JP2010509570A5 - - Google Patents
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- JP2010509570A5 JP2010509570A5 JP2009535333A JP2009535333A JP2010509570A5 JP 2010509570 A5 JP2010509570 A5 JP 2010509570A5 JP 2009535333 A JP2009535333 A JP 2009535333A JP 2009535333 A JP2009535333 A JP 2009535333A JP 2010509570 A5 JP2010509570 A5 JP 2010509570A5
- Authority
- JP
- Japan
- Prior art keywords
- folate
- detection reagent
- chromophore
- pathogenic cells
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 210000004027 cell Anatomy 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 230000001717 pathogenic effect Effects 0.000 claims 11
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 238000001514 detection method Methods 0.000 claims 8
- 239000003446 ligand Substances 0.000 claims 7
- 239000013610 patient sample Substances 0.000 claims 5
- 238000000684 flow cytometry Methods 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 2
- 102000006815 folate receptor Human genes 0.000 claims 2
- 108020005243 folate receptor Proteins 0.000 claims 2
- 239000012216 imaging agent Substances 0.000 claims 2
- VGIRNWJSIRVFRT-UHFFFAOYSA-N 2',7'-difluorofluorescein Chemical compound OC(=O)C1=CC=CC=C1C1=C2C=C(F)C(=O)C=C2OC2=CC(O)=C(F)C=C21 VGIRNWJSIRVFRT-UHFFFAOYSA-N 0.000 claims 1
- 239000012103 Alexa Fluor 488 Substances 0.000 claims 1
- 239000012099 Alexa Fluor family Substances 0.000 claims 1
- 108010004729 Phycoerythrin Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
- 210000004880 lymph fluid Anatomy 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85666706P | 2006-11-03 | 2006-11-03 | |
| US95656207P | 2007-08-17 | 2007-08-17 | |
| PCT/US2007/023176 WO2008057437A2 (en) | 2006-11-03 | 2007-11-02 | Ex vivo flow cytometry method and device |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014144399A Division JP2014238406A (ja) | 2006-11-03 | 2014-07-14 | エクスビボフローサイトメトリーの方法および装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010509570A JP2010509570A (ja) | 2010-03-25 |
| JP2010509570A5 true JP2010509570A5 (https=) | 2012-01-12 |
Family
ID=39365074
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535333A Ceased JP2010509570A (ja) | 2006-11-03 | 2007-11-02 | エクスビボフローサイトメトリーの方法および装置 |
| JP2014144399A Pending JP2014238406A (ja) | 2006-11-03 | 2014-07-14 | エクスビボフローサイトメトリーの方法および装置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014144399A Pending JP2014238406A (ja) | 2006-11-03 | 2014-07-14 | エクスビボフローサイトメトリーの方法および装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8685752B2 (https=) |
| EP (1) | EP2087337A4 (https=) |
| JP (2) | JP2010509570A (https=) |
| CA (1) | CA2668197A1 (https=) |
| WO (1) | WO2008057437A2 (https=) |
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-
2007
- 2007-11-02 JP JP2009535333A patent/JP2010509570A/ja not_active Ceased
- 2007-11-02 CA CA002668197A patent/CA2668197A1/en not_active Abandoned
- 2007-11-02 US US12/513,028 patent/US8685752B2/en active Active
- 2007-11-02 EP EP07867348A patent/EP2087337A4/en not_active Withdrawn
- 2007-11-02 WO PCT/US2007/023176 patent/WO2008057437A2/en not_active Ceased
-
2014
- 2014-02-24 US US14/187,844 patent/US9279813B2/en active Active
- 2014-07-14 JP JP2014144399A patent/JP2014238406A/ja active Pending
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