JP2010506844A5 - - Google Patents
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- Publication number
- JP2010506844A5 JP2010506844A5 JP2009532504A JP2009532504A JP2010506844A5 JP 2010506844 A5 JP2010506844 A5 JP 2010506844A5 JP 2009532504 A JP2009532504 A JP 2009532504A JP 2009532504 A JP2009532504 A JP 2009532504A JP 2010506844 A5 JP2010506844 A5 JP 2010506844A5
- Authority
- JP
- Japan
- Prior art keywords
- leu
- arg
- val
- glu
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MISPMPVBBRXIDJ-GKAPJAKFSA-N CC([C@H](CCCCNC=O)NC)O Chemical compound CC([C@H](CCCCNC=O)NC)O MISPMPVBBRXIDJ-GKAPJAKFSA-N 0.000 description 1
- 0 CCCCN(*C)I(C)O Chemical compound CCCCN(*C)I(C)O 0.000 description 1
- AJIJHIJNLPIHJQ-ZETCQYMHSA-N CCC[C@@H](C(C)=O)NC Chemical compound CCC[C@@H](C(C)=O)NC AJIJHIJNLPIHJQ-ZETCQYMHSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82938306P | 2006-10-13 | 2006-10-13 | |
| US60/829,383 | 2006-10-13 | ||
| PCT/US2007/080367 WO2008048784A1 (en) | 2006-10-13 | 2007-10-04 | Pegylated pth as pth receptor modulators and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010506844A JP2010506844A (ja) | 2010-03-04 |
| JP2010506844A5 true JP2010506844A5 (https=) | 2010-10-07 |
| JP5200027B2 JP5200027B2 (ja) | 2013-05-15 |
Family
ID=42828673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009532504A Expired - Fee Related JP5200027B2 (ja) | 2006-10-13 | 2007-10-04 | Ｐｔｈ受容体モジュレーターとしてのペグ化ｐｔｈおよびその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7820179B2 (https=) |
| EP (1) | EP2084183B1 (https=) |
| JP (1) | JP5200027B2 (https=) |
| KR (1) | KR101108354B1 (https=) |
| CN (1) | CN101522709B (https=) |
| AT (1) | ATE469173T1 (https=) |
| AU (1) | AU2007313001B2 (https=) |
| BR (1) | BRPI0719885B8 (https=) |
| CA (1) | CA2672907C (https=) |
| DK (1) | DK2084183T3 (https=) |
| EA (1) | EA014696B1 (https=) |
| MX (1) | MX2009003740A (https=) |
| NO (1) | NO341986B1 (https=) |
| PL (1) | PL2084183T3 (https=) |
| SI (1) | SI2084183T1 (https=) |
| WO (1) | WO2008048784A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| MX2018009938A (es) * | 2016-03-01 | 2019-03-14 | Ascendis Pharma Bone Diseases As | Profarmacos de hormona paratiroidea (pth). |
| EP3518961B1 (en) * | 2016-09-29 | 2023-02-22 | Ascendis Pharma Bone Diseases A/S | Pth compounds with low peak-to-trough ratios |
| MA46428B1 (fr) | 2016-09-29 | 2025-02-28 | Ascendis Pharma Bone Diseases A/S | Composés de pth à libération contrôlée |
| CN109789189B (zh) | 2016-09-29 | 2024-01-23 | 阿森迪斯药物骨疾病股份有限公司 | 控释pth化合物的剂量方案 |
| WO2019232285A1 (en) * | 2018-05-30 | 2019-12-05 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| CA3129357A1 (en) | 2019-02-11 | 2020-08-20 | Ascendis Pharma Bone Diseases A/S | Liquid pharmaceutical formulations of pth conjugates |
| EP4593867A2 (en) | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
| JPS6360940A (ja) | 1986-09-01 | 1988-03-17 | Toyo Jozo Co Ltd | 白内障の予防または治療剤 |
| US4771124A (en) * | 1987-05-26 | 1988-09-13 | Merck & Co., Inc. | Parathyroid hormone antagonists with simplified synthetic methodology |
| EP0293158A3 (en) | 1987-05-26 | 1990-05-09 | Merck & Co. Inc. | Parathyroid hormone antagonists |
| JPH0532696A (ja) * | 1990-09-28 | 1993-02-09 | Takeda Chem Ind Ltd | 副甲状腺ホルモン誘導体 |
| JPH05271279A (ja) * | 1991-08-07 | 1993-10-19 | Takeda Chem Ind Ltd | ヒト副甲状腺ホルモンムテインおよびその製造法 |
| US5814603A (en) * | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| CA2126299C (en) * | 1994-06-20 | 2000-12-12 | Gordon E. Willick | Parathyroid hormone analogues for the treatment of osteoporosis |
| US6110892A (en) * | 1994-06-20 | 2000-08-29 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| US5747456A (en) | 1994-12-19 | 1998-05-05 | Beth Israel Deaconess Medical Center | Continuous low-dose administration of parathyroid hormone or its agonist |
| US5717062A (en) | 1995-06-07 | 1998-02-10 | Beth Israel Hospital Association | Cyclic analogs of PTH and PTHrP |
| CA2178894A1 (en) | 1995-06-15 | 1996-12-16 | Tsunehiko Fukuda | Parathyroid hormone derivatives and their use |
| US5955574A (en) * | 1995-07-13 | 1999-09-21 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. | Analogs of parathyroid hormone |
| US5723577A (en) | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
| US6544949B1 (en) * | 1995-07-13 | 2003-04-08 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Analogs of parathyroid hormone |
| DK0915911T3 (da) | 1996-08-02 | 2004-03-08 | Ca Nat Research Council | Analoger til parathyreoideahormon til behandling af osteoporose |
| SK151599A3 (en) * | 1997-05-14 | 2000-09-12 | Rhone Poulenc Rorer Pharma | Peptide parathyroid hormone analogs |
| EP1030658A1 (en) * | 1997-10-14 | 2000-08-30 | Eli Lilly And Company | Method of building and maintaining bone |
| JP4394279B2 (ja) | 1998-03-09 | 2010-01-06 | ジーランド ファーマ アクティーゼルスカブ | 酵素加水分解に対する傾向が減少した薬理学的に活性なペプチド複合体 |
| HUP0101629A2 (en) * | 1998-04-15 | 2003-03-28 | Aventis Pharma Inc | Process for the preparation of resin-bound cyclic peptides |
| HUP0300891A2 (hu) | 1998-05-05 | 2003-07-28 | Beth Israel Deaconess Medical Center, Inc. | PTH2 receptor szelektív vegyületek és alkalmazásuk gyógyszerkészítmények előállÍtására |
| US6316410B1 (en) * | 1999-09-22 | 2001-11-13 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| AU7734800A (en) | 1999-09-29 | 2001-04-30 | General Hospital Corporation, The | Polypeptide derivatives of parathyroid hormone (pth) |
| US7022815B1 (en) * | 1999-09-29 | 2006-04-04 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (PTH) |
| US20050124537A1 (en) * | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| CA2454275C (en) * | 2001-07-23 | 2012-10-23 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
| JPWO2003064462A1 (ja) * | 2002-02-01 | 2005-05-26 | 中外製薬株式会社 | Ｐｅｇ結合ｐｔｈ又はｐｅｇ結合ｐｔｈ誘導体 |
| EP1551438A2 (en) | 2002-06-13 | 2005-07-13 | Beth Israel Deaconess Medical Center, Inc. | Analogs of parathyroid hormone and pth-related protein as bone anabolic agents |
| TW533925U (en) * | 2002-09-26 | 2003-05-21 | Lee Yeong Ind Co Ltd | Improvement of speed-changing transmission mechanism for cutting tools of drill sharpening machine |
| EP1567178A4 (en) | 2002-11-01 | 2009-07-15 | Amgen Inc | MODULATORS OF RECEPTORS FOR NEUTRAL THERAPY HORMONE AND SIDE-HORSE HORMONE-RELATED PROTEINS |
| WO2004060965A2 (en) | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| JPWO2004084918A1 (ja) * | 2003-03-25 | 2006-06-29 | 積水化学工業株式会社 | 皮膚止痒外用組成物 |
| US20040220094A1 (en) * | 2003-05-01 | 2004-11-04 | Skinner Keith K. | Inverse agonist and agonist peptides that stimulate/inhibit hair growth |
| US20050215476A1 (en) | 2004-01-21 | 2005-09-29 | Unigene Laboratories Inc. | Amidated parathyroid hormone fragments and uses thereof |
-
2007
- 2007-10-04 AU AU2007313001A patent/AU2007313001B2/en not_active Ceased
- 2007-10-04 WO PCT/US2007/080367 patent/WO2008048784A1/en not_active Ceased
- 2007-10-04 CA CA2672907A patent/CA2672907C/en not_active Expired - Fee Related
- 2007-10-04 PL PL07843791T patent/PL2084183T3/pl unknown
- 2007-10-04 SI SI200730296T patent/SI2084183T1/sl unknown
- 2007-10-04 EA EA200970376A patent/EA014696B1/ru not_active IP Right Cessation
- 2007-10-04 JP JP2009532504A patent/JP5200027B2/ja not_active Expired - Fee Related
- 2007-10-04 US US12/440,619 patent/US7820179B2/en not_active Expired - Fee Related
- 2007-10-04 MX MX2009003740A patent/MX2009003740A/es active IP Right Grant
- 2007-10-04 BR BRPI0719885A patent/BRPI0719885B8/pt not_active IP Right Cessation
- 2007-10-04 AT AT07843791T patent/ATE469173T1/de active
- 2007-10-04 DK DK07843791.0T patent/DK2084183T3/da active
- 2007-10-04 EP EP07843791A patent/EP2084183B1/en active Active
- 2007-10-04 KR KR1020097007424A patent/KR101108354B1/ko not_active Expired - Fee Related
- 2007-10-04 CN CN2007800382095A patent/CN101522709B/zh not_active Expired - Fee Related
-
2009
- 2009-04-28 NO NO20091691A patent/NO341986B1/no not_active IP Right Cessation
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