ES2602629T3 - Compuestos y métodos para tratar trastornos de los huesos y controlar el peso - Google Patents

Compuestos y métodos para tratar trastornos de los huesos y controlar el peso Download PDF

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Publication number
ES2602629T3
ES2602629T3 ES10784143.9T ES10784143T ES2602629T3 ES 2602629 T3 ES2602629 T3 ES 2602629T3 ES 10784143 T ES10784143 T ES 10784143T ES 2602629 T3 ES2602629 T3 ES 2602629T3
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Spain
Prior art keywords
bone
peptide
hbd
igfbp
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10784143.9T
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English (en)
Spanish (es)
Inventor
David R. Clemmons
Clifford J. Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Maine Medical Center
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University of North Carolina at Chapel Hill
Maine Medical Center
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Application filed by University of North Carolina at Chapel Hill, Maine Medical Center filed Critical University of North Carolina at Chapel Hill
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Publication of ES2602629T3 publication Critical patent/ES2602629T3/es
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES10784143.9T 2009-06-04 2010-06-04 Compuestos y métodos para tratar trastornos de los huesos y controlar el peso Active ES2602629T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18420909P 2009-06-04 2009-06-04
US184209P 2009-06-04
PCT/US2010/037390 WO2010141811A2 (en) 2009-06-04 2010-06-04 Compounds and methods for treating bone disorders and controlling weight

Publications (1)

Publication Number Publication Date
ES2602629T3 true ES2602629T3 (es) 2017-02-21

Family

ID=43298544

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10784143.9T Active ES2602629T3 (es) 2009-06-04 2010-06-04 Compuestos y métodos para tratar trastornos de los huesos y controlar el peso

Country Status (5)

Country Link
US (1) US9220746B2 (https=)
EP (1) EP2437768B1 (https=)
JP (2) JP5906183B2 (https=)
ES (1) ES2602629T3 (https=)
WO (1) WO2010141811A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100183212A1 (en) * 2009-01-08 2010-07-22 Numira Biosciences, Inc. Methods and compositions for imaging cartilage and bone
US9220746B2 (en) * 2009-06-04 2015-12-29 The University Of North Carolina At Chapel Hill Compounds and methods for treating bone disorders and controlling weight
US20160039897A1 (en) * 2013-03-12 2016-02-11 The University Of North Carolina At Chapel Hill Compounds and methods for treating obesity and controlling weight
US20190352358A1 (en) * 2017-02-06 2019-11-21 Alize Pharma Iii Sas Compounds, compositions and uses thereof for improvement of bone disorders
CN112566653A (zh) * 2018-05-24 2021-03-26 阿莫利特制药公司 Igfbp-2的肝素结合域在治疗代谢紊乱中的作用
US20210009639A1 (en) 2019-07-12 2021-01-14 Northwestern University Insulin like growth factor binding protein bioactive peptide fragments
CN114634552B (zh) * 2022-04-14 2022-12-13 中国农业大学 一种抗肥胖十三肽及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
DE69835878T2 (de) * 1997-05-05 2007-04-26 Mayo Foundation For Medical Education And Research, Rochester IGFIIE/ IGFBP2 Komplex
DE19757250A1 (de) * 1997-12-22 1999-07-01 Forssmann Wolf Georg Prof Dr Insulin-like growth factor binding protein und seine Verwendung
AU2001266787A1 (en) 2000-06-07 2002-01-08 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US7504374B2 (en) 2000-10-24 2009-03-17 Warsaw Orthopedic, Inc. Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2
US20080227125A1 (en) 2003-07-15 2008-09-18 Guilaine Argoud-Puy Secreted Polypeptide Species Reduced in Cardiovascular Disorders
EP1799250A2 (en) 2004-09-27 2007-06-27 Höflich, Andreas Use of igfbp-2 in senescence diseases and for the maintenance of organ functions
AU2006228989B2 (en) 2005-03-30 2012-06-14 Murdoch Childrens Research Institute Methods and agents for modulating cellular activity
EP2462945B1 (en) * 2006-08-16 2014-06-04 National Research Council of Canada Method of inhibiting angiogenesis, tumorigenesis and cathepsin activity
WO2009019254A1 (en) * 2007-08-03 2009-02-12 Pharis Biotec Gmbh Igfbp-2 c-terminal fragments and uses thereof
JP2011502484A (ja) 2007-11-01 2011-01-27 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ Hla−dr結合性ペプチドおよびそれらの使用
US9220746B2 (en) * 2009-06-04 2015-12-29 The University Of North Carolina At Chapel Hill Compounds and methods for treating bone disorders and controlling weight

Also Published As

Publication number Publication date
WO2010141811A3 (en) 2011-01-27
JP5906183B2 (ja) 2016-04-20
US9220746B2 (en) 2015-12-29
JP2016106098A (ja) 2016-06-16
EP2437768B1 (en) 2016-08-10
EP2437768A4 (en) 2013-03-06
JP2012528887A (ja) 2012-11-15
EP2437768A2 (en) 2012-04-11
US20120149634A1 (en) 2012-06-14
WO2010141811A2 (en) 2010-12-09

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