JP2010511632A5 - - Google Patents
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- Publication number
- JP2010511632A5 JP2010511632A5 JP2009539527A JP2009539527A JP2010511632A5 JP 2010511632 A5 JP2010511632 A5 JP 2010511632A5 JP 2009539527 A JP2009539527 A JP 2009539527A JP 2009539527 A JP2009539527 A JP 2009539527A JP 2010511632 A5 JP2010511632 A5 JP 2010511632A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- nhc
- pharmaceutical composition
- nhs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86802406P | 2006-11-30 | 2006-11-30 | |
| PCT/US2007/086188 WO2008067566A1 (en) | 2006-11-30 | 2007-11-30 | Compositions and treatments comprising 5-lipoxygenase-activating protein inhibitors and nitric oxide modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010511632A JP2010511632A (ja) | 2010-04-15 |
| JP2010511632A5 true JP2010511632A5 (enExample) | 2011-01-20 |
Family
ID=39468284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539527A Pending JP2010511632A (ja) | 2006-11-30 | 2007-11-30 | 5−リポキシゲナーゼ活性化タンパク質インヒビターおよび一酸化窒素モジュレーターを含んでいる組成物および治療法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100068301A1 (enExample) |
| EP (1) | EP2086531A4 (enExample) |
| JP (1) | JP2010511632A (enExample) |
| WO (1) | WO2008067566A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| TW200920369A (en) | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
| JP5791500B2 (ja) | 2008-05-23 | 2015-10-07 | パンミラ ファーマシューティカルズ,エルエルシー. | 5−リポキシゲナーゼ活性化タンパク質阻害剤 |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| EP2582365B1 (en) * | 2010-06-16 | 2019-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions for stimulating reepithelialisation during wound healing |
| US20130310421A1 (en) * | 2012-05-18 | 2013-11-21 | Temple University - Of The Commonwealth System Of Higher Education | Treatment of amyloid beta amyloidosis |
| WO2014031586A2 (en) * | 2012-08-20 | 2014-02-27 | Tallikut Pharmaceuticals, Inc. | Methods for treating cardiovascular diseases |
| HK1220136A1 (zh) * | 2013-03-14 | 2017-04-28 | Shire Human Genetic Therapies, Inc. | 治疗b2-缓激肽受体介导的血管性水肿的方法 |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| ES2878405T3 (es) | 2014-02-04 | 2021-11-18 | Bioscience Pharma Partners Llc | Uso de inhibidores de flap para reducir la lesión mediada por neuroinflamación en el sistema nervioso central |
| JP6861634B2 (ja) | 2015-03-03 | 2021-04-21 | イー,リチャード,ダブリュ. | 眼疾患を処置するための組成物及び方法 |
| US20180177724A1 (en) * | 2015-07-02 | 2018-06-28 | The Regents Of The University Of California | Site-targeted nano-liposomal nitroglycerin therapeutics |
| CN108434439B (zh) * | 2018-01-23 | 2020-02-07 | 中国人民解放军总医院 | 钙网蛋白的医药用途 |
| US12419905B2 (en) * | 2018-07-06 | 2025-09-23 | Yale University | Methods and compositions for the treatment of amyloid-related disorders |
| CN109187832B (zh) * | 2018-09-30 | 2021-07-30 | 华润三九医药股份有限公司 | Lc-ms/ms测定去氧肾上腺素浓度的方法及样品的前处理方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5081138A (en) | 1986-12-17 | 1992-01-14 | Merck Frosst Canada, Inc. | 3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith |
| DE3814504A1 (de) | 1988-04-29 | 1989-11-09 | Bayer Ag | (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| DE3900261A1 (de) | 1988-05-31 | 1989-12-07 | Bayer Ag | Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate |
| US5204344A (en) | 1989-08-22 | 1993-04-20 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| US5272145A (en) | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| DE3927931A1 (de) | 1989-08-24 | 1991-02-28 | Bayer Ag | Disubstituierte (chinolin-2-yl-methoxy)phenylessigsaeure-derivate |
| US5229516A (en) | 1989-10-27 | 1993-07-20 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| US5221678A (en) | 1990-07-26 | 1993-06-22 | Merck Frosst Canada, Inc. | (quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes |
| US5095031A (en) | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
| DE4139751A1 (de) | 1991-12-03 | 1993-06-09 | Bayer Ag, 5090 Leverkusen, De | Thiazolyl substituierte chinolylmethoxyphenylessigsaeurederivate |
| US5304563A (en) | 1991-02-22 | 1994-04-19 | Bayer Aktiengesellschaft | 2-substituted quinolines, and their use in medicaments |
| DE4128681A1 (de) | 1991-08-29 | 1993-03-04 | Bayer Ag | Substituierte mandelsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| DE4226519A1 (de) | 1992-08-11 | 1994-02-17 | Bayer Ag | 3-Substituierte Chinolylmethoxy-phenylessigsäurederivate |
| US5288743A (en) | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
| IL109254A (en) | 1993-04-29 | 1999-03-12 | Zeneca Ltd | Tetrahydropyran and tetrahydrofuran ether derivatives their preparation and pharmaceutical compositions comprising them |
| US5399699A (en) | 1994-01-24 | 1995-03-21 | Abbott Laboratories | Indole iminooxy derivatives which inhibit leukotriene biosynthesis |
| US5512581A (en) | 1994-07-18 | 1996-04-30 | Abbott Laboratories | Iminoxycarboxylates and derivatives as inhibitors of leukotriene biosynthesis |
| US5668146A (en) | 1995-10-03 | 1997-09-16 | Abbott Laboratories | Symmetrical bis-heteroarylmethoxyphenyliminoxyalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US5795900A (en) | 1995-10-03 | 1998-08-18 | Abbott Laboratories | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US5714488A (en) | 1995-10-03 | 1998-02-03 | Abbott Laboratories | Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors of leukotriene biosynthesis |
| US5691351A (en) | 1996-02-06 | 1997-11-25 | Abbott Laboratories | Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US5668150A (en) | 1996-07-26 | 1997-09-16 | Abbott Laboratories | Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| US5783586A (en) | 1996-10-01 | 1998-07-21 | Abbott Laboratories | Heteroarylmethoxyphenylthioalkyl carboxylates as inhibitors of leukotriene biosynthesis |
| DE69933661T3 (de) | 1998-04-15 | 2012-01-26 | Merck Serono Biodevelopment | Genomische sequenz des 5-lipoxygenase-aktivierenden proteins (flap), polymorphische marker und ihre anwendung in der diagnose von asthma |
| DE10007203A1 (de) | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
| US6545019B2 (en) | 2000-07-13 | 2003-04-08 | Bristol-Myers Squibb Company | Method of modulating microglial activation for the treatment of acute and chronic neurodegenerative disorders |
| US6756399B2 (en) | 2001-06-29 | 2004-06-29 | The United States Of America As Represented By The Department Of Health And Human Services | Use of lipoxygenase inhibitors and PPAR ligands as anti-cancer therapeutic and intervention agents |
| US7851486B2 (en) | 2002-10-17 | 2010-12-14 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment |
| US7405302B2 (en) | 2005-10-11 | 2008-07-29 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US20070244128A1 (en) | 2005-11-04 | 2007-10-18 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
| US20070219206A1 (en) | 2005-11-04 | 2007-09-20 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US20070225285A1 (en) | 2005-11-04 | 2007-09-27 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
| CA2625638C (en) | 2005-11-08 | 2014-03-11 | Surmodics, Inc. | Ultra-thin photo-polymer coatings and uses thereof |
| TW200920369A (en) * | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
-
2007
- 2007-11-30 WO PCT/US2007/086188 patent/WO2008067566A1/en not_active Ceased
- 2007-11-30 US US12/517,166 patent/US20100068301A1/en not_active Abandoned
- 2007-11-30 EP EP07865056A patent/EP2086531A4/en not_active Withdrawn
- 2007-11-30 JP JP2009539527A patent/JP2010511632A/ja active Pending
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