-12-20 AR ARP070105801A patent/AR064635A1/es not_active Application Discontinuation
- 2007-12-20 CL CL200703765A patent/CL2007003765A1/es unknown
- 2007-12-29 SA SA7280728A patent/SA07280728B1/ar unknown
-
2008
- 2008-01-02 PE PE2008000009A patent/PE20081544A1/es not_active Application Discontinuation
-
2009
- 2009-05-27 CO CO09054440A patent/CO6190554A2/es not_active Application Discontinuation
- 2009-05-27 IL IL199014A patent/IL199014A0/en unknown
- 2009-06-15 EC EC2009009426A patent/ECSP099426A/es unknown
- 2009-07-15 NO NO20092691A patent/NO20092691L/no not_active Application Discontinuation
-
2010
- 2010-03-30 US US12/750,014 patent/US20100249200A1/en not_active Abandoned
- 2010-04-24 HK HK10104038.4A patent/HK1136572A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20081544A1 (es) | 2009-01-11 |
| US20100022491A1 (en) | 2010-01-28 |
| KR20090091342A (ko) | 2009-08-27 |
| JP2010513440A (ja) | 2010-04-30 |
| MX2009006009A (es) | 2009-06-16 |
| TW200833670A (en) | 2008-08-16 |
| CL2007003765A1 (es) | 2008-08-22 |
| BRPI0722096A2 (pt) | 2014-04-01 |
| US20100249200A1 (en) | 2010-09-30 |
| EP2121642B1 (en) | 2011-07-27 |
| ECSP099426A (es) | 2009-07-31 |
| AU2007336075A1 (en) | 2008-06-26 |
| AU2007336075B2 (en) | 2011-10-27 |
| CA2672811A1 (en) | 2008-06-26 |
| ATE517879T1 (de) | 2011-08-15 |
| HK1136572A1 (en) | 2010-07-02 |
| IL199014A0 (en) | 2010-02-17 |
| SA07280728B1 (ar) | 2010-12-01 |
| WO2008075026A1 (en) | 2008-06-26 |
| US7700782B2 (en) | 2010-04-20 |
| AR064635A1 (es) | 2009-04-15 |
| US20080207698A1 (en) | 2008-08-28 |
| UY30808A1 (es) | 2008-07-31 |
| NO20092691L (no) | 2009-09-16 |
| EP2121642A1 (en) | 2009-11-25 |
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