JP2007500757A5 - - Google Patents
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- Publication number
- JP2007500757A5 JP2007500757A5 JP2006533806A JP2006533806A JP2007500757A5 JP 2007500757 A5 JP2007500757 A5 JP 2007500757A5 JP 2006533806 A JP2006533806 A JP 2006533806A JP 2006533806 A JP2006533806 A JP 2006533806A JP 2007500757 A5 JP2007500757 A5 JP 2007500757A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- spinal cord
- recovery
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 238000011084 recovery Methods 0.000 claims 8
- 230000004770 neurodegeneration Effects 0.000 claims 6
- 210000005036 nerve Anatomy 0.000 claims 5
- 208000015122 neurodegenerative disease Diseases 0.000 claims 5
- 230000008929 regeneration Effects 0.000 claims 5
- 238000011069 regeneration method Methods 0.000 claims 5
- 208000032382 Ischaemic stroke Diseases 0.000 claims 4
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 4
- 208000020431 spinal cord injury Diseases 0.000 claims 4
- 230000009529 traumatic brain injury Effects 0.000 claims 4
- 230000001149 cognitive effect Effects 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000036982 Spinal cord ischaemia Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 210000003792 cranial nerve Anatomy 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 230000008449 language Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 230000008447 perception Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000037152 sensory function Effects 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47873503P | 2003-06-12 | 2003-06-12 | |
| US47832903P | 2003-06-12 | 2003-06-12 | |
| US60/478,329 | 2003-06-12 | ||
| US60/478,735 | 2003-06-12 | ||
| US49813203P | 2003-08-26 | 2003-08-26 | |
| US60/498,132 | 2003-08-26 | ||
| US55261304P | 2004-03-12 | 2004-03-12 | |
| US60/552,613 | 2004-03-12 | ||
| PCT/US2004/019139 WO2004110387A2 (en) | 2003-06-12 | 2004-06-14 | Sigma ligands for neuronal regeneration and functional recovery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007500757A JP2007500757A (ja) | 2007-01-18 |
| JP2007500757A5 true JP2007500757A5 (https=) | 2007-07-26 |
| JP4963607B2 JP4963607B2 (ja) | 2012-06-27 |
Family
ID=33556648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533806A Expired - Fee Related JP4963607B2 (ja) | 2003-06-12 | 2004-06-14 | 神経再生及び機能回復のためのシグマリガンド |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20050032827A1 (https=) |
| EP (2) | EP1644026A4 (https=) |
| JP (1) | JP4963607B2 (https=) |
| CA (1) | CA2528160C (https=) |
| WO (3) | WO2004110387A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003061658A1 (en) * | 2002-01-22 | 2003-07-31 | Eisai Co., Ltd. | Sigma receptor binder containing indanone derivative |
| US20050032827A1 (en) * | 2003-06-12 | 2005-02-10 | Donna Oksenberg | Sigma ligands for neuronal regeneration and functional recovery |
| US20060052386A1 (en) * | 2003-06-12 | 2006-03-09 | Tadeusz Wieloch | Sigma ligands for neuronal regeneration and functional recovery |
| US8299062B2 (en) * | 2003-09-17 | 2012-10-30 | Franklin Volvovitz | Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction |
| US20060106064A1 (en) * | 2004-11-03 | 2006-05-18 | University Of North Texas Health Science Center At Fort Worth | Butyrophenones and sigma-1 receptor antagonists protect against oxidative-stress |
| CA2607598A1 (en) * | 2005-06-06 | 2006-12-14 | University Of South Florida | Treatment with sigma receptor agonists post-stroke |
| EP1787679A1 (en) * | 2005-07-29 | 2007-05-23 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain |
| US7985751B2 (en) | 2005-08-09 | 2011-07-26 | M's Science Corporation | Piperazine derivatives |
| US7758954B2 (en) * | 2005-08-18 | 2010-07-20 | James Hardie Technology Limited | Coated substrate having one or more cross-linked interfacial zones |
| US20070142396A1 (en) * | 2005-12-16 | 2007-06-21 | Vela Pharmaceuticals, Inc. | Treatment of pain with 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2(1H)-quinolone or salt thereof |
| WO2007081946A2 (en) * | 2006-01-09 | 2007-07-19 | University Of South Florida | Method for the identification of drugs to treat stroke at delayed timepoints |
| NZ570078A (en) | 2006-01-27 | 2011-10-28 | Ms Science Corp | Piperidine and piperazine derivatives |
| AU2009217031B2 (en) * | 2008-02-18 | 2013-12-19 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor ligands for the treatment of neuropathic pain developing as a consequence of chemotherapy |
| CN101970427A (zh) | 2008-02-29 | 2011-02-09 | Vm生物医药公司 | 治疗疼痛症状及其它失调的方法 |
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| WO2010048164A2 (en) * | 2008-10-20 | 2010-04-29 | University Of South Florida | N,n'-di-p-bromophenyl guanidine treatment for stroke at delayed timepoints |
| AU2009310926A1 (en) * | 2008-10-27 | 2010-05-06 | M's Science Corporation | Cyclohexylamine derivative containing phenyl group, and therapeutic agent for diseases accompanied by central nervous system disorders |
| SG10201404913QA (en) | 2009-04-09 | 2014-11-27 | Cognition Therapeutics Inc | Inhibitors of cognitive decline |
| RU2012107457A (ru) | 2009-07-31 | 2013-09-10 | Когнишн Терапьютикс, Инк. | Ингибиторы ухудшения когнитивных способностей |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| WO2011130347A2 (en) * | 2010-04-13 | 2011-10-20 | The Johns Hopkins University | Methods for enhancing axonal regeneration |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| CA2846611A1 (en) * | 2011-08-25 | 2013-02-28 | Cognition Therapeutics, Inc. | Compositions and methods for treating neurodegenerative disease |
| KR101129303B1 (ko) * | 2011-10-19 | 2012-03-26 | 경희대학교 산학협력단 | 플루옥세틴을 유효성분으로 함유하는 중추신경계 질환의 예방 및 치료용 약학적 조성물 |
| WO2013166307A2 (en) * | 2012-05-02 | 2013-11-07 | University Of South Florida | N,n'-di-1 naphthylguanidine hcl (nagh) and n,n'-di-p-nitrophenylguanidine hcl (nad) treatment for stroke at delayed timepoints |
| CN104519891B (zh) | 2012-05-16 | 2019-03-22 | 桑比欧公司 | 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 |
| TW201607538A (zh) | 2013-12-17 | 2016-03-01 | 以斯提夫博士實驗室股份有限公司 | 血清素－去甲腎上腺素再攝取抑制劑（ＳＮＲＩＳ）和σ受體配體組合物 |
| DK3099296T3 (en) | 2014-01-31 | 2019-04-15 | Cognition Therapeutics Inc | ISO-INDOLINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE |
| EP3364976B1 (en) * | 2015-10-19 | 2026-03-18 | Board of Regents, The University of Texas System | Piperazinyl norbenzomorphan compounds and methods for using the same |
| US11129801B2 (en) * | 2016-02-11 | 2021-09-28 | Sigmathera Sas | Igmesine for use in the treatment of neurodegenerative diseases |
| AU2017257153A1 (en) | 2016-04-29 | 2018-11-22 | Board Of Regents, The University Of Texas System | Sigma receptor binders |
| EP3634394B1 (en) | 2017-05-15 | 2025-12-24 | Cognition Therapeutics, Inc. | Compositions for treating neurodegenerative diseases |
| EP3684463B1 (en) | 2017-09-19 | 2025-05-14 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US11478603B2 (en) | 2017-12-31 | 2022-10-25 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| WO2020047185A1 (en) * | 2018-08-31 | 2020-03-05 | Texas Tech University System | Enhancers of neurolysin activity |
| CN113382683A (zh) | 2018-09-14 | 2021-09-10 | 纽罗因恒思蒙特实验有限责任公司 | 改善睡眠的系统和方法 |
| CN111848549B (zh) * | 2019-04-29 | 2022-04-22 | 苏州大学 | 芳基肟类化合物及其制备和应用 |
| WO2022125925A1 (en) * | 2020-12-11 | 2022-06-16 | Cognition Therapeutics, Inc. | Compositions for treating dry age-related macular degeneration (amd) |
| CN117979972A (zh) * | 2021-09-20 | 2024-05-03 | 埃斯特韦制药股份公司 | 用于治疗运动神经元退化或神经保护的氧杂二氮杂螺化合物 |
| US20250134902A1 (en) * | 2022-02-09 | 2025-05-01 | Univesrity Of North Texas Health Science Center | Drug repurposing for delayed treatment of ischemic stroke |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5055470A (en) | 1989-06-01 | 1991-10-08 | Bristol-Myers Squibb Co. | Method of treatment of ischemia in brain |
| US5109002A (en) | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
| US5005470A (en) * | 1989-11-09 | 1991-04-09 | Denker James G | Portable work station |
| US5229394A (en) | 1990-07-30 | 1993-07-20 | Arch Development Corporation | Method for treatment of amyotrophic lateral sclerosis comprising administration of dmp |
| NZ243065A (en) | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| WO1993009094A1 (en) | 1991-10-30 | 1993-05-13 | The Du Pont Merck Pharmaceutical Company | Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents |
| US5428037A (en) | 1993-04-09 | 1995-06-27 | Syntex Pharmaceuticals, Ltd. | Heterocyclic derivatives in the treatment of Ischaemia and related diseases |
| CA2166100A1 (en) * | 1993-06-23 | 1995-01-05 | Richard A. Glennon | Sigma receptor ligands and the use thereof |
| EP0711763B1 (en) * | 1993-07-28 | 2000-10-18 | Santen Pharmaceutical Co., Ltd. | 1,4-di(phenylalkyl)piperazine derivatives |
| GB9416571D0 (en) | 1994-08-16 | 1994-10-12 | Battelle Memorial Institute | Novel alkylamino derivatives as sigma 2 selective ligands |
| UA64769C2 (uk) | 1997-11-07 | 2004-03-15 | Х. Луннбек А/С | Гідрогалогеніди 1'-[4-[1-(4-фторофеніл)-1н-індол-3-іл]-1-бутил]-спіро[ізобензофуран-1(3н),4'-піперидину], фармацевтична композиція та спосіб лікування |
| CN1296409A (zh) * | 1998-04-07 | 2001-05-23 | H·隆德贝克有限公司 | 恐慌发作的治疗 |
| US20030087840A1 (en) * | 1998-05-19 | 2003-05-08 | Medinox, Inc. | Conjugates of dithiocarbamates with pharmacologically active agents and uses therefor |
| GB0007842D0 (en) * | 2000-03-31 | 2000-05-17 | Spruce Barbara | Sigma receptor ligands and their medical uses |
| US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
| US7829562B2 (en) * | 2003-06-12 | 2010-11-09 | M's Science Corporation | Sigma ligands for neuronal regeneration and functional recovery |
| US20060052386A1 (en) | 2003-06-12 | 2006-03-09 | Tadeusz Wieloch | Sigma ligands for neuronal regeneration and functional recovery |
| US20050032827A1 (en) | 2003-06-12 | 2005-02-10 | Donna Oksenberg | Sigma ligands for neuronal regeneration and functional recovery |
-
2004
- 2004-06-14 US US10/868,267 patent/US20050032827A1/en not_active Abandoned
- 2004-06-14 EP EP04776629A patent/EP1644026A4/en not_active Withdrawn
- 2004-06-14 EP EP04755359A patent/EP1635805A4/en not_active Withdrawn
- 2004-06-14 WO PCT/US2004/019139 patent/WO2004110387A2/en not_active Ceased
- 2004-06-14 US US10/868,423 patent/US7863272B2/en not_active Expired - Fee Related
- 2004-06-14 WO PCT/US2004/019140 patent/WO2004110388A2/en not_active Ceased
- 2004-06-14 WO PCT/US2004/019141 patent/WO2004110389A2/en not_active Ceased
- 2004-06-14 CA CA2528160A patent/CA2528160C/en not_active Expired - Fee Related
- 2004-06-14 US US10/868,048 patent/US20050020483A1/en not_active Abandoned
- 2004-06-14 JP JP2006533806A patent/JP4963607B2/ja not_active Expired - Fee Related
-
2010
- 2010-11-29 US US12/926,594 patent/US20110082154A1/en not_active Abandoned
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