JP2010502751A - キナーゼ阻害物質、およびキナーゼ阻害物質の使用および同定方法 - Google Patents

キナーゼ阻害物質、およびキナーゼ阻害物質の使用および同定方法 Download PDF

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JP2010502751A
JP2010502751A JP2009527627A JP2009527627A JP2010502751A JP 2010502751 A JP2010502751 A JP 2010502751A JP 2009527627 A JP2009527627 A JP 2009527627A JP 2009527627 A JP2009527627 A JP 2009527627A JP 2010502751 A JP2010502751 A JP 2010502751A
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btk
methyl
optionally substituted
less
phenyl
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JP2010502751A5 (enExample
Inventor
エー． ホイットニー，ジェイムズ
パオロ，ジュリー ディ
エー． ベレカ，マーク
アール． ブリッテリ，デイビッド
エス． カリー，ケビン
ダブリュ． ダロウ，ジェイムズ
イー． クロプフ，ジェフリー
エイチ． リー，ソン
エル． ガリオン，スティーブン
エー． ミッチェル，スコット
エー．アイ． ピッペン，ダグラス
エー． ブロムグレン，ピーター
グレゴリー スタッフォード，ダグラス
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シージーアイ ファーマシューティカルズ，インコーポレイティド
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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JP2009527627A 2006-09-11 2007-09-11 キナーゼ阻害物質、およびキナーゼ阻害物質の使用および同定方法 Pending JP2010502751A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84385306P 2006-09-11 2006-09-11
PCT/US2007/078186 WO2008033858A2 (en) 2006-09-11 2007-09-11 Kinase inhibitors, and methods of using and identifying kinase inhibitors

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JP2010502751A true JP2010502751A (ja) 2010-01-28
JP2010502751A5 JP2010502751A5 (enExample) 2010-10-21

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US (1) US20100160292A1 (enExample)
EP (2) EP2270200A3 (enExample)
JP (1) JP2010502751A (enExample)
WO (1) WO2008033858A2 (enExample)

Cited By (5)

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WO2013161848A1 (ja) * 2012-04-27 2013-10-31 カルナバイオサイエンス株式会社 新規１，２，４－トリアジン誘導体
JP2015518903A (ja) * 2012-06-08 2015-07-06 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． ピリミジニルチロシンキナーゼ阻害剤
JP2017502933A (ja) * 2013-12-05 2017-01-26 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 求電子性官能基を有するヘテロアリールピリドン及びアザ−ピリドン化合物
US10577374B2 (en) 2009-09-04 2020-03-03 Sunesis Pharmaceuticals, Inc. Bruton's tyrosine kinase inhibitors
US11174243B2 (en) 2016-07-21 2021-11-16 Sunesis Pharmaceuticals, Inc. Succinate forms and compositions of Bruton's tyrosine kinase inhibitors

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AR063706A1 (es) * 2006-09-11 2009-02-11 Cgi Pharmaceuticals Inc Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
CL2008002793A1 (es) * 2007-09-20 2009-09-04 Cgi Pharmaceuticals Inc Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras
CA2701275C (en) * 2007-10-23 2016-06-21 F. Hoffmann-La Roche Ag Kinase inhibitors
US7683064B2 (en) 2008-02-05 2010-03-23 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
AU2009244291B2 (en) * 2008-05-06 2014-02-13 Genentech, Inc. Substituted amides, method of making, and use as Btk inhibitors
CN103709148B (zh) 2008-06-24 2015-10-21 霍夫曼-拉罗奇有限公司 取代的吡啶-2-酮和哒嗪-3-酮
JP5490789B2 (ja) 2008-07-02 2014-05-14 エフ．ホフマン−ラ ロシュ アーゲー キナーゼ阻害剤としての新規なフェニルピラジノン
ES2552681T3 (es) * 2008-07-15 2015-12-01 F. Hoffmann-La Roche Ag Nuevas fenil-imidazopiridinas y piridazinas
EP2307418B1 (en) 2008-07-18 2014-03-12 F.Hoffmann-La Roche Ag Novel phenylimidazopyrazines
JP2011529073A (ja) 2008-07-24 2011-12-01 ブリストル−マイヤーズ スクイブ カンパニー キナーゼ調節因子として有用な縮合ヘテロ環化合物
WO2010068806A1 (en) * 2008-12-10 2010-06-17 Cgi Pharmaceuticals, Inc. Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer
SG171815A1 (en) 2008-12-19 2011-07-28 Bristol Myers Squibb Co Carbazole carboxamide compounds useful as kinase inhibitors
ES2444777T3 (es) 2009-06-12 2014-02-26 Bristol-Myers Squibb Company Compuestos de nicotinamida útiles como moduladores de quinasas
EP2789615B1 (en) 2009-08-11 2017-05-03 Bristol-Myers Squibb Company Azaindazoles as Btk kinase modulators and use thereof
EP2582668B1 (en) 2010-06-16 2016-01-13 Bristol-Myers Squibb Company Carboline carboxamide compounds useful as kinase inhibitors
AR082590A1 (es) 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
US8791112B2 (en) 2011-03-30 2014-07-29 Arrien Pharmaceuticals Llc Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors
ES2548414T3 (es) 2011-07-08 2015-10-16 Novartis Ag Novedosos derivados de pirrolo pirimidina
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
SG11201408324QA (en) 2012-06-12 2015-01-29 Abbvie Inc Pyridinone and pyridazinone derivatives
ES2984771T3 (es) 2012-06-13 2024-10-31 Incyte Holdings Corp Compuestos tricíclicos sustituidos como inhibidores de FGFR
WO2014018567A1 (en) 2012-07-24 2014-01-30 Pharmacyclics, Inc. Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
WO2014108820A1 (en) * 2013-01-08 2014-07-17 Aurigene Discovery Technologies Limited Substituted 2-pyrazinone derivatives as kinase inhibitors
WO2014125410A1 (en) * 2013-02-12 2014-08-21 Aurigene Discovery Technologies Limited N-substituted heterocyclic derivatives as kinase inhibitors
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