JP2010507578A5 - - Google Patents
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- Publication number
- JP2010507578A5 JP2010507578A5 JP2009533541A JP2009533541A JP2010507578A5 JP 2010507578 A5 JP2010507578 A5 JP 2010507578A5 JP 2009533541 A JP2009533541 A JP 2009533541A JP 2009533541 A JP2009533541 A JP 2009533541A JP 2010507578 A5 JP2010507578 A5 JP 2010507578A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- receptor tyrosine
- tyrosine kinase
- kinase
- leukemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 4
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 4
- 102000001253 Protein Kinase Human genes 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 108060006633 protein kinase Proteins 0.000 claims 3
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 2
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000008022 Proto-Oncogene Proteins c-met Human genes 0.000 claims 2
- 108010089836 Proto-Oncogene Proteins c-met Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000779641 Homo sapiens ALK tyrosine kinase receptor Proteins 0.000 claims 1
- 101000606129 Homo sapiens Tyrosine-protein kinase receptor TYRO3 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000018142 Leiomyosarcoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 108010091528 Proto-Oncogene Proteins B-raf Proteins 0.000 claims 1
- 102000018471 Proto-Oncogene Proteins B-raf Human genes 0.000 claims 1
- 102000001788 Proto-Oncogene Proteins c-raf Human genes 0.000 claims 1
- 108010029869 Proto-Oncogene Proteins c-raf Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 101150098329 Tyro3 gene Proteins 0.000 claims 1
- 102100039127 Tyrosine-protein kinase receptor TYRO3 Human genes 0.000 claims 1
- 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 108010023337 axl receptor tyrosine kinase Proteins 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000012830 cancer therapeutic Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 210000003292 kidney cell Anatomy 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 102000047459 trkC Receptor Human genes 0.000 claims 1
- 108010064892 trkC Receptor Proteins 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86255206P | 2006-10-23 | 2006-10-23 | |
| US60/862,552 | 2006-10-23 | ||
| US87030906P | 2006-12-15 | 2006-12-15 | |
| US60/870,309 | 2006-12-15 | ||
| US91376607P | 2007-04-24 | 2007-04-24 | |
| US60/913,766 | 2007-04-24 | ||
| US95284007P | 2007-07-30 | 2007-07-30 | |
| US60/952,840 | 2007-07-30 | ||
| PCT/US2007/081841 WO2008051808A2 (en) | 2006-10-23 | 2007-10-18 | Bicyclic triazoles as protein kinase modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010507578A JP2010507578A (ja) | 2010-03-11 |
| JP2010507578A5 true JP2010507578A5 (enExample) | 2010-12-02 |
| JP5378222B2 JP5378222B2 (ja) | 2013-12-25 |
Family
ID=38956385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533541A Expired - Fee Related JP5378222B2 (ja) | 2006-10-23 | 2007-10-18 | タンパク質キナーゼ調節物質としての二環式トリアゾール |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8507489B2 (enExample) |
| EP (1) | EP2084162B1 (enExample) |
| JP (1) | JP5378222B2 (enExample) |
| KR (1) | KR20090071612A (enExample) |
| AR (1) | AR063520A1 (enExample) |
| AU (1) | AU2007309149C1 (enExample) |
| BR (1) | BRPI0717320A2 (enExample) |
| CA (1) | CA2667428A1 (enExample) |
| CO (1) | CO6190620A2 (enExample) |
| CR (1) | CR10803A (enExample) |
| DK (1) | DK2084162T3 (enExample) |
| EA (1) | EA200970403A1 (enExample) |
| ES (1) | ES2393130T3 (enExample) |
| IL (1) | IL197958A0 (enExample) |
| MA (1) | MA30871B1 (enExample) |
| MX (1) | MX2009004059A (enExample) |
| NO (1) | NO20091618L (enExample) |
| NZ (1) | NZ575336A (enExample) |
| PE (1) | PE20080893A1 (enExample) |
| PL (1) | PL2084162T3 (enExample) |
| PT (1) | PT2084162E (enExample) |
| SV (1) | SV2009003235A (enExample) |
| TN (1) | TN2009000142A1 (enExample) |
| TW (1) | TW200835492A (enExample) |
| WO (1) | WO2008051808A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8792501A1 (es) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
| TWI365185B (en) | 2008-07-24 | 2012-06-01 | Lilly Co Eli | Amidophenoxyindazoles useful as inhibitors of c-met |
| UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
| EP2165710A1 (en) * | 2008-09-19 | 2010-03-24 | Institut Curie | Tyrosine kinase receptor Tyro3 as a therapeutic target in the treatment of a bladder tumor |
| JP2012509342A (ja) | 2008-11-20 | 2012-04-19 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン |
| FR2941950B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941949B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941951B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941952B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| KR20120089643A (ko) | 2009-08-12 | 2012-08-13 | 노파르티스 아게 | 헤테로시클릭 히드라존 화합물, 및 암 및 염증을 치료하기 위한 그의 용도 |
| JP5775871B2 (ja) | 2009-08-20 | 2015-09-09 | ノバルティス アーゲー | ヘテロ環式オキシム化合物 |
| EP2719699B1 (en) | 2009-12-31 | 2015-07-08 | Hutchison Medipharma Limited | Certain triazolopyrazines, compositions thereof and methods of use therefor |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| US20130072495A1 (en) | 2010-05-14 | 2013-03-21 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
| AR085183A1 (es) | 2010-07-30 | 2013-09-18 | Lilly Co Eli | Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer |
| UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
| WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
| CN102532141A (zh) | 2010-12-08 | 2012-07-04 | 中国科学院上海药物研究所 | [1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途 |
| US8765760B2 (en) | 2011-01-11 | 2014-07-01 | Sunovion Pharmaceuticals, Inc. | [1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases |
| EP2673277A1 (en) * | 2011-02-10 | 2013-12-18 | Novartis AG | [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase |
| CN103459396B (zh) * | 2011-02-10 | 2015-08-19 | 诺瓦提斯公司 | 作为c-Met酪氨酸激酶抑制剂的[1,2,4]三唑并[4,3-b]哒嗪化合物 |
| JP2014513724A (ja) | 2011-05-16 | 2014-06-05 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 融合二環キナーゼ阻害剤 |
| US9062045B2 (en) * | 2011-09-15 | 2015-06-23 | Novartis Ag | Triazolopyridine compounds |
| CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
| ES2894830T3 (es) | 2012-04-03 | 2022-02-16 | Novartis Ag | Productos combinados con inhibidores de tirosina·cinasa y su uso |
| WO2013151913A1 (en) | 2012-04-03 | 2013-10-10 | Novartis Ag | Tyrosine kinase inhibitor combinations and their use |
| CN103122000B (zh) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术（太仓）有限公司 | 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂 |
| WO2014089904A1 (en) * | 2012-12-10 | 2014-06-19 | Abbvie Inc. | Triazinone compounds |
| WO2014164200A1 (en) | 2013-03-13 | 2014-10-09 | Avon Products, Inc | Tyrosinase inhibitors |
| WO2014140073A1 (en) * | 2013-03-13 | 2014-09-18 | F. Hoffmann-La Roche Ag | Process for making benzoxazepin compounds |
| US9364405B2 (en) | 2013-03-13 | 2016-06-14 | Avon Products, Inc. | Tyrosinase inhibitors |
| US20150152122A1 (en) * | 2013-03-13 | 2015-06-04 | Avon Products, Inc. | Tyrosinase inhibitors |
| WO2014174478A1 (en) | 2013-04-26 | 2014-10-30 | Novartis Ag | Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor |
| US9512121B2 (en) | 2013-05-10 | 2016-12-06 | Jiangsu Hansoh Pharmaceutical Co., Ltd. | [1,2,4] triazol [4,3-A] pyridine derivative, preparation method therefor or medical application thereof |
| WO2017049711A1 (zh) | 2015-09-24 | 2017-03-30 | 上海海聚生物科技有限公司 | 喹啉类衍生物、其药物组合物、制备方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604091A (en) | 1984-03-01 | 1997-02-18 | Microgenics Corporation | Methods for protein binding enzyme complementation |
| JPS60194443A (ja) * | 1984-03-16 | 1985-10-02 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| JPS62228086A (ja) * | 1985-12-23 | 1987-10-06 | Takeda Chem Ind Ltd | セフエム化合物 |
| EP0228061A3 (en) * | 1985-12-23 | 1988-12-14 | Takeda Chemical Industries, Ltd. | Cephem compounds |
| GB9918035D0 (en) | 1999-07-30 | 1999-09-29 | Novartis Ag | Organic compounds |
| AU2002251266A1 (en) | 2001-04-10 | 2002-10-28 | Merck Sharp And Dohme Limited | Inhibitors of akt activity |
| WO2002083139A1 (en) | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
| US20030229453A1 (en) | 2002-04-09 | 2003-12-11 | Antonysamy Stephen Suresh | Crystals and structures of PAK4KD kinase PAK4KD |
| EP1575959B1 (en) * | 2002-12-18 | 2010-07-14 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| US7122548B2 (en) * | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| CA2573573A1 (en) * | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| EA011725B1 (ru) | 2004-08-26 | 2009-04-28 | Пфайзер Инк. | Пиразолзамещённые аминогетероарильные соединения в качестве ингибиторов протеинкиназы |
| BRPI0519508A2 (pt) | 2004-12-27 | 2009-03-17 | Alcon Inc | análogos de aminopirazina para tratamento de glaucoma e outras doenças ou condições mediadas por rho cinase |
-
2007
- 2007-10-18 DK DK07844414.8T patent/DK2084162T3/da active
- 2007-10-18 KR KR1020097008200A patent/KR20090071612A/ko not_active Abandoned
- 2007-10-18 EP EP07844414A patent/EP2084162B1/en active Active
- 2007-10-18 AU AU2007309149A patent/AU2007309149C1/en not_active Ceased
- 2007-10-18 WO PCT/US2007/081841 patent/WO2008051808A2/en not_active Ceased
- 2007-10-18 US US12/442,566 patent/US8507489B2/en not_active Expired - Fee Related
- 2007-10-18 PT PT07844414T patent/PT2084162E/pt unknown
- 2007-10-18 JP JP2009533541A patent/JP5378222B2/ja not_active Expired - Fee Related
- 2007-10-18 CA CA002667428A patent/CA2667428A1/en not_active Abandoned
- 2007-10-18 MX MX2009004059A patent/MX2009004059A/es active IP Right Grant
- 2007-10-18 PL PL07844414T patent/PL2084162T3/pl unknown
- 2007-10-18 EA EA200970403A patent/EA200970403A1/ru unknown
- 2007-10-18 ES ES07844414T patent/ES2393130T3/es active Active
- 2007-10-18 BR BRPI0717320-2A2A patent/BRPI0717320A2/pt not_active IP Right Cessation
- 2007-10-18 NZ NZ575336A patent/NZ575336A/en not_active IP Right Cessation
- 2007-10-22 TW TW096139480A patent/TW200835492A/zh unknown
- 2007-10-23 PE PE2007001437A patent/PE20080893A1/es not_active Application Discontinuation
- 2007-10-23 AR ARP070104680A patent/AR063520A1/es not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL197958A patent/IL197958A0/en unknown
- 2009-04-15 TN TNP2009000142A patent/TN2009000142A1/fr unknown
- 2009-04-22 CO CO09040677A patent/CO6190620A2/es not_active Application Discontinuation
- 2009-04-23 SV SV2009003235A patent/SV2009003235A/es not_active Application Discontinuation
- 2009-04-23 NO NO20091618A patent/NO20091618L/no not_active Application Discontinuation
- 2009-05-07 MA MA31849A patent/MA30871B1/fr unknown
- 2009-05-19 CR CR10803A patent/CR10803A/es not_active Application Discontinuation
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