JP2010510809A5 - - Google Patents
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- Publication number
- JP2010510809A5 JP2010510809A5 JP2009539435A JP2009539435A JP2010510809A5 JP 2010510809 A5 JP2010510809 A5 JP 2010510809A5 JP 2009539435 A JP2009539435 A JP 2009539435A JP 2009539435 A JP2009539435 A JP 2009539435A JP 2010510809 A5 JP2010510809 A5 JP 2010510809A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- group
- ovr110
- antigen
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 210000000822 natural killer cell Anatomy 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 230000004663 cell proliferation Effects 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 229940127121 immunoconjugate Drugs 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 230000009545 invasion Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 230000001629 suppression Effects 0.000 claims 3
- 230000003844 B-cell-activation Effects 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000006051 NK cell activation Effects 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 230000006044 T cell activation Effects 0.000 claims 2
- 230000006052 T cell proliferation Effects 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 230000004709 cell invasion Effects 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 108700012359 toxins Proteins 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010003445 Ascites Diseases 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 108010039491 Ricin Proteins 0.000 claims 1
- 108010084592 Saporins Proteins 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
- 229930195731 calicheamicin Natural products 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 230000001293 nucleolytic effect Effects 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 239000003330 peritoneal dialysis fluid Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86165706P | 2006-11-27 | 2006-11-27 | |
| US60/861,657 | 2006-11-27 | ||
| PCT/US2007/085585 WO2008067283A2 (en) | 2006-11-27 | 2007-11-27 | Ovr110 antibody compositions and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010510809A JP2010510809A (ja) | 2010-04-08 |
| JP2010510809A5 true JP2010510809A5 (cg-RX-API-DMAC10.html) | 2012-04-05 |
| JP5391073B2 JP5391073B2 (ja) | 2014-01-15 |
Family
ID=39468637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539435A Expired - Fee Related JP5391073B2 (ja) | 2006-11-27 | 2007-11-27 | Ｏｖｒ１１０抗体組成物および使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8444971B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP2104513B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5391073B2 (cg-RX-API-DMAC10.html) |
| AU (1) | AU2007325283B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2670696A1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2543350T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2008067283A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (57)
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| US7619068B2 (en) * | 2003-05-09 | 2009-11-17 | Diadexus, Inc. | Ovr110 antibody compositions and methods of use |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
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| MX356367B (es) | 2008-12-09 | 2018-05-25 | Genentech Inc | Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t. |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| WO2012145568A1 (en) * | 2011-04-21 | 2012-10-26 | Albert Einstein College Of Medicine Of Yeshiva University | Antibodies to human b7x for treatment of metastatic cancer |
| CA2853943C (en) | 2011-11-02 | 2015-12-08 | University Of Rochester | Anti-glucosaminidase passive immunization for staphylococcus aureus infections |
| US9422351B2 (en) * | 2011-11-03 | 2016-08-23 | The Trustees Of The University Of Pennsylvania | Isolated B7-H4 specific compositions and methods of use thereof |
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| EP3041484B1 (en) | 2013-09-06 | 2021-03-03 | Academia Sinica | Human inkt cell activation using glycolipids with altered glycosyl groups |
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| PL3099717T3 (pl) | 2014-01-31 | 2019-10-31 | Novartis Ag | Cząsteczki przeciwciała dla TIM-3 i ich zastosowanie |
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| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| JP2017518989A (ja) | 2014-05-27 | 2017-07-13 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 抗ｃｄ２０糖操作抗体群およびその使用 |
| EP4116329A1 (en) | 2014-05-27 | 2023-01-11 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
| JP7063538B2 (ja) | 2014-05-28 | 2022-05-09 | アカデミア シニカ | 抗ＴＮＦα糖操作抗体群およびその使用 |
| EP3191500A4 (en) | 2014-09-08 | 2018-04-11 | Academia Sinica | HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS |
| TW201625689A (zh) * | 2014-09-12 | 2016-07-16 | 建南德克公司 | 抗－ｂ７－ｈ４抗體及免疫結合物 |
| EP3191126B1 (en) | 2014-09-13 | 2020-05-13 | Novartis AG | Combination therapies of alk inhibitors |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| AU2015378564A1 (en) | 2015-01-24 | 2017-07-13 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| CN114702581B (zh) * | 2015-01-30 | 2025-08-01 | 台湾地区“中央研究院” | 增进抗体功效的通用糖型组合物及方法 |
| US20180340025A1 (en) | 2015-07-29 | 2018-11-29 | Novartis Ag | Combination therapies comprising antibody molecules to lag-3 |
| EP3344806A4 (en) | 2015-09-04 | 2019-03-20 | OBI Pharma, Inc. | GLYCANARRAYS AND METHOD OF USE |
| CN108495651A (zh) | 2015-12-17 | 2018-09-04 | 诺华股份有限公司 | 抗pd-1的抗体分子及其用途 |
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| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| AU2017239637A1 (en) * | 2016-03-29 | 2018-11-15 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
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| KR102528998B1 (ko) | 2016-07-29 | 2023-05-03 | 오비아이 파머 인코퍼레이티드 | 인간 항체, 제약 조성물 및 방법 |
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| WO2018094414A1 (en) | 2016-11-21 | 2018-05-24 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
| RS67792B1 (sr) | 2016-12-01 | 2026-03-31 | Regeneron Pharma | Radio-obeležena anti-pd-l1 antitela za imuno-pet snimanje |
| SG11202000387YA (en) | 2017-08-25 | 2020-03-30 | Five Prime Therapeutics Inc | B7-h4 antibodies and methods of use thereof |
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| TW202504930A (zh) | 2018-06-27 | 2025-02-01 | 台灣浩鼎生技股份有限公司 | 用於糖蛋白工程的糖苷合成酶變體及其使用方法 |
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| CN110095463B (zh) * | 2019-03-15 | 2021-10-22 | 中国人民解放军陆军军医大学第二附属医院 | 一种乳糜定性检测的试剂盒 |
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-
2007
- 2007-11-27 AU AU2007325283A patent/AU2007325283B2/en not_active Ceased
- 2007-11-27 CA CA002670696A patent/CA2670696A1/en not_active Abandoned
- 2007-11-27 US US12/516,397 patent/US8444971B2/en not_active Expired - Fee Related
- 2007-11-27 JP JP2009539435A patent/JP5391073B2/ja not_active Expired - Fee Related
- 2007-11-27 WO PCT/US2007/085585 patent/WO2008067283A2/en not_active Ceased
- 2007-11-27 EP EP07868854.6A patent/EP2104513B1/en active Active
- 2007-11-27 EP EP15168204.4A patent/EP2962697A1/en not_active Withdrawn
- 2007-11-27 ES ES07868854.6T patent/ES2543350T3/es active Active
-
2013
- 2013-04-24 US US13/869,448 patent/US8906369B2/en not_active Expired - Fee Related
-
2014
- 2014-12-04 US US14/559,946 patent/US20150175701A1/en not_active Abandoned
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