JP2010505958A - 神経防護作用組成物および方法 - Google Patents

神経防護作用組成物および方法 Download PDF

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JP2010505958A
JP2010505958A JP2009532414A JP2009532414A JP2010505958A JP 2010505958 A JP2010505958 A JP 2010505958A JP 2009532414 A JP2009532414 A JP 2009532414A JP 2009532414 A JP2009532414 A JP 2009532414A JP 2010505958 A JP2010505958 A JP 2010505958A
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acid
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nrf2
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エー. リプトン,スチュアート
拓己 佐藤
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バーンハム インスティトゥート フォー メディカル リサーチ
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30Unsaturated compounds
    • C07C62/32Unsaturated compounds containing hydroxy or O-metal groups
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P27/02Ophthalmic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30Unsaturated compounds
    • C07C62/38Unsaturated compounds containing keto groups
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    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/26All rings being cycloaliphatic the ring system containing ten carbon atoms

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  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009532414A 2006-10-10 2007-10-10 神経防護作用組成物および方法 Pending JP2010505958A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85091806P 2006-10-10 2006-10-10
US85086006P 2006-10-10 2006-10-10
PCT/US2007/021748 WO2008108825A2 (en) 2006-10-10 2007-10-10 Neuroprotective compositions and methods

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JP2010505958A true JP2010505958A (ja) 2010-02-25
JP2010505958A5 JP2010505958A5 (https=) 2010-11-25

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JP2009532414A Pending JP2010505958A (ja) 2006-10-10 2007-10-10 神経防護作用組成物および方法

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US (2) US8022246B2 (https=)
EP (1) EP2086318A4 (https=)
JP (1) JP2010505958A (https=)
CA (1) CA2666461A1 (https=)
WO (1) WO2008108825A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015519873A (ja) * 2012-03-30 2015-07-16 ネステク ソシエテ アノニム 4−オキソ−2−ペンテン酸及び脳の健康
JP2016511282A (ja) * 2013-03-14 2016-04-14 ユニバーシティ オブ マカオUniversity Of Macau ヤクチ(益智(alpiniaeoxyphyllaefructus))およびその全合成から単離される新規な抗神経変性天然化合物

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EP2142182B1 (en) 2007-02-06 2017-09-27 Neuroquest Inc. Composition comprising terpene compounds and methods for inhibiting nerve transmission
CA2732784C (en) 2008-08-13 2018-09-18 Neuroquest Inc. Compositions comprising terpene compounds for treating negative sensory phenomena
EP2344142B1 (en) 2008-09-10 2024-06-26 PTC Therapeutics, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
GB2464813A (en) * 2009-10-23 2010-05-05 Univ Sheffield Treatments for neurodegenerative disorders
US20130102477A1 (en) 2010-06-23 2013-04-25 Ryan D. Morin Biomarkers for non-hodgkin lymphomas and uses thereof
BR112013005806B1 (pt) 2010-09-10 2022-05-10 Epizyme, Inc Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
US20130267571A1 (en) * 2010-09-14 2013-10-10 Neuroquest Inc. Terpenoid analogues and uses thereof for treating neurological conditions
WO2012094580A2 (en) 2011-01-07 2012-07-12 High Point Pharmaceuticals, Llc Compounds that modulate oxidative stress
TWI598336B (zh) 2011-04-13 2017-09-11 雅酶股份有限公司 經取代之苯化合物
JO3363B1 (ar) 2011-04-13 2019-03-13 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
WO2013067036A1 (en) * 2011-10-31 2013-05-10 Rutgers, The State University Of New Jersey Direct inhibitors of keap1-nrf2 interaction as antioxidant inflammation modulators
PT3184523T (pt) 2012-04-13 2019-09-26 Eisai R&D Man Co Ltd Bromidrato de n-((4,6-dimetil-2-oxo-l,2-di-hidropiridin- 3-il)metil)-5-(etil(tetra-hidro-2h-piran-4-il)amino)-4- metil-4¿-(morfolinometil)-[l,1¿-bofenil]-3-carboxamida para utilização no tratamento de uma doença proliferativa celular do sistema hematológico
MX2015004721A (es) 2012-10-15 2016-01-25 Epizyme Inc Compuestos de benceno sustituidos.
EP2931292B1 (en) 2012-12-13 2018-06-13 Warsaw Orthopedic, Inc. Compositions and methods comprising polyethylene glycol and magnesium for treatment of neuronal injury
MA38949A1 (fr) 2013-10-16 2017-07-31 Eisai R&D Man Co Ltd Forme saline d'hydrochlorure pour inhibition d'ezh2
US10441562B2 (en) 2015-04-30 2019-10-15 Institute Of Microbiology, Chinese Academy Of Sciences Aromatic farnesyl compound and application thereof
US10123991B2 (en) 2015-05-15 2018-11-13 Global Biolife Inc. Electrophilically enhanced phenolic compounds for treating inflammatory related diseases and disorders
ES2767086T3 (es) 2015-06-15 2020-06-16 Neuralia Composición de combinación que comprende huperzina
WO2017106803A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
EP3833662B1 (en) 2018-08-20 2024-01-17 Janssen Pharmaceutica NV Inhibitors of keap1-nrf2 protein-protein interaction
CN111166885B (zh) * 2020-01-16 2022-03-15 上海交通大学医学院 神经保护剂及其用途
CN114588143B (zh) * 2020-12-03 2023-06-06 中国科学院大连化学物理研究所 药物组合物及化合物作为或在制备阿片受体拮抗剂中的应用
US20250122146A1 (en) * 2021-09-30 2025-04-17 The Scripps Research Institute Compounds for reducing neuroinflammation

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US20010034370A1 (en) * 2000-02-28 2001-10-25 Kunio Kosaka Carnosic acid derivatives for promoting synthesis of nerve growth factor
JP2009515821A (ja) * 2005-10-16 2009-04-16 リコレッド リミテッド 眼疾患を治療するための組成物

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US20010034370A1 (en) * 2000-02-28 2001-10-25 Kunio Kosaka Carnosic acid derivatives for promoting synthesis of nerve growth factor
JP2009515821A (ja) * 2005-10-16 2009-04-16 リコレッド リミテッド 眼疾患を治療するための組成物

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015519873A (ja) * 2012-03-30 2015-07-16 ネステク ソシエテ アノニム 4−オキソ−2−ペンテン酸及び脳の健康
JP2016511282A (ja) * 2013-03-14 2016-04-14 ユニバーシティ オブ マカオUniversity Of Macau ヤクチ(益智(alpiniaeoxyphyllaefructus))およびその全合成から単離される新規な抗神経変性天然化合物
US10011555B2 (en) 2013-03-14 2018-07-03 University Of Macau Methods of treating Parkinson's disease

Also Published As

Publication number Publication date
WO2008108825A2 (en) 2008-09-12
US8466311B2 (en) 2013-06-18
US20120296112A1 (en) 2012-11-22
WO2008108825A3 (en) 2008-12-18
US20090042980A1 (en) 2009-02-12
US8022246B2 (en) 2011-09-20
CA2666461A1 (en) 2008-09-12
EP2086318A4 (en) 2009-12-23
EP2086318A2 (en) 2009-08-12

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