JP2010504318A - ｐＨ標的化薬剤送達のための組成物及び方法 - Google Patents

ｐＨ標的化薬剤送達のための組成物及び方法 Download PDF

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JP2010504318A
JP2010504318A JP2009528813A JP2009528813A JP2010504318A JP 2010504318 A JP2010504318 A JP 2010504318A JP 2009528813 A JP2009528813 A JP 2009528813A JP 2009528813 A JP2009528813 A JP 2009528813A JP 2010504318 A JP2010504318 A JP 2010504318A
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composition
pharmaceutically active
active agent
integer ranging
solution
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JP2010504318A5 (enExample
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ディヴィッド ルサール
レバン ルオ
ガレック ドロテー ル
デイモン スミス
Original Assignee
ラボファーム インコーポレイテッド
ラボファーム ユーロープ リミテッド
ラボファーム （バルバドス） リミテッド
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Publication of JP2010504318A publication Critical patent/JP2010504318A/ja
Publication of JP2010504318A5 publication Critical patent/JP2010504318A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F297/00—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer
    • C08F297/02—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type
    • C08F297/026—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type polymerising acrylic acid, methacrylic acid or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2009528813A 2006-09-22 2007-09-24 ｐＨ標的化薬剤送達のための組成物及び方法 Pending JP2010504318A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84635506P 2006-09-22 2006-09-22
PCT/IB2007/004171 WO2008035229A2 (en) 2006-09-22 2007-09-24 Compositions and methods for ph targeted drug delivery

Publications (2)

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JP2010504318A true JP2010504318A (ja) 2010-02-12
JP2010504318A5 JP2010504318A5 (enExample) 2010-11-11

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Country Link
US (1) US20090258071A1 (enExample)
EP (1) EP2081548A2 (enExample)
JP (1) JP2010504318A (enExample)
KR (1) KR20090080046A (enExample)
AU (1) AU2007298674A1 (enExample)
BR (1) BRPI0716890A2 (enExample)
CA (1) CA2699184A1 (enExample)
IL (1) IL197680A0 (enExample)
MX (1) MX2009003092A (enExample)
WO (1) WO2008035229A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013530931A (ja) * 2010-04-23 2013-08-01 ラボファーマ インコーポレイテッド 液状生物学的活性成分の固形製剤を含む非静脈内剤型およびその使用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
CA2635187A1 (en) * 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
FR2932485A1 (fr) * 2008-06-12 2009-12-18 Univ Pasteur Polymere a liberation colique specifique quel que soit le ph
WO2011119995A2 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Formulations and methods of use
CN102675500B (zh) * 2011-03-07 2015-05-13 深圳英利华生物技术有限公司 利用有机镁试剂制备高分子负载有机锡化合物的方法及应用
EP3749276B1 (en) 2018-02-06 2024-01-03 3M Innovative Properties Company Microcapsule with a porous or hollow core and ph-sensitive shell and use thereof

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2013530931A (ja) * 2010-04-23 2013-08-01 ラボファーマ インコーポレイテッド 液状生物学的活性成分の固形製剤を含む非静脈内剤型およびその使用

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EP2081548A2 (en) 2009-07-29
WO2008035229A3 (en) 2009-08-13
CA2699184A1 (en) 2008-03-27
KR20090080046A (ko) 2009-07-23
IL197680A0 (en) 2009-12-24
WO2008035229A2 (en) 2008-03-27
MX2009003092A (es) 2009-05-08
AU2007298674A1 (en) 2008-03-27
US20090258071A1 (en) 2009-10-15
BRPI0716890A2 (pt) 2013-10-22

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