JP2010501519A5 - - Google Patents

Info

Publication number

JP2010501519A5

JP2010501519A5 JP2009525046A JP2009525046A JP2010501519A5 JP 2010501519 A5 JP2010501519 A5 JP 2010501519A5 JP 2009525046 A JP2009525046 A JP 2009525046A JP 2009525046 A JP2009525046 A JP 2009525046A JP 2010501519 A5 JP2010501519 A5 JP 2010501519A5

Authority

JP

Japan

Prior art keywords

compound according

methyl

oxazol

azabicyclo

triazol

Prior art date

2007-08-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 19
• 238000001228 spectrum Methods 0.000 claims 7
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 6
• -1 4-methyl-1,3-oxazol-5-yl Chemical group 0.000 claims 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
• 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 4
• 241000124008 Mammalia Species 0.000 claims 3
• 238000005481 NMR spectroscopy Methods 0.000 claims 3
• 238000000113 differential scanning calorimetry Methods 0.000 claims 3
• 229960003638 dopamine Drugs 0.000 claims 3
• 239000007787 solid Substances 0.000 claims 3
• 239000012453 solvate Substances 0.000 claims 3
• 201000009031 substance-related disease Diseases 0.000 claims 3
• 238000001757 thermogravimetry curve Methods 0.000 claims 3
• FEWJPZIEWOKRBE-JCYAYHJZSA-N (+)-tartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
• FEWJPZIEWOKRBE-JCYAYHJZSA-L L-tartrate(2-) Chemical compound [O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-L 0.000 claims 2
• OKTJSMMVPCPJKN-OUBTZVSYSA-N carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 claims 2
• RYGMFSIKBFXOCR-UHFFFAOYSA-N copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 2
• 229910052802 copper Inorganic materials 0.000 claims 2
• 239000010949 copper Substances 0.000 claims 2
• VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 2
• 230000000051 modifying Effects 0.000 claims 2
• 238000000634 powder X-ray diffraction Methods 0.000 claims 2
• OTXHYNSABCZZKN-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;5-[5-[3-[1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound OC(=O)C(O)C(O)C(O)=O.N1=COC(C=2N(C(SCCCN3CC4(CC4C3)C=3C(=CC(=CC=3)C(F)(F)F)F)=NN=2)C)=C1C OTXHYNSABCZZKN-UHFFFAOYSA-N 0.000 claims 1
• ZKRWPAYTJMRKLJ-UHFFFAOYSA-N 5-[5-[3-[1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3CC4(CC4C3)C=3C(=CC(=CC=3)C(F)(F)F)F)=NN=2)C)=C1C ZKRWPAYTJMRKLJ-UHFFFAOYSA-N 0.000 claims 1
• 238000002441 X-ray diffraction Methods 0.000 claims 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000008079 hexane Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000001575 pathological Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 229960001367 tartaric acid Drugs 0.000 claims 1
• 235000002906 tartaric acid Nutrition 0.000 claims 1
• 239000011975 tartaric acid Substances 0.000 claims 1
• 229940095064 tartrate Drugs 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1