CO6150139A2 - Sal de tartrato de 1-[2- fluoruro-4-(trifluorometil)fenil]-3-(3-{[4-metil-5-(4-metil-1,3 oxazol-5-il)-4h-1,2,4-triazol-3 il]tio}propil)-3-azabiciclo[3.1.0]-hexano y a sus solvatos, formulaciones farmaceuticas, procedimientos para su preparacion y su - Google Patents

Sal de tartrato de 1-[2- fluoruro-4-(trifluorometil)fenil]-3-(3-{[4-metil-5-(4-metil-1,3 oxazol-5-il)-4h-1,2,4-triazol-3 il]tio}propil)-3-azabiciclo[3.1.0]-hexano y a sus solvatos, formulaciones farmaceuticas, procedimientos para su preparacion y su

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Publication number
CO6150139A2
CO6150139A2 CO09017330A CO09017330A CO6150139A2 CO 6150139 A2 CO6150139 A2 CO 6150139A2 CO 09017330 A CO09017330 A CO 09017330A CO 09017330 A CO09017330 A CO 09017330A CO 6150139 A2 CO6150139 A2 CO 6150139A2
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CO
Colombia
Prior art keywords
methyl
oxazol
triazol
phenyl
azabiciclo
Prior art date
Application number
CO09017330A
Other languages
English (en)
Inventor
Clare Louise Anderton
Sergio Bacchi
Stefania Beato
Franco Sartor
Original Assignee
Glaxo Group Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37081324&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6150139(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2006/008314 external-priority patent/WO2007022980A1/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CO6150139A2 publication Critical patent/CO6150139A2/es

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Plural Heterocyclic Compounds (AREA)

Abstract

1.- Tartrato de 1-[2-fluoro-4-(trifluorometil)fenil]-3-(3{[4-metil-5-(4-metil-1,3-oxazol-5-il)-4H-1,2,4-triazol-3-il]tio}propil)-3-azabiciclo[3.1.0)-hexano o su solvato farmacéuticamente aceptable. 2.- Tartrato de (1S,5R)-1-[2-fluoro-4-(trifluorometil)fenil)-3-(3-{[4-metil-5-(4-metil-1,3-oxazol-5-il)-4H-1,2,4-triazol-3-il)tio}propil)-3-azabiciclo[3.1.0)-hexano o su solvato farmacéutícamente aceptable. 3.- Tartrato de (1S,5R)-1-[2-fluoro-4-(trlfluorometil)fenil]-3-(3-{[4-metil-5-(4-metil-1,3-oxazol-5-il)-4H-1,2,4-triazol-3-iI)tio}propil)-3-azabiciclo[3.1.0)-hexano (2R,3R) o su solvato farmacéuticamente aceptable. 4.- Un compuesto según la reivindicación 1, la reivindicación 2 o la reivindicación 3, en el que la relación de 1-[2-fluoro-4-(trifluorometil)fenil]-3-(3-{[4-metil-5-(4-metil-1,3-oxazol-5-il)-4H-1,2,4-triazol-3-il]tio}propil)-3-azabiciclo [3.1.0)-hexano o (1S,5R)-1-[2-fluoro-4-(trifluoro-metil)fenil]-3-(3-{[4-metil-5-(4-metil-1,3-oxazol-5-il)-4H-1,2,4-triazol-3-il)tio}propil)-3-azabiciclo[3.1.0)-hexano a ácido tartárico (en moles) es 1:1. 5.- Un compuesto según cualquiera de las reivindicaciones 2-4, en el que la relación de (1S, 5R)-1-[2-fluoro-4-(trifluoro-metil)fenil)-3-(3-{(4-metil-5-(4-metil-1,3- oxazol-5-il)-4H-1,2,4-triazol-3-il]tio}propil)-3-azabiciclo[3.1.0)-hexano a (2R,3R) ácido tartárico (en moles) es 1:1.6.- Un compuesto según cualquiera de las reivindicaciones 2-5, que es un hidrato. 7.- Un compuesto según cualquiera de las reivindicaciones 2-6, que es un sesquihidrato. 8.- Un compuesto según cualquiera de las reivindicaciones 2-7, en forma cristalina.
CO09017330A 2006-08-21 2009-02-20 Sal de tartrato de 1-[2- fluoruro-4-(trifluorometil)fenil]-3-(3-{[4-metil-5-(4-metil-1,3 oxazol-5-il)-4h-1,2,4-triazol-3 il]tio}propil)-3-azabiciclo[3.1.0]-hexano y a sus solvatos, formulaciones farmaceuticas, procedimientos para su preparacion y su CO6150139A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2006/008314 WO2007022980A1 (en) 2005-08-22 2006-08-21 Use of azabicyclo hexane derivatives
GBGB0616574.0A GB0616574D0 (en) 2006-08-21 2006-08-21 Compounds

Publications (1)

Publication Number Publication Date
CO6150139A2 true CO6150139A2 (es) 2010-04-20

Family

ID=37081324

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09017330A CO6150139A2 (es) 2006-08-21 2009-02-20 Sal de tartrato de 1-[2- fluoruro-4-(trifluorometil)fenil]-3-(3-{[4-metil-5-(4-metil-1,3 oxazol-5-il)-4h-1,2,4-triazol-3 il]tio}propil)-3-azabiciclo[3.1.0]-hexano y a sus solvatos, formulaciones farmaceuticas, procedimientos para su preparacion y su

Country Status (22)

Country Link
US (1) US20080058398A1 (es)
EP (1) EP2054054A1 (es)
JP (1) JP5315244B2 (es)
KR (1) KR101495362B1 (es)
CN (1) CN101528221B (es)
AR (1) AR062471A1 (es)
AU (1) AU2007287527B2 (es)
BR (1) BRPI0716454A2 (es)
CA (1) CA2661437A1 (es)
CL (1) CL2007002422A1 (es)
CO (1) CO6150139A2 (es)
CR (1) CR10638A (es)
EA (1) EA017917B1 (es)
GB (1) GB0616574D0 (es)
IL (1) IL196976A0 (es)
MA (1) MA30672B1 (es)
MX (1) MX2009001941A (es)
NO (1) NO20090834L (es)
PE (1) PE20080609A1 (es)
TW (1) TW200825074A (es)
WO (1) WO2008022994A1 (es)
ZA (1) ZA200900886B (es)

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Publication number Priority date Publication date Assignee Title
PL2070922T3 (pl) * 2004-02-23 2012-01-31 Glaxo Group Ltd Pochodne azabicyklo[3.1.0]heksanu użyteczne jako modulatory receptorów dopaminowych D3
GB0507602D0 (en) * 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0507601D0 (en) * 2005-04-14 2005-05-18 Glaxo Group Ltd Compounds
GB0512099D0 (en) * 2005-06-14 2005-07-20 Glaxo Group Ltd Compounds
WO2006133945A1 (en) * 2005-06-14 2006-12-21 Glaxo Group Limited Novel compounds
GB0517191D0 (en) 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
GB0517175D0 (en) 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
US7799815B2 (en) * 2005-08-22 2010-09-21 Glaxo Group Limited Triazole derivatives as modulators of dopamine D3 receptors
GB0517187D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Compounds
GB0517193D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Novel use
JP5189076B2 (ja) * 2006-04-03 2013-04-24 グラクソ グループ リミテッド ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキシル誘導体
DE602007012531D1 (de) * 2006-04-03 2011-03-31 Glaxo Group Ltd Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20090069374A1 (en) * 2007-06-06 2009-03-12 Phil Skolnick Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments
US11447484B2 (en) 2018-01-26 2022-09-20 Shionogi & Co., Ltd. Cyclic compound having dopamine D3 receptor antagonistic effect
AR127055A1 (es) * 2021-09-14 2023-12-13 Lilly Co Eli Sales agonistas de sstr4

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JP4260941B2 (ja) * 1998-11-09 2009-04-30 株式会社片山製薬所 アゼチジン−３−オール
AU3147800A (en) * 1999-03-15 2000-10-04 Novo Nordisk A/S New salt of (2r,3r,4r)-3,4-dihydroxy-2-hydroxymethylpyrrolidine
GB0019228D0 (en) * 2000-08-04 2000-09-27 Smithkline Beecham Plc Novel pharmaceutical
PL2070922T3 (pl) * 2004-02-23 2012-01-31 Glaxo Group Ltd Pochodne azabicyklo[3.1.0]heksanu użyteczne jako modulatory receptorów dopaminowych D3
SE526837C2 (sv) * 2004-02-24 2005-11-08 Kongsberg Automotive Asa Växelspakstransmission
CN1984903A (zh) * 2004-06-30 2007-06-20 伊莱利利公司 1－(吲哚－6－羰基－d－苯基甘氨酰基)－4－(1－甲基哌啶－4－基)哌嗪d－酒石酸盐
GB0517193D0 (en) * 2005-08-22 2005-09-28 Glaxo Group Ltd Novel use

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AR062471A1 (es) 2008-11-12
AU2007287527B2 (en) 2013-01-31
NO20090834L (no) 2009-03-19
JP2010501519A (ja) 2010-01-21
CN101528221B (zh) 2013-05-08
EP2054054A1 (en) 2009-05-06
MX2009001941A (es) 2009-03-05
KR101495362B1 (ko) 2015-02-24
TW200825074A (en) 2008-06-16
JP5315244B2 (ja) 2013-10-16
US20080058398A1 (en) 2008-03-06
BRPI0716454A2 (pt) 2014-03-04
AU2007287527A1 (en) 2008-02-28
CL2007002422A1 (es) 2008-03-14
WO2008022994A1 (en) 2008-02-28
KR20090052327A (ko) 2009-05-25
CR10638A (es) 2009-03-20
EA200970211A1 (ru) 2009-08-28
MA30672B1 (fr) 2009-08-03
CN101528221A (zh) 2009-09-09
IL196976A0 (en) 2009-11-18
GB0616574D0 (en) 2006-09-27
EA017917B1 (ru) 2013-04-30
ZA200900886B (en) 2011-05-25
CA2661437A1 (en) 2008-02-28
PE20080609A1 (es) 2008-07-26

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