JP2012528887A5 - - Google Patents
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- Publication number
- JP2012528887A5 JP2012528887A5 JP2012514171A JP2012514171A JP2012528887A5 JP 2012528887 A5 JP2012528887 A5 JP 2012528887A5 JP 2012514171 A JP2012514171 A JP 2012514171A JP 2012514171 A JP2012514171 A JP 2012514171A JP 2012528887 A5 JP2012528887 A5 JP 2012528887A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- pharmaceutical composition
- joint
- subject
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 150000001413 amino acids Chemical class 0.000 claims 26
- 210000000988 bone and bone Anatomy 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 230000007547 defect Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000037396 body weight Effects 0.000 claims 3
- 210000001185 bone marrow Anatomy 0.000 claims 3
- 239000007943 implant Substances 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 230000037221 weight management Effects 0.000 claims 3
- 208000006386 Bone Resorption Diseases 0.000 claims 2
- 229940078581 Bone resorption inhibitor Drugs 0.000 claims 2
- 210000000544 articulatio talocruralis Anatomy 0.000 claims 2
- 230000010256 bone deposition Effects 0.000 claims 2
- 230000024279 bone resorption Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000007850 degeneration Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000002310 elbow joint Anatomy 0.000 claims 2
- 210000004394 hip joint Anatomy 0.000 claims 2
- 210000000629 knee joint Anatomy 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 230000035800 maturation Effects 0.000 claims 2
- 230000011164 ossification Effects 0.000 claims 2
- 210000003131 sacroiliac joint Anatomy 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 210000000323 shoulder joint Anatomy 0.000 claims 2
- 210000004341 tarsal joint Anatomy 0.000 claims 2
- 230000004580 weight loss Effects 0.000 claims 2
- 210000003857 wrist joint Anatomy 0.000 claims 2
- 208000032467 Aplastic anaemia Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 206010013883 Dwarfism Diseases 0.000 claims 1
- 229940086609 Lipase inhibitor Drugs 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 230000001773 anti-convulsant effect Effects 0.000 claims 1
- 230000001430 anti-depressive effect Effects 0.000 claims 1
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 229940005513 antidepressants Drugs 0.000 claims 1
- 229960003965 antiepileptics Drugs 0.000 claims 1
- 239000002830 appetite depressant Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000004053 dental implant Substances 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18420909P | 2009-06-04 | 2009-06-04 | |
| US61/184,209 | 2009-06-04 | ||
| PCT/US2010/037390 WO2010141811A2 (en) | 2009-06-04 | 2010-06-04 | Compounds and methods for treating bone disorders and controlling weight |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253422A Division JP2016106098A (ja) | 2009-06-04 | 2015-12-25 | 骨障害を治療するための、および、体重を管理するための化合物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012528887A JP2012528887A (ja) | 2012-11-15 |
| JP2012528887A5 true JP2012528887A5 (https=) | 2013-07-25 |
| JP5906183B2 JP5906183B2 (ja) | 2016-04-20 |
Family
ID=43298544
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514171A Expired - Fee Related JP5906183B2 (ja) | 2009-06-04 | 2010-06-04 | 骨障害を治療するための、および、体重を管理するための化合物および方法 |
| JP2015253422A Pending JP2016106098A (ja) | 2009-06-04 | 2015-12-25 | 骨障害を治療するための、および、体重を管理するための化合物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253422A Pending JP2016106098A (ja) | 2009-06-04 | 2015-12-25 | 骨障害を治療するための、および、体重を管理するための化合物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9220746B2 (https=) |
| EP (1) | EP2437768B1 (https=) |
| JP (2) | JP5906183B2 (https=) |
| ES (1) | ES2602629T3 (https=) |
| WO (1) | WO2010141811A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100183212A1 (en) * | 2009-01-08 | 2010-07-22 | Numira Biosciences, Inc. | Methods and compositions for imaging cartilage and bone |
| US9220746B2 (en) * | 2009-06-04 | 2015-12-29 | The University Of North Carolina At Chapel Hill | Compounds and methods for treating bone disorders and controlling weight |
| US20160039897A1 (en) * | 2013-03-12 | 2016-02-11 | The University Of North Carolina At Chapel Hill | Compounds and methods for treating obesity and controlling weight |
| US20190352358A1 (en) * | 2017-02-06 | 2019-11-21 | Alize Pharma Iii Sas | Compounds, compositions and uses thereof for improvement of bone disorders |
| CN112566653A (zh) * | 2018-05-24 | 2021-03-26 | 阿莫利特制药公司 | Igfbp-2的肝素结合域在治疗代谢紊乱中的作用 |
| US20210009639A1 (en) | 2019-07-12 | 2021-01-14 | Northwestern University | Insulin like growth factor binding protein bioactive peptide fragments |
| CN114634552B (zh) * | 2022-04-14 | 2022-12-13 | 中国农业大学 | 一种抗肥胖十三肽及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| DE69835878T2 (de) * | 1997-05-05 | 2007-04-26 | Mayo Foundation For Medical Education And Research, Rochester | IGFIIE/ IGFBP2 Komplex |
| DE19757250A1 (de) * | 1997-12-22 | 1999-07-01 | Forssmann Wolf Georg Prof Dr | Insulin-like growth factor binding protein und seine Verwendung |
| AU2001266787A1 (en) | 2000-06-07 | 2002-01-08 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| US7504374B2 (en) | 2000-10-24 | 2009-03-17 | Warsaw Orthopedic, Inc. | Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2 |
| US20080227125A1 (en) | 2003-07-15 | 2008-09-18 | Guilaine Argoud-Puy | Secreted Polypeptide Species Reduced in Cardiovascular Disorders |
| EP1799250A2 (en) | 2004-09-27 | 2007-06-27 | Höflich, Andreas | Use of igfbp-2 in senescence diseases and for the maintenance of organ functions |
| AU2006228989B2 (en) | 2005-03-30 | 2012-06-14 | Murdoch Childrens Research Institute | Methods and agents for modulating cellular activity |
| EP2462945B1 (en) * | 2006-08-16 | 2014-06-04 | National Research Council of Canada | Method of inhibiting angiogenesis, tumorigenesis and cathepsin activity |
| WO2009019254A1 (en) * | 2007-08-03 | 2009-02-12 | Pharis Biotec Gmbh | Igfbp-2 c-terminal fragments and uses thereof |
| JP2011502484A (ja) | 2007-11-01 | 2011-01-27 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | Ｈｌａ−ｄｒ結合性ペプチドおよびそれらの使用 |
| US9220746B2 (en) * | 2009-06-04 | 2015-12-29 | The University Of North Carolina At Chapel Hill | Compounds and methods for treating bone disorders and controlling weight |
-
2010
- 2010-06-04 US US13/375,562 patent/US9220746B2/en not_active Expired - Fee Related
- 2010-06-04 EP EP10784143.9A patent/EP2437768B1/en active Active
- 2010-06-04 JP JP2012514171A patent/JP5906183B2/ja not_active Expired - Fee Related
- 2010-06-04 ES ES10784143.9T patent/ES2602629T3/es active Active
- 2010-06-04 WO PCT/US2010/037390 patent/WO2010141811A2/en not_active Ceased
-
2015
- 2015-12-25 JP JP2015253422A patent/JP2016106098A/ja active Pending
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