JP2010508296A5 - - Google Patents

Download PDF

Info

Publication number
JP2010508296A5
JP2010508296A5 JP2009534891A JP2009534891A JP2010508296A5 JP 2010508296 A5 JP2010508296 A5 JP 2010508296A5 JP 2009534891 A JP2009534891 A JP 2009534891A JP 2009534891 A JP2009534891 A JP 2009534891A JP 2010508296 A5 JP2010508296 A5 JP 2010508296A5
Authority
JP
Japan
Prior art keywords
alkyl
oxazepin
benzamide
hydroxy
hydroxybenzamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009534891A
Other languages
English (en)
Japanese (ja)
Other versions
JP5583406B2 (ja
JP2010508296A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/082668 external-priority patent/WO2008055068A2/en
Publication of JP2010508296A publication Critical patent/JP2010508296A/ja
Publication of JP2010508296A5 publication Critical patent/JP2010508296A5/ja
Application granted granted Critical
Publication of JP5583406B2 publication Critical patent/JP5583406B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009534891A 2006-10-28 2007-10-26 ヒストンデアセチラーゼの阻害剤 Expired - Fee Related JP5583406B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86334706P 2006-10-28 2006-10-28
US60/863,347 2006-10-28
US88428707P 2007-01-10 2007-01-10
US60/884,287 2007-01-10
PCT/US2007/082668 WO2008055068A2 (en) 2006-10-28 2007-10-26 Inhibitors of histone deacetylase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014111281A Division JP5727649B2 (ja) 2006-10-28 2014-05-29 ヒストンデアセチラーゼの阻害剤

Publications (3)

Publication Number Publication Date
JP2010508296A JP2010508296A (ja) 2010-03-18
JP2010508296A5 true JP2010508296A5 (cg-RX-API-DMAC7.html) 2010-12-02
JP5583406B2 JP5583406B2 (ja) 2014-09-03

Family

ID=39309979

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009534891A Expired - Fee Related JP5583406B2 (ja) 2006-10-28 2007-10-26 ヒストンデアセチラーゼの阻害剤
JP2014111281A Expired - Fee Related JP5727649B2 (ja) 2006-10-28 2014-05-29 ヒストンデアセチラーゼの阻害剤
JP2015075545A Pending JP2015145401A (ja) 2006-10-28 2015-04-02 ヒストンデアセチラーゼの阻害剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014111281A Expired - Fee Related JP5727649B2 (ja) 2006-10-28 2014-05-29 ヒストンデアセチラーゼの阻害剤
JP2015075545A Pending JP2015145401A (ja) 2006-10-28 2015-04-02 ヒストンデアセチラーゼの阻害剤

Country Status (19)

Country Link
US (4) US8399452B2 (cg-RX-API-DMAC7.html)
EP (4) EP2966078A3 (cg-RX-API-DMAC7.html)
JP (3) JP5583406B2 (cg-RX-API-DMAC7.html)
KR (1) KR101312993B1 (cg-RX-API-DMAC7.html)
CN (3) CN101573333B (cg-RX-API-DMAC7.html)
AR (1) AR063720A1 (cg-RX-API-DMAC7.html)
AU (1) AU2007313818B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0718089A2 (cg-RX-API-DMAC7.html)
CA (2) CA2667826C (cg-RX-API-DMAC7.html)
CL (1) CL2007003108A1 (cg-RX-API-DMAC7.html)
DK (1) DK2343286T3 (cg-RX-API-DMAC7.html)
ES (1) ES2532899T3 (cg-RX-API-DMAC7.html)
HK (1) HK1220179A1 (cg-RX-API-DMAC7.html)
PL (1) PL2343286T3 (cg-RX-API-DMAC7.html)
PT (1) PT2343286E (cg-RX-API-DMAC7.html)
RU (1) RU2459811C2 (cg-RX-API-DMAC7.html)
SI (1) SI2343286T1 (cg-RX-API-DMAC7.html)
TW (3) TWI427070B (cg-RX-API-DMAC7.html)
WO (1) WO2008055068A2 (cg-RX-API-DMAC7.html)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
AU2006226861B2 (en) 2005-03-22 2012-08-16 Dana-Farber Cancer Institute, Inc. Treatment of protein degradation disorders
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
AU2007296743B2 (en) 2006-09-11 2012-02-16 Curis, Inc. Tyrosine kinase inhibitors containing a zinc binding moiety
KR101434164B1 (ko) 2006-09-11 2014-08-26 쿠리스 인코퍼레이션 아연 결합 부분을 함유한 퀴나졸린 계열 egfr 억제제
CA2663147A1 (en) 2006-09-11 2008-03-20 Curis, Inc. Substituted 2-indolinone as ptk inhibitors containing a zinc binding moiety
CN101573333B (zh) * 2006-10-28 2013-06-12 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
CN101578265B (zh) 2007-01-10 2013-05-08 霍夫曼-拉罗奇有限公司 用作糜蛋白酶抑制剂的磺酰胺衍生物
BRPI0808301B1 (pt) 2007-03-20 2022-05-03 Curis, Inc Composto e composição farmacêutica
JP5746860B2 (ja) * 2007-04-09 2015-07-08 メチルジーン インコーポレイテッド ヒストンデアセチラーゼ阻害剤
TW200922564A (en) 2007-09-10 2009-06-01 Curis Inc CDK inhibitors containing a zinc binding moiety
ES2526718T3 (es) 2007-09-10 2015-01-14 Curis, Inc. Inhibidores de EGFR basados en sales de tartrato o complejos de quinazolina que contienen un resto que se une al cinc
US8119616B2 (en) 2007-09-10 2012-02-21 Curis, Inc. Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety
BRPI0817897A2 (pt) * 2007-11-02 2019-09-24 Methylgene Inc composto, composição, e, métodos de inibição da atividade hdac, e de tratamento de uma doença responsiva a um inibidor de atividade hdac
ITFI20070288A1 (it) * 2007-12-21 2009-06-22 A I L Firenze Sezione Autonoma Inibitori delle deacetilasi istoniche
AU2009274549B2 (en) 2008-07-23 2014-05-01 Dana-Farber Cancer Institute, Inc. Deacetylase inhibitors and uses thereof
WO2010018836A2 (ja) * 2008-08-11 2010-02-18 独立行政法人科学技術振興機構 ポリグルタミン凝集阻害剤
WO2010062565A1 (en) * 2008-10-27 2010-06-03 Acadia Pharmaceuticals Inc. Muscarinic agonists
EP2385832B1 (en) 2009-01-08 2015-07-15 Curis, Inc. Phosphoinositide 3-kinase inhibitors with a zinc binding moiety
MX2011007612A (es) 2009-01-16 2012-01-20 Curis Inc Aminopiridinas fusionadas para el tratamiento de tumores del cerebro.
JP5597649B2 (ja) * 2009-01-28 2014-10-01 カルス セラピューティクス リミテッド スクリプタイドアイソスター(scriptaidisosteres)およびその治療における使用
AR077033A1 (es) 2009-06-11 2011-07-27 Hoffmann La Roche Compuestos inhibidores de las quinasas de janus y su uso en el tratamiento de enfermedades inmunologicas
CA2768466C (en) * 2009-07-22 2018-08-14 The Board Of Trustees Of The University Of Illinois Hdac inhibitors and therapeutic methods using the same
EA025824B1 (ru) 2009-07-27 2017-02-28 Джилид Сайэнс, Инк. Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
WO2011084991A2 (en) * 2010-01-08 2011-07-14 President And Fellows Of Harvard College Fluorinated hdac inhibitors and uses thereof
US20110245154A1 (en) 2010-03-11 2011-10-06 Hemaquest Pharmaceuticals, Inc. Methods and Compositions for Treating Viral or Virally-Induced Conditions
BR112012033402A2 (pt) 2010-07-02 2017-01-24 Gilead Sciences Inc moduladores de canais de íons conforme os compostos heterocíclicos fundidos
ES2568260T3 (es) * 2010-11-16 2016-04-28 Acetylon Pharmaceuticals, Inc. Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos
US8404738B2 (en) 2011-01-21 2013-03-26 Hoffmann-La Roche Inc. 4-amino-N-hydroxy-benzamides for the treatment of cancer
CN103328446B (zh) * 2011-01-21 2016-01-20 霍夫曼-拉罗奇有限公司 用于治疗癌症的新的4-氨基-n-羟基-苯甲酰胺
EP2670733B1 (en) * 2011-02-01 2019-04-10 The Board of Trustees of the University of Illionis N-hydroxybenzamide derivatives as hdac inhibitors and therapeutic methods using the same
CA2831291A1 (en) * 2011-03-26 2012-10-04 Envivo Pharmaceuticals, Inc. Methods of targeted treatment of frontotemporal lobar degeneration
PT3111938T (pt) 2011-04-01 2019-07-10 Curis Inc Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco
WO2012154760A1 (en) 2011-05-10 2012-11-15 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
NO3175985T3 (cg-RX-API-DMAC7.html) 2011-07-01 2018-04-28
TWI549944B (zh) 2011-07-01 2016-09-21 吉李德科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
EP2758403B1 (en) 2011-09-21 2016-04-27 Inception Orion, Inc. Tricyclic compounds useful as neurogenic and neuroprotective agents
AU2012319188B2 (en) 2011-10-03 2016-11-24 Sloan-Kettering Institute For Cancer Research Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1
CN104136410A (zh) * 2011-12-29 2014-11-05 药品循环公司 作为组蛋白脱乙酰酶8抑制剂的肉桂酸羟基酰胺
CN103788014B (zh) * 2012-10-29 2016-04-27 安徽安腾药业有限责任公司 制备10H-二苯并[b,f][1,4]硫氮杂卓-11-酮和喹硫平的方法
NZ707366A (en) 2012-11-07 2018-11-30 Karus Therapeutics Ltd Novel histone deacetylase inhibitors and their use in therapy
NZ714283A (en) * 2013-05-10 2020-04-24 Karus Therapeutics Ltd Novel histone deacetylase inhibitors
JP6626437B2 (ja) 2013-10-08 2019-12-25 アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. ヒストンデアセチラーゼ阻害剤とHer2阻害剤またはPI3K阻害剤のいずれかの組み合わせ
ES2862126T3 (es) 2013-10-10 2021-10-07 Acetylon Pharmaceuticals Inc Compuestos de pirimidín-hidroxiamida como inhibidores de histona desacetilasa
EP3060217B1 (en) 2013-10-24 2022-06-08 Mayo Foundation for Medical Education and Research Treatment of polycystic diseases with an hdac6 inhibitor
US9949972B2 (en) 2013-12-03 2018-04-24 Acetylon Pharmaceuticals, Inc Combinations of histone deacetylase inhibitors and immunomodulatory drugs
CA2933907A1 (en) 2013-12-23 2015-07-02 The Trustees Of Columbia University In The City Of New York Selective hdac6 inhibitors
US9464073B2 (en) 2014-02-26 2016-10-11 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
CN107205988A (zh) 2014-07-07 2017-09-26 埃斯泰隆制药公司 利用组蛋白脱乙酰酶抑制剂治疗白血病
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
US9937174B2 (en) 2014-12-05 2018-04-10 University of Modena and Reggio Emilia Combinations of histone deacetylase inhibitors and bendamustine
US10183934B2 (en) 2015-02-02 2019-01-22 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors
SG11201706146UA (en) 2015-02-02 2017-08-30 Forma Therapeutics Inc 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors
HUE059218T2 (hu) 2015-04-08 2022-11-28 Novartis Ag CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel
CN106279044B (zh) * 2015-05-28 2021-02-19 厦门市博瑞来医药科技有限公司 嘧啶异羟肟酸衍生物及其制备方法和应用
US10272084B2 (en) 2015-06-01 2019-04-30 Regenacy Pharmaceuticals, Llc Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy
US10836733B2 (en) 2015-09-03 2020-11-17 The Board Of Trustees Of The University Of Illinois HDAC inhibitors and therapeutic methods using the same
TW201711999A (zh) 2015-09-03 2017-04-01 佛瑪治療公司 ﹝6,6﹞稠合雙環組蛋白脫乙醯基酶8(hdac8)抑制劑
EP3416633B1 (en) 2016-02-16 2025-07-23 The Board of Trustees of the University of Illinois Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors
WO2017184774A1 (en) 2016-04-19 2017-10-26 Acetylon Pharmaceuticals, Inc. Hdac inhibitors, alone or in combination with btk inhibitors, for treating chronic lymphocytic leukemia
WO2017218950A1 (en) 2016-06-17 2017-12-21 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
EP4596053A3 (en) 2016-07-15 2025-10-15 Viracta Subsidiary, Inc. Hdac inhibitors for use with nk cell based therapies
TW201821105A (zh) 2016-10-20 2018-06-16 美商弗瑪治療公司 使用hdac11抑制劑之方法
JP7068297B2 (ja) * 2016-11-10 2022-05-16 アセチロン ファーマシューティカルズ インコーポレイテッド フェニル及びピリジニルヒドロキサム酸
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds
CN107011238B (zh) * 2017-03-14 2020-05-01 北京化工大学 一类组蛋白去乙酰化酶抑制剂及其制备方法和用途
EP3600295A4 (en) 2017-03-29 2021-04-07 The George Washington University, A Congressionally Chartered Not-For-Profit Corporation ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS
CN110730660A (zh) 2017-04-26 2020-01-24 伊利诺伊大学评议会 Nrf和HIF活化剂/HDAC抑制剂和使用其的治疗方法
WO2019173761A1 (en) 2018-03-09 2019-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services C-abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
US11535607B2 (en) 2018-04-20 2022-12-27 Valo Health, Inc. Isoindolines as HDAC inhibitors
US11548882B2 (en) 2018-04-27 2023-01-10 Osaka University Benzisoxazole compound
CN109020921B (zh) * 2018-07-10 2020-08-04 山东大学 一种组蛋白去乙酰化酶hdac6抑制剂及其制备方法与应用
CN113164466B (zh) 2018-09-11 2025-07-08 柯瑞斯公司 使用具有锌结合部分的磷酸肌醇3-激酶抑制剂的联合治疗
US20220226322A1 (en) 2019-05-31 2022-07-21 Viracta Subsidiary, Inc. Methods of treating virally associated cancers with histone deacetylase inhibitors
IL292924A (en) 2019-11-26 2022-07-01 Novartis Ag Cd19 and cd22 chimeric antigen receptors and uses thereof
CN114315736B (zh) * 2020-03-30 2025-11-18 甫康(上海)健康科技有限责任公司 二氢化茚胺类衍生物、其制备方法和用途
CN113527206B (zh) * 2020-04-17 2022-12-30 上海中泽医药科技有限公司 一种苯并氮杂环类化合物、其制备方法及用途
CN112358455B (zh) * 2020-11-16 2022-07-19 吉林奥来德光电材料股份有限公司 一种二苯并七元杂环类化合物及其制备方法与应用
CN112500395B (zh) * 2020-12-02 2022-03-08 吉林奥来德光电材料股份有限公司 一种二苯并含氮七元杂环类有机化合物、其制备方法及有机电致发光器件
CN115073424A (zh) * 2021-03-10 2022-09-20 微境生物医药科技(上海)有限公司 组蛋白去乙酰化酶抑制剂及其应用
CN117580577A (zh) * 2021-06-29 2024-02-20 国立大学法人大阪大学 肾损伤的预防和/或治疗用医药组合物以及自噬活化剂
WO2023020416A1 (zh) * 2021-08-16 2023-02-23 勤浩医药(苏州)有限公司 三环化合物、包含其的药物组合物及其用途
CN120917006A (zh) * 2023-03-14 2025-11-07 米拉林制药有限公司 作为选择性hdac6抑制剂的杂环化合物

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US3510476A (en) * 1967-02-08 1970-05-05 American Home Prod Dibenzazepine-5-hydroxamic acid and derivatives thereof
DE2337154C2 (de) * 1973-07-18 1986-04-24 Schering AG, 1000 Berlin und 4709 Bergkamen Neue Carbazolderivate
CH620891A5 (en) 1975-12-19 1980-12-31 Teijin Ltd Isomerisation process
GB1574822A (en) * 1976-03-23 1980-09-10 Lafon Labor Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
JPS5643283A (en) * 1979-08-29 1981-04-21 Schering Ag Betaacarbolinee33carboxylic acid derivative* its manufacture and psychotic medicine containing it
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
US5149797A (en) 1990-02-15 1992-09-22 The Worcester Foundation For Experimental Biology Method of site-specific alteration of rna and production of encoded polypeptides
GB9021813D0 (en) 1990-10-08 1990-11-21 Ici Plc Tricyclic heterocycles
US5652355A (en) 1992-07-23 1997-07-29 Worcester Foundation For Experimental Biology Hybrid oligonucleotide phosphorothioates
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
DE19510957A1 (de) 1995-03-25 1996-09-26 Huels Chemische Werke Ag Eingedickter Bodenverfestiger, sowie diesen enthaltende verpackte Fertigmischung für Bodenbehandlungen
WO1996033983A1 (en) * 1995-04-25 1996-10-31 Daiichi Radioisotope Laboratories, Ltd. Dibenzoxazepine n-oxide derivatives and drug containing the same as the active ingredient
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
AU731737B2 (en) * 1996-10-16 2001-04-05 Wyeth Holdings Corporation The preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US6117869A (en) * 1998-08-04 2000-09-12 Warner-Lambert Company Compounds for and methods of inhibiting matrix metalloproteinases
AR035311A1 (es) * 1999-01-27 2004-05-12 Wyeth Corp Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento
US6677355B1 (en) * 1999-08-18 2004-01-13 Warner-Lambert Company Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors
EP1748046A3 (en) 1999-11-23 2007-08-22 Methylgene, Inc. Inhibitors of histone deacetylase
DE60143520D1 (de) 2000-03-24 2011-01-05 Methylgene Inc Inhibitoren der histon-deacetylase
AR035455A1 (es) * 2001-04-23 2004-05-26 Hoffmann La Roche Derivados triciclicos de alquilhidroxamato , procesos para su elaboracion, composiciones farmaceuticas que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos
CN101851173A (zh) 2001-09-14 2010-10-06 梅特希尔基因公司 组蛋白脱乙酰化酶抑制剂
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
AU2002340253C1 (en) 2001-10-16 2011-03-31 Sloan-Kettering Institute For Cancer Research Treatment of neurodegenerative diseases and cancer of the brain
EP1472216A2 (en) * 2002-02-07 2004-11-03 Axys Pharmaceuticals Novel bicyclic hydroxamates as inhibitors of histone deacetylase
US7205304B2 (en) * 2002-03-13 2007-04-17 Janssen Pharmaceutica N.V. Sulfonyl-Derivatives as novel inhibitors of histone deacetylase
HRP20040801A2 (en) * 2002-03-13 2005-04-30 Janssen Pharmaceutica N.V. Sulfonylamino derivatives as novel inhibitors of histone deacetylase
US7282608B2 (en) 2002-10-17 2007-10-16 Methylgene, Inc. Inhibitors of histone deacetylase
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
BRPI0407052A (pt) 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
US7094791B2 (en) * 2003-07-31 2006-08-22 Avalon Pharmaceuticals, Inc. Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof
US20060074124A1 (en) 2003-09-12 2006-04-06 Andrew Napper Methods of treating a disorder
US7868205B2 (en) 2003-09-24 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
US20050152323A1 (en) 2004-01-12 2005-07-14 Vincent Bonnassieux Plug-in Wi-Fi access point device and system
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US20050197336A1 (en) 2004-03-08 2005-09-08 Miikana Therapeutics Corporation Inhibitors of histone deacetylase
WO2006010751A1 (en) * 2004-07-26 2006-02-02 Applied Research Systems Ars Holding N.V. N-hydroxyamide derivatives and use thereof
DK1804804T3 (da) * 2004-09-21 2012-02-20 Hypnion Inc 3-[4-(dibenzo[b,f][1,4]oxazepin-11-yl)-piperazin-1-yl]-2,2-dimethylpropansyre til anvendelse ved behandlingen af søvnforstyrrelser
JP2008530136A (ja) * 2005-02-14 2008-08-07 ミイカナ セラピューティクス インコーポレイテッド ヒストンデアセチラーゼの阻害剤として有用な縮合複素環化合物
IT1362675B (it) * 2005-03-15 2009-06-25 Menarini Internat Operations Luxembourg Sa N-idrossiammidi -sostituiti con gruppi triciclici come inibitori dell'istone deacelitasi,loro preparazione ed impiego in formulazioni farmaceutiche
GB0510204D0 (en) 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
ATE533058T1 (de) 2005-08-16 2011-11-15 Genentech Inc Apoptosesensitivität gegenüber apo2l/trail mittels testen auf galnac-t14-expression in zellen/gewebe
KR101495611B1 (ko) 2006-04-07 2015-02-25 메틸진 인코포레이티드 히스톤 데아세틸라아제의 억제제
CN101573333B (zh) * 2006-10-28 2013-06-12 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂

Similar Documents

Publication Publication Date Title
JP2010508296A5 (cg-RX-API-DMAC7.html)
RU2459811C2 (ru) Ингибиторы гистоновой деацетилазы
RU2006107653A (ru) Связующее вспомогательное вещество и приготовленная на его основе таблетка в форме капли
JP2006517572A5 (cg-RX-API-DMAC7.html)
JP2006077019A5 (cg-RX-API-DMAC7.html)
RU2011103741A (ru) Композиции и способы лечения заболевания сетчатки
JP2007502806A5 (cg-RX-API-DMAC7.html)
JP2019509276A5 (cg-RX-API-DMAC7.html)
JP2006501295A5 (cg-RX-API-DMAC7.html)
JP2008531537A5 (cg-RX-API-DMAC7.html)
JP2014530900A5 (cg-RX-API-DMAC7.html)
JP2013512277A5 (cg-RX-API-DMAC7.html)
JP2003528852A5 (cg-RX-API-DMAC7.html)
RU2004117887A (ru) Ариланилиновые агонисты бета2 адренергических рецепторов
JP2012526728A5 (cg-RX-API-DMAC7.html)
JP2005516967A5 (cg-RX-API-DMAC7.html)
JP2011518811A5 (cg-RX-API-DMAC7.html)
JP2005533835A5 (cg-RX-API-DMAC7.html)
JP2010526819A5 (cg-RX-API-DMAC7.html)
JP2017214387A5 (cg-RX-API-DMAC7.html)
CN113825754A (zh) 包括甲基和三氟甲基的双取代磺酰胺类选择性bcl-2抑制剂
JP2007522142A5 (cg-RX-API-DMAC7.html)
JP2004532894A5 (cg-RX-API-DMAC7.html)
RU2009108275A (ru) Соединение сульфонамида или его соль
RU2489433C2 (ru) Производное циклобутилпурина, агент, активирующий ангиогенез, агент, активирующий образование просвета, агент, активирующий рост нейронов, и лекарственное средство