JP2010059183A5 - - Google Patents
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- Publication number
- JP2010059183A5 JP2010059183A5 JP2009256184A JP2009256184A JP2010059183A5 JP 2010059183 A5 JP2010059183 A5 JP 2010059183A5 JP 2009256184 A JP2009256184 A JP 2009256184A JP 2009256184 A JP2009256184 A JP 2009256184A JP 2010059183 A5 JP2010059183 A5 JP 2010059183A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- lipoxin
- substituent
- analog
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 239000004480 active ingredient Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 230000033115 angiogenesis Effects 0.000 claims 5
- UXVRTOKOJOMENI-ICTGYCPSSA-N (6e,8e,10e,12e)-5,14,15-trihydroxyicosa-6,8,10,12-tetraenoic acid Chemical compound CCCCCC(O)C(O)\C=C\C=C\C=C\C=C\C(O)CCCC(O)=O UXVRTOKOJOMENI-ICTGYCPSSA-N 0.000 claims 4
- IXAQOQZEOGMIQS-ORRYEOPJSA-N Lipoxin A Natural products CCCCCC(O)C=CC=C/C=C/C=C/C(O)C(O)CCCC(=O)O IXAQOQZEOGMIQS-ORRYEOPJSA-N 0.000 claims 4
- IXAQOQZEOGMIQS-SSQFXEBMSA-N lipoxin A4 Chemical compound CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O IXAQOQZEOGMIQS-SSQFXEBMSA-N 0.000 claims 4
- 230000001737 promoting effect Effects 0.000 claims 4
- 208000037803 restenosis Diseases 0.000 claims 2
- 230000015590 smooth muscle cell migration Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- RDLVTAMOKVDZDQ-INJLQNTRSA-N C[C@](CCCC(O)=O)(/C=C/C=C\C=C\C=C\[C@@H]([C@@H](CCCCC(F)(F)F)O)O)O Chemical compound C[C@](CCCC(O)=O)(/C=C/C=C\C=C\C=C\[C@@H]([C@@H](CCCCC(F)(F)F)O)O)O RDLVTAMOKVDZDQ-INJLQNTRSA-N 0.000 description 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27293101P | 2001-03-02 | 2001-03-02 | |
| US60/272,931 | 2001-03-02 | ||
| US10/086,609 | 2002-03-01 | ||
| US10/086,609 US6627658B2 (en) | 2001-03-02 | 2002-03-01 | Lipoxin analogs as novel inhibitors of angiogenesis |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569237A Division JP2005508282A (ja) | 2001-03-02 | 2002-03-01 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012195046A Division JP2012255025A (ja) | 2001-03-02 | 2012-09-05 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010059183A JP2010059183A (ja) | 2010-03-18 |
| JP2010059183A5 true JP2010059183A5 (enExample) | 2012-02-16 |
| JP5302856B2 JP5302856B2 (ja) | 2013-10-02 |
Family
ID=26774943
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569237A Withdrawn JP2005508282A (ja) | 2001-03-02 | 2002-03-01 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
| JP2009256184A Expired - Fee Related JP5302856B2 (ja) | 2001-03-02 | 2009-11-09 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
| JP2012195046A Ceased JP2012255025A (ja) | 2001-03-02 | 2012-09-05 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569237A Withdrawn JP2005508282A (ja) | 2001-03-02 | 2002-03-01 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012195046A Ceased JP2012255025A (ja) | 2001-03-02 | 2012-09-05 | 新規な脈管形成抑制剤としてのリポキシン類似物 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6627658B2 (enExample) |
| EP (2) | EP1406698B1 (enExample) |
| JP (3) | JP2005508282A (enExample) |
| AT (1) | ATE412448T1 (enExample) |
| AU (1) | AU2002252175A1 (enExample) |
| CY (1) | CY1108670T1 (enExample) |
| DE (1) | DE60229640D1 (enExample) |
| DK (1) | DK1406698T3 (enExample) |
| ES (1) | ES2316553T3 (enExample) |
| PT (1) | PT1406698E (enExample) |
| WO (1) | WO2002070068A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1762557B1 (en) | 2000-02-16 | 2011-04-06 | The Brigham And Women's Hospital, Inc. | Aspirin-triggered lipid mediators |
| EP1268393A2 (en) | 2000-03-20 | 2003-01-02 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
| EP1406698B1 (en) * | 2001-03-02 | 2008-10-29 | The Brigham and Women's Hospital | Lipoxin analogs as novel inhibitors of angiogenesis |
| US8722654B2 (en) | 2001-03-02 | 2014-05-13 | The Brigham And Women's Hospital, Inc. | Lipoxin analogs as novel inhibitors of angiogenesis |
| US7902257B2 (en) * | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| AU2003258194B2 (en) * | 2002-08-12 | 2009-11-12 | The Brigham And Women's Hospital, Inc. | Resolvins: biotemplates for therapeutic interventions |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| EP1755537A4 (en) * | 2004-04-14 | 2009-12-09 | Univ Boston | METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA |
| BRPI0517972A (pt) * | 2004-11-09 | 2008-10-21 | Alcon Inc | ácido 5,6,7-triidroxiheptanóico e análogos para o tratamento de doenças oculares e doenças associadas com respostas hiperproliferativas e angiogênicas |
| US8273792B2 (en) | 2005-10-03 | 2012-09-25 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and it's natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| AU2007243282A1 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| MX2009000657A (es) * | 2006-07-19 | 2009-05-28 | Resolvyx Pharmaceuticals Inc | Composiciones y metodos para el tratamiento de mucositis. |
| US20080161274A1 (en) * | 2006-10-26 | 2008-07-03 | Resolvyx Pharmaceuticals, Inc. | Compounds and methods for inhibition of bone loss |
| WO2008070129A2 (en) * | 2006-12-05 | 2008-06-12 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| TW200915984A (en) * | 2007-08-08 | 2009-04-16 | Basf Se | Aqueous microemulsions containing organic insecticide compounds |
| WO2009038671A2 (en) * | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Oxylipin compounds for treating autoimmune diseases |
| EP2214660A2 (en) * | 2007-10-12 | 2010-08-11 | Resolvyx Pharmaceuticals, Inc. | Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for the treatment of ophthalmic conditions |
| US20100324138A1 (en) * | 2007-10-29 | 2010-12-23 | Bazan Nicolas G | Lipoxin A4 Protection for Retinal Cells |
| US7601693B2 (en) * | 2008-02-05 | 2009-10-13 | National Taiwan University | Composition for treating cancer and use thereof |
| US20100105772A1 (en) * | 2008-04-25 | 2010-04-29 | Serhan Charles N | Use of novel lipid mediators to inhibit angiogenesis |
| CA2902232C (en) * | 2013-02-22 | 2020-12-29 | University Of Southern California | Methods for treatment of ophthalmic diseases and disorders |
| JP2016509863A (ja) * | 2013-03-15 | 2016-04-04 | ラーソン、マルクス カーレ、トールレイフＬＡＲＳＳＯＮ， Ｍａｒｃｕｓ Ｋａｒｅ， Ｔｏｒｌｅｉｆ | 細胞、臍帯血収集のための方法及び装置、並びに細胞の単離のための方法及び装置 |
| EP3020398A1 (en) * | 2014-11-17 | 2016-05-18 | Nitto Denko Corporation | Compounds and formulations for reducing scarring |
| CA3026264A1 (en) | 2016-06-03 | 2017-12-07 | Thetis Pharmaceuticals Llc | Compositions and methods relating to salts of specialized pro-resolving mediators |
| WO2018073615A1 (en) | 2016-10-21 | 2018-04-26 | Longboat Explorers Ab | Methods and compositions for generating hematopoietic cells |
| CN110709138A (zh) | 2017-01-31 | 2020-01-17 | 布里格姆及妇女医院股份有限公司 | Alx受体配体定义炎症性疾病的生化内型 |
| US11439615B2 (en) * | 2017-03-09 | 2022-09-13 | University Health Network | Lipoxin and lipoxin analogue mediated neuroprotection and treatments |
| WO2020256628A1 (en) | 2019-06-20 | 2020-12-24 | Amniotics Ab | An apparatus for filtering amniotic fluid |
| JP7714535B2 (ja) | 2019-10-18 | 2025-07-29 | アムニオティクス・アーベー | 羊水およびそれに由来する細胞から羊水間葉系幹細胞を得るためのプロセスならびに装置 |
| US12435308B2 (en) | 2020-11-06 | 2025-10-07 | Amniotics Ab | Immunomodulation by amniotic fluid mesenchymal stem cells |
| WO2023168245A2 (en) | 2022-03-03 | 2023-09-07 | Thetis Pharmaceuticals Llc | Cyclodextrin complexes of specialized proresolving mediators |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4560514A (en) | 1984-05-04 | 1985-12-24 | Bengt Samuelsson | Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds |
| US4576758A (en) | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
| US4780281A (en) | 1985-06-14 | 1988-10-25 | Wayne State University | Method for assay of peroxidase enzyme or reducing substrate activity |
| JPS62198677A (ja) | 1986-02-26 | 1987-09-02 | Nissan Chem Ind Ltd | テトラオ−ル誘導体 |
| JPH0739368B2 (ja) | 1986-10-01 | 1995-05-01 | 旭硝子株式会社 | ２０，２０，２０−トリフルオロアラキドン酸誘導体およびその製造法 |
| CA1329809C (en) | 1987-07-08 | 1994-05-24 | Nissan Chemical Industries, Ltd. | Optically active allyl alcohol and process for producing leucotriene b_ using thereof |
| JPH01228994A (ja) | 1988-03-10 | 1989-09-12 | Fumie Satou | γ−シリルアリルアルコール及びその製造法 |
| US5079261A (en) | 1989-04-28 | 1992-01-07 | Brigham And Women's Hospital | Use of lipoxin a4 and its derivatives as antagonists for slow-reacting substances of anaphylaxis |
| JP2834512B2 (ja) | 1990-01-30 | 1998-12-09 | 帝人株式会社 | リポキシン誘導体を有効成分とする疾患治療剤 |
| US5322699A (en) | 1991-02-04 | 1994-06-21 | The Rockefeller University | Leukocyte-derived CR3 modulator, integrin modulating factor-1 (IMF-1) |
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| JP3227922B2 (ja) | 1993-01-20 | 2001-11-12 | 富士電機株式会社 | 自動販売機 |
| US6048897A (en) * | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| US5441951A (en) | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| DE69435125D1 (de) * | 1993-06-15 | 2008-10-02 | Brigham & Womens Hospital | Lipoxinverbindungen mit verlängerter halbwertszeit |
| WO1995001179A1 (en) * | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| US5750354A (en) | 1994-03-11 | 1998-05-12 | Brigham And Women's Hospital | Lipoxin transport system and uses therefor |
| DE69703121D1 (de) * | 1996-10-25 | 2000-10-19 | Us Health | Verfahren und zusammensetzungen zur verhinderung von entzündungen und angiogenese enthaltend säugetieren cd97 alpha untereinheit |
| US5837283A (en) * | 1997-03-12 | 1998-11-17 | The Regents Of The University Of California | Cationic lipid compositions targeting angiogenic endothelial cells |
| JP2002522540A (ja) * | 1998-08-13 | 2002-07-23 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体拮抗薬 |
| CA2615917C (en) * | 1999-03-18 | 2011-10-04 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha)initiated neutrophil response |
| CA2365204C (en) * | 1999-03-18 | 2009-10-27 | Brigham And Women's Hospital | Lipoxin compounds and their use |
| EP1762557B1 (en) * | 2000-02-16 | 2011-04-06 | The Brigham And Women's Hospital, Inc. | Aspirin-triggered lipid mediators |
| EP1268393A2 (en) | 2000-03-20 | 2003-01-02 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
| EP1406698B1 (en) | 2001-03-02 | 2008-10-29 | The Brigham and Women's Hospital | Lipoxin analogs as novel inhibitors of angiogenesis |
-
2002
- 2002-03-01 EP EP02721234A patent/EP1406698B1/en not_active Expired - Lifetime
- 2002-03-01 PT PT02721234T patent/PT1406698E/pt unknown
- 2002-03-01 EP EP10003357A patent/EP2221089A1/en not_active Ceased
- 2002-03-01 US US10/086,609 patent/US6627658B2/en not_active Expired - Fee Related
- 2002-03-01 ES ES02721234T patent/ES2316553T3/es not_active Expired - Lifetime
- 2002-03-01 AU AU2002252175A patent/AU2002252175A1/en not_active Abandoned
- 2002-03-01 AT AT02721234T patent/ATE412448T1/de active
- 2002-03-01 JP JP2002569237A patent/JP2005508282A/ja not_active Withdrawn
- 2002-03-01 DE DE60229640T patent/DE60229640D1/de not_active Expired - Lifetime
- 2002-03-01 DK DK02721234T patent/DK1406698T3/da active
- 2002-03-01 WO PCT/US2002/006404 patent/WO2002070068A2/en not_active Ceased
-
2003
- 2003-07-08 US US10/615,361 patent/US20040053998A1/en not_active Abandoned
-
2005
- 2005-09-08 US US11/222,458 patent/US8008282B2/en not_active Expired - Fee Related
-
2007
- 2007-08-13 US US11/837,657 patent/US20080064749A1/en not_active Abandoned
-
2008
- 2008-12-29 CY CY20081101498T patent/CY1108670T1/el unknown
-
2009
- 2009-11-09 JP JP2009256184A patent/JP5302856B2/ja not_active Expired - Fee Related
-
2012
- 2012-09-05 JP JP2012195046A patent/JP2012255025A/ja not_active Ceased
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