JP2010505958A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010505958A5 JP2010505958A5 JP2009532414A JP2009532414A JP2010505958A5 JP 2010505958 A5 JP2010505958 A5 JP 2010505958A5 JP 2009532414 A JP2009532414 A JP 2009532414A JP 2009532414 A JP2009532414 A JP 2009532414A JP 2010505958 A5 JP2010505958 A5 JP 2010505958A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- group
- absent
- composition according
- disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 208000012902 Nervous system disease Diseases 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical class CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- -1 X 22 Chemical compound 0.000 claims 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 208000012661 Dyskinesia Diseases 0.000 claims 2
- 208000010496 Heart Arrest Diseases 0.000 claims 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000005018 aryl alkenyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- QRYRORQUOLYVBU-VBKZILBWSA-N carnosic acid Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 230000003111 delayed effect Effects 0.000 claims 2
- ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 230000002218 hypoglycaemic effect Effects 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 206010048962 Brain oedema Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010013754 Drug withdrawal syndrome Diseases 0.000 claims 1
- 208000020564 Eye injury Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000033892 Hyperhomocysteinemia Diseases 0.000 claims 1
- 208000013016 Hypoglycemia Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000007101 Muscle Cramp Diseases 0.000 claims 1
- 208000037212 Neonatal hypoxic and ischemic brain injury Diseases 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000027089 Parkinsonian disease Diseases 0.000 claims 1
- 206010034010 Parkinsonism Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 208000005392 Spasm Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000008499 blood brain barrier function Effects 0.000 claims 1
- 210000001218 blood-brain barrier Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000006752 brain edema Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 230000003225 hyperhomocysteinemia Effects 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 201000011475 meningoencephalitis Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 231100000878 neurological injury Toxicity 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 229940127240 opiate Drugs 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 208000005877 painful neuropathy Diseases 0.000 claims 1
- 208000033300 perinatal asphyxia Diseases 0.000 claims 1
- 208000032253 retinal ischemia Diseases 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
- 0 *C(*)c1cc(C(*)C(*[I+])C2C3(*)CCCC2(*)*)c3c(O)c1O Chemical compound *C(*)c1cc(C(*)C(*[I+])C2C3(*)CCCC2(*)*)c3c(O)c1O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85091806P | 2006-10-10 | 2006-10-10 | |
| US85086006P | 2006-10-10 | 2006-10-10 | |
| PCT/US2007/021748 WO2008108825A2 (en) | 2006-10-10 | 2007-10-10 | Neuroprotective compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010505958A JP2010505958A (ja) | 2010-02-25 |
| JP2010505958A5 true JP2010505958A5 (https=) | 2010-11-25 |
Family
ID=39738942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009532414A Pending JP2010505958A (ja) | 2006-10-10 | 2007-10-10 | 神経防護作用組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8022246B2 (https=) |
| EP (1) | EP2086318A4 (https=) |
| JP (1) | JP2010505958A (https=) |
| CA (1) | CA2666461A1 (https=) |
| WO (1) | WO2008108825A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008095297A1 (en) | 2007-02-06 | 2008-08-14 | Origin Biomed Inc. | Composition comprising terpene compounds and methods for inhibiting nerve transmission |
| CA2732784C (en) | 2008-08-13 | 2018-09-18 | Neuroquest Inc. | Compositions comprising terpene compounds for treating negative sensory phenomena |
| MX363223B (es) | 2008-09-10 | 2019-03-15 | Bioelectron Tech Corp | Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox. |
| GB2464813A (en) * | 2009-10-23 | 2010-05-05 | Univ Sheffield | Treatments for neurodegenerative disorders |
| WO2011160206A1 (en) | 2010-06-23 | 2011-12-29 | Morin Ryan D | Biomarkers for non-hodgkin lymphomas and uses thereof |
| BR112013005806B1 (pt) | 2010-09-10 | 2022-05-10 | Epizyme, Inc | Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2 |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| CN103153297A (zh) * | 2010-09-14 | 2013-06-12 | 安元有限公司 | 类萜类似物及其用于治疗神经病症的用途 |
| WO2012094580A2 (en) | 2011-01-07 | 2012-07-12 | High Point Pharmaceuticals, Llc | Compounds that modulate oxidative stress |
| JO3363B1 (ar) | 2011-04-13 | 2019-03-13 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| TW201733984A (zh) | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
| US20140256767A1 (en) | 2011-10-31 | 2014-09-11 | The Broad Institute, Inc. | Direct inhibitors of keap1-nrf2 interaction as antioxidant inflammation modulators |
| CN104220056B (zh) * | 2012-03-30 | 2017-11-03 | 雀巢产品技术援助有限公司 | 4‑氧代‑2‑戊烯酸和脑健康 |
| US9394283B2 (en) | 2012-04-13 | 2016-07-19 | Epizyme, Inc. | Salt form of a human histone methyltransferase EZH2 inhibitor |
| PE20150887A1 (es) | 2012-10-15 | 2015-06-04 | Epizyme Inc | Compuestos de benceno sustituidos |
| WO2014093918A1 (en) | 2012-12-13 | 2014-06-19 | Warsaw Orthopedic, Inc. | Compositions and methods comprising polyethylene glycol and magnesium for treatment of neuronal injury |
| JP6422452B2 (ja) | 2013-03-14 | 2018-11-14 | ユニバーシティ オブ マカオＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｃａｕ | ヤクチ（益智（ａｌｐｉｎｉａｅｏｘｙｐｈｙｌｌａｅｆｒｕｃｔｕｓ））およびその全合成から単離される新規な抗神経変性天然化合物 |
| KR102142177B1 (ko) | 2013-10-16 | 2020-08-07 | 에피자임, 인코포레이티드 | Ezh2 억제용 하이드로클로라이드 염 형태 |
| EP3202400A4 (en) * | 2015-04-30 | 2018-06-13 | Institute Of Microbiology, Chinese Academy Of Sciences | Aromatic farnesyl compound and application thereof |
| US10123991B2 (en) | 2015-05-15 | 2018-11-13 | Global Biolife Inc. | Electrophilically enhanced phenolic compounds for treating inflammatory related diseases and disorders |
| EP3106160B8 (en) | 2015-06-15 | 2019-12-11 | Neuralia | Combination composition comprising huperzine |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| HUE065501T2 (hu) | 2018-08-20 | 2024-05-28 | Janssen Pharmaceutica Nv | A KEAP1-NRF2 protein-protein kölcsönhatás inhibitorok |
| CN111166885B (zh) * | 2020-01-16 | 2022-03-15 | 上海交通大学医学院 | 神经保护剂及其用途 |
| CN114588143B (zh) * | 2020-12-03 | 2023-06-06 | 中国科学院大连化学物理研究所 | 药物组合物及化合物作为或在制备阿片受体拮抗剂中的应用 |
| WO2023055733A1 (en) * | 2021-09-30 | 2023-04-06 | The Scripps Research Institute | Compounds for reducing neuroinflammation |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3976782A (en) * | 1975-03-25 | 1976-08-24 | Merck & Co., Inc. | 3-(2,5-Dihydroxyphenyl)-alanine as a cardiac stimulant |
| US4938949A (en) * | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5192817A (en) * | 1990-03-06 | 1993-03-09 | Otsuka Pharmaceutical Co., Ltd. | Phenanthrene derivatives |
| DK0582318T3 (da) * | 1990-10-06 | 2000-03-20 | Nestle Sa | Udnyttelse af de anticarcinogene og antivirale egenskaber hos carnosinsyre |
| WO1996034534A1 (en) * | 1995-05-05 | 1996-11-07 | Hauser Inc. | High purity carnosic acid from rosemary and sage extracts by ph-controlled precipitation |
| DE69726612T2 (de) * | 1997-04-16 | 2004-09-16 | Lycored Natural Products Industies Ltd. | Ein neues verfahren zur herstellung von stabilisierter carnosinsäure in hoher kontentration |
| JP2001233835A (ja) * | 2000-02-28 | 2001-08-28 | Nagase & Co Ltd | カルノジン酸誘導体およびそれを用いた神経成長因子合成促進剤 |
| WO2002002190A2 (en) * | 2000-07-05 | 2002-01-10 | Johns Hopkins School Of Medicine | Prevention and treatment of neurodegenerative diseases by glutathione and phase ii detoxification enzymes |
| AU2003231527A1 (en) * | 2002-04-09 | 2003-10-27 | Kemin Industries, Inc. | Novel derivatives of carnosic acid |
| GB0216371D0 (en) * | 2002-07-13 | 2002-08-21 | Rowett Res Inst The | Compounds |
| AU2003298020A1 (en) * | 2002-11-26 | 2004-06-18 | Florida Atlantic University | Catalytic antioxidants and methods of use |
| US20040224995A1 (en) * | 2003-05-09 | 2004-11-11 | University Of North Texas Health Science Center At Fort Worth | Neuroprotective effects of PPARy agonists against cellular oxidative insults |
| MXPA06006980A (es) * | 2003-12-22 | 2006-12-14 | Alcon Inc | Agentes para tratamiento de retinopatia glaucomatosa y neuropatia optica. |
| MX2008004981A (es) * | 2005-10-16 | 2008-10-17 | Lycored Ltd | Composiciones para el tratamiento de enfermedades de los ojos. |
-
2007
- 2007-10-10 US US11/974,114 patent/US8022246B2/en not_active Expired - Fee Related
- 2007-10-10 EP EP07873874A patent/EP2086318A4/en not_active Withdrawn
- 2007-10-10 JP JP2009532414A patent/JP2010505958A/ja active Pending
- 2007-10-10 CA CA002666461A patent/CA2666461A1/en not_active Abandoned
- 2007-10-10 WO PCT/US2007/021748 patent/WO2008108825A2/en not_active Ceased
-
2011
- 2011-09-19 US US13/236,579 patent/US8466311B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010505958A5 (https=) | ||
| JP2007523168A5 (https=) | ||
| JP2013523846A5 (https=) | ||
| JP2022515293A5 (https=) | ||
| JP2013526544A5 (https=) | ||
| JP2018518537A5 (https=) | ||
| JP2013545730A5 (https=) | ||
| RU2014151622A (ru) | Композиции и способы лечения нейродегенеративных заболеваний | |
| JP2014507455A5 (https=) | ||
| JP2007500757A5 (https=) | ||
| JP2022533311A5 (https=) | ||
| JP2009504748A5 (https=) | ||
| BR112014009927A2 (pt) | "derivado de azol, composição farmacêutica que o compreende e uso do mesmo" | |
| JP2013519675A5 (https=) | ||
| JP2014526508A5 (https=) | ||
| JP6628252B2 (ja) | 虚血性眼疾患の処置用の医薬組成物 | |
| MX2018012442A (es) | Profarmaco de derivado de aminoacido. | |
| JP2004536111A5 (https=) | ||
| JP2022518003A (ja) | ケタミンパモエート及びその使用 | |
| JP2013544245A5 (ja) | ネプリライシンの発現および活性を増大させるための医薬組成物 | |
| JPWO2014129495A1 (ja) | 眼疾患処置薬 | |
| NZ702237A (en) | Prodrug of fluorine-containing amino acid | |
| JP2016537432A5 (https=) | ||
| CA2407345A1 (en) | 4-benzyl-1-[2-(4-hydroxy-phenoxy)-ethyl]-piperidine-3,4-diol | |
| RU2013153140A (ru) | Новая ассоциация между 4-{3-[цис-гексагидроциклопента[c] пиррол-2 (1н )- ил] пропокси} бензамидом и ингибитором ацетилхолинэстеразы и фармацевтические композиции, которые ее содержат |