IL197680A0 - COMPOSITIONS AND METHODS FOR pH TARGETED DRUG DELIVERY - Google Patents

COMPOSITIONS AND METHODS FOR pH TARGETED DRUG DELIVERY

Info

Publication number
IL197680A0
IL197680A0 IL197680A IL19768009A IL197680A0 IL 197680 A0 IL197680 A0 IL 197680A0 IL 197680 A IL197680 A IL 197680A IL 19768009 A IL19768009 A IL 19768009A IL 197680 A0 IL197680 A0 IL 197680A0
Authority
IL
Israel
Prior art keywords
compositions
methods
drug delivery
targeted drug
targeted
Prior art date
Application number
IL197680A
Original Assignee
Labopharm Inc
Labopharm Europe Ltd
Labopharm Barbados Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Inc, Labopharm Europe Ltd, Labopharm Barbados Ltd filed Critical Labopharm Inc
Publication of IL197680A0 publication Critical patent/IL197680A0/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F297/00Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer
    • C08F297/02Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type
    • C08F297/026Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type polymerising acrylic acid, methacrylic acid or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL197680A 2006-09-22 2009-03-19 COMPOSITIONS AND METHODS FOR pH TARGETED DRUG DELIVERY IL197680A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84635506P 2006-09-22 2006-09-22
PCT/IB2007/004171 WO2008035229A2 (en) 2006-09-22 2007-09-24 Compositions and methods for ph targeted drug delivery

Publications (1)

Publication Number Publication Date
IL197680A0 true IL197680A0 (en) 2009-12-24

Family

ID=39153921

Family Applications (1)

Application Number Title Priority Date Filing Date
IL197680A IL197680A0 (en) 2006-09-22 2009-03-19 COMPOSITIONS AND METHODS FOR pH TARGETED DRUG DELIVERY

Country Status (10)

Country Link
US (1) US20090258071A1 (en)
EP (1) EP2081548A2 (en)
JP (1) JP2010504318A (en)
KR (1) KR20090080046A (en)
AU (1) AU2007298674A1 (en)
BR (1) BRPI0716890A2 (en)
CA (1) CA2699184A1 (en)
IL (1) IL197680A0 (en)
MX (1) MX2009003092A (en)
WO (1) WO2008035229A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
FR2932485A1 (en) * 2008-06-12 2009-12-18 Univ Pasteur SPECIFIC COLLECTIVE RELEASE POLYMER WHATEVER PH
WO2011119995A2 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Formulations and methods of use
WO2011130834A1 (en) * 2010-04-23 2011-10-27 Labopharm Inc. Non-intravenous dosage form comprising solid formulation of liquid biologically active agent and uses thereof
CN102675500B (en) * 2011-03-07 2015-05-13 深圳英利华生物技术有限公司 Method for preparing polymer-supported organotin compound by using organic magneson and application of organotin compound

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US284267A (en) * 1883-09-04 Full size
US4016332A (en) * 1972-05-01 1977-04-05 Ppg Industries, Inc. Mercaptan blocked thermosetting copolymers
US3933940A (en) * 1973-02-08 1976-01-20 Ppg Industries, Inc. Mercaptan blocked thermosetting copolymers
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
DE3001013A1 (en) * 1980-01-12 1981-07-23 Basf Ag, 6700 Ludwigshafen VINYLPYRROLIDONE POLYMERISATES, THEIR PRODUCTION AND THEIR USE FOR THE PRODUCTION OF BLOOD REPLACEMENT LIQUIDS
JPS5767860A (en) * 1980-10-15 1982-04-24 Fuji Photo Film Co Ltd Material for multilayer analysis
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
US4565854A (en) * 1983-04-07 1986-01-21 Kuraray Co., Ltd. Polymer having thiol end group
JPS6019790A (en) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd Novel camptothecin derivative
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US6312679B1 (en) * 1986-08-18 2001-11-06 The Dow Chemical Company Dense star polymer conjugates as dyes
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
JP2517760B2 (en) * 1989-05-11 1996-07-24 新技術事業団 Water-soluble polymerized pharmaceutical preparation
US5041516A (en) * 1989-06-21 1991-08-20 Cornell Research Foundation, Inc. Dendritic molecules and method of production
US5206410A (en) * 1989-08-31 1993-04-27 University Of South Florida Multifunctional synthons as used in the preparation of cascade polymers or unimolecular micelles
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5154853A (en) * 1991-02-19 1992-10-13 University Of South Florida Unimolecular micelles and method of making the same
FR2678168B1 (en) * 1991-06-28 1993-09-03 Rhone Poulenc Rorer Sa NANOPARTICLES HAVING CAPTURE TIME BY THE EXTENDED RETICULO ENDOTHELIAL DYSTEM.
CA2087125A1 (en) * 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
KR940003548U (en) * 1992-08-14 1994-02-21 김형술 Laundry dryer
US5840319A (en) * 1992-10-08 1998-11-24 Alakhov; Valery Yu Biological agent compositions
US5552156A (en) * 1992-10-23 1996-09-03 Ohio State University Liposomal and micellular stabilization of camptothecin drugs
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
AU2118195A (en) * 1994-03-07 1995-09-25 Dendritech Inc. Bioactive and/or targeted dendrimer conjugates
JP3631755B2 (en) * 1994-03-23 2005-03-23 明治製菓株式会社 Polyoxyethylene-containing lipid double-chain derivatives
NL9401886A (en) * 1994-05-27 1996-01-02 Dsm Nv Composition consisting of a dendrimer and an active substance contained in the dendrimer, a method of preparing such a composition and a method of releasing the active substance.
US5863919A (en) * 1994-07-25 1999-01-26 University Of South Florida Lock and key micelles and monomer building blocks therefor
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6221959B1 (en) * 1994-11-18 2001-04-24 Supratek Pharma, Inc. Polynucleotide compositions
US5656611A (en) * 1994-11-18 1997-08-12 Supratek Pharma Inc. Polynucleotide compositions
US5492996A (en) * 1995-02-21 1996-02-20 The United States Of America As Represented By The Secretary Of The Air Force Alcohol soluble benzazole polymers
US5736156A (en) * 1995-03-22 1998-04-07 The Ohio State University Liposomal anf micellular stabilization of camptothecin drugs
HUP9801633A3 (en) * 1995-04-19 1999-03-01 Kataoka Kazunori Heterotelechelic block copolymers and process for producing the same
US5908777A (en) * 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
CA2228118A1 (en) * 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents
AU726749B2 (en) * 1995-08-10 2000-11-16 Kazunori Kataoka Block polymer having functional groups on its both ends
US5770627A (en) * 1995-08-16 1998-06-23 University Of Washington Hydrophobically-modified bioadhesive polyelectrolytes and methods relating thereto
KR0180334B1 (en) * 1995-09-21 1999-03-20 김윤 Drug messenger using el-2l-2 micelle and method for sealing drug to it
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5955509A (en) * 1996-05-01 1999-09-21 Board Of Regents, The University Of Texas System pH dependent polymer micelles
EP0907666A1 (en) * 1996-06-27 1999-04-14 G.D. Searle & Co. Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
US6060518A (en) * 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
TW520297B (en) * 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
GB9623051D0 (en) * 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
CA2296381A1 (en) * 1997-07-15 1999-01-28 Rhodia Chimie Method for producing polymers using micellar polymerization
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
US20030059465A1 (en) * 1998-05-11 2003-03-27 Unger Evan C. Stabilized nanoparticle formulations of camptotheca derivatives
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6407117B1 (en) * 1998-06-18 2002-06-18 The George Washington University Method of administering camptothecin compounds for the treatment of cancer with reduced side effects
WO2000002950A1 (en) * 1998-07-13 2000-01-20 Expression Genetics, Inc. Polyester analogue of poly-l-lysine as a soluble, biodegradable gene delivery carrier
IN191203B (en) * 1999-02-17 2003-10-04 Amarnath Prof Maitra
WO2000066125A1 (en) * 1999-04-29 2000-11-09 Aventis Pharma S.A. Method for treating cancer using camptothecin derivatives and 5-fluorouracil
DE19919785A1 (en) * 1999-04-30 2000-12-07 Wella Ag Hair treatment agent with polymers of unsaturated saccharides, unsaturated saccharic acids or their derivatives
KR100360827B1 (en) * 1999-08-14 2002-11-18 주식회사 삼양사 Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
JP3523821B2 (en) * 2000-02-09 2004-04-26 ナノキャリア株式会社 Method for producing polymer micelle in which drug is encapsulated and polymer micelle composition
DE10008895A1 (en) * 2000-02-25 2001-08-30 Beiersdorf Ag Stabilization of active substances that are sensitive to oxidation and / or UV
GB2359747B (en) * 2000-02-29 2002-04-24 Maelor Pharmaceuticals Ltd Anaesthetic formulations
CA2408548C (en) * 2000-05-12 2008-03-11 Samyang Corporation Method for the preparation of polymeric micelle via phase separation of block copolymer
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
CA2427467C (en) * 2000-11-09 2010-01-12 Neopharm, Inc. Sn-38 lipid complexes and methods of use
KR100446101B1 (en) * 2000-12-07 2004-08-30 주식회사 삼양사 Sustained delivery composition for poorly water soluble drugs
EP1399131A2 (en) * 2001-06-08 2004-03-24 Powderject Vaccines, Inc. Spray freeze-dried compositions
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US7094810B2 (en) * 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US6756449B2 (en) * 2002-02-27 2004-06-29 Medtronic, Inc. AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods
US6780324B2 (en) * 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
US7018655B2 (en) * 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
JP2003342168A (en) * 2002-05-24 2003-12-03 Nano Career Kk Method for producing polymer micelle preparation containing drug for injection
EP1393719A1 (en) * 2002-08-23 2004-03-03 Munich Biotech AG Camptothecin-carboxylate formulations
WO2004035032A2 (en) * 2002-08-20 2004-04-29 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
KR100502840B1 (en) * 2002-09-04 2005-07-21 학교법인 포항공과대학교 A block copolymer micelle composition having an improved drug loading capacity
ATE388758T1 (en) * 2002-10-21 2008-03-15 Oreal METHOD FOR DISSOLVING LIPOPHILIC COMPOUNDS, AND COSMETIC COMPOSITION.
US20040091528A1 (en) * 2002-11-12 2004-05-13 Yamanouchi Pharma Technologies, Inc. Soluble drug extended release system
US7332527B2 (en) * 2003-05-16 2008-02-19 Board Of Regents Of The University Of Nebraska Cross-linked ionic core micelles
US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US20040258754A1 (en) * 2003-06-18 2004-12-23 Valery Alakhov Compositions for oral administration of camptothecin and its analogs
US7262253B2 (en) * 2003-12-02 2007-08-28 Labopharm, Inc. Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers
EP1708694B1 (en) * 2004-01-30 2012-07-11 Angiotech International Ag Compositions and methods for treating contracture
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
US20060127459A1 (en) * 2004-12-15 2006-06-15 Lei Huang Urogenital infection inhibition
US7383600B2 (en) * 2005-04-05 2008-06-10 Carrigan Stephen A Convertible dock ramp

Also Published As

Publication number Publication date
WO2008035229A3 (en) 2009-08-13
CA2699184A1 (en) 2008-03-27
WO2008035229A2 (en) 2008-03-27
AU2007298674A1 (en) 2008-03-27
MX2009003092A (en) 2009-05-08
US20090258071A1 (en) 2009-10-15
EP2081548A2 (en) 2009-07-29
JP2010504318A (en) 2010-02-12
BRPI0716890A2 (en) 2013-10-22
KR20090080046A (en) 2009-07-23

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